BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
1561099	CCC1(c2ccc(F)cc2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			778685	US20250313563, Compound 772965	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778685	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778685&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561100	CCC1(c2ccc(F)cc2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			778685	US20250313563, Compound 772965	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778685	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778685&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561101	CCC1(c2cccc(S(=O)(=O)C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778686	US20250313563, Compound 947396	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778686	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778686&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561102	CCC1(c2cccc(S(=O)(=O)C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778686	US20250313563, Compound 947396	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778686	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778686&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561103	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)[C@]21CCc2cc(F)ccc21			778687	US20250313563, Compound 782424	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778687	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778687&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561104	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)[C@]21CCc2cc(F)ccc21			778687	US20250313563, Compound 782424	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778687	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778687&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561105	CCC1(c2cccc(-c3ccnc(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778688	US20250313563, Compound 947399	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778688	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778688&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561106	CCC1(c2cccc(-c3ccnc(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778688	US20250313563, Compound 947399	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778688	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778688&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561107	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)[C@@]21CCc2cc(F)ccc21			778689	US20250313563, Compound 782425	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778689	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778689&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561108	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)[C@@]21CCc2cc(F)ccc21			778689	US20250313563, Compound 782425	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778689	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778689&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561109	CCC1(c2cccc(-c3cc(C)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778690	US20250313563, Compound 947401	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778690	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778690&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561110	CCC1(c2cccc(-c3cc(C)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778690	US20250313563, Compound 947401	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778690	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778690&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561111	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)C21CCc2ccc(F)cc21			778691	US20250313563, Compound 784440	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778691	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778691&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561112	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)C21CCc2ccc(F)cc21			778691	US20250313563, Compound 784440	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778691	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778691&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561113	CCC1(c2cccc(-c3ccnc(C)c3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778692	US20250313563, Compound 947402	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778692	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778692&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561114	CCC1(c2cccc(-c3ccnc(C)c3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778692	US20250313563, Compound 947402	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778692	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778692&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561115	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(C)c1cc(F)cc(F)c1			778693	US20250313563, Compound 785735	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778693	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778693&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561116	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(C)c1cc(F)cc(F)c1			778693	US20250313563, Compound 785735	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778693	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778693&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561117	CCC1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778694	US20250313563, Compound 947403	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778694	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778694&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561118	CCC1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778694	US20250313563, Compound 947403	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778694	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778694&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561119	Cc1cccc(C2(C)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)c1			778695	US20250313563, Compound 785736	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778695	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778695&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561120	Cc1cccc(C2(C)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)c1			778695	US20250313563, Compound 785736	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778695	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778695&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561121	CCC1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)NC2=O)Nc2[nH]nc(C(F)(F)F)c21			778696	US20250313563, Compound 947404	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778696	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778696&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561122	CCC1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)NC2=O)Nc2[nH]nc(C(F)(F)F)c21			778696	US20250313563, Compound 947404	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778696	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778696&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561123	CCC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CC1(CCCC1)C2			778697	US20250313563, Compound 785737	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778697	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778697&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561124	CCC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CC1(CCCC1)C2			778697	US20250313563, Compound 785737	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778697	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778697&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561125	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778698	US20250313563, Compound 947405	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778698	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778698&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561126	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778698	US20250313563, Compound 947405	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778698	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778698&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561127	CCC1(c2cccc(C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778699	US20250313563, Compound 785738	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778699	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778699&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561128	CCC1(c2cccc(C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778699	US20250313563, Compound 785738	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778699	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778699&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561129	CC[C@@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778700	US20250313563, Compound 947408	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778700	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778700&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561130	CC[C@@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778700	US20250313563, Compound 947408	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778700	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778700&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561131	CCC1(c2ccc(C)cc2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			778701	US20250313563, Compound 785739	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778701	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778701&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561132	CCC1(c2ccc(C)cc2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			778701	US20250313563, Compound 785739	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778701	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778701&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561133	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778702	US20250313563, Compound 947409	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778702	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778702&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561134	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778702	US20250313563, Compound 947409	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778702	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778702&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561135	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778703	US20250313563, Compound 785762	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778703	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778703&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561136	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778703	US20250313563, Compound 785762	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778703	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778703&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561137	CC[C@@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778704	US20250313563, Compound 947410	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778704	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778704&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561138	CC[C@@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778704	US20250313563, Compound 947410	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778704	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778704&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561139	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			778705	US20250313563, Compound 789009	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778705	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778705&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561140	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			778705	US20250313563, Compound 789009	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778705	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778705&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561141	CC[C@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778706	US20250313563, Compound 947413	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778706	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778706&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561142	CC[C@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778706	US20250313563, Compound 947413	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778706	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778706&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561143	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			778707	US20250313563, Compound 789010	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778707	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778707&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561144	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			778707	US20250313563, Compound 789010	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778707	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778707&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561145	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778708	US20250313563, Compound 947414	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778708	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778708&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561146	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778708	US20250313563, Compound 947414	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778708	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778708&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561147	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			778709	US20250313563, Compound 789011	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778709	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778709&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561148	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			778709	US20250313563, Compound 789011	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778709	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778709&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561149	CC[C@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778710	US20250313563, Compound 947415	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778710	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778710&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561150	CC[C@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778710	US20250313563, Compound 947415	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778710	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778710&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561151	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			778711	US20250313563, Compound 789013	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778711	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778711&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561152	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			778711	US20250313563, Compound 789013	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778711	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778711&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561153	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cccnc1)CC2			778712	US20250313563, Compound 947432	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778712	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778712&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561154	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cccnc1)CC2			778712	US20250313563, Compound 947432	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778712	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778712&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561155	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(C)c1cccc(Br)c1			778713	US20250313563, Compound 789277	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778713	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778713&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561156	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(C)c1cccc(Br)c1			778713	US20250313563, Compound 789277	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778713	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778713&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561157	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cccnc1)CC2			778714	US20250313563, Compound 947433	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778714	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778714&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561158	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cccnc1)CC2			778714	US20250313563, Compound 947433	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778714	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778714&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561159	CCC1(c2cccc(Br)c2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			778715	US20250313563, Compound 789312	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778715	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778715&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561160	CCC1(c2cccc(Br)c2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			778715	US20250313563, Compound 789312	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778715	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778715&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561161	CCC1(c2cccc(S(=O)(=O)C3CC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778716	US20250313563, Compound 947562	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778716	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778716&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561162	CCC1(c2cccc(S(=O)(=O)C3CC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778716	US20250313563, Compound 947562	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778716	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778716&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561163	CCC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CC1(CC1)C2			778717	US20250313563, Compound 789330	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778717	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778717&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561164	CCC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CC1(CC1)C2			778717	US20250313563, Compound 789330	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778717	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778717&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561165	CCC1(c2cccc(-c3ccnc(C)c3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778718	US20250313563, Compound 947563	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778718	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778718&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561166	CCC1(c2cccc(-c3ccnc(C)c3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778718	US20250313563, Compound 947563	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778718	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778718&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561167	C[C@@H]1CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]2(C)c1ccccc1			778719	US20250313563, Compound 789331	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778719	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778719&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561168	C[C@@H]1CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]2(C)c1ccccc1			778719	US20250313563, Compound 789331	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778719	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778719&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561169	CCC5(c2cccc(N1CCOCC1)c2)C3=C(CC(C)(C)NC3=O)NC4N=NC(C)=C45			778720	US20250313563, Compound 947564	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778720	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778720&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177893558	523297066							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561170	CCC5(c2cccc(N1CCOCC1)c2)C3=C(CC(C)(C)NC3=O)NC4N=NC(C)=C45			778720	US20250313563, Compound 947564	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778720	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778720&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177893558	523297066							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561171	C[C@H]1CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]2(C)c1ccccc1			778721	US20250313563, Compound 789332	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778721	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778721&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561172	C[C@H]1CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]2(C)c1ccccc1			778721	US20250313563, Compound 789332	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778721	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778721&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561173	CCC1(c2cccc(-c3cncn3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778722	US20250313563, Compound 947565	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778722	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778722&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561174	CCC1(c2cccc(-c3cncn3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778722	US20250313563, Compound 947565	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778722	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778722&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561175	C[C@@H]1CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]2(C)c1ccccc1			778723	US20250313563, Compound 789333	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778723	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778723&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561176	C[C@@H]1CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]2(C)c1ccccc1			778723	US20250313563, Compound 789333	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778723	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778723&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561177	CCC1(c2cccc(N3CCCCC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778724	US20250313563, Compound 947566	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778724	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778724&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561178	CCC1(c2cccc(N3CCCCC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778724	US20250313563, Compound 947566	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778724	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778724&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561179	C[C@H]1CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]2(C)c1ccccc1			778725	US20250313563, Compound 789334	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778725	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778725&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561180	C[C@H]1CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]2(C)c1ccccc1			778725	US20250313563, Compound 789334	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778725	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778725&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561181	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778726	US20250313563, Compound 947567	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778726	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778726&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561182	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778726	US20250313563, Compound 947567	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778726	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778726&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561183	CCC1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778727	US20250313563, Compound 947568	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778727	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778727&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561184	CCC1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778727	US20250313563, Compound 947568	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778727	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778727&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561185	CCC1(c2cccc(Cl)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			778728	US20250313563, Compound 789336	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778728	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778728&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561186	CCC1(c2cccc(Cl)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			778728	US20250313563, Compound 789336	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778728	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778728&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561187	CC[C@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778729	US20250313563, Compound 947573	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778729	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778729&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561188	CC[C@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778729	US20250313563, Compound 947573	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778729	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778729&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561189	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(C)c1cc(Cl)cc(Cl)c1			778730	US20250313563, Compound 789337	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778730	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778730&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561190	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(C)c1cc(Cl)cc(Cl)c1			778730	US20250313563, Compound 789337	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778730	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778730&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561191	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778731	US20250313563, Compound 947574	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778731	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778731&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561192	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778731	US20250313563, Compound 947574	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778731	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778731&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561193	CC[C@]1(c2ccc(C)cc2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778732	US20250313563, Compound 789457	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778732	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778732&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561194	CC[C@]1(c2ccc(C)cc2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778732	US20250313563, Compound 789457	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778732	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778732&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561195	CC[C@@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778733	US20250313563, Compound 947575	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778733	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778733&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561196	CC[C@@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778733	US20250313563, Compound 947575	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778733	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778733&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561197	CC[C@@]1(c2ccc(C)cc2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778734	US20250313563, Compound 789458	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778734	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778734&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561198	CC[C@@]1(c2ccc(C)cc2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778734	US20250313563, Compound 789458	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778734	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778734&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561199	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778735	US20250313563, Compound 947576	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778735	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778735&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561200	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778735	US20250313563, Compound 947576	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778735	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778735&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561201	CCC1(c2ccccc2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778736	US20250313563, Compound 789459	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778736	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778736&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561202	CCC1(c2ccccc2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778736	US20250313563, Compound 789459	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778736	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778736&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561203	CCC1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778737	US20250313563, Compound 947673	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778737	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778737&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561204	CCC1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778737	US20250313563, Compound 947673	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778737	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778737&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561205	CC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CC1(CCCC1)C2			778738	US20250313563, Compound 789460	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778738	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778738&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561206	CC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CC1(CCCC1)C2			778738	US20250313563, Compound 789460	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778738	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778738&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561207	CCC1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778739	US20250313563, Compound 947674	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778739	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778739&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561208	CCC1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778739	US20250313563, Compound 947674	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778739	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778739&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561209	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(c1ccccc1)c1ccccc1			778740	US20250313563, Compound 789461	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778740	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778740&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561210	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(c1ccccc1)c1ccccc1			778740	US20250313563, Compound 789461	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778740	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778740&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561211	CCC1(c2cccc(-c3ccnc4c3CCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778741	US20250313563, Compound 947675	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778741	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778741&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561212	CCC1(c2cccc(-c3ccnc4c3CCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778741	US20250313563, Compound 947675	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778741	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778741&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561213	CCC1(c2cccc(-c3ccnc4c3CCC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778742	US20250313563, Compound 947676	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778742	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778742&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561214	CCC1(c2cccc(-c3ccnc4c3CCC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778742	US20250313563, Compound 947676	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778742	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778742&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561215	CCC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CCC2			778743	US20250313563, Compound 789497	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778743	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778743&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561216	CCC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CCC2			778743	US20250313563, Compound 789497	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778743	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778743&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561217	CCC1(c2cccc(C3=CN=NC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778744	US20250313563, Compound 947677	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778744	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778744&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561218	CCC1(c2cccc(C3=CN=NC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778744	US20250313563, Compound 947677	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778744	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778744&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561219	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)[C@]21CCc2ccc(F)cc21			778745	US20250313563, Compound 789504	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778745	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778745&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561220	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)[C@]21CCc2ccc(F)cc21			778745	US20250313563, Compound 789504	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778745	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778745&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561221	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccc(F)cc1)CC2			778746	US20250313563, Compound 947748	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778746	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778746&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561222	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccc(F)cc1)CC2			778746	US20250313563, Compound 947748	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778746	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778746&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561223	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)[C@@]21CCc2ccc(F)cc21			778747	US20250313563, Compound 789505	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778747	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778747&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561224	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)[C@@]21CCc2ccc(F)cc21			778747	US20250313563, Compound 789505	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778747	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778747&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561225	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778748	US20250313563, Compound 947798	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778748	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778748&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561226	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778748	US20250313563, Compound 947798	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778748	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778748&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561227	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(C)c1cccc(-c2ccccc2)c1			778749	US20250313563, Compound 789513	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778749	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778749&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561228	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(C)c1cccc(-c2ccccc2)c1			778749	US20250313563, Compound 789513	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778749	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778749&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561229	CCC1(c2cccc(S(C)(=O)=O)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778750	US20250313563, Compound 947799	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778750	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778750&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561230	CCC1(c2cccc(S(C)(=O)=O)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778750	US20250313563, Compound 947799	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778750	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778750&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561231	CCC1(c2cccc(-c3ccccc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778751	US20250313563, Compound 789514	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778751	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778751&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561232	CCC1(c2cccc(-c3ccccc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778751	US20250313563, Compound 789514	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778751	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778751&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561233	CCC1(c2cccc(S(=O)(=O)C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778752	US20250313563, Compound 947800	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778752	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778752&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561234	CCC1(c2cccc(S(=O)(=O)C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778752	US20250313563, Compound 947800	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778752	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778752&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561235	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)C21CCc2c(F)cccc21			778753	US20250313563, Compound 789524	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778753	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778753&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561236	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)C21CCc2c(F)cccc21			778753	US20250313563, Compound 789524	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778753	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778753&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561237	CCC1(c2cccc(-c3cnn4c3CCCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778754	US20250313563, Compound 947801	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778754	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778754&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561238	CCC1(c2cccc(-c3cnn4c3CCCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778754	US20250313563, Compound 947801	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778754	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778754&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561239	CC[C@]1(c2cccc(C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778755	US20250313563, Compound 789560	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778755	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778755&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561240	CC[C@]1(c2cccc(C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778755	US20250313563, Compound 789560	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778755	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778755&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561241	CC[C@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778756	US20250313563, Compound 947803	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778756	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778756&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561242	CC[C@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778756	US20250313563, Compound 947803	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778756	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778756&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561243	CC[C@@]1(c2cccc(C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778757	US20250313563, Compound 789561	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778757	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778757&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561244	CC[C@@]1(c2cccc(C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778757	US20250313563, Compound 789561	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778757	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778757&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561245	CC[C@]1(c2cccc(-c3cc(C)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778758	US20250313563, Compound 947804	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778758	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778758&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561246	CC[C@]1(c2cccc(-c3cc(C)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778758	US20250313563, Compound 947804	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778758	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778758&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561247	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC1(CCCC1)C2			778759	US20250313563, Compound 789562	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778759	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778759&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561248	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC1(CCCC1)C2			778759	US20250313563, Compound 789562	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778759	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778759&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561249	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778760	US20250313563, Compound 947805	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778760	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778760&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561250	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778760	US20250313563, Compound 947805	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778760	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778760&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561251	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC1(CCCC1)C2			778761	US20250313563, Compound 789563	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778761	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778761&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561252	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC1(CCCC1)C2			778761	US20250313563, Compound 789563	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778761	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778761&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561253	CC[C@@]1(c2cccc(-c3cncn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778762	US20250313563, Compound 947806	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778762	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778762&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561254	CC[C@@]1(c2cccc(-c3cncn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778762	US20250313563, Compound 947806	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778762	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778762&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561255	CCC1(c2cccc(Cl)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778763	US20250313563, Compound 789564	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778763	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778763&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561256	CCC1(c2cccc(Cl)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778763	US20250313563, Compound 789564	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778763	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778763&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561257	CC[C@]1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778764	US20250313563, Compound 947807	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778764	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778764&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561258	CC[C@]1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778764	US20250313563, Compound 947807	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778764	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778764&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561259	CCC1(c2cccc(C)c2)C2=C(N=NC2)NC2=C1C(=O)CC1(CCCC1)C2			778765	US20250313563, Compound 789565	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778765	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778765&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561260	CCC1(c2cccc(C)c2)C2=C(N=NC2)NC2=C1C(=O)CC1(CCCC1)C2			778765	US20250313563, Compound 789565	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778765	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778765&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561261	CC[C@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778766	US20250313563, Compound 947809	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778766	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778766&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561262	CC[C@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778766	US20250313563, Compound 947809	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778766	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778766&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561263	CCC1(c2cccc(Cl)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778767	US20250313563, Compound 789566	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778767	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778767&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561264	CCC1(c2cccc(Cl)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778767	US20250313563, Compound 789566	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778767	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778767&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561265	CC[C@]1(c2cccc(S(C)(=O)=O)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778768	US20250313563, Compound 947811	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778768	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778768&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561266	CC[C@]1(c2cccc(S(C)(=O)=O)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778768	US20250313563, Compound 947811	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778768	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778768&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561267	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)C21CCc2cccc(F)c21			778769	US20250313563, Compound 789583	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778769	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778769&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561268	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)C21CCc2cccc(F)c21			778769	US20250313563, Compound 789583	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778769	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778769&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561269	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778770	US20250313563, Compound 947812	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778770	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778770&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561270	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778770	US20250313563, Compound 947812	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778770	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778770&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561271	CCC1(c2cccc(C(F)(F)F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778771	US20250313563, Compound 789584	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778771	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778771&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561272	CCC1(c2cccc(C(F)(F)F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778771	US20250313563, Compound 789584	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778771	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778771&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561273	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778772	US20250313563, Compound 947814	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778772	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778772&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561274	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778772	US20250313563, Compound 947814	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778772	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778772&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561275	CC[C@@]1(c2cccc(Cl)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			778773	US20250313563, Compound 790611	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778773	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778773&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561276	CC[C@@]1(c2cccc(Cl)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			778773	US20250313563, Compound 790611	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778773	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778773&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561277	CC[C@@]1(c2cccc(S(C)(=O)=O)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778774	US20250313563, Compound 947815	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778774	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778774&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561278	CC[C@@]1(c2cccc(S(C)(=O)=O)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778774	US20250313563, Compound 947815	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778774	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778774&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561279	CC[C@]1(c2cccc(Cl)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			778775	US20250313563, Compound 790612	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778775	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778775&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561280	CC[C@]1(c2cccc(Cl)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			778775	US20250313563, Compound 790612	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778775	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778775&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561281	CC[C@@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778776	US20250313563, Compound 947817	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778776	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778776&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561282	CC[C@@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778776	US20250313563, Compound 947817	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778776	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778776&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561283	CC[C@@]1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778777	US20250313563, Compound 947819	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778777	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778777&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561284	CC[C@@]1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778777	US20250313563, Compound 947819	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778777	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778777&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561285	CC[C@@]1(c2cccc(-c3cncn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778778	US20250313563, Compound 947820	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778778	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778778&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561286	CC[C@@]1(c2cccc(-c3cncn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778778	US20250313563, Compound 947820	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778778	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778778&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561287	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC1(CC1)C2			778779	US20250313563, Compound 790615	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778779	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778779&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561288	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC1(CC1)C2			778779	US20250313563, Compound 790615	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778779	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778779&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561289	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778780	US20250313563, Compound 947821	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778780	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778780&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561290	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778780	US20250313563, Compound 947821	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778780	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778780&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561291	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC1(CC1)C2			778781	US20250313563, Compound 790616	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778781	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778781&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561292	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC1(CC1)C2			778781	US20250313563, Compound 790616	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778781	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778781&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561293	CC[C@@]1(c2cccc(-c3cc(C)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778782	US20250313563, Compound 947822	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778782&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561294	CC[C@@]1(c2cccc(-c3cc(C)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778782	US20250313563, Compound 947822	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778782&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561295	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC1(CCCC1)C2			778783	US20250313563, Compound 790617	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778783	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778783&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561296	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC1(CCCC1)C2			778783	US20250313563, Compound 790617	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778783	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778783&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561297	CC[C@@]1(c2cccc(S(=O)(=O)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778784	US20250313563, Compound 947823	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778784	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778784&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561298	CC[C@@]1(c2cccc(S(=O)(=O)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778784	US20250313563, Compound 947823	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778784	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778784&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561299	CC[C@]1(c2cccc(N(C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778785	US20250313563, Compound 947825	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778785&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561300	CC[C@]1(c2cccc(N(C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778785	US20250313563, Compound 947825	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778785&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561301	CCC1(c2ccn(C)n2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			778786	US20250313563, Compound 790619	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778786	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778786&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561302	CCC1(c2ccn(C)n2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			778786	US20250313563, Compound 790619	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778786	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778786&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561303	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778787	US20250313563, Compound 947826	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778787	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778787&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561304	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778787	US20250313563, Compound 947826	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778787	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778787&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561305	CC1(C)CC(=O)C2=C(C1)NC1N=NC(C(F)(F)F)=C1C21CCCOc2ccccc21			778788	US20250313563, Compound 790632	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778788	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778788&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561306	CC1(C)CC(=O)C2=C(C1)NC1N=NC(C(F)(F)F)=C1C21CCCOc2ccccc21			778788	US20250313563, Compound 790632	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778788	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778788&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561307	CC1(C)CC2=C(C(=O)N1)C1(CCN(S(=O)(=O)c3cnn(C(C)(C)C)c3)CC1)C1=C(N=NC1)N2			778789	US20250313563, Compound 947835	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778789	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778789&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561308	CC1(C)CC2=C(C(=O)N1)C1(CCN(S(=O)(=O)c3cnn(C(C)(C)C)c3)CC1)C1=C(N=NC1)N2			778789	US20250313563, Compound 947835	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778789	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778789&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561309	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(C)c1cccc(-c2ccncc2)c1			778790	US20250313563, Compound 790730	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778790	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778790&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561310	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(C)c1cccc(-c2ccncc2)c1			778790	US20250313563, Compound 790730	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778790	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778790&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561311	CCn1ccc(S(=O)(=O)N2CCC3(CC2)C2=CN=NC2NC2=C3C(=O)NC(C)(C)C2)n1			778791	US20250313563, Compound 947836	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778791	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778791&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561312	CCn1ccc(S(=O)(=O)N2CCC3(CC2)C2=CN=NC2NC2=C3C(=O)NC(C)(C)C2)n1			778791	US20250313563, Compound 947836	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778791	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778791&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561313	CC[C@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778792	US20250313563, Compound 790733	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778792	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778792&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561314	CC[C@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778792	US20250313563, Compound 790733	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778792	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778792&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561315	CCc1ncc(S(=O)(=O)N2CCC3(CC2)C2=CN=NC2NC2=C3C(=O)NC(C)(C)C2)s1			778793	US20250313563, Compound 947837	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778793	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778793&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561316	CCc1ncc(S(=O)(=O)N2CCC3(CC2)C2=CN=NC2NC2=C3C(=O)NC(C)(C)C2)s1			778793	US20250313563, Compound 947837	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778793	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778793&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561317	CC[C@@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778794	US20250313563, Compound 790734	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778794	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778794&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561318	CC[C@@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778794	US20250313563, Compound 790734	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778794	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778794&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561319	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778795	US20250313563, Compound 947858	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778795	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778795&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561320	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778795	US20250313563, Compound 947858	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778795	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778795&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561321	CC1(C)CC(=O)C2=C(C1)NC1N=NC(C(F)(F)F)=C1C21CCCc2ccccc21			778796	US20250313563, Compound 790745	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778796	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778796&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561322	CC1(C)CC(=O)C2=C(C1)NC1N=NC(C(F)(F)F)=C1C21CCCc2ccccc21			778796	US20250313563, Compound 790745	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778796	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778796&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561323	CCC1(c2cccc(S(=O)(=O)C3CC3)c2)C2=C(CC(C)(C)NC2=O)NC2=C1C(C(F)(F)F)N=N2			778797	US20250313563, Compound 947859	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778797	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778797&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561324	CCC1(c2cccc(S(=O)(=O)C3CC3)c2)C2=C(CC(C)(C)NC2=O)NC2=C1C(C(F)(F)F)N=N2			778797	US20250313563, Compound 947859	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778797	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778797&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561325	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778798	US20250313563, Compound 790754	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778798&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561326	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778798	US20250313563, Compound 790754	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778798&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561327	CCC1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778799	US20250313563, Compound 947860	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778799	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778799&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561328	CCC1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778799	US20250313563, Compound 947860	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778799	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778799&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561329	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778800	US20250313563, Compound 790755	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778800	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778800&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561330	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778800	US20250313563, Compound 790755	Glycogen synthase kinase-3 beta	Homo sapiens		>1700							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778800	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778800&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561331	CCC1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778801	US20250313563, Compound 947861	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778801	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778801&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561332	CCC1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778801	US20250313563, Compound 947861	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778801	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778801&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561333	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)[C@]21CCc2c(F)cccc21			778802	US20250313563, Compound 791256	Glycogen synthase kinase-3 alpha	Homo sapiens		>1700							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778802	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778802&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561334	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)[C@]21CCc2c(F)cccc21			778802	US20250313563, Compound 791256	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778802	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778802&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561335	CCC1(c2cccc(-c3ccnc4c3CCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778803	US20250313563, Compound 947862	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778803	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778803&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561336	CCC1(c2cccc(-c3ccnc4c3CCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778803	US20250313563, Compound 947862	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778803	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778803&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561337	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)[C@@]21CCc2c(F)cccc21			778804	US20250313563, Compound 791257	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778804	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778804&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561338	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)[C@@]21CCc2c(F)cccc21			778804	US20250313563, Compound 791257	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778804	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778804&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561339	CCC1(c2cccc(N3CCOCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778805	US20250313563, Compound 947863	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778805	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778805&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561340	CCC1(c2cccc(N3CCOCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778805	US20250313563, Compound 947863	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778805	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778805&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561341	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@H](c1ccccc1)C2			778806	US20250313563, Compound 791262	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778806&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561342	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@H](c1ccccc1)C2			778806	US20250313563, Compound 791262	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778806&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561343	CCC1(c2cccc(C(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778807	US20250313563, Compound 947864	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778807&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561344	CCC1(c2cccc(C(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778807	US20250313563, Compound 947864	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778807&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561345	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@H](c1ccccc1)C2			778808	US20250313563, Compound 791263	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778808	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778808&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561346	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@H](c1ccccc1)C2			778808	US20250313563, Compound 791263	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778808	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778808&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561347	CCC1(c2cccc(C(F)F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778809	US20250313563, Compound 947865	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778809	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778809&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561348	CCC1(c2cccc(C(F)F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778809	US20250313563, Compound 947865	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778809	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778809&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561349	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@H](c1ccccc1)C2			778810	US20250313563, Compound 791264	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778810	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778810&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561350	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@H](c1ccccc1)C2			778810	US20250313563, Compound 791264	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778810	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778810&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561351	CCC1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778811	US20250313563, Compound 947866	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778811	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778811&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561352	CCC1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778811	US20250313563, Compound 947866	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778811	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778811&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561353	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@H](c1ccccc1)C2			778812	US20250313563, Compound 791265	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778812	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778812&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561354	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@H](c1ccccc1)C2			778812	US20250313563, Compound 791265	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778812	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778812&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561355	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778813	US20250313563, Compound 947869	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778813&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561356	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778813	US20250313563, Compound 947869	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778813&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561357	CCC1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778814	US20250313563, Compound 791271	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778814	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778814&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561358	CCC1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778814	US20250313563, Compound 791271	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778814	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778814&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561359	CC[C@]1(c2cccc(S(=O)(=O)C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2=C1C(C)N=N2			778815	US20250313563, Compound 947870	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778815	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778815&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561360	CC[C@]1(c2cccc(S(=O)(=O)C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2=C1C(C)N=N2			778815	US20250313563, Compound 947870	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778815	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778815&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561361	CCC1(c2cccc(-c3cccnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778816	US20250313563, Compound 791272	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778816	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778816&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561362	CCC1(c2cccc(-c3cccnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778816	US20250313563, Compound 791272	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778816	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778816&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561363	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778817	US20250313563, Compound 947871	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778817	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778817&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561364	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778817	US20250313563, Compound 947871	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778817	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778817&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561365	CCC4(c2cccc(C1CCOCC1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			778818	US20250313563, Compound 791273	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778818	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778818&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177893655	523297164							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561366	CCC4(c2cccc(C1CCOCC1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			778818	US20250313563, Compound 791273	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778818	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778818&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177893655	523297164							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561367	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778819	US20250313563, Compound 947874	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778819&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561368	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778819	US20250313563, Compound 947874	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778819&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561369	CC[C@@]1(c2cccc(S(=O)(=O)C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778820	US20250313563, Compound 947876	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778820	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778820&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561370	CC[C@@]1(c2cccc(S(=O)(=O)C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778820	US20250313563, Compound 947876	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778820	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778820&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561371	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778821	US20250313563, Compound 947877	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778821	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778821&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561372	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778821	US20250313563, Compound 947877	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778821	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778821&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561373	C[C@]1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CC1(CCCC1)C2			778822	US20250313563, Compound 792338	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778822	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778822&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561374	C[C@]1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CC1(CCCC1)C2			778822	US20250313563, Compound 792338	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778822	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778822&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561375	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@](C)(COC)C2			778823	US20250313563, Compound 947905	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778823	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778823&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561376	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@](C)(COC)C2			778823	US20250313563, Compound 947905	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778823	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778823&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561377	C[C@@]1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CC1(CCCC1)C2			778824	US20250313563, Compound 792339	Glycogen synthase kinase-3 alpha	Homo sapiens		>1700							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778824	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778824&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561378	C[C@@]1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CC1(CCCC1)C2			778824	US20250313563, Compound 792339	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778824	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778824&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561379	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@@](C)(C[IH]C)C2			778825	US20250313563, Compound 947906	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778825	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778825&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561380	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@@](C)(C[IH]C)C2			778825	US20250313563, Compound 947906	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778825	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778825&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561381	CC[C@@]1(c2ccccc2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778826	US20250313563, Compound 792340	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778826&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561382	CC[C@@]1(c2ccccc2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778826	US20250313563, Compound 792340	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778826&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561383	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@@](C)(COC)C2			778827	US20250313563, Compound 947907	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778827	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778827&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561384	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@@](C)(COC)C2			778827	US20250313563, Compound 947907	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778827	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778827&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561385	CC[C@]1(c2ccccc2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778828	US20250313563, Compound 792341	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778828	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778828&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561386	CC[C@]1(c2ccccc2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778828	US20250313563, Compound 792341	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778828	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778828&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561387	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@](C)(COC)C2			778829	US20250313563, Compound 947908	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778829	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778829&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561388	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@](C)(COC)C2			778829	US20250313563, Compound 947908	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778829	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778829&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561389	COc1cccc(C2(C)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)c1			778830	US20250313563, Compound 792342	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778830	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778830&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561390	COc1cccc(C2(C)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)c1			778830	US20250313563, Compound 792342	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778830	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778830&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561391	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCCOC1)C2			778831	US20250313563, Compound 947909	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778831	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778831&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561392	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCCOC1)C2			778831	US20250313563, Compound 947909	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778831	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778831&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561393	CCC1(c2ccccc2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778832	US20250313563, Compound 792343	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778832	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778832&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561394	CCC1(c2ccccc2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778832	US20250313563, Compound 792343	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778832	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778832&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561395	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCCOC1)C2			778833	US20250313563, Compound 947910	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778833	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778833&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561396	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCCOC1)C2			778833	US20250313563, Compound 947910	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778833	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778833&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561397	CC[C@]1(c2cccc(Cl)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778834	US20250313563, Compound 801308	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778834	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778834&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561398	CC[C@]1(c2cccc(Cl)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778834	US20250313563, Compound 801308	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778834	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778834&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561399	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCCOC1)C2			778835	US20250313563, Compound 947911	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778835	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778835&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561400	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCCOC1)C2			778835	US20250313563, Compound 947911	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778835	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778835&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561401	CC[C@@]1(c2cccc(Cl)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778836	US20250313563, Compound 801309	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778836	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778836&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561402	CC[C@@]1(c2cccc(Cl)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778836	US20250313563, Compound 801309	Glycogen synthase kinase-3 beta	Homo sapiens		>1670							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778836	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778836&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561403	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCCOC1)C2			778837	US20250313563, Compound 947912	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778837	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778837&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561404	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCCOC1)C2			778837	US20250313563, Compound 947912	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778837	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778837&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561405	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC1(CCCC1)C2			778838	US20250313563, Compound 801310	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778838	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778838&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561406	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC1(CCCC1)C2			778838	US20250313563, Compound 801310	Glycogen synthase kinase-3 beta	Homo sapiens		>1670							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778838	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778838&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561407	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCOC1)C2			778839	US20250313563, Compound 948014	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778839	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778839&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561408	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCOC1)C2			778839	US20250313563, Compound 948014	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778839	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778839&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561409	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC1(CCCC1)C2			778840	US20250313563, Compound 801311	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778840&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561410	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC1(CCCC1)C2			778840	US20250313563, Compound 801311	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778840&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561411	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCOC1)C2			778841	US20250313563, Compound 948015	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778841	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778841&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561412	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCOC1)C2			778841	US20250313563, Compound 948015	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778841	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778841&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561413	CC[C@@]1(c2cccc(C)c2)C2=CN=NC2NC2=C1C(=O)CC1(CCCC1)C2			778842	US20250313563, Compound 801312	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778842	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778842&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561414	CC[C@@]1(c2cccc(C)c2)C2=CN=NC2NC2=C1C(=O)CC1(CCCC1)C2			778842	US20250313563, Compound 801312	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778842	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778842&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561415	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCOC1)C2			778843	US20250313563, Compound 948016	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778843	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778843&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561416	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCOC1)C2			778843	US20250313563, Compound 948016	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778843	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778843&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561417	CC[C@]1(c2cccc(C)c2)C2=CN=NC2NC2=C1C(=O)CC1(CCCC1)C2			778844	US20250313563, Compound 801313	Glycogen synthase kinase-3 alpha	Homo sapiens		>1670							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778844	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778844&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561418	CC[C@]1(c2cccc(C)c2)C2=CN=NC2NC2=C1C(=O)CC1(CCCC1)C2			778844	US20250313563, Compound 801313	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778844	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778844&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561419	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCOC1)C2			778845	US20250313563, Compound 948017	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778845&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561420	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCOC1)C2			778845	US20250313563, Compound 948017	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778845&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561421	CC[C@]1(c2cccc(Cl)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778846	US20250313563, Compound 801314	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778846	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778846&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561422	CC[C@]1(c2cccc(Cl)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778846	US20250313563, Compound 801314	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778846	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778846&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561423	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCCC1)C2			778847	US20250313563, Compound 948018	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778847	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778847&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561424	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCCC1)C2			778847	US20250313563, Compound 948018	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778847	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778847&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561425	CC[C@@]1(c2cccc(Cl)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778848	US20250313563, Compound 801315	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778848	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778848&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561426	CC[C@@]1(c2cccc(Cl)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778848	US20250313563, Compound 801315	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778848	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778848&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561427	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCCC1)C2			778849	US20250313563, Compound 948019	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778849&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561428	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCCC1)C2			778849	US20250313563, Compound 948019	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778849&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561429	CCC1(c2cccc(C3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778850	US20250313563, Compound 801316	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778850	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778850&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561430	CCC1(c2cccc(C3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778850	US20250313563, Compound 801316	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778850	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778850&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561431	CC[C@]1(c2cccc(-c3ccncc3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778851	US20250313563, Compound 948020	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778851&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561432	CC[C@]1(c2cccc(-c3ccncc3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778851	US20250313563, Compound 948020	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778851&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561433	CCC1(c2cccc(N3CCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778852	US20250313563, Compound 801317	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778852	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778852&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561434	CCC1(c2cccc(N3CCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778852	US20250313563, Compound 801317	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778852	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778852&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561435	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCCC1)C2			778853	US20250313563, Compound 948021	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778853	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778853&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561436	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCCC1)C2			778853	US20250313563, Compound 948021	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778853	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778853&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561437	CCC4(c2cccc(N1CCOCC1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			778854	US20250313563, Compound 801318	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778854	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778854&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177893691	523297200							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561438	CCC4(c2cccc(N1CCOCC1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			778854	US20250313563, Compound 801318	Glycogen synthase kinase-3 beta	Homo sapiens		>1670							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778854	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778854&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177893691	523297200							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561439	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCCC1)C2			778855	US20250313563, Compound 948022	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778855&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561440	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCCC1)C2			778855	US20250313563, Compound 948022	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778855&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561441	CCC1(c2cccc(N(C)C(C)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778856	US20250313563, Compound 801319	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778856&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561442	CCC1(c2cccc(N(C)C(C)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778856	US20250313563, Compound 801319	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778856&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561443	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cccc(C)c1)CC2			778857	US20250313563, Compound 948052	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778857&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561444	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cccc(C)c1)CC2			778857	US20250313563, Compound 948052	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778857&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561445	CCC1(c2cccc(N3CCCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778858	US20250313563, Compound 801320	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778858&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561446	CCC1(c2cccc(N3CCCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778858	US20250313563, Compound 801320	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778858&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561447	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(COC)C2			778859	US20250313563, Compound 948127	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778859&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561448	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(COC)C2			778859	US20250313563, Compound 948127	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778859&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561449	CCC1(c2cccc(C(F)(F)F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			778860	US20250313563, Compound 801321	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778860&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561450	CCC1(c2cccc(C(F)(F)F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			778860	US20250313563, Compound 801321	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778860&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561451	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCOC1)C2			778861	US20250313563, Compound 948140	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778861&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561452	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCOC1)C2			778861	US20250313563, Compound 948140	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778861&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561453	CCC1(c2cccc(C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778862	US20250313563, Compound 801322	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778862	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778862&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561454	CCC1(c2cccc(C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778862	US20250313563, Compound 801322	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778862	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778862&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561455	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCOC1)C2			778863	US20250313563, Compound 948141	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778863&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561456	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCOC1)C2			778863	US20250313563, Compound 948141	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778863&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561457	CCC1(c2cccc(COC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778864	US20250313563, Compound 801323	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778864&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561458	CCC1(c2cccc(COC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778864	US20250313563, Compound 801323	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778864&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561459	CC[C@@]1(c2cccc(-c3ccncc3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778865	US20250313563, Compound 948142	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778865&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561460	CC[C@@]1(c2cccc(-c3ccncc3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778865	US20250313563, Compound 948142	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778865&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561461	CCC1(c2cccc(Br)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778866	US20250313563, Compound 801324	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778866&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561462	CCC1(c2cccc(Br)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778866	US20250313563, Compound 801324	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778866&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561463	CC[C@@]1(c2cccc(C3=C4CC=C(C)N=C4N=CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778867	US20250313563, Compound 948143	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778867&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561464	CC[C@@]1(c2cccc(C3=C4CC=C(C)N=C4N=CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778867	US20250313563, Compound 948143	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778867&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561465	CC(C)(C)CC1N=NC2=C1[C@@]1(CCc3cccc(F)c31)C1=C(CC(C)(C)CC1=O)N2			778868	US20250313563, Compound 801351	Glycogen synthase kinase-3 alpha	Homo sapiens		>1670							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778868&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561466	CC(C)(C)CC1N=NC2=C1[C@@]1(CCc3cccc(F)c31)C1=C(CC(C)(C)CC1=O)N2			778868	US20250313563, Compound 801351	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778868&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561467	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCCOC1)C2			778869	US20250313563, Compound 948144	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778869&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561468	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCCOC1)C2			778869	US20250313563, Compound 948144	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778869&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561469	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)[C@@]21CCc2cccc(F)c21			778870	US20250313563, Compound 801352	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778870&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561470	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)[C@@]21CCc2cccc(F)c21			778870	US20250313563, Compound 801352	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778870&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561471	CC[C@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778871	US20250313563, Compound 948145	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778871&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561472	CC[C@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778871	US20250313563, Compound 948145	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778871&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561473	CC1(C)CC(=O)C2=C(C1)NC1N=NC(C(F)(F)F)=C1C21CCc2c(F)cccc21			778872	US20250313563, Compound 801356	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778872&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561474	CC1(C)CC(=O)C2=C(C1)NC1N=NC(C(F)(F)F)=C1C21CCc2c(F)cccc21			778872	US20250313563, Compound 801356	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778872&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561475	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCCOC1)C2			778873	US20250313563, Compound 948146	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778873&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561476	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCCOC1)C2			778873	US20250313563, Compound 948146	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778873&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561477	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCc2c(F)cccc21			778874	US20250313563, Compound 801357	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778874&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561478	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCc2c(F)cccc21			778874	US20250313563, Compound 801357	Glycogen synthase kinase-3 beta	Homo sapiens		>1670							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778874&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561479	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(COC)C2			778875	US20250313563, Compound 948147	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778875&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561480	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(COC)C2			778875	US20250313563, Compound 948147	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778875&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561481	CC1(C)CC(=O)C2=C(C1)NC1N=NC(Br)=C1C21CCc2c(F)cccc21			778876	US20250313563, Compound 801358	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778876&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561482	CC1(C)CC(=O)C2=C(C1)NC1N=NC(Br)=C1C21CCc2c(F)cccc21			778876	US20250313563, Compound 801358	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778876&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561483	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCOC1)C2			778877	US20250313563, Compound 948148	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778877&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561484	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCOC1)C2			778877	US20250313563, Compound 948148	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778877&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561485	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]2(C)c1cccc(-c2ccccc2)c1			778878	US20250313563, Compound 801366	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778878&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561486	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]2(C)c1cccc(-c2ccccc2)c1			778878	US20250313563, Compound 801366	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778878&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561487	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCOC1)C2			778879	US20250313563, Compound 948149	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778879	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778879&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561488	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCOC1)C2			778879	US20250313563, Compound 948149	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778879	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778879&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561489	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]2(C)c1cccc(-c2ccccc2)c1			778880	US20250313563, Compound 801367	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778880	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778880&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561490	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]2(C)c1cccc(-c2ccccc2)c1			778880	US20250313563, Compound 801367	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778880	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778880&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561491	CC[C@@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778881	US20250313563, Compound 948150	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778881&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561492	CC[C@@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778881	US20250313563, Compound 948150	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778881&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561493	CC[C@@]1(c2cccc(-c3ccccc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778882	US20250313563, Compound 801368	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778882	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778882&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561494	CC[C@@]1(c2cccc(-c3ccccc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778882	US20250313563, Compound 801368	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778882	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778882&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561495	CC[C@]1(c2cccc(C3=C4CC=C(C)N=C4N=CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778883	US20250313563, Compound 948151	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778883	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778883&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561496	CC[C@]1(c2cccc(C3=C4CC=C(C)N=C4N=CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778883	US20250313563, Compound 948151	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778883	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778883&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561497	CC[C@]1(c2cccc(-c3ccccc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778884	US20250313563, Compound 801369	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778884	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778884&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561498	CC[C@]1(c2cccc(-c3ccccc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778884	US20250313563, Compound 801369	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778884	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778884&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561499	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCCOC1)C2			778885	US20250313563, Compound 948152	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778885	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778885&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561500	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCCOC1)C2			778885	US20250313563, Compound 948152	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778885	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778885&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561501	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)C2			778886	US20250313563, Compound 801397	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778886	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778886&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561502	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)C2			778886	US20250313563, Compound 801397	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778886	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778886&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561503	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCCOC1)C2			778887	US20250313563, Compound 948153	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778887	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778887&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561504	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCCOC1)C2			778887	US20250313563, Compound 948153	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778887	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778887&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561505	CC[C@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778888	US20250313563, Compound 801412	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778888	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778888&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561506	CC[C@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778888	US20250313563, Compound 801412	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778888	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778888&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561507	CCC1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778889	US20250313563, Compound 948175	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778889	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778889&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561508	CCC1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778889	US20250313563, Compound 948175	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778889	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778889&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561509	CC[C@@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778890	US20250313563, Compound 801413	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778890&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561510	CC[C@@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778890	US20250313563, Compound 801413	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778890&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561511	CCC1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778891	US20250313563, Compound 948176	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778891	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778891&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561512	CCC1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778891	US20250313563, Compound 948176	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778891	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778891&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561513	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778892	US20250313563, Compound 801445	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778892&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561514	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778892	US20250313563, Compound 801445	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778892&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561515	CCC1(c2cccc(S(=O)(=O)CC3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778893	US20250313563, Compound 948177	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778893	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778893&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561516	CCC1(c2cccc(S(=O)(=O)CC3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778893	US20250313563, Compound 948177	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778893	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778893&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561517	CCC1(c2cccc(OCCOC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778894	US20250313563, Compound 801446	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778894&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561518	CCC1(c2cccc(OCCOC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778894	US20250313563, Compound 801446	Glycogen synthase kinase-3 beta	Homo sapiens		>1670							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778894&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561519	CCC1(c2cccc(S(=O)(=O)CC3CC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778895	US20250313563, Compound 948178	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778895	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778895&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561520	CCC1(c2cccc(S(=O)(=O)CC3CC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778895	US20250313563, Compound 948178	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778895	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778895&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561521	CCC1(c2cccc(OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778896	US20250313563, Compound 801447	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778896	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778896&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561522	CCC1(c2cccc(OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778896	US20250313563, Compound 801447	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778896	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778896&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561523	CCC1(c2cccc(S(=O)(=O)CC3CC3)c2)C2=C(CC(C)(C)NC2=O)NC2=C1C(C(F)(F)F)N=N2			778897	US20250313563, Compound 948179	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778897&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561524	CCC1(c2cccc(S(=O)(=O)CC3CC3)c2)C2=C(CC(C)(C)NC2=O)NC2=C1C(C(F)(F)F)N=N2			778897	US20250313563, Compound 948179	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778897&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561525	CCC1(c2cccc(OC(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778898	US20250313563, Compound 801448	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778898&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561526	CCC1(c2cccc(OC(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778898	US20250313563, Compound 801448	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778898&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561527	CCC1(c2cccc(-c3cncn3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778899	US20250313563, Compound 948180	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778899&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561528	CCC1(c2cccc(-c3cncn3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778899	US20250313563, Compound 948180	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778899&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561529	CCC1(c2cccc(C(F)(F)F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778900	US20250313563, Compound 802358	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778900	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778900&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561530	CCC1(c2cccc(C(F)(F)F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778900	US20250313563, Compound 802358	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778900	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778900&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561531	CC[C@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778901	US20250313563, Compound 948181	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778901	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778901&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561532	CC[C@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778901	US20250313563, Compound 948181	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778901	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778901&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561533	CC1(C)CC(=O)C2=C(C1)NC1N=NC(C(F)(F)F)=C1[C@@]21CCc2c(F)cccc21			778902	US20250313563, Compound 806568	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778902	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778902&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561534	CC1(C)CC(=O)C2=C(C1)NC1N=NC(C(F)(F)F)=C1[C@@]21CCc2c(F)cccc21			778902	US20250313563, Compound 806568	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778902	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778902&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561535	CC[C@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778903	US20250313563, Compound 948183	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778903	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778903&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561536	CC[C@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778903	US20250313563, Compound 948183	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778903	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778903&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561537	CC1(C)CC(=O)C2=C(C1)NC1N=NC(C(F)(F)F)=C1[C@]21CCc2c(F)cccc21			778904	US20250313563, Compound 806569	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778904	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778904&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561538	CC1(C)CC(=O)C2=C(C1)NC1N=NC(C(F)(F)F)=C1[C@]21CCc2c(F)cccc21			778904	US20250313563, Compound 806569	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778904	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778904&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561539	CC[C@@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778905	US20250313563, Compound 948184	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778905	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778905&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561540	CC[C@@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778905	US20250313563, Compound 948184	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778905	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778905&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561541	Cc1cccc2c1CCC21C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			778906	US20250313563, Compound 806603	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778906&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561542	Cc1cccc2c1CCC21C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			778906	US20250313563, Compound 806603	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778906&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561543	CC[C@@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778907	US20250313563, Compound 948185	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778907&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561544	CC[C@@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778907	US20250313563, Compound 948185	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778907&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561545	CCC1(c2cccc(N3CCNCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778908	US20250313563, Compound 806604	Glycogen synthase kinase-3 alpha	Homo sapiens		>1670							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778908	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778908&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561546	CCC1(c2cccc(N3CCNCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778908	US20250313563, Compound 806604	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778908	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778908&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561547	CC[C@@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778909	US20250313563, Compound 948187	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778909	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778909&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561548	CC[C@@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778909	US20250313563, Compound 948187	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778909	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778909&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561549	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(C)c1cc(Cl)ccc1Cl			778910	US20250313563, Compound 806605	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778910&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561550	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(C)c1cc(Cl)ccc1Cl			778910	US20250313563, Compound 806605	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778910&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561551	CC[C@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778911	US20250313563, Compound 948188	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778911	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778911&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561552	CC[C@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778911	US20250313563, Compound 948188	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778911	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778911&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561553	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@H](C(F)(F)F)C2			778912	US20250313563, Compound 806607	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778912	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778912&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561554	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@H](C(F)(F)F)C2			778912	US20250313563, Compound 806607	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778912	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778912&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561555	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccc(F)cc1)CC2			778913	US20250313563, Compound 948224	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778913	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778913&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561556	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccc(F)cc1)CC2			778913	US20250313563, Compound 948224	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778913	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778913&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561557	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@H](C(F)(F)F)C2			778914	US20250313563, Compound 806608	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778914	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778914&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561558	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@H](C(F)(F)F)C2			778914	US20250313563, Compound 806608	Glycogen synthase kinase-3 beta	Homo sapiens		>1670							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778914	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778914&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561559	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccc(F)cc1)CC2			778915	US20250313563, Compound 948225	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778915	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778915&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561560	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccc(F)cc1)CC2			778915	US20250313563, Compound 948225	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778915	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778915&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561561	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C(F)(F)F)C2			778916	US20250313563, Compound 806609	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778916	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778916&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561562	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C(F)(F)F)C2			778916	US20250313563, Compound 806609	Glycogen synthase kinase-3 beta	Homo sapiens		>1670							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778916	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778916&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561563	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(CCN(c3ccc(OC)cc3)C2=O)NC2N=NC(C)=C21			778917	US20250313563, Compound 948226	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778917	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778917&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561564	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(CCN(c3ccc(OC)cc3)C2=O)NC2N=NC(C)=C21			778917	US20250313563, Compound 948226	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778917	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778917&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561565	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C(F)(F)F)C2			778918	US20250313563, Compound 806611	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778918	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778918&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561566	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C(F)(F)F)C2			778918	US20250313563, Compound 806611	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778918	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778918&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561567	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccc(OC)cc1)CC2			778919	US20250313563, Compound 948227	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778919	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778919&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561568	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccc(OC)cc1)CC2			778919	US20250313563, Compound 948227	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778919	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778919&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561569	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1[C@@]21CCc2c(F)cccc21			778920	US20250313563, Compound 806632	Glycogen synthase kinase-3 alpha	Homo sapiens		>1670							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778920	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778920&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561570	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1[C@@]21CCc2c(F)cccc21			778920	US20250313563, Compound 806632	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778920	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778920&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561571	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cncnc1)CC2			778921	US20250313563, Compound 948238	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778921	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778921&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561572	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cncnc1)CC2			778921	US20250313563, Compound 948238	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778921	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778921&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561573	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCc2c(F)cccc21			778922	US20250313563, Compound 806633	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778922	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778922&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561574	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCc2c(F)cccc21			778922	US20250313563, Compound 806633	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778922	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778922&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561575	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccc(C)cc1)CC2			778923	US20250313563, Compound 948241	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778923	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778923&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561576	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccc(C)cc1)CC2			778923	US20250313563, Compound 948241	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778923	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778923&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561577	CCC1(c2cccc(-c3ccncn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778924	US20250313563, Compound 806637	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778924	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778924&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561578	CCC1(c2cccc(-c3ccncn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778924	US20250313563, Compound 806637	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778924	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778924&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561579	CCC1(c2cccc(OC)c2)C2=C(N=NC2)NC2=C1C(=O)NC(C)(C)C2			778925	US20250313563, Compound 948296	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778925	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778925&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561580	CCC1(c2cccc(OC)c2)C2=C(N=NC2)NC2=C1C(=O)NC(C)(C)C2			778925	US20250313563, Compound 948296	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778925	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778925&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561581	CC1(C)CC(=O)C2=C(C1)NC1N=NC(Br)=C1[C@@]21CCc2c(F)cccc21			778926	US20250313563, Compound 806938	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778926	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778926&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561582	CC1(C)CC(=O)C2=C(C1)NC1N=NC(Br)=C1[C@@]21CCc2c(F)cccc21			778926	US20250313563, Compound 806938	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778926	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778926&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561583	CCC1(c2cccc(-c3ccnc(C)c3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778927	US20250313563, Compound 948297	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778927	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778927&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561584	CCC1(c2cccc(-c3ccnc(C)c3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778927	US20250313563, Compound 948297	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778927	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778927&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561585	CC1(C)CC(=O)C2=C(C1)NC1N=NC(Br)=C1[C@]21CCc2c(F)cccc21			778928	US20250313563, Compound 806939	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778928	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778928&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561586	CC1(C)CC(=O)C2=C(C1)NC1N=NC(Br)=C1[C@]21CCc2c(F)cccc21			778928	US20250313563, Compound 806939	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778928	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778928&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561587	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			778929	US20250313563, Compound 948299	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778929	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778929&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561588	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			778929	US20250313563, Compound 948299	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778929	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778929&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561589	CC[C@]1(c2cccc(N(C)C(C)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778930	US20250313563, Compound 810358	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778930	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778930&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561590	CC[C@]1(c2cccc(N(C)C(C)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778930	US20250313563, Compound 810358	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778930	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778930&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561591	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			778931	US20250313563, Compound 948300	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778931	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778931&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561592	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			778931	US20250313563, Compound 948300	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778931	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778931&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561593	CC[C@@]1(c2cccc(N(C)C(C)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778932	US20250313563, Compound 810359	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778932	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778932&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561594	CC[C@@]1(c2cccc(N(C)C(C)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778932	US20250313563, Compound 810359	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778932	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778932&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561595	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			778933	US20250313563, Compound 948301	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778933	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778933&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561596	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			778933	US20250313563, Compound 948301	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778933	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778933&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561597	CC[C@]1(c2cccc(COC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778934	US20250313563, Compound 810360	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778934	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778934&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561598	CC[C@]1(c2cccc(COC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778934	US20250313563, Compound 810360	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778934	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778934&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561599	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			778935	US20250313563, Compound 948302	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778935	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778935&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561600	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			778935	US20250313563, Compound 948302	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778935	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778935&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561601	CC[C@@]1(c2cccc(COC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778936	US20250313563, Compound 810362	Glycogen synthase kinase-3 alpha	Homo sapiens		>1670							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778936	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778936&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561602	CC[C@@]1(c2cccc(COC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778936	US20250313563, Compound 810362	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778936	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778936&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561603	CCC1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			778937	US20250313563, Compound 948303	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778937	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778937&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561604	CCC1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			778937	US20250313563, Compound 948303	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778937	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778937&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561605	CC[C@@]4(c2cccc(N1CCOCC1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			778938	US20250313563, Compound 810363	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778938	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778938&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177893775	523297284							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561606	CC[C@@]4(c2cccc(N1CCOCC1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			778938	US20250313563, Compound 810363	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778938	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778938&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177893775	523297284							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561607	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			778939	US20250313563, Compound 948304	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778939	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778939&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561608	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			778939	US20250313563, Compound 948304	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778939	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778939&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561609	CC[C@]4(c2cccc(N1CCOCC1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			778940	US20250313563, Compound 810364	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778940	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778940&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177893777	523297286							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561610	CC[C@]4(c2cccc(N1CCOCC1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			778940	US20250313563, Compound 810364	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778940	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778940&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177893777	523297286							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561611	CCC1(c2cccc(C(F)F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778941	US20250313563, Compound 948305	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778941	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778941&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561612	CCC1(c2cccc(C(F)F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778941	US20250313563, Compound 948305	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778941	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778941&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561613	CC[C@@]1(c2cccc(Br)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778942	US20250313563, Compound 810365	Glycogen synthase kinase-3 alpha	Homo sapiens		>1670							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778942	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778942&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561614	CC[C@@]1(c2cccc(Br)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778942	US20250313563, Compound 810365	Glycogen synthase kinase-3 beta	Homo sapiens		>1670							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778942	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778942&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561615	CC[C@@]1(c2cccc(-c3ccnc(C)c3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778943	US20250313563, Compound 948306	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778943	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778943&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561616	CC[C@@]1(c2cccc(-c3ccnc(C)c3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778943	US20250313563, Compound 948306	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778943	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778943&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561617	CC[C@]1(c2cccc(Br)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778944	US20250313563, Compound 810366	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778944	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778944&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561618	CC[C@]1(c2cccc(Br)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778944	US20250313563, Compound 810366	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778944	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778944&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561619	CC[C@]1(c2cccc(C3=CN=NC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778945	US20250313563, Compound 948307	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778945	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778945&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561620	CC[C@]1(c2cccc(C3=CN=NC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778945	US20250313563, Compound 948307	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778945	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778945&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561621	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			778946	US20250313563, Compound 810367	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778946	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778946&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561622	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			778946	US20250313563, Compound 810367	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778946	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778946&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561623	CC[C@@]1(c2cccc(-c3ccnc4c3CCC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778947	US20250313563, Compound 948308	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778947	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778947&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561624	CC[C@@]1(c2cccc(-c3ccnc4c3CCC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778947	US20250313563, Compound 948308	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778947	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778947&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561625	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			778948	US20250313563, Compound 810368	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778948	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778948&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561626	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			778948	US20250313563, Compound 810368	Glycogen synthase kinase-3 beta	Homo sapiens		>1670							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778948	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778948&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561627	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778949	US20250313563, Compound 948309	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778949	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778949&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561628	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778949	US20250313563, Compound 948309	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778949	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778949&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561629	CC[C@@]1(c2cccc(N3CCCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778950	US20250313563, Compound 810369	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778950	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778950&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561630	CC[C@@]1(c2cccc(N3CCCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778950	US20250313563, Compound 810369	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778950	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778950&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561631	CC[C@]1(c2cccc(-c3ccnc(C)c3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778951	US20250313563, Compound 948311	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778951	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778951&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561632	CC[C@]1(c2cccc(-c3ccnc(C)c3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778951	US20250313563, Compound 948311	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778951	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778951&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561633	CC[C@]1(c2cccc(N3CCCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778952	US20250313563, Compound 810371	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778952	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778952&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561634	CC[C@]1(c2cccc(N3CCCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778952	US20250313563, Compound 810371	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778952	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778952&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561635	CC[C@@]1(c2cccc(C3=CN=NC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778953	US20250313563, Compound 948312	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778953	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778953&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561636	CC[C@@]1(c2cccc(C3=CN=NC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778953	US20250313563, Compound 948312	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778953	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778953&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561637	CC[C@]1(c2cccc(C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778954	US20250313563, Compound 810373	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778954	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778954&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561638	CC[C@]1(c2cccc(C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778954	US20250313563, Compound 810373	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778954	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778954&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561639	CC[C@]1(c2cccc(-c3ccnc4c3CCC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778955	US20250313563, Compound 948313	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778955	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778955&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561640	CC[C@]1(c2cccc(-c3ccnc4c3CCC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778955	US20250313563, Compound 948313	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778955	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778955&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561641	CC[C@@]1(c2cccc(C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778956	US20250313563, Compound 810375	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778956	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778956&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561642	CC[C@@]1(c2cccc(C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778956	US20250313563, Compound 810375	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778956	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778956&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561643	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778957	US20250313563, Compound 948314	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778957	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778957&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561644	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778957	US20250313563, Compound 948314	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778957	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778957&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561645	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(C)c1cc(C(F)(F)F)ccc1F			778958	US20250313563, Compound 810376	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778958	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778958&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561646	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(C)c1cc(C(F)(F)F)ccc1F			778958	US20250313563, Compound 810376	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778958	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778958&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561647	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			778959	US20250313563, Compound 948358	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778959	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778959&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561648	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			778959	US20250313563, Compound 948358	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778959	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778959&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561649	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(C)c1cc(Cl)ccc1F			778960	US20250313563, Compound 810377	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778960	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778960&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561650	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(C)c1cc(Cl)ccc1F			778960	US20250313563, Compound 810377	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778960	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778960&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561651	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCOCC1)C2			778961	US20250313563, Compound 948359	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778961	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778961&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561652	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCOCC1)C2			778961	US20250313563, Compound 948359	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778961	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778961&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561653	CCC1(c2cccc(N3CCN(C)CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778962	US20250313563, Compound 810379	Glycogen synthase kinase-3 alpha	Homo sapiens		>1670							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778962	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778962&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561654	CCC1(c2cccc(N3CCN(C)CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778962	US20250313563, Compound 810379	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778962	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778962&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561655	CCc1cc(-c2cccc([C@@]3(CC)C4=CN=NC4NC4=C3C(=O)NC(C)(C)C4)c2)ccn1			778963	US20250313563, Compound 948360	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778963	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778963&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561656	CCc1cc(-c2cccc([C@@]3(CC)C4=CN=NC4NC4=C3C(=O)NC(C)(C)C4)c2)ccn1			778963	US20250313563, Compound 948360	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778963	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778963&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561657	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			778964	US20250313563, Compound 810450	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778964	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778964&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561658	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			778964	US20250313563, Compound 810450	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778964	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778964&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561659	CC[C@@]1(c2cccc(-c3ccnc(C)c3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778965	US20250313563, Compound 948361	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778965	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778965&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561660	CC[C@@]1(c2cccc(-c3ccnc(C)c3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778965	US20250313563, Compound 948361	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778965	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778965&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561661	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			778966	US20250313563, Compound 810451	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778966	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778966&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561662	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			778966	US20250313563, Compound 810451	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778966	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778966&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561663	CC[C@]1(c2cccc(C3=C4CC=C(Cl)C=C4N=CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778967	US20250313563, Compound 948362	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778967	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778967&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561664	CC[C@]1(c2cccc(C3=C4CC=C(Cl)C=C4N=CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778967	US20250313563, Compound 948362	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778967	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778967&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561665	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			778968	US20250313563, Compound 810452	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778968	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778968&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561666	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			778968	US20250313563, Compound 810452	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778968	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778968&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561667	CC[C@]1(c2cccc(-c3c(F)cncc3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778969	US20250313563, Compound 948363	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778969	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778969&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561668	CC[C@]1(c2cccc(-c3c(F)cncc3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778969	US20250313563, Compound 948363	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778969	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778969&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561669	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			778970	US20250313563, Compound 810453	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778970	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778970&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561670	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			778970	US20250313563, Compound 810453	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778970	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778970&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561671	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCCOC1)C2			778971	US20250313563, Compound 948365	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778971	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778971&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561672	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCCOC1)C2			778971	US20250313563, Compound 948365	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778971	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778971&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561673	CC1(C)CC(=O)C2=C(C1)NC1=NN=C(Br)C1C21CCNc2ccccc21			778972	US20250313563, Compound 810460	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778972	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778972&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561674	CC1(C)CC(=O)C2=C(C1)NC1=NN=C(Br)C1C21CCNc2ccccc21			778972	US20250313563, Compound 810460	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778972	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778972&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561675	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCCOC1)C2			778973	US20250313563, Compound 948366	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778973	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778973&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561676	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCCOC1)C2			778973	US20250313563, Compound 948366	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778973	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778973&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561677	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778974	US20250313563, Compound 810464	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778974	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778974&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561678	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778974	US20250313563, Compound 810464	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778974	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778974&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561679	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCOCC1)C2			778975	US20250313563, Compound 948367	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778975	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778975&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561680	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCOCC1)C2			778975	US20250313563, Compound 948367	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778975	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778975&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561681	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778976	US20250313563, Compound 810466	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778976	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778976&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561682	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778976	US20250313563, Compound 810466	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778976	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778976&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561683	CC[C@@]1(c2cccc(C3=C4CC=C(Cl)C=C4N=CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778977	US20250313563, Compound 948368	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778977	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778977&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561684	CC[C@@]1(c2cccc(C3=C4CC=C(Cl)C=C4N=CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778977	US20250313563, Compound 948368	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778977	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778977&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561685	CC[C@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			778978	US20250313563, Compound 810484	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778978	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778978&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561686	CC[C@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			778978	US20250313563, Compound 810484	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778978	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778978&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561687	CC[C@]1(c2cccc(-c3ccnc(C)c3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778979	US20250313563, Compound 948369	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778979	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778979&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561688	CC[C@]1(c2cccc(-c3ccnc(C)c3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778979	US20250313563, Compound 948369	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778979	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778979&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561689	CC[C@@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			778980	US20250313563, Compound 810485	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778980	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778980&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561690	CC[C@@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			778980	US20250313563, Compound 810485	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778980	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778980&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561691	CCc1cc(-c2cccc([C@]3(CC)C4=CN=NC4NC4=C3C(=O)NC(C)(C)C4)c2)ccn1			778981	US20250313563, Compound 948370	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778981	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778981&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561692	CCc1cc(-c2cccc([C@]3(CC)C4=CN=NC4NC4=C3C(=O)NC(C)(C)C4)c2)ccn1			778981	US20250313563, Compound 948370	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778981	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778981&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561693	CC[C@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			778982	US20250313563, Compound 810486	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778982	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778982&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561694	CC[C@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			778982	US20250313563, Compound 810486	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778982	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778982&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561695	CC[C@@]1(c2cccc(-c3c(F)cncc3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778983	US20250313563, Compound 948371	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778983	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778983&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561696	CC[C@@]1(c2cccc(-c3c(F)cncc3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778983	US20250313563, Compound 948371	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778983	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778983&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561697	CC[C@@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			778984	US20250313563, Compound 810487	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778984	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778984&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561698	CC[C@@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			778984	US20250313563, Compound 810487	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778984	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778984&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561699	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cncnc1)CC2			778985	US20250313563, Compound 948379	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778985	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778985&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561700	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cncnc1)CC2			778985	US20250313563, Compound 948379	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778985	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778985&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561701	CC[C@]1(c2cccc(-c3ccncn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778986	US20250313563, Compound 810488	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778986	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778986&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561702	CC[C@]1(c2cccc(-c3ccncn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778986	US20250313563, Compound 810488	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778986	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778986&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561703	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cncnc1)CC2			778987	US20250313563, Compound 948380	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778987	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778987&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561704	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cncnc1)CC2			778987	US20250313563, Compound 948380	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778987	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778987&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561705	CC[C@@]1(c2cccc(-c3ccncn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778988	US20250313563, Compound 810489	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778988	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778988&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561706	CC[C@@]1(c2cccc(-c3ccncn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778988	US20250313563, Compound 810489	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778988	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778988&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561707	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778989	US20250313563, Compound 948414	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778989	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778989&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561708	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778989	US20250313563, Compound 948414	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778989	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778989&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561709	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)C21CCCc2ccccc21			778990	US20250313563, Compound 810495	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778990	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778990&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561710	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)C21CCCc2ccccc21			778990	US20250313563, Compound 810495	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778990	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778990&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561711	CC[C@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778991	US20250313563, Compound 948417	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778991	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778991&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561712	CC[C@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778991	US20250313563, Compound 948417	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778991	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778991&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561713	CCC1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778992	US20250313563, Compound 810506	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778992	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778992&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561714	CCC1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778992	US20250313563, Compound 810506	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778992	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778992&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561715	CC[C@]1(c2cccc(S(C)(=O)=O)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778993	US20250313563, Compound 948418	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778993	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778993&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561716	CC[C@]1(c2cccc(S(C)(=O)=O)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778993	US20250313563, Compound 948418	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778993	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778993&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561717	CCC1(c2cccc(N3CCOCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778994	US20250313563, Compound 810507	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778994	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778994&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561718	CCC1(c2cccc(N3CCOCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778994	US20250313563, Compound 810507	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778994	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778994&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561719	CC[C@]1(c2cccc(S(=O)(=O)C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778995	US20250313563, Compound 948419	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778995	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778995&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561720	CC[C@]1(c2cccc(S(=O)(=O)C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778995	US20250313563, Compound 948419	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778995	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778995&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561721	CCC1(c2cccc(SC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778996	US20250313563, Compound 810508	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778996	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778996&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561722	CCC1(c2cccc(SC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778996	US20250313563, Compound 810508	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778996	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778996&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561723	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778997	US20250313563, Compound 948420	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778997	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778997&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561724	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778997	US20250313563, Compound 948420	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778997	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778997&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561725	CC[C@]1(c2cccc(N3CCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778998	US20250313563, Compound 810509	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778998	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778998&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561726	CC[C@]1(c2cccc(N3CCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778998	US20250313563, Compound 810509	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778998	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778998&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561727	CC[C@@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778999	US20250313563, Compound 948421	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778999	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778999&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561728	CC[C@@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778999	US20250313563, Compound 948421	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778999	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778999&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561729	CC[C@@]1(c2cccc(N3CCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779000	US20250313563, Compound 810510	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779000	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779000&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561730	CC[C@@]1(c2cccc(N3CCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779000	US20250313563, Compound 810510	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779000	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779000&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561731	CC[C@@]1(c2cccc(S(C)(=O)=O)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779001	US20250313563, Compound 948422	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779001	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779001&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561732	CC[C@@]1(c2cccc(S(C)(=O)=O)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779001	US20250313563, Compound 948422	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779001	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779001&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561733	CC1(C)CC(=O)C2=C(C1)NC1N=NC(CC(F)(F)F)=C1C21CCc2c(F)cccc21			779002	US20250313563, Compound 810590	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779002	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779002&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561734	CC1(C)CC(=O)C2=C(C1)NC1N=NC(CC(F)(F)F)=C1C21CCc2c(F)cccc21			779002	US20250313563, Compound 810590	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779002	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779002&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561735	CC[C@@]1(c2cccc(S(=O)(=O)C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779003	US20250313563, Compound 948423	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779003	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779003&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561736	CC[C@@]1(c2cccc(S(=O)(=O)C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779003	US20250313563, Compound 948423	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779003	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779003&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561737	CC1(C)CC(=O)C2=C(C1)NC1N=NC(C3(C(F)(F)F)CC3)=C1C21CCc2c(F)cccc21			779004	US20250313563, Compound 810591	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779004	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779004&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561738	CC1(C)CC(=O)C2=C(C1)NC1N=NC(C3(C(F)(F)F)CC3)=C1C21CCc2c(F)cccc21			779004	US20250313563, Compound 810591	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779004	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779004&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561739	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(COC)C2			779005	US20250313563, Compound 948493	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779005	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779005&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561740	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(COC)C2			779005	US20250313563, Compound 948493	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779005	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779005&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561741	CCC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CC1(CCC1)C2			779006	US20250313563, Compound 811555	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779006	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779006&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561742	CCC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CC1(CCC1)C2			779006	US20250313563, Compound 811555	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779006	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779006&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561743	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			779007	US20250313563, Compound 948512	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779007	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779007&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561744	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			779007	US20250313563, Compound 948512	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779007	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779007&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561745	CC1N=NC2=C1C(C)(c1cccc(C(F)(F)F)c1)C1=C(CC(C)(C)CC1=O)N2			779008	US20250313563, Compound 811556	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779008	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779008&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561746	CC1N=NC2=C1C(C)(c1cccc(C(F)(F)F)c1)C1=C(CC(C)(C)CC1=O)N2			779008	US20250313563, Compound 811556	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779008	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779008&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561747	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC3(CCOCC3)NC2=O)NC2N=NC(C)=C21			779009	US20250313563, Compound 948513	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779009	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779009&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561748	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC3(CCOCC3)NC2=O)NC2N=NC(C)=C21			779009	US20250313563, Compound 948513	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779009	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779009&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561749	CC[C@@]1(c2cccc(C3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779010	US20250313563, Compound 811557	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779010	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779010&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561750	CC[C@@]1(c2cccc(C3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779010	US20250313563, Compound 811557	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779010	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779010&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561751	CC[C@]1(c2cccc(-c3c(F)cncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779011	US20250313563, Compound 948514	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779011	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779011&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561752	CC[C@]1(c2cccc(-c3c(F)cncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779011	US20250313563, Compound 948514	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779011	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779011&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561753	CC[C@@]1(c2cccc(C3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779012	US20250313563, Compound 811558	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779012	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779012&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561754	CC[C@@]1(c2cccc(C3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779012	US20250313563, Compound 811558	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779012	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779012&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561755	CC[C@@]1(c2cccc(-c3c(Cl)cncc3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779013	US20250313563, Compound 948515	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779013	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779013&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561756	CC[C@@]1(c2cccc(-c3c(Cl)cncc3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779013	US20250313563, Compound 948515	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779013	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779013&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561757	CC[C@@]1(c2cccc(OC)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			779014	US20250313563, Compound 811559	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779014	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779014&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561758	CC[C@@]1(c2cccc(OC)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			779014	US20250313563, Compound 811559	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779014	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779014&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561759	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCOCC1)C2			779015	US20250313563, Compound 948516	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779015	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779015&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561760	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCOCC1)C2			779015	US20250313563, Compound 948516	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779015	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779015&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561761	CC[C@]1(c2cccc(OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779016	US20250313563, Compound 811561	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779016	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779016&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561762	CC[C@]1(c2cccc(OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779016	US20250313563, Compound 811561	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779016	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779016&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561763	CC[C@@]1(c2cccc(-c3ccnc4ccc(Cl)cc34)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			779017	US20250313563, Compound 948517	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779017	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779017&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561764	CC[C@@]1(c2cccc(-c3ccnc4ccc(Cl)cc34)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			779017	US20250313563, Compound 948517	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779017	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779017&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561765	CC[C@@]1(c2cccc(OC(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779018	US20250313563, Compound 811563	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779018	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779018&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561766	CC[C@@]1(c2cccc(OC(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779018	US20250313563, Compound 811563	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779018	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779018&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561767	CC[C@]1(c2cccc(-c3ccnc4ccc(OC)cc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779019	US20250313563, Compound 948518	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779019	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779019&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561768	CC[C@]1(c2cccc(-c3ccnc4ccc(OC)cc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779019	US20250313563, Compound 948518	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779019	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779019&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561769	CC[C@]1(c2cccc(OC(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779020	US20250313563, Compound 811564	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779020	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779020&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561770	CC[C@]1(c2cccc(OC(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779020	US20250313563, Compound 811564	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779020	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779020&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561771	CC[C@]1(c2cccc(C3=C4CC=C(F)C=C4N=CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779021	US20250313563, Compound 948519	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779021	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779021&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561772	CC[C@]1(c2cccc(C3=C4CC=C(F)C=C4N=CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779021	US20250313563, Compound 948519	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779021	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779021&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561773	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779022	US20250313563, Compound 811565	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779022	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779022&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561774	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779022	US20250313563, Compound 811565	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779022	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779022&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561775	CC[C@]1(c2cccc(-c3ccnc(OC)c3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779023	US20250313563, Compound 948520	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779023	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779023&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561776	CC[C@]1(c2cccc(-c3ccnc(OC)c3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779023	US20250313563, Compound 948520	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779023	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779023&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561777	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779024	US20250313563, Compound 811567	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779024	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779024&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561778	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779024	US20250313563, Compound 811567	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779024	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779024&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561779	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(COC)C2			779025	US20250313563, Compound 948521	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779025	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779025&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561780	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(COC)C2			779025	US20250313563, Compound 948521	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779025	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779025&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561781	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)[C@]21CCCc2ccccc21			779026	US20250313563, Compound 811595	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779026	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779026&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561782	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)[C@]21CCCc2ccccc21			779026	US20250313563, Compound 811595	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779026	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779026&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561783	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			779027	US20250313563, Compound 948522	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779027	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779027&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561784	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			779027	US20250313563, Compound 948522	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779027	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779027&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561785	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)[C@@]21CCCc2ccccc21			779028	US20250313563, Compound 811596	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779028	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779028&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561786	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)[C@@]21CCCc2ccccc21			779028	US20250313563, Compound 811596	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779028	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779028&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561787	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			779029	US20250313563, Compound 948523	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779029	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779029&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561788	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			779029	US20250313563, Compound 948523	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779029	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779029&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561789	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)C2			779030	US20250313563, Compound 816752	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779030	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779030&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561790	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)C2			779030	US20250313563, Compound 816752	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779030	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779030&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561791	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCOCC1)C2			779031	US20250313563, Compound 948524	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779031	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779031&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561792	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCOCC1)C2			779031	US20250313563, Compound 948524	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779031	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779031&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561793	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCc2c(Cl)cccc21			779032	US20250313563, Compound 816795	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779032	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779032&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561794	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCc2c(Cl)cccc21			779032	US20250313563, Compound 816795	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779032	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779032&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561795	CC[C@@]1(c2cccc(-c3c(F)cncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779033	US20250313563, Compound 948525	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779033	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779033&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561796	CC[C@@]1(c2cccc(-c3c(F)cncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779033	US20250313563, Compound 948525	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779033	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779033&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561797	CCC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C(F)(F)F)C2			779034	US20250313563, Compound 816796	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779034	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779034&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561798	CCC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C(F)(F)F)C2			779034	US20250313563, Compound 816796	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779034	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779034&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561799	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCOCC1)C2			779035	US20250313563, Compound 948526	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779035	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779035&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561800	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCOCC1)C2			779035	US20250313563, Compound 948526	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779035	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779035&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561801	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]2(C)c1cc(C(F)(F)F)ccc1F			779036	US20250313563, Compound 816797	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779036	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779036&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561802	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]2(C)c1cc(C(F)(F)F)ccc1F			779036	US20250313563, Compound 816797	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779036	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779036&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561803	CC[C@@]1(c2cccc(-c3ccnc4ccc(OC)cc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779037	US20250313563, Compound 948527	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779037	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779037&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561804	CC[C@@]1(c2cccc(-c3ccnc4ccc(OC)cc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779037	US20250313563, Compound 948527	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779037	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779037&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561805	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]2(C)c1cc(C(F)(F)F)ccc1F			779038	US20250313563, Compound 816798	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779038	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779038&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561806	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]2(C)c1cc(C(F)(F)F)ccc1F			779038	US20250313563, Compound 816798	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779038	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779038&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561807	CC[C@@]1(c2cccc(C3=C4CC=C(F)C=C4N=CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779039	US20250313563, Compound 948528	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779039	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779039&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561808	CC[C@@]1(c2cccc(C3=C4CC=C(F)C=C4N=CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779039	US20250313563, Compound 948528	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779039	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779039&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561809	CC[C@@]1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779040	US20250313563, Compound 816799	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779040	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779040&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561810	CC[C@@]1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779040	US20250313563, Compound 816799	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779040	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779040&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561811	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCCOC1)C2			779041	US20250313563, Compound 948529	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779041	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779041&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561812	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCCOC1)C2			779041	US20250313563, Compound 948529	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779041	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779041&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561813	CC[C@]1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779042	US20250313563, Compound 816800	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779042	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779042&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561814	CC[C@]1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779042	US20250313563, Compound 816800	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779042	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779042&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561815	CC[C@]1(c2cccc(-c3ccnc4ccc(Cl)cc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779043	US20250313563, Compound 948530	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779043	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779043&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561816	CC[C@]1(c2cccc(-c3ccnc4ccc(Cl)cc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779043	US20250313563, Compound 948530	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779043	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779043&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561817	CC1(C)CC(=O)C2=C(C1)NC1N=NC(CC(F)(F)F)=C1[C@@]21CCc2c(F)cccc21			779044	US20250313563, Compound 816837	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779044	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779044&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561818	CC1(C)CC(=O)C2=C(C1)NC1N=NC(CC(F)(F)F)=C1[C@@]21CCc2c(F)cccc21			779044	US20250313563, Compound 816837	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779044	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779044&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561819	CC[C@@]1(c2cccc(-c3ccnc(OC)c3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779045	US20250313563, Compound 948531	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779045	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779045&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561820	CC[C@@]1(c2cccc(-c3ccnc(OC)c3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779045	US20250313563, Compound 948531	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779045	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779045&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561821	CC1(C)CC(=O)C2=C(C1)NC1N=NC(CC(F)(F)F)=C1[C@]21CCc2c(F)cccc21			779046	US20250313563, Compound 816838	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779046	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779046&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561822	CC1(C)CC(=O)C2=C(C1)NC1N=NC(CC(F)(F)F)=C1[C@]21CCc2c(F)cccc21			779046	US20250313563, Compound 816838	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779046	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779046&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561823	CC[C@@]1(c2cccc(-c3ccnc4cc(F)c(F)cc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779047	US20250313563, Compound 948638	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779047	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779047&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561824	CC[C@@]1(c2cccc(-c3ccnc4cc(F)c(F)cc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779047	US20250313563, Compound 948638	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779047	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779047&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561825	CC1(C)CC(=O)C2=C(C1)NC1N=NC(C3(C(F)(F)F)CC3)=C1[C@@]21CCc2c(F)cccc21			779048	US20250313563, Compound 816839	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779048	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779048&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561826	CC1(C)CC(=O)C2=C(C1)NC1N=NC(C3(C(F)(F)F)CC3)=C1[C@@]21CCc2c(F)cccc21			779048	US20250313563, Compound 816839	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779048	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779048&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561827	CCc1cnccc1-c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)NC(C)(C)C3)c1			779049	US20250313563, Compound 948639	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779049	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779049&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561828	CCc1cnccc1-c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)NC(C)(C)C3)c1			779049	US20250313563, Compound 948639	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779049	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779049&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561829	CC1(C)CC(=O)C2=C(C1)NC1N=NC(C3(C(F)(F)F)CC3)=C1[C@]21CCc2c(F)cccc21			779050	US20250313563, Compound 816840	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779050	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779050&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561830	CC1(C)CC(=O)C2=C(C1)NC1N=NC(C3(C(F)(F)F)CC3)=C1[C@]21CCc2c(F)cccc21			779050	US20250313563, Compound 816840	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779050	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779050&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561831	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCOC1)C2			779051	US20250313563, Compound 948640	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779051	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779051&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561832	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCOC1)C2			779051	US20250313563, Compound 948640	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779051	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779051&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561833	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779052	US20250313563, Compound 816871	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779052	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779052&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561834	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779052	US20250313563, Compound 816871	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779052	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779052&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561835	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCCC1)C2			779053	US20250313563, Compound 948641	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779053	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779053&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561836	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCCC1)C2			779053	US20250313563, Compound 948641	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779053	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779053&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561837	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@](C)(COC)C2			779054	US20250313563, Compound 816872	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779054	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779054&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561838	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@](C)(COC)C2			779054	US20250313563, Compound 816872	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779054	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779054&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561839	CC[C@]1(c2cccc(-c3ccncc3C3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779055	US20250313563, Compound 948642	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779055	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779055&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561840	CC[C@]1(c2cccc(-c3ccncc3C3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779055	US20250313563, Compound 948642	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779055	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779055&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561841	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@](C)(COC)C2			779056	US20250313563, Compound 816873	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779056	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779056&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561842	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@](C)(COC)C2			779056	US20250313563, Compound 816873	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779056	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779056&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561843	CC[C@]1(c2cccc(-c3ccncc3OC3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779057	US20250313563, Compound 948643	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779057	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779057&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561844	CC[C@]1(c2cccc(-c3ccncc3OC3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779057	US20250313563, Compound 948643	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779057	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779057&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561845	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@](C)(COC)C2			779058	US20250313563, Compound 816874	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779058	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779058&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561846	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@](C)(COC)C2			779058	US20250313563, Compound 816874	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779058	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779058&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561847	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCOC1)C2			779059	US20250313563, Compound 948644	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779059	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779059&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561848	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCOC1)C2			779059	US20250313563, Compound 948644	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779059	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779059&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561849	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@](C)(COC)C2			779060	US20250313563, Compound 816875	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779060	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779060&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561850	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@](C)(COC)C2			779060	US20250313563, Compound 816875	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779060	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779060&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561851	CC[C@]1(c2cccc(-c3ccnc4cc(Cl)c(C)cc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779061	US20250313563, Compound 948645	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779061	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779061&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561852	CC[C@]1(c2cccc(-c3ccnc4cc(Cl)c(C)cc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779061	US20250313563, Compound 948645	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779061	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779061&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561853	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCCOC1)C2			779062	US20250313563, Compound 816876	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779062	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779062&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561854	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCCOC1)C2			779062	US20250313563, Compound 816876	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779062	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779062&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561855	CC[C@]1(c2cccc(-c3ccnc(N4CCCCC4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779063	US20250313563, Compound 948646	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779063	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779063&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561856	CC[C@]1(c2cccc(-c3ccnc(N4CCCCC4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779063	US20250313563, Compound 948646	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779063	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779063&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561857	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCCOC1)C2			779064	US20250313563, Compound 816877	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779064	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779064&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561858	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCCOC1)C2			779064	US20250313563, Compound 816877	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779064	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779064&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561859	CC[C@]1(c2cccc(-c3cc(OC)nc4ccccc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779065	US20250313563, Compound 948647	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779065	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779065&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561860	CC[C@]1(c2cccc(-c3cc(OC)nc4ccccc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779065	US20250313563, Compound 948647	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779065	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779065&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561861	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCCOC1)C2			779066	US20250313563, Compound 816878	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779066	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779066&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561862	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCCOC1)C2			779066	US20250313563, Compound 816878	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779066	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779066&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561863	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCOC1)C2			779067	US20250313563, Compound 948648	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779067	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779067&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561864	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCOC1)C2			779067	US20250313563, Compound 948648	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779067	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779067&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561865	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCCOC1)C2			779068	US20250313563, Compound 816879	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779068	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779068&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561866	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCCOC1)C2			779068	US20250313563, Compound 816879	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779068	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779068&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561867	CC[C@@]1(c2cccc(-c3ccnc4cc(OC)ccc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779069	US20250313563, Compound 948649	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779069	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779069&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561868	CC[C@@]1(c2cccc(-c3ccnc4cc(OC)ccc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779069	US20250313563, Compound 948649	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779069	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779069&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561869	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCOC1)C2			779070	US20250313563, Compound 816880	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779070	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779070&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561870	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCOC1)C2			779070	US20250313563, Compound 816880	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779070	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779070&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561871	CC[C@]1(c2cccc(C3=C4CC=CC(Cl)=C4N=CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779071	US20250313563, Compound 948650	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779071	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779071&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561872	CC[C@]1(c2cccc(C3=C4CC=CC(Cl)=C4N=CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779071	US20250313563, Compound 948650	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779071	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779071&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561873	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCOC1)C2			779072	US20250313563, Compound 816881	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779072	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779072&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561874	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCOC1)C2			779072	US20250313563, Compound 816881	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779072	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779072&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561875	CC[C@@]1(c2cccc(-c3ccnc4ccc(C)cc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779073	US20250313563, Compound 948651	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779073	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779073&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561876	CC[C@@]1(c2cccc(-c3ccnc4ccc(C)cc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779073	US20250313563, Compound 948651	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779073	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779073&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561877	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCOC1)C2			779074	US20250313563, Compound 816882	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779074	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779074&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561878	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCOC1)C2			779074	US20250313563, Compound 816882	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779074	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779074&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561879	CC[C@@]1(c2cccc(-c3c4c(nn3C)CCCC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779075	US20250313563, Compound 948652	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779075	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779075&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561880	CC[C@@]1(c2cccc(-c3c4c(nn3C)CCCC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779075	US20250313563, Compound 948652	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779075	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779075&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561881	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCOC1)C2			779076	US20250313563, Compound 816884	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779076	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779076&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561882	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCOC1)C2			779076	US20250313563, Compound 816884	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779076	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779076&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561883	CC[C@]1(c2cccc(-c3ccnc(N4CCOCC4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779077	US20250313563, Compound 948653	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779077	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779077&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561884	CC[C@]1(c2cccc(-c3ccnc(N4CCOCC4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779077	US20250313563, Compound 948653	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779077	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779077&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561885	CC[C@]1(c2cccc(N3CCOCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779078	US20250313563, Compound 816885	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779078	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779078&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561886	CC[C@]1(c2cccc(N3CCOCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779078	US20250313563, Compound 816885	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779078	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779078&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561887	CC[C@@]1(c2cccc(-c3ccnc4cc(Cl)c(C)cc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779079	US20250313563, Compound 948654	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779079	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779079&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561888	CC[C@@]1(c2cccc(-c3ccnc4cc(Cl)c(C)cc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779079	US20250313563, Compound 948654	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779079	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779079&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561889	CC[C@@]1(c2cccc(N3CCOCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779080	US20250313563, Compound 816886	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779080	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779080&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561890	CC[C@@]1(c2cccc(N3CCOCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779080	US20250313563, Compound 816886	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779080	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779080&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561891	CC[C@]1(c2cccc(-c3c4c(cn3C)CCCC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779081	US20250313563, Compound 948655	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779081	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779081&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561892	CC[C@]1(c2cccc(-c3c4c(cn3C)CCCC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779081	US20250313563, Compound 948655	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779081	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779081&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561893	CCC1(c2cccc(CN3CCCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779082	US20250313563, Compound 819560	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779082	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779082&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561894	CCC1(c2cccc(CN3CCCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779082	US20250313563, Compound 819560	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779082	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779082&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561895	CC[C@@]1(c2cccc(-c3ccncc3OC3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779083	US20250313563, Compound 948656	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779083	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779083&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561896	CC[C@@]1(c2cccc(-c3ccncc3OC3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779083	US20250313563, Compound 948656	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779083	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779083&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561897	CCC1(c2cccc(S(C)(=O)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779084	US20250313563, Compound 819561	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779084	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779084&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561898	CCC1(c2cccc(S(C)(=O)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779084	US20250313563, Compound 819561	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779084	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779084&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561899	CCc1cnccc1-c1cccc([C@]2(CC)C3=CN=NC3NC3=C2C(=O)NC(C)(C)C3)c1			779085	US20250313563, Compound 948657	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779085	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779085&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561900	CCc1cnccc1-c1cccc([C@]2(CC)C3=CN=NC3NC3=C2C(=O)NC(C)(C)C3)c1			779085	US20250313563, Compound 948657	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779085	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779085&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561901	CCC1(c2cccc(C(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779086	US20250313563, Compound 819564	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779086	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779086&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561902	CCC1(c2cccc(C(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779086	US20250313563, Compound 819564	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779086	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779086&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561903	CC[C@]1(c2cccc(-c3ccnc4ccc(C)cc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779087	US20250313563, Compound 948658	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779087	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779087&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561904	CC[C@]1(c2cccc(-c3ccnc4ccc(C)cc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779087	US20250313563, Compound 948658	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779087	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779087&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561905	CCC1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)CC(C(F)(F)F)C2			779088	US20250313563, Compound 819565	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779088	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779088&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561906	CCC1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)CC(C(F)(F)F)C2			779088	US20250313563, Compound 819565	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779088	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779088&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561907	CC[C@@]1(c2cccc(-c3ccnc4c(Cl)cccc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779089	US20250313563, Compound 948659	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779089	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779089&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561908	CC[C@@]1(c2cccc(-c3ccnc4c(Cl)cccc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779089	US20250313563, Compound 948659	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779089	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779089&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561909	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@](C)(C(F)(F)F)C2			779090	US20250313563, Compound 819568	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779090	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779090&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561910	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@](C)(C(F)(F)F)C2			779090	US20250313563, Compound 819568	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779090	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779090&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561911	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCCC1)C2			779091	US20250313563, Compound 948660	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779091	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779091&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561912	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCCC1)C2			779091	US20250313563, Compound 948660	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779091	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779091&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561913	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@](C)(C(F)(F)F)C2			779092	US20250313563, Compound 819569	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779092	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779092&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561914	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@](C)(C(F)(F)F)C2			779092	US20250313563, Compound 819569	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779092	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779092&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561915	CC[C@]1(c2cccc(C3=C4CC=C(OC)C=C4N=CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779093	US20250313563, Compound 948661	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779093	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779093&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561916	CC[C@]1(c2cccc(C3=C4CC=C(OC)C=C4N=CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779093	US20250313563, Compound 948661	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779093	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779093&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561917	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@](C)(C(F)(F)F)C2			779094	US20250313563, Compound 819570	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779094	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779094&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561918	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@](C)(C(F)(F)F)C2			779094	US20250313563, Compound 819570	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779094	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779094&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561919	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCOC1)C2			779095	US20250313563, Compound 948662	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779095	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779095&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561920	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCOC1)C2			779095	US20250313563, Compound 948662	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779095	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779095&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561921	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@](C)(C(F)(F)F)C2			779096	US20250313563, Compound 819571	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779096	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779096&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561922	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@](C)(C(F)(F)F)C2			779096	US20250313563, Compound 819571	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779096	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779096&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561923	CC[C@@]1(c2cccc(-c3ccnc(N4CCCCC4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779097	US20250313563, Compound 948663	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779097	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779097&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561924	CC[C@@]1(c2cccc(-c3ccnc(N4CCCCC4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779097	US20250313563, Compound 948663	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779097	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779097&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561925	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC1(CCC1)C2			779098	US20250313563, Compound 819572	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779098	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779098&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561926	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC1(CCC1)C2			779098	US20250313563, Compound 819572	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779098	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779098&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561927	CC[C@]1(c2cccc(-c3ccnc4cc(F)c(F)cc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779099	US20250313563, Compound 948664	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779099	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779099&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561928	CC[C@]1(c2cccc(-c3ccnc4cc(F)c(F)cc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779099	US20250313563, Compound 948664	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779099	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779099&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561929	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC1(CCC1)C2			779100	US20250313563, Compound 819573	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779100	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779100&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561930	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC1(CCC1)C2			779100	US20250313563, Compound 819573	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779100	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779100&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561931	CCC1(c2cccc(-c3cc(C)ncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779101	US20250313563, Compound 948761	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779101	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779101&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561932	CCC1(c2cccc(-c3cc(C)ncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779101	US20250313563, Compound 948761	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779101	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779101&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561933	CC[C@]1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779102	US20250313563, Compound 819574	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779102	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779102&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561934	CC[C@]1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779102	US20250313563, Compound 819574	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779102	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779102&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561935	CCC1(c2cccc(-c3cc(C)ncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779103	US20250313563, Compound 948762	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779103	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779103&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561936	CCC1(c2cccc(-c3cc(C)ncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779103	US20250313563, Compound 948762	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779103	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779103&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561937	CC[C@@]1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779104	US20250313563, Compound 819575	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779104	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779104&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561938	CC[C@@]1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779104	US20250313563, Compound 819575	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779104	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779104&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561939	CCC1(c2cccc(OC)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779105	US20250313563, Compound 948763	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779105	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779105&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561940	CCC1(c2cccc(OC)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779105	US20250313563, Compound 948763	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779105	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779105&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561941	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779106	US20250313563, Compound 819576	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779106	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779106&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561942	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779106	US20250313563, Compound 819576	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779106	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779106&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561943	CCC1(c2cccc(Oc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779107	US20250313563, Compound 948764	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779107	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779107&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561944	CCC1(c2cccc(Oc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779107	US20250313563, Compound 948764	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779107	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779107&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561945	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779108	US20250313563, Compound 819577	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779108	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779108&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561946	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779108	US20250313563, Compound 819577	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779108	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779108&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561947	CCC1(c2cccc(-c3cc(C)nnc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779109	US20250313563, Compound 948765	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779109	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779109&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561948	CCC1(c2cccc(-c3cc(C)nnc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779109	US20250313563, Compound 948765	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779109	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779109&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561949	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2F			779110	US20250313563, Compound 819622	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779110	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779110&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561950	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2F			779110	US20250313563, Compound 819622	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779110	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779110&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561951	CCC1(c2cccc(-c3cc(C)nnc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779111	US20250313563, Compound 948766	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779111	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779111&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561952	CCC1(c2cccc(-c3cc(C)nnc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779111	US20250313563, Compound 948766	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779111	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779111&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561953	CC[C@]4(c2cccc(C1CCOCC1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			779112	US20250313563, Compound 819638	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779112	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779112&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177893945	523297458							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561954	CC[C@]4(c2cccc(C1CCOCC1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			779112	US20250313563, Compound 819638	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779112	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779112&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177893945	523297458							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561955	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779113	US20250313563, Compound 948767	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779113	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779113&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561956	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779113	US20250313563, Compound 948767	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779113	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779113&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561957	CC[C@@]4(c2cccc(C1CCOCC1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			779114	US20250313563, Compound 819639	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779114	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779114&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177893947	523297460							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561958	CC[C@@]4(c2cccc(C1CCOCC1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			779114	US20250313563, Compound 819639	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779114	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779114&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177893947	523297460							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561959	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779115	US20250313563, Compound 948768	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779115	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779115&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561960	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779115	US20250313563, Compound 948768	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779115	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779115&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561961	CC[C@]1(c2cccc(-c3ccnc4c3CCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779116	US20250313563, Compound 948769	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779116	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779116&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561962	CC[C@]1(c2cccc(-c3ccnc4c3CCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779116	US20250313563, Compound 948769	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779116	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779116&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561963	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779117	US20250313563, Compound 948770	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779117	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779117&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561964	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779117	US20250313563, Compound 948770	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779117	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779117&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561965	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			779118	US20250313563, Compound 823720	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779118	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779118&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561966	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			779118	US20250313563, Compound 823720	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779118	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779118&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561967	CC[C@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=C(CC(C)(C)NC2=O)NC2=C1C(C(F)(F)F)N=N2			779119	US20250313563, Compound 948771	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779119	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779119&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561968	CC[C@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=C(CC(C)(C)NC2=O)NC2=C1C(C(F)(F)F)N=N2			779119	US20250313563, Compound 948771	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779119	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779119&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561969	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			779120	US20250313563, Compound 823721	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779120	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779120&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561970	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			779120	US20250313563, Compound 823721	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779120	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779120&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561971	CC[C@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779121	US20250313563, Compound 948772	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779121	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779121&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561972	CC[C@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779121	US20250313563, Compound 948772	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779121	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779121&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561973	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			779122	US20250313563, Compound 823724	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779122	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779122&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561974	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			779122	US20250313563, Compound 823724	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779122	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779122&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561975	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779123	US20250313563, Compound 948773	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779123	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779123&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561976	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779123	US20250313563, Compound 948773	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779123	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779123&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561977	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			779124	US20250313563, Compound 823726	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779124	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779124&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561978	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			779124	US20250313563, Compound 823726	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779124	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779124&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561979	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779125	US20250313563, Compound 948774	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779125	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779125&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561980	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779125	US20250313563, Compound 948774	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779125	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779125&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561981	CCC1(c2cccc(CNC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779126	US20250313563, Compound 826651	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779126	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779126&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561982	CCC1(c2cccc(CNC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779126	US20250313563, Compound 826651	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779126	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779126&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561983	CC[C@@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779127	US20250313563, Compound 948775	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779127	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779127&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561984	CC[C@@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779127	US20250313563, Compound 948775	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779127	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779127&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561985	CC[C@@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C(F)(F)F)C2			779128	US20250313563, Compound 826652	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779128	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779128&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561986	CC[C@@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C(F)(F)F)C2			779128	US20250313563, Compound 826652	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779128	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779128&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561987	CC[C@@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779129	US20250313563, Compound 948776	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779129	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779129&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561988	CC[C@@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779129	US20250313563, Compound 948776	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779129	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779129&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561989	CC[C@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C(F)(F)F)C2			779130	US20250313563, Compound 826653	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779130	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779130&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561990	CC[C@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C(F)(F)F)C2			779130	US20250313563, Compound 826653	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779130	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779130&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561991	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779131	US20250313563, Compound 948777	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779131	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779131&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561992	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779131	US20250313563, Compound 948777	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779131	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779131&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561993	CC[C@@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C(F)(F)F)C2			779132	US20250313563, Compound 826654	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779132	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779132&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561994	CC[C@@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C(F)(F)F)C2			779132	US20250313563, Compound 826654	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779132	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779132&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561995	CC[C@@]1(c2cccc(-c3ccnc4c3CCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779133	US20250313563, Compound 948778	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779133	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779133&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561996	CC[C@@]1(c2cccc(-c3ccnc4c3CCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779133	US20250313563, Compound 948778	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779133	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779133&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561997	CC[C@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C(F)(F)F)C2			779134	US20250313563, Compound 826655	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779134	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779134&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1561998	CC[C@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C(F)(F)F)C2			779134	US20250313563, Compound 826655	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779134	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779134&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1561999	CCC1(c2cccc(-c3ccnc(C)c3OC)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779135	US20250313563, Compound 948794	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779135	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779135&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562000	CCC1(c2cccc(-c3ccnc(C)c3OC)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779135	US20250313563, Compound 948794	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779135	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779135&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562001	CCC1(c2cccc(Br)c2)C2=C(CC(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779136	US20250313563, Compound 826715	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779136	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779136&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562002	CCC1(c2cccc(Br)c2)C2=C(CC(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779136	US20250313563, Compound 826715	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779136	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779136&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562003	CC[C@@]1(c2cccc(-c3c(C)cncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779137	US20250313563, Compound 948812	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779137	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779137&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562004	CC[C@@]1(c2cccc(-c3c(C)cncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779137	US20250313563, Compound 948812	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779137	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779137&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562005	CC[C@@]1(c2cccc(C(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779138	US20250313563, Compound 826716	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779138	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779138&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562006	CC[C@@]1(c2cccc(C(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779138	US20250313563, Compound 826716	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779138	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779138&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562007	CC[C@]1(c2cccc(C3=C4CC=CC(F)=C4N=CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779139	US20250313563, Compound 948813	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779139	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779139&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562008	CC[C@]1(c2cccc(C3=C4CC=CC(F)=C4N=CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779139	US20250313563, Compound 948813	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779139	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779139&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562009	CC[C@]1(c2cccc(C(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779140	US20250313563, Compound 826717	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779140	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779140&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562010	CC[C@]1(c2cccc(C(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779140	US20250313563, Compound 826717	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779140	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779140&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562011	CC[C@]1(c2cccc(-c3cnn(C)c3C#N)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779141	US20250313563, Compound 948814	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779141	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779141&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562012	CC[C@]1(c2cccc(-c3cnn(C)c3C#N)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779141	US20250313563, Compound 948814	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779141	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779141&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562013	CC[C@]1(c2cccc(S(C)(=O)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779142	US20250313563, Compound 826718	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779142	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779142&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562014	CC[C@]1(c2cccc(S(C)(=O)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779142	US20250313563, Compound 826718	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779142	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779142&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562015	CC[C@@]1(c2cccc(-c3cnn(C)c3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779143	US20250313563, Compound 948815	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779143	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779143&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562016	CC[C@@]1(c2cccc(-c3cnn(C)c3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779143	US20250313563, Compound 948815	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779143	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779143&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562017	CC[C@@]1(c2cccc(S(C)(=O)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779144	US20250313563, Compound 826719	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779144	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779144&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562018	CC[C@@]1(c2cccc(S(C)(=O)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779144	US20250313563, Compound 826719	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779144	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779144&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562019	CC[C@]1(c2cccc(-c3cnn(C(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779145	US20250313563, Compound 948816	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779145	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779145&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562020	CC[C@]1(c2cccc(-c3cnn(C(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779145	US20250313563, Compound 948816	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779145	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779145&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562021	CCC1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)C(F)C(C)(C)C2			779146	US20250313563, Compound 826764	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779146	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779146&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562022	CCC1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)C(F)C(C)(C)C2			779146	US20250313563, Compound 826764	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779146	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779146&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562023	CC[C@]1(c2cccc(-c3ccnc4c3cnn4C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779147	US20250313563, Compound 948817	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779147	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779147&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562024	CC[C@]1(c2cccc(-c3ccnc4c3cnn4C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779147	US20250313563, Compound 948817	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779147	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779147&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562025	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@H](F)C(C)(C)C2			779148	US20250313563, Compound 826766	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779148	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779148&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562026	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@H](F)C(C)(C)C2			779148	US20250313563, Compound 826766	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779148	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779148&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562027	CC[C@@]1(c2cccc(-c3c(C)c(C)nn3C)c2)C2=C(CC(C)(C)NC2=O)Nc2[nH]ncc21			779149	US20250313563, Compound 948818	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779149	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779149&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562028	CC[C@@]1(c2cccc(-c3c(C)c(C)nn3C)c2)C2=C(CC(C)(C)NC2=O)Nc2[nH]ncc21			779149	US20250313563, Compound 948818	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779149	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779149&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562029	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@@H](F)C(C)(C)C2			779150	US20250313563, Compound 826767	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779150	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779150&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562030	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@@H](F)C(C)(C)C2			779150	US20250313563, Compound 826767	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779150	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779150&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562031	CC[C@]1(c2cccc(-c3ccnc4cnccc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779151	US20250313563, Compound 948819	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779151	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779151&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562032	CC[C@]1(c2cccc(-c3ccnc4cnccc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779151	US20250313563, Compound 948819	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779151	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779151&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562033	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@H](F)C(C)(C)C2			779152	US20250313563, Compound 826768	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779152	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779152&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562034	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@H](F)C(C)(C)C2			779152	US20250313563, Compound 826768	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779152	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779152&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562035	CC[C@]1(c2cccc(-c3c(Cl)cncc3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779153	US20250313563, Compound 948824	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779153	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779153&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562036	CC[C@]1(c2cccc(-c3c(Cl)cncc3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779153	US20250313563, Compound 948824	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779153	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779153&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562037	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@@H](F)C(C)(C)C2			779154	US20250313563, Compound 826769	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779154	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779154&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562038	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@@H](F)C(C)(C)C2			779154	US20250313563, Compound 826769	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779154	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779154&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562039	CC[C@@]1(c2cccc(-c3ccnc(N4CCOCC4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779155	US20250313563, Compound 948825	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779155	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779155&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562040	CC[C@@]1(c2cccc(-c3ccnc(N4CCOCC4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779155	US20250313563, Compound 948825	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779155	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779155&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562041	CC1(C)CC(=O)C2=C(C1)NC1N=NC(CCC(F)(F)F)=C1C2(C)c1ccccc1			779156	US20250313563, Compound 828845	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779156	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779156&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562042	CC1(C)CC(=O)C2=C(C1)NC1N=NC(CCC(F)(F)F)=C1C2(C)c1ccccc1			779156	US20250313563, Compound 828845	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779156	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779156&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562043	CC[C@]1(c2cccc(-c3cnn(C)c3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779157	US20250313563, Compound 948826	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779157	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779157&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562044	CC[C@]1(c2cccc(-c3cnn(C)c3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779157	US20250313563, Compound 948826	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779157	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779157&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562045	CC[C@]1(c2cccc(Br)c2)C2=C(C[C@@H](C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779158	US20250313563, Compound 828847	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779158	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779158&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562046	CC[C@]1(c2cccc(Br)c2)C2=C(C[C@@H](C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779158	US20250313563, Compound 828847	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779158	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779158&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562047	CC[C@@]1(c2cccc(-c3cnn(C)c3C#N)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779159	US20250313563, Compound 948827	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779159	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779159&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562048	CC[C@@]1(c2cccc(-c3cnn(C)c3C#N)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779159	US20250313563, Compound 948827	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779159	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779159&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562049	CC[C@]1(c2cccc(Br)c2)C2=C(C[C@H](C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779160	US20250313563, Compound 828848	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779160	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779160&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562050	CC[C@]1(c2cccc(Br)c2)C2=C(C[C@H](C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779160	US20250313563, Compound 828848	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779160	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779160&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562051	CC[C@@]1(c2cccc(-c3ccnc4c(F)cccc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779161	US20250313563, Compound 948828	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779161	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779161&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562052	CC[C@@]1(c2cccc(-c3ccnc4c(F)cccc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779161	US20250313563, Compound 948828	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779161	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779161&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562053	CC[C@@]1(c2cccc(Br)c2)C2=C(C[C@@H](C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779162	US20250313563, Compound 828849	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779162	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779162&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562054	CC[C@@]1(c2cccc(Br)c2)C2=C(C[C@@H](C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779162	US20250313563, Compound 828849	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779162	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779162&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562055	CC[C@]1(c2cccc(-c3c(C)cncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779163	US20250313563, Compound 948829	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779163	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779163&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562056	CC[C@]1(c2cccc(-c3c(C)cncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779163	US20250313563, Compound 948829	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779163	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779163&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562057	CC[C@@]1(c2cccc(Br)c2)C2=C(C[C@H](C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779164	US20250313563, Compound 828850	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779164	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779164&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562058	CC[C@@]1(c2cccc(Br)c2)C2=C(C[C@H](C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779164	US20250313563, Compound 828850	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779164	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779164&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562059	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779165	US20250313563, Compound 948998	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779165	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779165&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562060	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779165	US20250313563, Compound 948998	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779165	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779165&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562061	CCC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)CC2			779166	US20250313563, Compound 835310	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779166	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779166&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562062	CCC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)CC2			779166	US20250313563, Compound 835310	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779166	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779166&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562063	CCC1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779167	US20250313563, Compound 948999	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779167	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779167&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562064	CCC1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779167	US20250313563, Compound 948999	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779167	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779167&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562065	CC[C@@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)[C@@H](F)C(C)(C)C2			779168	US20250313563, Compound 835312	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779168	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779168&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562066	CC[C@@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)[C@@H](F)C(C)(C)C2			779168	US20250313563, Compound 835312	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779168	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779168&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562067	CC[C@]1(c2cccc(N3CCOCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779169	US20250313563, Compound 949000	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779169	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779169&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562068	CC[C@]1(c2cccc(N3CCOCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779169	US20250313563, Compound 949000	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779169	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779169&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562069	CC[C@@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)[C@H](F)C(C)(C)C2			779170	US20250313563, Compound 835313	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779170	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779170&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562070	CC[C@@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)[C@H](F)C(C)(C)C2			779170	US20250313563, Compound 835313	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779170	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779170&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562071	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779171	US20250313563, Compound 949001	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779171	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779171&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562072	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779171	US20250313563, Compound 949001	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779171	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779171&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562073	CC[C@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)[C@H](F)C(C)(C)C2			779172	US20250313563, Compound 835314	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779172	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779172&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562074	CC[C@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)[C@H](F)C(C)(C)C2			779172	US20250313563, Compound 835314	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779172	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779172&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562075	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779173	US20250313563, Compound 949002	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779173	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779173&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562076	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779173	US20250313563, Compound 949002	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779173	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779173&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562077	CC[C@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)[C@@H](F)C(C)(C)C2			779174	US20250313563, Compound 835315	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779174	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779174&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562078	CC[C@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)[C@@H](F)C(C)(C)C2			779174	US20250313563, Compound 835315	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779174	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779174&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562079	CC[C@]1(c2cccc(-c3cncn3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779175	US20250313563, Compound 949003	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779175	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779175&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562080	CC[C@]1(c2cccc(-c3cncn3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779175	US20250313563, Compound 949003	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779175	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779175&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562081	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			779176	US20250313563, Compound 837646	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779176	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779176&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562082	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			779176	US20250313563, Compound 837646	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779176	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779176&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562083	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			779177	US20250313563, Compound 949004	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779177	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779177&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562084	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			779177	US20250313563, Compound 949004	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779177	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779177&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562085	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			779178	US20250313563, Compound 837683	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779178	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779178&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562086	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			779178	US20250313563, Compound 837683	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779178	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779178&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562087	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			779179	US20250313563, Compound 949005	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779179	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779179&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562088	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			779179	US20250313563, Compound 949005	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779179	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779179&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562089	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			779180	US20250313563, Compound 837753	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779180	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779180&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562090	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			779180	US20250313563, Compound 837753	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779180	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779180&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562091	CC[C@@]1(c2cccc(C(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779181	US20250313563, Compound 949006	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779181	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779181&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562092	CC[C@@]1(c2cccc(C(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779181	US20250313563, Compound 949006	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779181	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779181&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562093	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			779182	US20250313563, Compound 837803	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779182	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779182&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562094	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			779182	US20250313563, Compound 837803	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779182	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779182&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562095	CC[C@]1(c2cccc(C(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779183	US20250313563, Compound 949007	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779183	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779183&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562096	CC[C@]1(c2cccc(C(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779183	US20250313563, Compound 949007	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779183	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779183&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562097	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779184	US20250313563, Compound 840857	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779184	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779184&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562098	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779184	US20250313563, Compound 840857	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779184	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779184&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562099	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			779185	US20250313563, Compound 949008	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779185	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779185&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562100	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			779185	US20250313563, Compound 949008	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779185	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779185&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562101	CC1(C)CC(=O)C2=C(C1)NC1N=NC(CCC(F)(F)F)=C1C21CCc2c(F)cccc21			779186	US20250313563, Compound 841868	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779186	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779186&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562102	CC1(C)CC(=O)C2=C(C1)NC1N=NC(CCC(F)(F)F)=C1C21CCc2c(F)cccc21			779186	US20250313563, Compound 841868	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779186	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779186&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562103	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			779187	US20250313563, Compound 949009	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779187	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779187&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562104	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			779187	US20250313563, Compound 949009	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779187	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779187&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562105	CCC1(c2cccc(N(C)c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779188	US20250313563, Compound 853910	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779188	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779188&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562106	CCC1(c2cccc(N(C)c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779188	US20250313563, Compound 853910	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779188	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779188&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562107	CC[C@@]1(c2cccc(-c3cncn3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779189	US20250313563, Compound 949010	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779189	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779189&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562108	CC[C@@]1(c2cccc(-c3cncn3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779189	US20250313563, Compound 949010	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779189	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779189&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562109	CCC1(c2cccc(-n3ccnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779190	US20250313563, Compound 854926	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779190	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779190&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562110	CCC1(c2cccc(-n3ccnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779190	US20250313563, Compound 854926	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779190	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779190&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562111	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779191	US20250313563, Compound 949011	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779191	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779191&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562112	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779191	US20250313563, Compound 949011	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779191	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779191&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562113	CCC1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)C2			779192	US20250313563, Compound 856947	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779192	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779192&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562114	CCC1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)C2			779192	US20250313563, Compound 856947	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779192	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779192&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562115	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779193	US20250313563, Compound 949012	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779193	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779193&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562116	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779193	US20250313563, Compound 949012	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779193	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779193&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562117	CC1(C)CC(=O)C2=C(C1)NC1N=NC(CCC(F)(F)F)=C1[C@@]2(C)c1ccccc1			779194	US20250313563, Compound 856948	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779194	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779194&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562118	CC1(C)CC(=O)C2=C(C1)NC1N=NC(CCC(F)(F)F)=C1[C@@]2(C)c1ccccc1			779194	US20250313563, Compound 856948	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779194	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779194&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562119	CC[C@@]1(c2cccc(N3CCOCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779195	US20250313563, Compound 949013	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779195	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779195&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562120	CC[C@@]1(c2cccc(N3CCOCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779195	US20250313563, Compound 949013	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779195	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779195&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562121	CC1(C)CC(=O)C2=C(C1)NC1N=NC(CCC(F)(F)F)=C1[C@]2(C)c1ccccc1			779196	US20250313563, Compound 856949	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779196	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779196&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562122	CC1(C)CC(=O)C2=C(C1)NC1N=NC(CCC(F)(F)F)=C1[C@]2(C)c1ccccc1			779196	US20250313563, Compound 856949	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779196	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779196&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562123	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cccc(C)c1)CC2			779197	US20250313563, Compound 949040	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779197	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779197&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562124	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cccc(C)c1)CC2			779197	US20250313563, Compound 949040	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779197	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779197&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562125	CCC1(c2cccc(N(C)c3cccnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779198	US20250313563, Compound 865168	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779198	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779198&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562126	CCC1(c2cccc(N(C)c3cccnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779198	US20250313563, Compound 865168	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779198	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779198&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562127	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cccc(C)c1)CC2			779199	US20250313563, Compound 949041	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779199	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779199&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562128	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cccc(C)c1)CC2			779199	US20250313563, Compound 949041	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779199	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779199&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562129	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779200	US20250313563, Compound 865169	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779200	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779200&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562130	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779200	US20250313563, Compound 865169	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779200	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779200&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562131	CC[C@@]1(c2cccc(-c3cnn(CCOC)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779201	US20250313563, Compound 949105	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779201	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779201&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562132	CC[C@@]1(c2cccc(-c3cnn(CCOC)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779201	US20250313563, Compound 949105	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779201	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779201&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562133	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779202	US20250313563, Compound 865170	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779202	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779202&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562134	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779202	US20250313563, Compound 865170	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779202	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779202&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562135	CC[C@]1(c2cccc(-c3cn(C)nc3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779203	US20250313563, Compound 949106	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779203	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779203&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562136	CC[C@]1(c2cccc(-c3cn(C)nc3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779203	US20250313563, Compound 949106	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779203	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779203&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562137	CCC1(c2cccc(N3CCCC3=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779204	US20250313563, Compound 865171	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779204	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779204&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562138	CCC1(c2cccc(N3CCCC3=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779204	US20250313563, Compound 865171	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779204	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779204&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562139	CC[C@]1(c2cccc(-c3cnn(C(C)(C)C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779205	US20250313563, Compound 949107	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779205	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779205&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562140	CC[C@]1(c2cccc(-c3cnn(C(C)(C)C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779205	US20250313563, Compound 949107	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779205	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779205&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562141	CCC1(c2cccc(N3[C@H](C)CCC[C@@H]3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779206	US20250313563, Compound 865172	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779206	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779206&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562142	CCC1(c2cccc(N3[C@H](C)CCC[C@@H]3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779206	US20250313563, Compound 865172	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779206	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779206&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562143	CC[C@]1(c2cccc(-c3cc(OC)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779207	US20250313563, Compound 949108	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779207	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779207&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562144	CC[C@]1(c2cccc(-c3cc(OC)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779207	US20250313563, Compound 949108	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779207	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779207&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562145	CCC1(c2cccc(CN(C)C(C)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779208	US20250313563, Compound 865194	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779208	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779208&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562146	CCC1(c2cccc(CN(C)C(C)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779208	US20250313563, Compound 865194	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779208	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779208&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562147	CC[C@@]1(c2cccc(-c3cc(OC)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779209	US20250313563, Compound 949109	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779209	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779209&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562148	CC[C@@]1(c2cccc(-c3cc(OC)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779209	US20250313563, Compound 949109	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779209	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779209&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562149	CCC1(c2cccc(CN(C)C(=O)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779210	US20250313563, Compound 865195	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779210	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779210&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562150	CCC1(c2cccc(CN(C)C(=O)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779210	US20250313563, Compound 865195	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779210	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779210&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562151	CC[C@@]1(c2cccc(-c3ccnc4cnccc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779211	US20250313563, Compound 949110	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779211	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779211&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562152	CC[C@@]1(c2cccc(-c3ccnc4cnccc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779211	US20250313563, Compound 949110	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779211	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779211&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562153	CCC1(c2cccc(CN(C)C(=O)COC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779212	US20250313563, Compound 865196	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779212	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779212&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562154	CCC1(c2cccc(CN(C)C(=O)COC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779212	US20250313563, Compound 865196	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779212	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779212&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562155	CC[C@@]1(c2cccc(-c3cn(C)nc3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779213	US20250313563, Compound 949111	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779213	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779213&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562156	CC[C@@]1(c2cccc(-c3cn(C)nc3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779213	US20250313563, Compound 949111	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779213	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779213&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562157	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@@H](C)C[C@@H]2C			779214	US20250313563, Compound 865198	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779214	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779214&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562158	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@@H](C)C[C@@H]2C			779214	US20250313563, Compound 865198	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779214	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779214&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562159	CC[C@@]1(c2cccc(-c3cnn(C(C)(C)C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779215	US20250313563, Compound 949112	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779215	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779215&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562160	CC[C@@]1(c2cccc(-c3cnn(C(C)(C)C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779215	US20250313563, Compound 949112	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779215	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779215&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562161	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@H](C)C[C@H]2C			779216	US20250313563, Compound 865199	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779216	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779216&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562162	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@H](C)C[C@H]2C			779216	US20250313563, Compound 865199	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779216	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779216&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562163	CC[C@]1(c2cccc(-c3cnn(CCOC)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779217	US20250313563, Compound 949114	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779217	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779217&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562164	CC[C@]1(c2cccc(-c3cnn(CCOC)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779217	US20250313563, Compound 949114	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779217	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779217&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562165	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@H](C)C[C@H]2C			779218	US20250313563, Compound 865201	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779218	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779218&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562166	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@H](C)C[C@H]2C			779218	US20250313563, Compound 865201	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779218	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779218&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562167	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCCOC1)C2			779219	US20250313563, Compound 949115	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779219	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779219&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562168	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCCOC1)C2			779219	US20250313563, Compound 949115	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779219	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779219&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562169	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@@H](C)C[C@@H]2C			779220	US20250313563, Compound 865202	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779220	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779220&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562170	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@@H](C)C[C@@H]2C			779220	US20250313563, Compound 865202	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779220	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779220&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562171	CC[C@@]1(c2cccc(-c3cc(OC)nc4ccccc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779221	US20250313563, Compound 949116	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779221	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779221&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562172	CC[C@@]1(c2cccc(-c3cc(OC)nc4ccccc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779221	US20250313563, Compound 949116	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779221	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779221&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562173	CC[C@]1(c2cccc(N(C)c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779222	US20250313563, Compound 874260	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779222	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779222&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562174	CC[C@]1(c2cccc(N(C)c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779222	US20250313563, Compound 874260	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779222	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779222&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562175	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccc(C)cc1)CC2			779223	US20250313563, Compound 949118	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779223	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779223&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562176	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccc(C)cc1)CC2			779223	US20250313563, Compound 949118	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779223	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779223&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562177	CC[C@@]1(c2cccc(N(C)c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779224	US20250313563, Compound 874261	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779224	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779224&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562178	CC[C@@]1(c2cccc(N(C)c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779224	US20250313563, Compound 874261	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779224	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779224&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562179	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccc(C)cc1)CC2			779225	US20250313563, Compound 949119	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779225	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779225&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562180	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccc(C)cc1)CC2			779225	US20250313563, Compound 949119	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779225	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779225&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562181	CCC1(c2cccc(N(C)c3ccccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779226	US20250313563, Compound 874294	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779226	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779226&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562182	CCC1(c2cccc(N(C)c3ccccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779226	US20250313563, Compound 874294	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779226	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779226&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562183	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(CCN(c3cnc(OC)nc3)C2=O)NC2N=NC(C)=C21			779227	US20250313563, Compound 949126	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779227	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779227&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562184	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(CCN(c3cnc(OC)nc3)C2=O)NC2N=NC(C)=C21			779227	US20250313563, Compound 949126	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779227	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779227&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562185	CC[C@]1(c2cccc(N(C)c3cccnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779228	US20250313563, Compound 874298	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779228	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779228&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562186	CC[C@]1(c2cccc(N(C)c3cccnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779228	US20250313563, Compound 874298	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779228	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779228&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562187	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnc(OC)nc1)CC2			779229	US20250313563, Compound 949127	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779229	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779229&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562188	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnc(OC)nc1)CC2			779229	US20250313563, Compound 949127	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779229	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779229&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562189	CC[C@@]1(c2cccc(N(C)c3cccnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779230	US20250313563, Compound 874299	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779230	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779230&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562190	CC[C@@]1(c2cccc(N(C)c3cccnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779230	US20250313563, Compound 874299	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779230	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779230&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562191	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccccc1C)CC2			779231	US20250313563, Compound 949128	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779231	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779231&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562192	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccccc1C)CC2			779231	US20250313563, Compound 949128	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779231	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779231&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562193	CCC1(c2cccc(N3CC[O:0]CC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779232	US20250313563, Compound 874312	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779232	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779232&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894065	523297578							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562194	CCC1(c2cccc(N3CC[O:0]CC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779232	US20250313563, Compound 874312	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779232	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779232&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894065	523297578							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562195	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccccc1C)CC2			779233	US20250313563, Compound 949129	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779233	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779233&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562196	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccccc1C)CC2			779233	US20250313563, Compound 949129	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779233	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779233&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562197	CCC1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779234	US20250313563, Compound 874314	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779234	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779234&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562198	CCC1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779234	US20250313563, Compound 874314	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779234	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779234&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562199	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779235	US20250313563, Compound 949169	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779235	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779235&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562200	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779235	US20250313563, Compound 949169	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779235	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779235&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562201	CC[C@@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			779236	US20250313563, Compound 874315	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779236	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779236&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562202	CC[C@@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			779236	US20250313563, Compound 874315	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779236	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779236&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562203	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779237	US20250313563, Compound 949170	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779237	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779237&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562204	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779237	US20250313563, Compound 949170	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779237	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779237&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562205	CC[C@@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			779238	US20250313563, Compound 874316	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779238	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779238&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562206	CC[C@@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			779238	US20250313563, Compound 874316	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779238	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779238&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562207	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779239	US20250313563, Compound 949171	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779239	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779239&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562208	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779239	US20250313563, Compound 949171	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779239	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779239&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562209	CC[C@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			779240	US20250313563, Compound 874317	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779240	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779240&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562210	CC[C@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			779240	US20250313563, Compound 874317	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779240	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779240&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562211	CCC1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779241	US20250313563, Compound 949172	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779241	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779241&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562212	CCC1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779241	US20250313563, Compound 949172	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779241	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779241&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562213	CC[C@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			779242	US20250313563, Compound 874318	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779242	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779242&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562214	CC[C@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			779242	US20250313563, Compound 874318	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779242	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779242&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562215	CCC1(c2cccc(C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779243	US20250313563, Compound 949173	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779243	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779243&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562216	CCC1(c2cccc(C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779243	US20250313563, Compound 949173	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779243	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779243&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562217	CC1(C)CC(=O)C2=C(C1)NC1N=NC(CCC(F)(F)F)=C1[C@@]21CCc2c(F)cccc21			779244	US20250313563, Compound 874323	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779244	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779244&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562218	CC1(C)CC(=O)C2=C(C1)NC1N=NC(CCC(F)(F)F)=C1[C@@]21CCc2c(F)cccc21			779244	US20250313563, Compound 874323	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779244	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779244&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562219	CCC1(c2cccc(-c3cc(C)nnc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779245	US20250313563, Compound 949174	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779245	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779245&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562220	CCC1(c2cccc(-c3cc(C)nnc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779245	US20250313563, Compound 949174	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779245	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779245&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562221	CC1(C)CC(=O)C2=C(C1)NC1N=NC(CCC(F)(F)F)=C1[C@]21CCc2c(F)cccc21			779246	US20250313563, Compound 874324	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779246	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779246&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562222	CC1(C)CC(=O)C2=C(C1)NC1N=NC(CCC(F)(F)F)=C1[C@]21CCc2c(F)cccc21			779246	US20250313563, Compound 874324	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779246	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779246&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562223	CC[C@]1(c2cccc(S(=O)(=O)CC3CC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779247	US20250313563, Compound 949175	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779247	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779247&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562224	CC[C@]1(c2cccc(S(=O)(=O)CC3CC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779247	US20250313563, Compound 949175	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779247	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779247&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562225	CC[C@@]1(c2ccccc2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)F)=C21			779248	US20250313563, Compound 874510	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779248	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779248&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562226	CC[C@@]1(c2ccccc2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)F)=C21			779248	US20250313563, Compound 874510	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779248	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779248&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562227	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779249	US20250313563, Compound 949176	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779249	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779249&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562228	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779249	US20250313563, Compound 949176	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779249	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779249&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562229	CC[C@]1(c2ccccc2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)F)=C21			779250	US20250313563, Compound 874511	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779250	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779250&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562230	CC[C@]1(c2ccccc2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)F)=C21			779250	US20250313563, Compound 874511	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779250	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779250&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562231	CC[C@@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			779251	US20250313563, Compound 949177	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779251	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779251&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562232	CC[C@@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			779251	US20250313563, Compound 949177	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779251	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779251&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562233	CC[C@]1(c2cccc(-n3ccnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779252	US20250313563, Compound 874531	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779252	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779252&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562234	CC[C@]1(c2cccc(-n3ccnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779252	US20250313563, Compound 874531	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779252	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779252&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562235	CC[C@]1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779253	US20250313563, Compound 949178	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779253	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779253&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562236	CC[C@]1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779253	US20250313563, Compound 949178	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779253	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779253&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562237	CC[C@@]1(c2cccc(-n3ccnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779254	US20250313563, Compound 874533	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779254	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779254&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562238	CC[C@@]1(c2cccc(-n3ccnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779254	US20250313563, Compound 874533	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779254	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779254&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562239	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779255	US20250313563, Compound 949179	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779255	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779255&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562240	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779255	US20250313563, Compound 949179	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779255	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779255&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562241	CC[C@@]1(c2cccc(N(C)c3ccccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779256	US20250313563, Compound 875568	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779256	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779256&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562242	CC[C@@]1(c2cccc(N(C)c3ccccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779256	US20250313563, Compound 875568	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779256	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779256&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562243	CC[C@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779257	US20250313563, Compound 949180	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779257	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779257&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562244	CC[C@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779257	US20250313563, Compound 949180	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779257	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779257&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562245	CC[C@]1(c2cccc(N(C)c3ccccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779258	US20250313563, Compound 875608	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779258	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779258&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562246	CC[C@]1(c2cccc(N(C)c3ccccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779258	US20250313563, Compound 875608	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779258	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779258&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562247	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779259	US20250313563, Compound 949181	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779259	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779259&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562248	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779259	US20250313563, Compound 949181	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779259	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779259&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562249	CCC1(c2cccc(NC(C)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779260	US20250313563, Compound 877310	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779260	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779260&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562250	CCC1(c2cccc(NC(C)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779260	US20250313563, Compound 877310	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779260	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779260&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562251	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779261	US20250313563, Compound 949182	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779261	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779261&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562252	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779261	US20250313563, Compound 949182	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779261	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779261&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562253	CCC1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779262	US20250313563, Compound 877311	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779262	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779262&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562254	CCC1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779262	US20250313563, Compound 877311	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779262	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779262&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562255	CC[C@@]1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779263	US20250313563, Compound 949183	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779263	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779263&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562256	CC[C@@]1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779263	US20250313563, Compound 949183	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779263	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779263&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562257	CCC1(c2cccc(-c3ccnc(OC)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779264	US20250313563, Compound 883850	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779264	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779264&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562258	CCC1(c2cccc(-c3ccnc(OC)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779264	US20250313563, Compound 883850	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779264	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779264&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562259	CC[C@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			779265	US20250313563, Compound 949184	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779265	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779265&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562260	CC[C@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			779265	US20250313563, Compound 949184	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779265	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779265&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562261	CCC1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779266	US20250313563, Compound 883851	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779266	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779266&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562262	CCC1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779266	US20250313563, Compound 883851	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779266	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779266&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562263	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779267	US20250313563, Compound 949185	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779267	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779267&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562264	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779267	US20250313563, Compound 949185	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779267	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779267&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562265	CCC1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779268	US20250313563, Compound 883852	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779268	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779268&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562266	CCC1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779268	US20250313563, Compound 883852	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779268	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779268&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562267	CC[C@@]1(c2cccc(S(=O)(=O)CC3CC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779269	US20250313563, Compound 949186	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779269	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779269&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562268	CC[C@@]1(c2cccc(S(=O)(=O)CC3CC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779269	US20250313563, Compound 949186	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779269	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779269&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562269	CCC1(c2ccc(C)cc2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779270	US20250313563, Compound 883866	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779270	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779270&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562270	CCC1(c2ccc(C)cc2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779270	US20250313563, Compound 883866	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779270	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779270&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562271	CC[C@]1(c2cccc(-c3cnn4ccncc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779271	US20250313563, Compound 949263	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779271	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779271&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562272	CC[C@]1(c2cccc(-c3cnn4ccncc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779271	US20250313563, Compound 949263	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779271	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779271&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562273	CC[C@]1(c2cccc(C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779272	US20250313563, Compound 883872	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779272	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779272&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562274	CC[C@]1(c2cccc(C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779272	US20250313563, Compound 883872	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779272	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779272&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562275	CC[C@]1(c2cccc(-c3cnn(-c4ccccn4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779273	US20250313563, Compound 949264	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779273	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779273&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562276	CC[C@]1(c2cccc(-c3cnn(-c4ccccn4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779273	US20250313563, Compound 949264	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779273	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779273&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562277	CC[C@@]1(c2cccc(C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779274	US20250313563, Compound 883873	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779274	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779274&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562278	CC[C@@]1(c2cccc(C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779274	US20250313563, Compound 883873	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779274	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779274&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562279	CC[C@]1(c2cccc(-c3cnn4c3CC(C)(C)CC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779275	US20250313563, Compound 949265	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779275	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779275&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562280	CC[C@]1(c2cccc(-c3cnn4c3CC(C)(C)CC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779275	US20250313563, Compound 949265	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779275	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779275&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562281	CC[C@@]1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779276	US20250313563, Compound 883874	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779276	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779276&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562282	CC[C@@]1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779276	US20250313563, Compound 883874	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779276	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779276&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562283	CC[C@]1(c2cccc(-c3cn(C)nc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779277	US20250313563, Compound 949266	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779277	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779277&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562284	CC[C@]1(c2cccc(-c3cn(C)nc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779277	US20250313563, Compound 949266	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779277	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779277&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562285	CC[C@]1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779278	US20250313563, Compound 883875	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779278	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779278&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562286	CC[C@]1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779278	US20250313563, Compound 883875	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779278	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779278&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562287	CC[C@]1(c2cccc(-c3cnn(C(C)C)c3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779279	US20250313563, Compound 949267	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779279	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779279&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562288	CC[C@]1(c2cccc(-c3cnn(C(C)C)c3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779279	US20250313563, Compound 949267	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779279	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779279&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562289	CCC1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779280	US20250313563, Compound 883984	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779280	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779280&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562290	CCC1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779280	US20250313563, Compound 883984	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779280	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779280&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562291	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnn(C)c1)CC2			779281	US20250313563, Compound 949270	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779281	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779281&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562292	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnn(C)c1)CC2			779281	US20250313563, Compound 949270	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779281	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779281&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562293	CCC1(c2cccc(-c3ccnc(OC)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779282	US20250313563, Compound 883985	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779282	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779282&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562294	CCC1(c2cccc(-c3ccnc(OC)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779282	US20250313563, Compound 883985	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779282	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779282&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562295	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnn(C)c1)CC2			779283	US20250313563, Compound 949271	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779283	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779283&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562296	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnn(C)c1)CC2			779283	US20250313563, Compound 949271	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779283	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779283&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562297	CCC1(c2cccc(-c3ccncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779284	US20250313563, Compound 883986	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779284	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779284&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562298	CCC1(c2cccc(-c3ccncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779284	US20250313563, Compound 883986	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779284	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779284&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562299	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccccn1)CC2			779285	US20250313563, Compound 949310	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779285	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779285&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562300	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccccn1)CC2			779285	US20250313563, Compound 949310	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779285	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779285&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562301	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779286	US20250313563, Compound 883987	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779286	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779286&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562302	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779286	US20250313563, Compound 883987	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779286	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779286&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562303	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccccn1)CC2			779287	US20250313563, Compound 949311	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779287	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779287&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562304	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccccn1)CC2			779287	US20250313563, Compound 949311	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779287	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779287&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562305	CCC1(c2cccc(-c3cc(C)ncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779288	US20250313563, Compound 883988	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779288	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779288&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562306	CCC1(c2cccc(-c3cc(C)ncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779288	US20250313563, Compound 883988	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779288	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779288&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562307	CCC1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779289	US20250313563, Compound 949324	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779289	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779289&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562308	CCC1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779289	US20250313563, Compound 949324	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779289	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779289&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562309	CCC1(c2cccc(-c3ccnc(C(F)(F)F)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779290	US20250313563, Compound 883989	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779290	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779290&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562310	CCC1(c2cccc(-c3ccnc(C(F)(F)F)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779290	US20250313563, Compound 883989	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779290	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779290&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562311	CCC1(c2cccc(C(C)C)c2)C2=C(N=NC2)NC2=C1C(=O)NC(C)(C)C2			779291	US20250313563, Compound 949326	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779291	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779291&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562312	CCC1(c2cccc(C(C)C)c2)C2=C(N=NC2)NC2=C1C(=O)NC(C)(C)C2			779291	US20250313563, Compound 949326	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779291	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779291&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562313	CCC1(c2cccc(-c3ccnc(N(C)C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779292	US20250313563, Compound 883990	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779292	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779292&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562314	CCC1(c2cccc(-c3ccnc(N(C)C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779292	US20250313563, Compound 883990	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779292	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779292&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562315	CC[C@]1(c2cccc(-c3cc(C)ncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779293	US20250313563, Compound 949327	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779293	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779293&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562316	CC[C@]1(c2cccc(-c3cc(C)ncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779293	US20250313563, Compound 949327	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779293	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779293&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562317	CCC1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779294	US20250313563, Compound 883991	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779294	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779294&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562318	CCC1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779294	US20250313563, Compound 883991	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779294	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779294&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562319	CC[C@]1(c2cccc(OC)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779295	US20250313563, Compound 949328	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779295	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779295&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562320	CC[C@]1(c2cccc(OC)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779295	US20250313563, Compound 949328	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779295	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779295&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562321	CCC1(c2cccc(-c3ccnn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779296	US20250313563, Compound 883992	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779296	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779296&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562322	CCC1(c2cccc(-c3ccnn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779296	US20250313563, Compound 883992	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779296	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779296&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562323	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779297	US20250313563, Compound 949329	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779297	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779297&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562324	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779297	US20250313563, Compound 949329	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779297	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779297&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562325	CCC1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779298	US20250313563, Compound 883993	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779298	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779298&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562326	CCC1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779298	US20250313563, Compound 883993	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779298	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779298&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562327	CC[C@@]1(c2cccc(Oc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779299	US20250313563, Compound 949330	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779299	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779299&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562328	CC[C@@]1(c2cccc(Oc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779299	US20250313563, Compound 949330	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779299	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779299&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562329	CCC1(c2cccc(C3=CN=NC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779300	US20250313563, Compound 883994	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779300	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779300&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562330	CCC1(c2cccc(C3=CN=NC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779300	US20250313563, Compound 883994	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779300	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779300&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562331	CC[C@@]1(c2cccc(-c3cc(C)nnc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779301	US20250313563, Compound 949331	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779301	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779301&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562332	CC[C@@]1(c2cccc(-c3cc(C)nnc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779301	US20250313563, Compound 949331	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779301	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779301&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562333	CCC1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779302	US20250313563, Compound 883995	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779302	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779302&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562334	CCC1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779302	US20250313563, Compound 883995	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779302	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779302&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562335	CC[C@]1(c2cccc(-c3cc(C)nnc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779303	US20250313563, Compound 949332	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779303	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779303&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562336	CC[C@]1(c2cccc(-c3cc(C)nnc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779303	US20250313563, Compound 949332	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779303	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779303&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562337	CCC1(c2cccc(-c3cnn(CCOC)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779304	US20250313563, Compound 883996	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779304	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779304&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562338	CCC1(c2cccc(-c3cnn(CCOC)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779304	US20250313563, Compound 883996	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779304	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779304&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562339	CC[C@@]1(c2cccc(-c3cc(C)nnc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779305	US20250313563, Compound 949333	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779305	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779305&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562340	CC[C@@]1(c2cccc(-c3cc(C)nnc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779305	US20250313563, Compound 949333	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779305	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779305&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562341	CCC1(c2cccc(-c3cnn(C4CC4)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779306	US20250313563, Compound 883997	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779306	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779306&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562342	CCC1(c2cccc(-c3cnn(C4CC4)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779306	US20250313563, Compound 883997	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779306	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779306&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562343	CC[C@]1(c2cccc(-c3cc(C)nnc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779307	US20250313563, Compound 949334	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779307	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779307&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562344	CC[C@]1(c2cccc(-c3cc(C)nnc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779307	US20250313563, Compound 949334	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779307	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779307&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562345	CCC1(c2cccc(-c3cn(C)nc3C(C)C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779308	US20250313563, Compound 883998	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779308	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779308&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562346	CCC1(c2cccc(-c3cn(C)nc3C(C)C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779308	US20250313563, Compound 883998	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779308	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779308&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562347	CC[C@]1(c2cccc(Oc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779309	US20250313563, Compound 949335	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779309	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779309&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562348	CC[C@]1(c2cccc(Oc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779309	US20250313563, Compound 949335	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779309	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779309&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562349	CCC1(c2cccc(-c3ccn(C)n3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779310	US20250313563, Compound 883999	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779310	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779310&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562350	CCC1(c2cccc(-c3ccn(C)n3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779310	US20250313563, Compound 883999	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779310	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779310&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562351	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)Nc2[nH]nc(Cl)c21			779311	US20250313563, Compound 949336	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779311	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779311&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562352	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)Nc2[nH]nc(Cl)c21			779311	US20250313563, Compound 949336	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779311	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779311&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562353	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779312	US20250313563, Compound 884000	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779312	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779312&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562354	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779312	US20250313563, Compound 884000	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779312	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779312&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562355	CC[C@@]1(c2cccc(OC)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779313	US20250313563, Compound 949337	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779313	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779313&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562356	CC[C@@]1(c2cccc(OC)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779313	US20250313563, Compound 949337	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779313	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779313&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562357	CCC1(c2cccc(-c3cncn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779314	US20250313563, Compound 884001	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779314	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779314&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562358	CCC1(c2cccc(-c3cncn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779314	US20250313563, Compound 884001	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779314	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779314&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562359	CC[C@@]1(c2cccc(-c3cc(C)ncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779315	US20250313563, Compound 949338	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779315	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779315&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562360	CC[C@@]1(c2cccc(-c3cc(C)ncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779315	US20250313563, Compound 949338	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779315	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779315&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562361	CCC1(c2cccc(-c3cnn4c3CCCC4)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779316	US20250313563, Compound 884002	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779316	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779316&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562362	CCC1(c2cccc(-c3cnn4c3CCCC4)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779316	US20250313563, Compound 884002	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779316	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779316&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562363	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnc(OC)nc1)[C@H](C)C2			779317	US20250313563, Compound 949351	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779317	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779317&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562364	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnc(OC)nc1)[C@H](C)C2			779317	US20250313563, Compound 949351	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779317	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779317&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562365	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779318	US20250313563, Compound 884003	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779318	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779318&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562366	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779318	US20250313563, Compound 884003	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779318	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779318&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562367	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnc(OC)nc1)[C@@H](C)C2			779319	US20250313563, Compound 949352	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779319	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779319&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562368	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnc(OC)nc1)[C@@H](C)C2			779319	US20250313563, Compound 949352	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779319	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779319&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562369	CCN(C(C)=O)c1cccc(C2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779320	US20250313563, Compound 884109	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779320	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779320&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562370	CCN(C(C)=O)c1cccc(C2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779320	US20250313563, Compound 884109	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779320	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779320&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562371	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnc(OC)nc1)[C@H](C)C2			779321	US20250313563, Compound 949353	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779321	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779321&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562372	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnc(OC)nc1)[C@H](C)C2			779321	US20250313563, Compound 949353	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779321	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779321&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562373	CCC1(c2cccc(N(Cc3ccccc3)C(C)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779322	US20250313563, Compound 884110	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779322	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779322&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562374	CCC1(c2cccc(N(Cc3ccccc3)C(C)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779322	US20250313563, Compound 884110	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779322	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779322&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562375	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnc(OC)nc1)[C@@H](C)C2			779323	US20250313563, Compound 949354	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779323	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779323&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562376	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnc(OC)nc1)[C@@H](C)C2			779323	US20250313563, Compound 949354	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779323	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779323&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562377	O=C1CCCC2=C1C1(CCOCC1)C1=C(N=NC1)N2			779324	US20250313563, Compound 884111	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779324	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779324&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562378	O=C1CCCC2=C1C1(CCOCC1)C1=C(N=NC1)N2			779324	US20250313563, Compound 884111	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779324	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779324&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562379	CC[C@]1(c2cccc(-c3ccnc(C(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779325	US20250313563, Compound 949388	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779325	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779325&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562380	CC[C@]1(c2cccc(-c3ccnc(C(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779325	US20250313563, Compound 949388	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779325	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779325&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562381	CC1CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCOCC1			779326	US20250313563, Compound 884112	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779326	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779326&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562382	CC1CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCOCC1			779326	US20250313563, Compound 884112	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779326	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779326&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562383	CC[C@]1(c2cccc(C3=CNN4CC=CN=C34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779327	US20250313563, Compound 949389	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779327	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779327&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562384	CC[C@]1(c2cccc(C3=CNN4CC=CN=C34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779327	US20250313563, Compound 949389	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779327	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779327&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562385	CC[C@]1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779328	US20250313563, Compound 884115	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779328	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779328&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562386	CC[C@]1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779328	US20250313563, Compound 884115	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779328	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779328&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562387	CC[C@]1(c2cccc(C3=CNN4CC(F)=CC(F)=C34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779329	US20250313563, Compound 949390	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779329	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779329&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562388	CC[C@]1(c2cccc(C3=CNN4CC(F)=CC(F)=C34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779329	US20250313563, Compound 949390	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779329	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779329&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562389	CC[C@@]1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779330	US20250313563, Compound 884116	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779330	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779330&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562390	CC[C@@]1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779330	US20250313563, Compound 884116	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779330	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779330&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562391	CC[C@@]1(c2cccc(-c3c(C)ccc4c(C)cccc34)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779331	US20250313563, Compound 949392	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779331	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779331&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562392	CC[C@@]1(c2cccc(-c3c(C)ccc4c(C)cccc34)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779331	US20250313563, Compound 949392	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779331	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779331&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562393	CC[C@@]1(c2cccc(OC)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779332	US20250313563, Compound 884117	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779332	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779332&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562394	CC[C@@]1(c2cccc(OC)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779332	US20250313563, Compound 884117	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779332	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779332&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562395	CC[C@]1(c2cccc(-c3cnn(C4CC4(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779333	US20250313563, Compound 949393	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779333	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779333&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562396	CC[C@]1(c2cccc(-c3cnn(C4CC4(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779333	US20250313563, Compound 949393	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779333	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779333&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562397	CC[C@]1(c2cccc(OC)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779334	US20250313563, Compound 884118	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779334	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779334&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562398	CC[C@]1(c2cccc(OC)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779334	US20250313563, Compound 884118	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779334	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779334&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562399	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCS(=O)(=O)CC1)C2			779335	US20250313563, Compound 949394	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779335	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779335&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562400	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCS(=O)(=O)CC1)C2			779335	US20250313563, Compound 949394	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779335	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779335&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562401	CCC1(c2cccc(N3CCCCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779336	US20250313563, Compound 885088	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779336	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779336&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562402	CCC1(c2cccc(N3CCCCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779336	US20250313563, Compound 885088	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779336	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779336&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562403	CC[C@]1(c2cccc(-c3cnn(C)c3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779337	US20250313563, Compound 949395	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779337	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779337&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562404	CC[C@]1(c2cccc(-c3cnn(C)c3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779337	US20250313563, Compound 949395	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779337	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779337&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562405	CCC1(c2cccc(N3CC4CCC(C4)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779338	US20250313563, Compound 885099	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779338	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779338&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562406	CCC1(c2cccc(N3CC4CCC(C4)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779338	US20250313563, Compound 885099	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779338	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779338&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562407	CC[C@]1(c2cccc(-c3ccnn3-c3ccc(F)cc3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779339	US20250313563, Compound 949396	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779339	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779339&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562408	CC[C@]1(c2cccc(-c3ccnn3-c3ccc(F)cc3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779339	US20250313563, Compound 949396	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779339	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779339&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562409	CCC1(c2cccc(N3CC4CCC3C4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779340	US20250313563, Compound 885110	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779340	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779340&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562410	CCC1(c2cccc(N3CC4CCC3C4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779340	US20250313563, Compound 885110	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779340	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779340&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562411	CC[C@]1(c2cccc(-c3c(C)cnc4ccccc34)c2)C2=C(CC(C)(C)NC2=O)NC2=NN=CC21			779341	US20250313563, Compound 949398	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779341	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779341&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562412	CC[C@]1(c2cccc(-c3c(C)cnc4ccccc34)c2)C2=C(CC(C)(C)NC2=O)NC2=NN=CC21			779341	US20250313563, Compound 949398	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779341	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779341&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562413	CCC1(c2cccc(N3CC4CCC3CC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779342	US20250313563, Compound 885120	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779342	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779342&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562414	CCC1(c2cccc(N3CC4CCC3CC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779342	US20250313563, Compound 885120	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779342	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779342&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562415	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCS(=O)(=O)CC1)C2			779343	US20250313563, Compound 949400	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779343	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779343&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562416	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCS(=O)(=O)CC1)C2			779343	US20250313563, Compound 949400	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779343	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779343&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562417	CCC1(c2cccc(N3CCC[C@@H]3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779344	US20250313563, Compound 885188	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779344	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779344&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562418	CCC1(c2cccc(N3CCC[C@@H]3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779344	US20250313563, Compound 885188	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779344	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779344&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562419	CCC1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779345	US20250313563, Compound 949417	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779345	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779345&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562420	CCC1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779345	US20250313563, Compound 949417	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779345	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779345&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562421	CCC1(c2cccc(N3CCC[C@H]3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779346	US20250313563, Compound 885204	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779346	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779346&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562422	CCC1(c2cccc(N3CCC[C@H]3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779346	US20250313563, Compound 885204	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779346	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779346&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562423	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779347	US20250313563, Compound 949421	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779347	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779347&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562424	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779347	US20250313563, Compound 949421	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779347	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779347&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562425	CCC1(c2cccc(N3CCCC[C@@H]3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779348	US20250313563, Compound 885217	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779348	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779348&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562426	CCC1(c2cccc(N3CCCC[C@@H]3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779348	US20250313563, Compound 885217	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779348	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779348&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562427	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779349	US20250313563, Compound 949422	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779349	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779349&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562428	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779349	US20250313563, Compound 949422	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779349	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779349&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562429	CCC1(c2cccc(N3CCCC[C@H]3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779350	US20250313563, Compound 885228	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779350	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779350&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562430	CCC1(c2cccc(N3CCCC[C@H]3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779350	US20250313563, Compound 885228	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779350	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779350&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562431	CC[C@]1(c2cccc(-c3cc(C4CCCC4)nn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779351	US20250313563, Compound 949509	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779351	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779351&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562432	CC[C@]1(c2cccc(-c3cc(C4CCCC4)nn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779351	US20250313563, Compound 949509	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779351	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779351&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562433	CCC1(c2cccc(N3C[C@H](C)C[C@H](C)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779352	US20250313563, Compound 885237	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779352	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779352&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562434	CCC1(c2cccc(N3C[C@H](C)C[C@H](C)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779352	US20250313563, Compound 885237	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779352	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779352&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562435	CC[C@]1(c2cccc(-c3cnn(CCN4CCCC4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779353	US20250313563, Compound 949510	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779353	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779353&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562436	CC[C@]1(c2cccc(-c3cnn(CCN4CCCC4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779353	US20250313563, Compound 949510	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779353	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779353&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562437	CCN(c1cccnc1)c1cccc(C2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779354	US20250313563, Compound 885331	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779354	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779354&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562438	CCN(c1cccnc1)c1cccc(C2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779354	US20250313563, Compound 885331	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779354	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779354&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562439	CC[C@]1(c2cccc(-c3cnn(Cc4ccc(C(F)(F)F)cc4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779355	US20250313563, Compound 949511	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779355	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779355&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562440	CC[C@]1(c2cccc(-c3cnn(Cc4ccc(C(F)(F)F)cc4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779355	US20250313563, Compound 949511	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779355	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779355&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562441	CCC1(c2cccc(N(c3cccnc3)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779356	US20250313563, Compound 885344	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779356	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779356&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562442	CCC1(c2cccc(N(c3cccnc3)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779356	US20250313563, Compound 885344	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779356	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779356&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562443	CC[C@@]1(c2cccc(-c3cc(C)ncc3OC)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779357	US20250313563, Compound 949512	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779357	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779357&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562444	CC[C@@]1(c2cccc(-c3cc(C)ncc3OC)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779357	US20250313563, Compound 949512	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779357	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779357&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562445	CCC1(c2cccc(N(C)c3cccnc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779358	US20250313563, Compound 885355	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779358	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779358&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562446	CCC1(c2cccc(N(C)c3cccnc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779358	US20250313563, Compound 885355	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779358	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779358&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562447	CC[C@]1(c2cccc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779359	US20250313563, Compound 949513	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779359	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779359&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562448	CC[C@]1(c2cccc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779359	US20250313563, Compound 949513	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779359	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779359&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562449	CCN(c1cccc(C2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1)c1cccnc1C			779360	US20250313563, Compound 885367	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779360	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779360&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562450	CCN(c1cccc(C2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1)c1cccnc1C			779360	US20250313563, Compound 885367	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779360	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779360&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562451	CC[C@]1(c2cccc(-c3cnn(-c4cccnc4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779361	US20250313563, Compound 949515	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779361	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779361&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562452	CC[C@]1(c2cccc(-c3cnn(-c4cccnc4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779361	US20250313563, Compound 949515	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779361	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779361&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562453	CCC1(c2cccc(N(C)c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779362	US20250313563, Compound 885382	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779362	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779362&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562454	CCC1(c2cccc(N(C)c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779362	US20250313563, Compound 885382	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779362	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779362&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562455	CC[C@]1(c2cccc(-c3ccncc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779363	US20250313563, Compound 949516	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779363	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779363&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562456	CC[C@]1(c2cccc(-c3ccncc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779363	US20250313563, Compound 949516	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779363	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779363&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562457	CCC1(c2cccc(N(C)c3nccn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779364	US20250313563, Compound 885402	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779364	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779364&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562458	CCC1(c2cccc(N(C)c3nccn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779364	US20250313563, Compound 885402	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779364	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779364&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562459	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			779365	US20250313563, Compound 949517	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779365	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779365&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562460	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			779365	US20250313563, Compound 949517	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779365	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779365&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562461	CC[C@]1(c2cccc([C@H]3CCOC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779366	US20250313563, Compound 889556	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779366	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779366&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562462	CC[C@]1(c2cccc([C@H]3CCOC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779366	US20250313563, Compound 889556	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779366	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779366&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562463	CC[C@]1(c2cccc(-c3ccnn3C3CC3(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779367	US20250313563, Compound 949518	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779367	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779367&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562464	CC[C@]1(c2cccc(-c3ccnn3C3CC3(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779367	US20250313563, Compound 949518	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779367	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779367&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562465	CC[C@]1(c2cccc([C@@H]3CCOC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779368	US20250313563, Compound 889557	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779368	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779368&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562466	CC[C@]1(c2cccc([C@@H]3CCOC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779368	US20250313563, Compound 889557	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779368	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779368&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562467	CC[C@]1(c2cccc(-c3cnn(-c4ccccc4)c3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779369	US20250313563, Compound 949519	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779369	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779369&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562468	CC[C@]1(c2cccc(-c3cnn(-c4ccccc4)c3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779369	US20250313563, Compound 949519	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779369	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779369&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562469	CC[C@@]1(c2cccc([C@H]3CCOC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779370	US20250313563, Compound 889558	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779370	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779370&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562470	CC[C@@]1(c2cccc([C@H]3CCOC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779370	US20250313563, Compound 889558	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779370	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779370&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562471	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			779371	US20250313563, Compound 949520	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779371	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779371&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562472	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			779371	US20250313563, Compound 949520	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779371	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779371&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562473	CC[C@@]1(c2cccc([C@@H]3CC[O:0]C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779372	US20250313563, Compound 889565	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779372	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779372&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894201	523297718							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562474	CC[C@@]1(c2cccc([C@@H]3CC[O:0]C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779372	US20250313563, Compound 889565	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779372	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779372&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894201	523297718							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562475	CC[C@]1(c2cccc(-c3cc(C)ncc3OC)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779373	US20250313563, Compound 949522	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779373	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779373&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562476	CC[C@]1(c2cccc(-c3cc(C)ncc3OC)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779373	US20250313563, Compound 949522	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779373	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779373&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562477	O=C1CC(C(F)(F)F)CC2=C1C1(CCOCC1)C1=C(N=NC1)N2			779374	US20250313563, Compound 889572	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779374	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779374&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562478	O=C1CC(C(F)(F)F)CC2=C1C1(CCOCC1)C1=C(N=NC1)N2			779374	US20250313563, Compound 889572	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779374	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779374&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562479	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(CCOC)CC2			779375	US20250313563, Compound 949599	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779375	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779375&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562480	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(CCOC)CC2			779375	US20250313563, Compound 949599	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779375	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779375&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562481	CCC1(c2cccc(S(=O)(=O)CC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779376	US20250313563, Compound 889579	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779376	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779376&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562482	CCC1(c2cccc(S(=O)(=O)CC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779376	US20250313563, Compound 889579	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779376	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779376&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562483	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(CCOC)CC2			779377	US20250313563, Compound 949600	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779377	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779377&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562484	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(CCOC)CC2			779377	US20250313563, Compound 949600	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779377	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779377&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562485	CCC1(c2cccc(N(C)C(=O)COC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779378	US20250313563, Compound 889580	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779378	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779378&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562486	CCC1(c2cccc(N(C)C(=O)COC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779378	US20250313563, Compound 889580	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779378	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779378&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562487	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cn(C)nc1C)CC2			779379	US20250313563, Compound 949641	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779379	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779379&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562488	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cn(C)nc1C)CC2			779379	US20250313563, Compound 949641	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779379	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779379&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562489	CC[C@]1(c2cccc(N3CC[O:0]CC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779380	US20250313563, Compound 889581	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779380	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779380&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894209	523297726							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562490	CC[C@]1(c2cccc(N3CC[O:0]CC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779380	US20250313563, Compound 889581	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779380	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779380&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894209	523297726							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562491	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cn(C)nc1C)CC2			779381	US20250313563, Compound 949642	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779381	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779381&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562492	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cn(C)nc1C)CC2			779381	US20250313563, Compound 949642	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779381	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779381&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562493	CC[C@@]1(c2cccc(N3CC[O:0]CC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779382	US20250313563, Compound 889582	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779382	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779382&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894211	523297728							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562494	CC[C@@]1(c2cccc(N3CC[O:0]CC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779382	US20250313563, Compound 889582	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779382	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779382&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894211	523297728							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562495	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779383	US20250313563, Compound 949643	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779383	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779383&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562496	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779383	US20250313563, Compound 949643	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779383	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779383&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562497	CCC1(c2cccc(N(C)c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779384	US20250313563, Compound 889604	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779384	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779384&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562498	CCC1(c2cccc(N(C)c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779384	US20250313563, Compound 889604	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779384	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779384&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562499	CC[C@]1(c2cccc(-c3cc(C)ncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779385	US20250313563, Compound 949644	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779385	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779385&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562500	CC[C@]1(c2cccc(-c3cc(C)ncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779385	US20250313563, Compound 949644	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779385	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779385&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562501	CCC1(c2cccc(C3CC4CCC(C3)O4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779386	US20250313563, Compound 889622	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779386	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779386&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562502	CCC1(c2cccc(C3CC4CCC(C3)O4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779386	US20250313563, Compound 889622	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779386	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779386&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562503	CC[C@@]1(c2cccc(C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779387	US20250313563, Compound 949646	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779387	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779387&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562504	CC[C@@]1(c2cccc(C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779387	US20250313563, Compound 949646	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779387	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779387&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562505	CC[C@]1(c2cccc(N3CCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779388	US20250313563, Compound 889631	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779388	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779388&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562506	CC[C@]1(c2cccc(N3CCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779388	US20250313563, Compound 889631	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779388	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779388&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562507	CC[C@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779389	US20250313563, Compound 949647	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779389	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779389&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562508	CC[C@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779389	US20250313563, Compound 949647	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779389	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779389&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562509	CC[C@@]1(c2cccc(N3CCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779390	US20250313563, Compound 889632	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779390	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779390&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562510	CC[C@@]1(c2cccc(N3CCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779390	US20250313563, Compound 889632	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779390	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779390&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562511	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779391	US20250313563, Compound 949648	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779391	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779391&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562512	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779391	US20250313563, Compound 949648	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779391	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779391&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562513	CCC1(c2cccc(N3CCCc4ncccc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779392	US20250313563, Compound 889639	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779392	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779392&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562514	CCC1(c2cccc(N3CCCc4ncccc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779392	US20250313563, Compound 889639	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779392	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779392&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562515	CC[C@]1(c2cccc(C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779393	US20250313563, Compound 949649	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779393	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779393&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562516	CC[C@]1(c2cccc(C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779393	US20250313563, Compound 949649	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779393	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779393&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562517	CCC1(c2cccc(N(C(C)=O)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779394	US20250313563, Compound 893305	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779394	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779394&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562518	CCC1(c2cccc(N(C(C)=O)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779394	US20250313563, Compound 893305	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779394	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779394&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562519	CC[C@@]1(c2cccc(-c3cc(C)ncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779395	US20250313563, Compound 949650	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779395	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779395&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562520	CC[C@@]1(c2cccc(-c3cc(C)ncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779395	US20250313563, Compound 949650	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779395	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779395&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562521	CCC1(c2cccc(N(CCOC)C(C)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779396	US20250313563, Compound 893306	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779396	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779396&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562522	CCC1(c2cccc(N(CCOC)C(C)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779396	US20250313563, Compound 893306	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779396	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779396&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562523	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779397	US20250313563, Compound 949651	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779397	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779397&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562524	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779397	US20250313563, Compound 949651	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779397	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779397&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562525	O=C1CC(c2ccccc2)CC2=C1C1(CCOCC1)C1=C(N=NC1)N2			779398	US20250313563, Compound 893309	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779398	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779398&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562526	O=C1CC(c2ccccc2)CC2=C1C1(CCOCC1)C1=C(N=NC1)N2			779398	US20250313563, Compound 893309	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779398	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779398&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562527	CCC1(c2cccc(C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779399	US20250313563, Compound 949747	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779399	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779399&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562528	CCC1(c2cccc(C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779399	US20250313563, Compound 949747	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779399	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779399&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562529	C[C@@H]1C[C@H](C)C(=O)C2=C1NC1=C(CN=N1)C21CCOCC1			779400	US20250313563, Compound 893316	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779400	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779400&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562530	C[C@@H]1C[C@H](C)C(=O)C2=C1NC1=C(CN=N1)C21CCOCC1			779400	US20250313563, Compound 893316	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779400	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779400&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562531	CCC1(c2cccc(OC)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779401	US20250313563, Compound 949748	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779401	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779401&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562532	CCC1(c2cccc(OC)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779401	US20250313563, Compound 949748	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779401	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779401&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562533	CC[C@]1(c2cc(-c3ccncc3)ccc2C)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779402	US20250313563, Compound 893323	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779402	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779402&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562534	CC[C@]1(c2cc(-c3ccncc3)ccc2C)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779402	US20250313563, Compound 893323	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779402	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779402&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562535	CC[C@@]1(c2cccc(C(C)C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779403	US20250313563, Compound 949752	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779403	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779403&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562536	CC[C@@]1(c2cccc(C(C)C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779403	US20250313563, Compound 949752	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779403	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779403&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562537	CC[C@@]1(c2cc(-c3ccncc3)ccc2F)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779404	US20250313563, Compound 893324	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779404	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779404&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562538	CC[C@@]1(c2cc(-c3ccncc3)ccc2F)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779404	US20250313563, Compound 893324	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779404	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779404&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562539	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779405	US20250313563, Compound 949756	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779405	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779405&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562540	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779405	US20250313563, Compound 949756	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779405	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779405&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562541	O=C1C[C@H](C(F)(F)F)CC2=C1C1(CCOCC1)C1=C(N=NC1)N2			779406	US20250313563, Compound 901477	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779406	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779406&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562542	O=C1C[C@H](C(F)(F)F)CC2=C1C1(CCOCC1)C1=C(N=NC1)N2			779406	US20250313563, Compound 901477	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779406	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779406&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562543	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779407	US20250313563, Compound 949757	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779407	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779407&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562544	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779407	US20250313563, Compound 949757	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779407	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779407&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562545	O=C1C[C@@H](C(F)(F)F)CC2=C1C1(CCOCC1)C1=C(N=NC1)N2			779408	US20250313563, Compound 901478	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779408	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779408&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562546	O=C1C[C@@H](C(F)(F)F)CC2=C1C1(CCOCC1)C1=C(N=NC1)N2			779408	US20250313563, Compound 901478	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779408	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779408&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562547	CC[C@]1(c2cccc(C(C)C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779409	US20250313563, Compound 949761	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779409	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779409&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562548	CC[C@]1(c2cccc(C(C)C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779409	US20250313563, Compound 949761	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779409	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779409&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562549	CC[C@]1(c2cccc(OC)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(=O)OC)=C21			779410	US20250313563, Compound 901479	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779410	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779410&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562550	CC[C@]1(c2cccc(OC)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(=O)OC)=C21			779410	US20250313563, Compound 901479	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779410	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779410&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562551	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccn(C)n1)CC2			779411	US20250313563, Compound 949835	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779411	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779411&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562552	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccn(C)n1)CC2			779411	US20250313563, Compound 949835	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779411	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779411&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562553	CC[C@@]1(c2cccc(OC)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(=O)OC)=C21			779412	US20250313563, Compound 901480	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779412	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779412&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562554	CC[C@@]1(c2cccc(OC)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(=O)OC)=C21			779412	US20250313563, Compound 901480	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779412	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779412&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562555	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccn(C)n1)CC2			779413	US20250313563, Compound 949836	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779413	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779413&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562556	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccn(C)n1)CC2			779413	US20250313563, Compound 949836	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779413	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779413&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562557	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			779414	US20250313563, Compound 902202	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779414	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779414&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562558	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			779414	US20250313563, Compound 902202	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779414	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779414&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562559	CCn1cc(N2CCC3=C(C2=O)[C@](CC)(c2cccc(C(F)(F)F)c2)C2=CN=NC2N3)cn1			779415	US20250313563, Compound 949867	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779415	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779415&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562560	CCn1cc(N2CCC3=C(C2=O)[C@](CC)(c2cccc(C(F)(F)F)c2)C2=CN=NC2N3)cn1			779415	US20250313563, Compound 949867	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779415	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779415&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562561	CCC1(c2cccc(N3CC(C)(C)C3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779416	US20250313563, Compound 902969	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779416	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779416&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562562	CCC1(c2cccc(N3CC(C)(C)C3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779416	US20250313563, Compound 902969	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779416	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779416&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562563	CCn1cc(N2CCC3=C(C2=O)[C@](CC)(c2cccc(C(F)(F)F)c2)C2=CN=NC2N3)cn1			779417	US20250313563, Compound 949868	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779417	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779417&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562564	CCn1cc(N2CCC3=C(C2=O)[C@](CC)(c2cccc(C(F)(F)F)c2)C2=CN=NC2N3)cn1			779417	US20250313563, Compound 949868	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779417	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779417&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562565	CCC1(c2cccc(N(C)c3ccncn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779418	US20250313563, Compound 902970	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779418	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779418&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562566	CCC1(c2cccc(N(C)c3ccncn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779418	US20250313563, Compound 902970	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779418	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779418&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562567	CC[C@@]1(c2cccc(-c3cc(C)nnc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779419	US20250313563, Compound 949910	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779419	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779419&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562568	CC[C@@]1(c2cccc(-c3cc(C)nnc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779419	US20250313563, Compound 949910	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779419	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779419&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562569	CCC1(c2cccc(N(C)c3cnccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779420	US20250313563, Compound 902971	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779420	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779420&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562570	CCC1(c2cccc(N(C)c3cnccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779420	US20250313563, Compound 902971	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779420	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779420&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562571	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779421	US20250313563, Compound 949911	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779421	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779421&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562572	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779421	US20250313563, Compound 949911	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779421	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779421&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562573	CCC1(c2cccc(N(C)C(=O)c3ccccc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779422	US20250313563, Compound 909201	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779422	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779422&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562574	CCC1(c2cccc(N(C)C(=O)c3ccccc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779422	US20250313563, Compound 909201	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779422	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779422&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562575	CC[C@]1(c2cccc(-c3cc(C)nnc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779423	US20250313563, Compound 949917	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779423	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779423&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562576	CC[C@]1(c2cccc(-c3cc(C)nnc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779423	US20250313563, Compound 949917	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779423	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779423&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562577	CCC1(c2cccc(N(C)C(=O)CN3CCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779424	US20250313563, Compound 909202	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779424	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779424&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562578	CCC1(c2cccc(N(C)C(=O)CN3CCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779424	US20250313563, Compound 909202	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779424	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779424&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562579	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779425	US20250313563, Compound 949919	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779425	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779425&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562580	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779425	US20250313563, Compound 949919	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779425	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779425&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562581	CCC1(c2cc(N3CC[O:0]CC3)ccc2F)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779426	US20250313563, Compound 909203	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779426	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779426&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894254	523297772							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562582	CCC1(c2cc(N3CC[O:0]CC3)ccc2F)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779426	US20250313563, Compound 909203	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779426	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779426&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894254	523297772							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562583	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			779427	US20250313563, Compound 950055	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779427	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779427&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562584	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			779427	US20250313563, Compound 950055	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779427	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779427&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562585	CCC1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779428	US20250313563, Compound 909204	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779428	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779428&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562586	CCC1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779428	US20250313563, Compound 909204	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779428	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779428&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562587	CC[C@@]1(c2cccc(C3=C(C)SN(C)C3)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			779429	US20250313563, Compound 950056	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779429	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779429&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562588	CC[C@@]1(c2cccc(C3=C(C)SN(C)C3)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			779429	US20250313563, Compound 950056	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779429	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779429&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562589	CCCC(C(C)=O)c1cccc(C2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779430	US20250313563, Compound 909205	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779430	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779430&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562590	CCCC(C(C)=O)c1cccc(C2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779430	US20250313563, Compound 909205	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779430	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779430&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562591	CC[C@@]1(c2cccc(-c3ccncc3C3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779431	US20250313563, Compound 950059	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779431	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779431&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562592	CC[C@@]1(c2cccc(-c3ccncc3C3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779431	US20250313563, Compound 950059	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779431	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779431&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562593	CC[C@]1(c2cc(-c3ccnc(C)c3)ccc2F)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779432	US20250313563, Compound 909212	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779432	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779432&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562594	CC[C@]1(c2cc(-c3ccnc(C)c3)ccc2F)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779432	US20250313563, Compound 909212	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779432	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779432&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562595	CC[C@@]1(c2cccc(-c3cnn(C4CC4(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779433	US20250313563, Compound 950060	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779433	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779433&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562596	CC[C@@]1(c2cccc(-c3cnn(C4CC4(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779433	US20250313563, Compound 950060	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779433	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779433&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562597	CC[C@@]1(c2cc(-c3ccnc(C)c3)ccc2F)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779434	US20250313563, Compound 909213	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779434	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779434&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562598	CC[C@@]1(c2cc(-c3ccnc(C)c3)ccc2F)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779434	US20250313563, Compound 909213	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779434	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779434&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562599	CC[C@@]1(c2cccc(-c3cnn(C(C)C)c3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779435	US20250313563, Compound 950061	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779435	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779435&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562600	CC[C@@]1(c2cccc(-c3cnn(C(C)C)c3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779435	US20250313563, Compound 950061	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779435	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779435&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562601	CCN(C(C)=O)c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779436	US20250313563, Compound 909214	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779436	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779436&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562602	CCN(C(C)=O)c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779436	US20250313563, Compound 909214	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779436	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779436&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562603	CC[C@@]1(c2cccc(-c3c(C)c(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779437	US20250313563, Compound 950062	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779437	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779437&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562604	CC[C@@]1(c2cccc(-c3c(C)c(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779437	US20250313563, Compound 950062	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779437	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779437&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562605	CCN(C(C)=O)c1cccc([C@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779438	US20250313563, Compound 909215	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779438	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779438&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562606	CCN(C(C)=O)c1cccc([C@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779438	US20250313563, Compound 909215	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779438	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779438&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562607	CCC1(c2cccc(Cc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779439	US20250313563, Compound 950151	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779439	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779439&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562608	CCC1(c2cccc(Cc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779439	US20250313563, Compound 950151	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779439	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779439&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562609	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@H](C)C[C@@H]2C			779440	US20250313563, Compound 909216	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779440	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779440&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562610	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@H](C)C[C@@H]2C			779440	US20250313563, Compound 909216	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779440	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779440&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562611	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779441	US20250313563, Compound 950162	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779441	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779441&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562612	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779441	US20250313563, Compound 950162	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779441	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779441&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562613	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@H](C)C[C@@H]2C			779442	US20250313563, Compound 909217	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779442	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779442&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562614	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@H](C)C[C@@H]2C			779442	US20250313563, Compound 909217	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779442	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779442&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562615	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779443	US20250313563, Compound 950163	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779443	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779443&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562616	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779443	US20250313563, Compound 950163	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779443	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779443&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562617	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@@H](C)C[C@H]2C			779444	US20250313563, Compound 909218	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779444	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779444&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562618	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@@H](C)C[C@H]2C			779444	US20250313563, Compound 909218	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779444	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779444&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562619	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCCC1)C2			779445	US20250313563, Compound 950252	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779445	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779445&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562620	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCCC1)C2			779445	US20250313563, Compound 950252	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779445	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779445&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562621	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@@H](C)C[C@H]2C			779446	US20250313563, Compound 909219	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779446	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779446&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562622	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@@H](C)C[C@H]2C			779446	US20250313563, Compound 909219	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779446	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779446&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562623	CC[C@@]1(c2cccc(-c3cnn(C(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779447	US20250313563, Compound 950254	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779447	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779447&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562624	CC[C@@]1(c2cccc(-c3cnn(C(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779447	US20250313563, Compound 950254	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779447	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779447&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562625	CC[C@]1(c2cc(-c3cnn(C)c3)ccc2F)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779448	US20250313563, Compound 909220	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779448	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779448&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562626	CC[C@]1(c2cc(-c3cnn(C)c3)ccc2F)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779448	US20250313563, Compound 909220	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779448	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779448&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562627	CC[C@@]1(c2cccc(C3=C(C)SN(C)C3)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCCC1)C2			779449	US20250313563, Compound 950255	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779449	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779449&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562628	CC[C@@]1(c2cccc(C3=C(C)SN(C)C3)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCCC1)C2			779449	US20250313563, Compound 950255	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779449	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779449&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562629	CC[C@@]1(c2cc(-c3cnn(C)c3)ccc2F)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779450	US20250313563, Compound 909223	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779450	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779450&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562630	CC[C@@]1(c2cc(-c3cnn(C)c3)ccc2F)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779450	US20250313563, Compound 909223	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779450	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779450&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562631	CCC1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779451	US20250313563, Compound 950318	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779451	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779451&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562632	CCC1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779451	US20250313563, Compound 950318	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779451	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779451&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562633	CC[C@H]1CCN1c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779452	US20250313563, Compound 911969	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779452	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779452&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562634	CC[C@H]1CCN1c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779452	US20250313563, Compound 911969	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779452	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779452&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562635	CCC1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779453	US20250313563, Compound 950320	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779453	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779453&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562636	CCC1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779453	US20250313563, Compound 950320	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779453	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779453&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562637	CC[C@@H]1CCN1c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779454	US20250313563, Compound 911970	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779454	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779454&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562638	CC[C@@H]1CCN1c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779454	US20250313563, Compound 911970	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779454	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779454&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562639	CCC1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779455	US20250313563, Compound 950323	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779455	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779455&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562640	CCC1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779455	US20250313563, Compound 950323	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779455	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779455&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562641	CC[C@H]1CCN1c1cccc([C@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779456	US20250313563, Compound 911972	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779456	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779456&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562642	CC[C@H]1CCN1c1cccc([C@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779456	US20250313563, Compound 911972	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779456	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779456&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562643	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C1=CN=NC1)CC2			779457	US20250313563, Compound 950479	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779457	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779457&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562644	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C1=CN=NC1)CC2			779457	US20250313563, Compound 950479	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779457	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779457&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562645	CC[C@]1(c2cccc(N(C)c3cccnn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779458	US20250313563, Compound 911975	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779458	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779458&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562646	CC[C@]1(c2cccc(N(C)c3cccnn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779458	US20250313563, Compound 911975	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779458	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779458&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562647	CCC1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779459	US20250313563, Compound 950484	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779459	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779459&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562648	CCC1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779459	US20250313563, Compound 950484	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779459	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779459&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562649	CC[C@@]1(c2cccc(N(C)c3cccnn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779460	US20250313563, Compound 911976	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779460	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779460&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562650	CC[C@@]1(c2cccc(N(C)c3cccnn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779460	US20250313563, Compound 911976	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779460	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779460&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562651	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1nn(C)cc1C)CC2			779461	US20250313563, Compound 950486	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779461	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779461&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562652	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1nn(C)cc1C)CC2			779461	US20250313563, Compound 950486	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779461	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779461&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562653	CC[C@]1(c2cccc(N(C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779462	US20250313563, Compound 911980	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779462	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779462&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562654	CC[C@]1(c2cccc(N(C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779462	US20250313563, Compound 911980	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779462	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779462&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562655	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779463	US20250313563, Compound 950490	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779463	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779463&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562656	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779463	US20250313563, Compound 950490	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779463	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779463&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562657	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779464	US20250313563, Compound 911981	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779464	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779464&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562658	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779464	US20250313563, Compound 911981	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779464	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779464&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562659	CC[C@]1(c2cccc(C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779465	US20250313563, Compound 950493	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779465	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779465&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562660	CC[C@]1(c2cccc(C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779465	US20250313563, Compound 950493	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779465	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779465&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562661	CC[C@]1(c2cccc(-c3ccnc(OC)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779466	US20250313563, Compound 911988	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779466	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779466&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562662	CC[C@]1(c2cccc(-c3ccnc(OC)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779466	US20250313563, Compound 911988	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779466	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779466&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562663	CC[C@@]1(c2cccc(C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779467	US20250313563, Compound 950494	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779467	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779467&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562664	CC[C@@]1(c2cccc(C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779467	US20250313563, Compound 950494	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779467	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779467&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562665	CC[C@@]1(c2cccc(-c3ccnc(OC)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779468	US20250313563, Compound 911989	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779468	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779468&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562666	CC[C@@]1(c2cccc(-c3ccnc(OC)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779468	US20250313563, Compound 911989	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779468	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779468&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562667	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779469	US20250313563, Compound 950497	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779469	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779469&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562668	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779469	US20250313563, Compound 950497	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779469	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779469&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562669	CC[C@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779470	US20250313563, Compound 911990	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779470	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779470&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562670	CC[C@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779470	US20250313563, Compound 911990	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779470	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779470&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562671	CC[C@@]1(c2cccc(-c3ccnc(C(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779471	US20250313563, Compound 950561	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779471	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779471&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562672	CC[C@@]1(c2cccc(-c3ccnc(C(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779471	US20250313563, Compound 950561	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779471	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779471&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562673	CC[C@@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779472	US20250313563, Compound 911991	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779472	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779472&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562674	CC[C@@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779472	US20250313563, Compound 911991	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779472	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779472&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562675	CC[C@@]1(c2cccc(-c3cnn(C)c3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779473	US20250313563, Compound 950562	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779473	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779473&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562676	CC[C@@]1(c2cccc(-c3cnn(C)c3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779473	US20250313563, Compound 950562	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779473	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779473&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562677	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779474	US20250313563, Compound 911992	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779474	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779474&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562678	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779474	US20250313563, Compound 911992	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779474	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779474&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562679	CC[C@@]1(c2cccc(-c3cn(C)nc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779475	US20250313563, Compound 950563	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779475&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562680	CC[C@@]1(c2cccc(-c3cn(C)nc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779475	US20250313563, Compound 950563	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779475&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562681	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779476	US20250313563, Compound 911993	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779476	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779476&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562682	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779476	US20250313563, Compound 911993	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779476	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779476&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562683	CC[C@@]1(c2cccc(-c3cnn4c3CC(C)(C)CC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779477	US20250313563, Compound 950564	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779477	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779477&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562684	CC[C@@]1(c2cccc(-c3cnn4c3CC(C)(C)CC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779477	US20250313563, Compound 950564	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779477	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779477&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562685	CC[C@]1(c2cccc(N3CCc4ccncc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779478	US20250313563, Compound 912003	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779478	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779478&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562686	CC[C@]1(c2cccc(N3CCc4ccncc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779478	US20250313563, Compound 912003	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779478	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779478&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562687	CC[C@@]1(c2cccc(-c3cnn4cc(F)cc(F)c34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779479	US20250313563, Compound 950565	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779479	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779479&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562688	CC[C@@]1(c2cccc(-c3cnn4cc(F)cc(F)c34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779479	US20250313563, Compound 950565	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779479	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779479&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562689	CC[C@@]1(c2cccc(N3CCc4ccncc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779480	US20250313563, Compound 912004	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779480	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779480&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562690	CC[C@@]1(c2cccc(N3CCc4ccncc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779480	US20250313563, Compound 912004	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779480	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779480&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562691	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cc(C)n(C)n1)CC2			779481	US20250313563, Compound 950608	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779481	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779481&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562692	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cc(C)n(C)n1)CC2			779481	US20250313563, Compound 950608	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779481	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779481&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562693	CCC1(c2cccc(N(CCc3ccccc3)C(C)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779482	US20250313563, Compound 912064	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779482	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779482&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562694	CCC1(c2cccc(N(CCc3ccccc3)C(C)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779482	US20250313563, Compound 912064	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779482	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779482&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562695	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnn(C)c1C)CC2			779483	US20250313563, Compound 950612	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779483	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779483&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562696	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnn(C)c1C)CC2			779483	US20250313563, Compound 950612	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779483	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779483&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562697	CCC1(c2cccc(N(C)C(=O)C3CCCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779484	US20250313563, Compound 912065	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779484	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779484&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562698	CCC1(c2cccc(N(C)C(=O)C3CCCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779484	US20250313563, Compound 912065	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779484	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779484&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562699	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cccs1)CC2			779485	US20250313563, Compound 950614	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779485	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779485&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562700	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cccs1)CC2			779485	US20250313563, Compound 950614	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779485	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779485&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562701	CCC1(c2cccc(N(C)C(=O)CCc3ccccc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779486	US20250313563, Compound 912066	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779486	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779486&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562702	CCC1(c2cccc(N(C)C(=O)CCc3ccccc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779486	US20250313563, Compound 912066	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779486	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779486&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562703	CCC1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779487	US20250313563, Compound 950615	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779487	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779487&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562704	CCC1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779487	US20250313563, Compound 950615	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779487	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779487&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562705	CCC1(c2cccc(N(C)C(O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779488	US20250313563, Compound 912067	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779488	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779488&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562706	CCC1(c2cccc(N(C)C(O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779488	US20250313563, Compound 912067	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779488	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779488&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562707	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccsc1)CC2			779489	US20250313563, Compound 950776	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779489	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779489&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562708	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccsc1)CC2			779489	US20250313563, Compound 950776	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779489	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779489&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562709	CCC1(c2cccc(N(C)C(=O)c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779490	US20250313563, Compound 912068	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779490	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779490&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562710	CCC1(c2cccc(N(C)C(=O)c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779490	US20250313563, Compound 912068	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779490	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779490&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562711	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cscn1)CC2			779491	US20250313563, Compound 950777	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779491	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779491&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562712	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cscn1)CC2			779491	US20250313563, Compound 950777	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779491	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779491&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562713	CCC1(c2cccc(N(C(C)=O)C3CCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779492	US20250313563, Compound 912069	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779492&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562714	CCC1(c2cccc(N(C(C)=O)C3CCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779492	US20250313563, Compound 912069	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779492&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562715	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCS(=O)(=O)CC1)C2			779493	US20250313563, Compound 950813	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779493	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779493&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562716	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCS(=O)(=O)CC1)C2			779493	US20250313563, Compound 950813	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779493	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779493&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562717	CCC1(c2cccc(N(C)C(=O)C3CC[O:0]CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779494	US20250313563, Compound 912070	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779494	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779494&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894322	523297840							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562718	CCC1(c2cccc(N(C)C(=O)C3CC[O:0]CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779494	US20250313563, Compound 912070	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779494	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779494&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894322	523297840							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562719	CC[C@@]1(c2cccc(C3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779495	US20250313563, Compound 950817	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779495&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562720	CC[C@@]1(c2cccc(C3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779495	US20250313563, Compound 950817	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779495&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562721	CCC1(c2cccc(N(C)C(=O)Cc3ccccc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779496	US20250313563, Compound 912071	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779496	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779496&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562722	CCC1(c2cccc(N(C)C(=O)Cc3ccccc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779496	US20250313563, Compound 912071	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779496	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779496&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562723	CC[C@@]1(c2cccc(-c3cnn(-c4ccccc4)c3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779497	US20250313563, Compound 950821	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779497	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779497&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562724	CC[C@@]1(c2cccc(-c3cnn(-c4ccccc4)c3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779497	US20250313563, Compound 950821	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779497	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779497&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562725	C[C@H]1CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCOCC1			779498	US20250313563, Compound 912078	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779498	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779498&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562726	C[C@H]1CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCOCC1			779498	US20250313563, Compound 912078	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779498	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779498&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562727	CC[C@@]1(c2cccc(-c3ccnn3-c3ccc(F)cc3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779499	US20250313563, Compound 950822	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779499	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779499&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562728	CC[C@@]1(c2cccc(-c3ccnn3-c3ccc(F)cc3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779499	US20250313563, Compound 950822	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779499	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779499&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562729	C[C@@H]1CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCOCC1			779500	US20250313563, Compound 912079	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779500	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779500&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562730	C[C@@H]1CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCOCC1			779500	US20250313563, Compound 912079	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779500	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779500&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562731	CC[C@@]1(c2cccc(-c3ccnn3C3CC3(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779501	US20250313563, Compound 950824	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779501&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562732	CC[C@@]1(c2cccc(-c3ccnn3C3CC3(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779501	US20250313563, Compound 950824	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779501&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562733	CC[C@]1(c2cccc([C@H]3CCOC(C)(C)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779502	US20250313563, Compound 912088	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779502	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779502&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562734	CC[C@]1(c2cccc([C@H]3CCOC(C)(C)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779502	US20250313563, Compound 912088	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779502	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779502&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562735	CC[C@]1(c2cccc(-c3c(C)cnc4ccccc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779503	US20250313563, Compound 950825	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779503	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779503&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562736	CC[C@]1(c2cccc(-c3c(C)cnc4ccccc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779503	US20250313563, Compound 950825	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779503	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779503&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562737	CC[C@]1(c2cccc([C@@H]3CCOC(C)(C)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779504	US20250313563, Compound 912089	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779504	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779504&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562738	CC[C@]1(c2cccc([C@@H]3CCOC(C)(C)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779504	US20250313563, Compound 912089	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779504	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779504&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562739	CC[C@@]1(c2cccc(C3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779505	US20250313563, Compound 950828	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779505	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779505&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562740	CC[C@@]1(c2cccc(C3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779505	US20250313563, Compound 950828	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779505	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779505&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562741	CC[C@@]1(c2cccc([C@H]3CCOC(C)(C)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779506	US20250313563, Compound 912090	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779506	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779506&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562742	CC[C@@]1(c2cccc([C@H]3CCOC(C)(C)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779506	US20250313563, Compound 912090	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779506	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779506&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562743	CC[C@@]1(c2cccc(C3=CNN4CC=CN=C34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779507	US20250313563, Compound 950830	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779507	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779507&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562744	CC[C@@]1(c2cccc(C3=CNN4CC=CN=C34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779507	US20250313563, Compound 950830	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779507	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779507&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562745	CC[C@@]1(c2cccc([C@@H]3CCOC(C)(C)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779508	US20250313563, Compound 912091	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779508	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779508&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562746	CC[C@@]1(c2cccc([C@@H]3CCOC(C)(C)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779508	US20250313563, Compound 912091	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779508	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779508&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562747	CC[C@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779509	US20250313563, Compound 951592	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779509	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779509&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562748	CC[C@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779509	US20250313563, Compound 951592	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779509	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779509&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562749	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCCCC1=O			779510	US20250313563, Compound 912105	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779510	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779510&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562750	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCCCC1=O			779510	US20250313563, Compound 912105	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779510	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779510&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562751	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ncn(C)c1C)CC2			779511	US20250313563, Compound 951598	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779511	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779511&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562752	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ncn(C)c1C)CC2			779511	US20250313563, Compound 951598	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779511	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779511&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562753	CCC1(c2cccc(N(CC3CCCC3)C(C)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779512	US20250313563, Compound 912166	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779512	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779512&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562754	CCC1(c2cccc(N(CC3CCCC3)C(C)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779512	US20250313563, Compound 912166	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779512	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779512&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562755	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779513	US20250313563, Compound 951599	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779513	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779513&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562756	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779513	US20250313563, Compound 951599	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779513	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779513&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562757	CCC1(c2cccc(N(C)C(=O)C3CCN(C)CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779514	US20250313563, Compound 912167	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779514	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779514&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562758	CCC1(c2cccc(N(C)C(=O)C3CCN(C)CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779514	US20250313563, Compound 912167	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779514	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779514&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562759	CC[C@@]1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779515	US20250313563, Compound 951604	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779515	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779515&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562760	CC[C@@]1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779515	US20250313563, Compound 951604	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779515	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779515&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562761	CCC1(c2cccc(S(=O)(=O)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779516	US20250313563, Compound 912169	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779516&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562762	CCC1(c2cccc(S(=O)(=O)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779516	US20250313563, Compound 912169	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779516&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562763	CC[C@@]1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779517	US20250313563, Compound 951605	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779517	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779517&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562764	CC[C@@]1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779517	US20250313563, Compound 951605	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779517	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779517&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562765	CC[C@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779518	US20250313563, Compound 912171	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779518	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779518&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562766	CC[C@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779518	US20250313563, Compound 912171	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779518	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779518&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562767	CC[C@]1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779519	US20250313563, Compound 951606	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779519	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779519&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562768	CC[C@]1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779519	US20250313563, Compound 951606	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779519	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779519&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562769	CC[C@]1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779520	US20250313563, Compound 951607	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779520&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562770	CC[C@]1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779520	US20250313563, Compound 951607	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779520&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562771	CC[C@@]1(c2cccc(-c3ccncc3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779521	US20250313563, Compound 913015	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779521	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779521&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562772	CC[C@@]1(c2cccc(-c3ccncc3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779521	US20250313563, Compound 913015	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779521	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779521&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562773	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779522	US20250313563, Compound 951612	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779522&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562774	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779522	US20250313563, Compound 951612	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779522&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562775	CC[C@@]1(c2cccc(-c3ccnc(OC)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779523	US20250313563, Compound 913016	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779523	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779523&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562776	CC[C@@]1(c2cccc(-c3ccnc(OC)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779523	US20250313563, Compound 913016	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779523	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779523&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562777	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779524	US20250313563, Compound 951618	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779524	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779524&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562778	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779524	US20250313563, Compound 951618	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779524	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779524&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562779	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779525	US20250313563, Compound 913017	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779525&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562780	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779525	US20250313563, Compound 913017	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779525&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562781	CC[C@@]1(c2cccc(-c3cn(C)nc3C3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779526	US20250313563, Compound 951706	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779526	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779526&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562782	CC[C@@]1(c2cccc(-c3cn(C)nc3C3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779526	US20250313563, Compound 951706	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779526	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779526&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562783	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779527	US20250313563, Compound 913018	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779527	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779527&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562784	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779527	US20250313563, Compound 913018	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779527	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779527&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562785	CC[C@@]1(c2cccc(-c3cnn(C4CCCCC4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779528	US20250313563, Compound 951707	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779528&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562786	CC[C@@]1(c2cccc(-c3cnn(C4CCCCC4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779528	US20250313563, Compound 951707	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779528&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562787	CC[C@@]1(c2cccc(-c3cc(C)ncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779529	US20250313563, Compound 913019	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779529	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779529&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562788	CC[C@@]1(c2cccc(-c3cc(C)ncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779529	US20250313563, Compound 913019	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779529	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779529&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562789	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnsc1)CC2			779530	US20250313563, Compound 951733	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779530	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779530&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562790	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnsc1)CC2			779530	US20250313563, Compound 951733	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779530	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779530&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562791	CC[C@]1(c2cccc(-c3ccnc(C(F)(F)F)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779531	US20250313563, Compound 913020	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779531&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562792	CC[C@]1(c2cccc(-c3ccnc(C(F)(F)F)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779531	US20250313563, Compound 913020	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779531&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562793	CC[C@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779532	US20250313563, Compound 951736	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779532	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779532&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562794	CC[C@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779532	US20250313563, Compound 951736	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779532	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779532&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562795	CC[C@@]1(c2cccc(-c3ccnc(N(C)C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779533	US20250313563, Compound 913021	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779533	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779533&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562796	CC[C@@]1(c2cccc(-c3ccnc(N(C)C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779533	US20250313563, Compound 913021	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779533	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779533&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562797	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779534	US20250313563, Compound 951740	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779534	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779534&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562798	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779534	US20250313563, Compound 951740	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779534	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779534&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562799	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779535	US20250313563, Compound 913022	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779535	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779535&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562800	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779535	US20250313563, Compound 913022	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779535	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779535&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562801	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnsc1)CC2			779536	US20250313563, Compound 951742	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779536	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779536&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562802	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnsc1)CC2			779536	US20250313563, Compound 951742	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779536	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779536&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562803	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779537	US20250313563, Compound 913023	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779537	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779537&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562804	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779537	US20250313563, Compound 913023	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779537	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779537&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562805	CC[C@@]1(c2cccc(-c3cnn(CC4CCOC4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779538	US20250313563, Compound 951836	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779538	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779538&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562806	CC[C@@]1(c2cccc(-c3cnn(CC4CCOC4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779538	US20250313563, Compound 951836	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779538	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779538&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562807	CC[C@@]1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779539	US20250313563, Compound 913024	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779539	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779539&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562808	CC[C@@]1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779539	US20250313563, Compound 913024	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779539	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779539&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562809	CC[C@@]1(c2cccc(-c3cnn(-c4ccccc4)c3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779540	US20250313563, Compound 951837	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779540&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562810	CC[C@@]1(c2cccc(-c3cnn(-c4ccccc4)c3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779540	US20250313563, Compound 951837	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779540&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562811	CC[C@@]1(c2cccc(C3=CN=NC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779541	US20250313563, Compound 913025	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779541	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779541&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562812	CC[C@@]1(c2cccc(C3=CN=NC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779541	US20250313563, Compound 913025	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779541	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779541&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562813	CC[C@@]1(c2cccc(-c3cnn(Cc4ccc(OC)cc4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779542	US20250313563, Compound 951838	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779542	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779542&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562814	CC[C@@]1(c2cccc(-c3cnn(Cc4ccc(OC)cc4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779542	US20250313563, Compound 951838	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779542	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779542&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562815	CC[C@@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779543	US20250313563, Compound 913026	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779543	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779543&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562816	CC[C@@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779543	US20250313563, Compound 913026	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779543	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779543&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562817	CC[C@@]1(c2cccc(-c3cnn(Cc4cccc(F)c4F)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779544	US20250313563, Compound 951840	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779544	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779544&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562818	CC[C@@]1(c2cccc(-c3cnn(Cc4cccc(F)c4F)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779544	US20250313563, Compound 951840	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779544	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779544&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562819	CC[C@@]1(c2cccc(-c3cnn(CCOC)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779545	US20250313563, Compound 913027	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779545	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779545&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562820	CC[C@@]1(c2cccc(-c3cnn(CCOC)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779545	US20250313563, Compound 913027	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779545	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779545&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562821	CC[C@@]1(c2cccc(-c3cc(C(C)C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779546	US20250313563, Compound 951842	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779546	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779546&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562822	CC[C@@]1(c2cccc(-c3cc(C(C)C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779546	US20250313563, Compound 951842	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779546	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779546&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562823	CC[C@]1(c2cccc(-c3cnn(C4CC4)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779547	US20250313563, Compound 913028	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779547	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779547&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562824	CC[C@]1(c2cccc(-c3cnn(C4CC4)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779547	US20250313563, Compound 913028	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779547	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779547&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562825	CC[C@@]1(c2cccc(-c3cc(C(C)(C)C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779548	US20250313563, Compound 951843	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779548	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779548&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562826	CC[C@@]1(c2cccc(-c3cc(C(C)(C)C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779548	US20250313563, Compound 951843	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779548	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779548&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562827	CC[C@@]1(c2cccc(-c3cn(C)nc3C(C)C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779549	US20250313563, Compound 913029	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779549	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779549&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562828	CC[C@@]1(c2cccc(-c3cn(C)nc3C(C)C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779549	US20250313563, Compound 913029	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779549	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779549&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562829	CC[C@@]1(c2cccc(-c3c(C#N)c(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779550	US20250313563, Compound 951844	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779550	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779550&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562830	CC[C@@]1(c2cccc(-c3c(C#N)c(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779550	US20250313563, Compound 951844	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779550	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779550&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562831	CC[C@@]1(c2cccc(-c3ccn(C)n3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779551	US20250313563, Compound 913030	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779551&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562832	CC[C@@]1(c2cccc(-c3ccn(C)n3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779551	US20250313563, Compound 913030	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779551&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562833	CC[C@]1(c2cccc(-c3cc(C)nn3-c3ccccc3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779552	US20250313563, Compound 951845	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779552	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779552&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562834	CC[C@]1(c2cccc(-c3cc(C)nn3-c3ccccc3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779552	US20250313563, Compound 951845	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779552	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779552&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562835	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779553	US20250313563, Compound 913031	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779553&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562836	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779553	US20250313563, Compound 913031	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779553&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562837	CC[C@@]1(c2cccc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779554	US20250313563, Compound 951848	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779554	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779554&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562838	CC[C@@]1(c2cccc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779554	US20250313563, Compound 951848	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779554	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779554&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562839	CC[C@@]1(c2cccc(-c3cncn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779555	US20250313563, Compound 913032	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779555&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562840	CC[C@@]1(c2cccc(-c3cncn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779555	US20250313563, Compound 913032	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779555&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562841	CC[C@@]1(c2cccc(-c3cnn(Cc4ccc(C(F)(F)F)cc4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779556	US20250313563, Compound 951849	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779556	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779556&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562842	CC[C@@]1(c2cccc(-c3cnn(Cc4ccc(C(F)(F)F)cc4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779556	US20250313563, Compound 951849	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779556	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779556&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562843	CC[C@@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779557	US20250313563, Compound 913033	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779557	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779557&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562844	CC[C@@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779557	US20250313563, Compound 913033	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779557	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779557&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562845	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cc(C)n(C)n1)CC2			779558	US20250313563, Compound 951939	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779558	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779558&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562846	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cc(C)n(C)n1)CC2			779558	US20250313563, Compound 951939	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779558	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779558&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562847	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779559	US20250313563, Compound 913034	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779559	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779559&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562848	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779559	US20250313563, Compound 913034	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779559	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779559&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562849	CC[C@@]1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779560	US20250313563, Compound 951944	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779560	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779560&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562850	CC[C@@]1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779560	US20250313563, Compound 951944	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779560	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779560&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562851	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779561	US20250313563, Compound 913035	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779561	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779561&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562852	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779561	US20250313563, Compound 913035	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779561	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779561&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562853	CC[C@]1(c2cccc(C(F)F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779562	US20250313563, Compound 951946	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779562	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779562&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562854	CC[C@]1(c2cccc(C(F)F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779562	US20250313563, Compound 951946	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779562	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779562&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562855	CC[C@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779563	US20250313563, Compound 913036	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779563	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779563&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562856	CC[C@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779563	US20250313563, Compound 913036	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779563	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779563&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562857	CC[C@@]1(c2cccc(C(F)F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779564	US20250313563, Compound 951948	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779564&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562858	CC[C@@]1(c2cccc(C(F)F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779564	US20250313563, Compound 951948	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779564&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562859	CC[C@]1(c2cccc(-c3cncn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779565	US20250313563, Compound 913037	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779565	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779565&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562860	CC[C@]1(c2cccc(-c3cncn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779565	US20250313563, Compound 913037	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779565	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779565&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562861	CC[C@]1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779566	US20250313563, Compound 951949	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779566&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562862	CC[C@]1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779566	US20250313563, Compound 951949	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779566&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562863	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779567	US20250313563, Compound 913038	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779567	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779567&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562864	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779567	US20250313563, Compound 913038	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779567	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779567&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562865	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cc(C)n(C)n1)CC2			779568	US20250313563, Compound 951954	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779568	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779568&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562866	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cc(C)n(C)n1)CC2			779568	US20250313563, Compound 951954	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779568	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779568&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562867	CC[C@]1(c2cccc(-c3ccn(C)n3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779569	US20250313563, Compound 913039	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779569&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562868	CC[C@]1(c2cccc(-c3ccn(C)n3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779569	US20250313563, Compound 913039	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779569&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562869	CC[C@@]1(c2cccc(-c3cnn(-c4ccncn4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779570	US20250313563, Compound 952016	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779570	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779570&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562870	CC[C@@]1(c2cccc(-c3cnn(-c4ccncn4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779570	US20250313563, Compound 952016	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779570	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779570&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562871	CC[C@]1(c2cccc(-c3cn(C)nc3C(C)C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779571	US20250313563, Compound 913040	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779571	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779571&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562872	CC[C@]1(c2cccc(-c3cn(C)nc3C(C)C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779571	US20250313563, Compound 913040	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779571	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779571&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562873	CC[C@@]1(c2cccc(-c3cnn(CCc4ccccc4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779572	US20250313563, Compound 952017	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779572&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562874	CC[C@@]1(c2cccc(-c3cnn(CCc4ccccc4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779572	US20250313563, Compound 952017	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779572&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562875	CC[C@@]1(c2cccc(-c3cnn(C4CC4)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779573	US20250313563, Compound 913041	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779573	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779573&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562876	CC[C@@]1(c2cccc(-c3cnn(C4CC4)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779573	US20250313563, Compound 913041	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779573	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779573&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562877	CC[C@@]1(c2cccc(-c3cc(C(F)(F)F)nn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779574	US20250313563, Compound 952018	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779574	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779574&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562878	CC[C@@]1(c2cccc(-c3cc(C(F)(F)F)nn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779574	US20250313563, Compound 952018	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779574	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779574&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562879	CC[C@]1(c2cccc(-c3cnn(CCOC)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779575	US20250313563, Compound 913042	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779575	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779575&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562880	CC[C@]1(c2cccc(-c3cnn(CCOC)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779575	US20250313563, Compound 913042	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779575	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779575&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562881	CC[C@@]1(c2cccc(-c3cnn4c3OCCC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779576	US20250313563, Compound 952019	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779576	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779576&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562882	CC[C@@]1(c2cccc(-c3cnn4c3OCCC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779576	US20250313563, Compound 952019	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779576	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779576&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562883	CC[C@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779577	US20250313563, Compound 913043	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779577	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779577&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562884	CC[C@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779577	US20250313563, Compound 913043	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779577	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779577&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562885	CC[C@@]1(c2cccc(-c3c(C)cnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779578	US20250313563, Compound 952021	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779578	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779578&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562886	CC[C@@]1(c2cccc(-c3c(C)cnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779578	US20250313563, Compound 952021	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779578	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779578&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562887	CC[C@]1(c2cccc(C3=CN=NC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779579	US20250313563, Compound 913044	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779579&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562888	CC[C@]1(c2cccc(C3=CN=NC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779579	US20250313563, Compound 913044	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779579&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562889	CC[C@@]1(c2cccc(-c3cnn(CCN4CCCC4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779580	US20250313563, Compound 952022	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779580	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779580&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562890	CC[C@@]1(c2cccc(-c3cnn(CCN4CCCC4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779580	US20250313563, Compound 952022	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779580	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779580&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562891	CC[C@]1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779581	US20250313563, Compound 913045	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779581	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779581&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562892	CC[C@]1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779581	US20250313563, Compound 913045	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779581	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779581&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562893	CC[C@@]1(c2cccc(-c3cc(C4CCCC4)nn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779582	US20250313563, Compound 952023	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779582	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779582&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562894	CC[C@@]1(c2cccc(-c3cc(C4CCCC4)nn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779582	US20250313563, Compound 952023	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779582	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779582&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562895	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779583	US20250313563, Compound 913046	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779583	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779583&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562896	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779583	US20250313563, Compound 913046	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779583	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779583&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562897	CC[C@@]1(c2cccc(-c3cnn(-c4cccnc4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779584	US20250313563, Compound 952024	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779584	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779584&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562898	CC[C@@]1(c2cccc(-c3cnn(-c4cccnc4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779584	US20250313563, Compound 952024	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779584	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779584&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562899	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779585	US20250313563, Compound 913047	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779585	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779585&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562900	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779585	US20250313563, Compound 913047	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779585	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779585&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562901	CC[C@@]1(c2cccc(-c3ccncc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779586	US20250313563, Compound 952025	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779586&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562902	CC[C@@]1(c2cccc(-c3ccncc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779586	US20250313563, Compound 952025	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779586&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562903	CC[C@]1(c2cccc(-c3ccnc(N(C)C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779587	US20250313563, Compound 913048	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779587	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779587&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562904	CC[C@]1(c2cccc(-c3ccnc(N(C)C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779587	US20250313563, Compound 913048	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779587	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779587&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562905	CC[C@@]1(c2cccc(-c3cnn(-c4cnccn4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779588	US20250313563, Compound 952207	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779588	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779588&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562906	CC[C@@]1(c2cccc(-c3cnn(-c4cnccn4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779588	US20250313563, Compound 952207	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779588	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779588&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562907	CC[C@]1(c2cccc(-c3ccnc(C(F)(F)F)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779589	US20250313563, Compound 913049	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779589	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779589&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562908	CC[C@]1(c2cccc(-c3ccnc(C(F)(F)F)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779589	US20250313563, Compound 913049	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779589	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779589&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562909	CC[C@@]1(c2cccc(-c3cnn(CC(=O)N(C)C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779590	US20250313563, Compound 952208	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779590	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779590&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562910	CC[C@@]1(c2cccc(-c3cnn(CC(=O)N(C)C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779590	US20250313563, Compound 952208	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779590	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779590&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562911	CC[C@]1(c2cccc(-c3cc(C)ncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779591	US20250313563, Compound 913050	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779591	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779591&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562912	CC[C@]1(c2cccc(-c3cc(C)ncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779591	US20250313563, Compound 913050	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779591	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779591&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562913	CC[C@@]1(c2cccc(-c3c([N+](=O)O)c(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779592	US20250313563, Compound 952209	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779592&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562914	CC[C@@]1(c2cccc(-c3c([N+](=O)O)c(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779592	US20250313563, Compound 952209	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779592&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562915	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779593	US20250313563, Compound 913051	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779593	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779593&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562916	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779593	US20250313563, Compound 913051	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779593	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779593&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562917	CC[C@@]1(c2cccc(-c3cnn(CC#N)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779594	US20250313563, Compound 952210	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779594	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779594&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562918	CC[C@@]1(c2cccc(-c3cnn(CC#N)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779594	US20250313563, Compound 952210	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779594	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779594&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562919	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779595	US20250313563, Compound 913052	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779595&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562920	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779595	US20250313563, Compound 913052	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779595&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562921	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnn(C)c1C)CC2			779596	US20250313563, Compound 952257	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779596&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562922	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnn(C)c1C)CC2			779596	US20250313563, Compound 952257	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779596&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562923	CC[C@]1(c2cccc(-c3ccnc(OC)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779597	US20250313563, Compound 913053	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779597&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562924	CC[C@]1(c2cccc(-c3ccnc(OC)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779597	US20250313563, Compound 913053	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779597&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562925	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnn(C)c1C)CC2			779598	US20250313563, Compound 952262	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779598	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779598&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562926	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnn(C)c1C)CC2			779598	US20250313563, Compound 952262	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779598	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779598&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562927	CC[C@]1(c2cccc(-c3ccncc3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779599	US20250313563, Compound 913054	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779599	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779599&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562928	CC[C@]1(c2cccc(-c3ccncc3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779599	US20250313563, Compound 913054	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779599	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779599&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562929	CC[C@]1(c2cccc(-c3c(C#N)cnn3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779600	US20250313563, Compound 952410	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779600&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562930	CC[C@]1(c2cccc(-c3c(C#N)cnn3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779600	US20250313563, Compound 952410	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779600&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562931	CCC1(c2cccc(N(C)c3cccc(OC)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779601	US20250313563, Compound 913121	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779601&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562932	CCC1(c2cccc(N(C)c3cccc(OC)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779601	US20250313563, Compound 913121	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779601&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562933	CC[C@@]1(c2cccc(-c3cc(-c4ccccc4)nn3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779602	US20250313563, Compound 952411	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779602&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562934	CC[C@@]1(c2cccc(-c3cc(-c4ccccc4)nn3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779602	US20250313563, Compound 952411	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779602&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562935	CCC1(c2cccc(N(C)c3cccc(C(F)(F)F)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779603	US20250313563, Compound 913122	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779603&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562936	CCC1(c2cccc(N(C)c3cccc(C(F)(F)F)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779603	US20250313563, Compound 913122	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779603&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562937	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cn(C)c(C)n1)CC2			779604	US20250313563, Compound 952478	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779604	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779604&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562938	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cn(C)c(C)n1)CC2			779604	US20250313563, Compound 952478	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779604	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779604&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562939	CCC1(c2cccc(S(=O)(=O)c3ccccc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779605	US20250313563, Compound 913123	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779605&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562940	CCC1(c2cccc(S(=O)(=O)c3ccccc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779605	US20250313563, Compound 913123	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779605&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562941	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cn(C)c(C)n1)CC2			779606	US20250313563, Compound 952479	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779606	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779606&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562942	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cn(C)c(C)n1)CC2			779606	US20250313563, Compound 952479	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779606	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779606&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562943	CCC1(c2cc(N(C)C(C)=O)ccc2F)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779607	US20250313563, Compound 913124	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779607	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779607&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562944	CCC1(c2cc(N(C)C(C)=O)ccc2F)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779607	US20250313563, Compound 913124	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779607	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779607&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562945	CC[C@@]1(c2cccc(-c3ccnc4cccnc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779608	US20250313563, Compound 952560	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779608&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562946	CC[C@@]1(c2cccc(-c3ccnc4cccnc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779608	US20250313563, Compound 952560	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779608&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562947	CCC1(c2cccc(N(C)C(=O)CN3CCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779609	US20250313563, Compound 913125	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779609	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779609&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562948	CCC1(c2cccc(N(C)C(=O)CN3CCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779609	US20250313563, Compound 913125	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779609	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779609&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562949	CCc1cc(-c2cccc([C@]3(CC)C4=CN=NC4NC4=C3C(=O)NC(C)(C)C4)c2)n(C)n1			779610	US20250313563, Compound 952561	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779610	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779610&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562950	CCc1cc(-c2cccc([C@]3(CC)C4=CN=NC4NC4=C3C(=O)NC(C)(C)C4)c2)n(C)n1			779610	US20250313563, Compound 952561	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779610	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779610&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562951	CC[C@]1(c2cccc(S(=O)(=O)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779611	US20250313563, Compound 913134	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779611	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779611&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562952	CC[C@]1(c2cccc(S(=O)(=O)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779611	US20250313563, Compound 913134	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779611	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779611&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562953	CC[C@@]1(c2cccc(-c3cc(C)nc4c3cnn4C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779612	US20250313563, Compound 952563	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779612	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779612&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562954	CC[C@@]1(c2cccc(-c3cc(C)nc4c3cnn4C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779612	US20250313563, Compound 952563	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779612	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779612&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562955	CC[C@@]1(c2cccc(S(=O)(=O)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779613	US20250313563, Compound 913135	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779613&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562956	CC[C@@]1(c2cccc(S(=O)(=O)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779613	US20250313563, Compound 913135	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779613&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562957	CC[C@@]1(c2cccc(-c3cnn4ccncc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779614	US20250313563, Compound 952565	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779614&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562958	CC[C@@]1(c2cccc(-c3cnn4ccncc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779614	US20250313563, Compound 952565	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779614&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562959	Cc1cccc2c1CC[C@@]21C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			779615	US20250313563, Compound 913136	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779615&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562960	Cc1cccc2c1CC[C@@]21C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			779615	US20250313563, Compound 913136	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779615&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562961	CC[C@@]1(c2cccc(-c3cnn(-c4ccccn4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779616	US20250313563, Compound 952566	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779616&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562962	CC[C@@]1(c2cccc(-c3cnn(-c4ccccn4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779616	US20250313563, Compound 952566	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779616&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562963	Cc1cccc2c1CC[C@]21C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			779617	US20250313563, Compound 913137	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779617	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779617&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562964	Cc1cccc2c1CC[C@]21C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			779617	US20250313563, Compound 913137	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779617	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779617&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562965	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cscn1)CC2			779618	US20250313563, Compound 952629	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779618&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562966	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cscn1)CC2			779618	US20250313563, Compound 952629	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779618&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562967	CC[C@]1(c2cccc(N3CCC3(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779619	US20250313563, Compound 913140	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779619&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562968	CC[C@]1(c2cccc(N3CCC3(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779619	US20250313563, Compound 913140	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779619&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562969	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccsc1)CC2			779620	US20250313563, Compound 952630	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779620	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779620&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562970	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccsc1)CC2			779620	US20250313563, Compound 952630	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779620	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779620&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562971	CC[C@@]1(c2cccc(N3CCC3(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779621	US20250313563, Compound 913141	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779621&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562972	CC[C@@]1(c2cccc(N3CCC3(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779621	US20250313563, Compound 913141	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779621&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562973	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccsc1)CC2			779622	US20250313563, Compound 952636	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779622&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562974	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccsc1)CC2			779622	US20250313563, Compound 952636	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779622&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562975	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCCc2ccccc21			779623	US20250313563, Compound 913219	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779623&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562976	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCCc2ccccc21			779623	US20250313563, Compound 913219	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779623&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562977	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cscn1)CC2			779624	US20250313563, Compound 952638	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779624	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779624&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562978	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cscn1)CC2			779624	US20250313563, Compound 952638	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779624	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779624&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562979	CC[C@]1(c2cccc(-c3cc(C)nc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779625	US20250313563, Compound 913222	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779625&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562980	CC[C@]1(c2cccc(-c3cc(C)nc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779625	US20250313563, Compound 913222	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779625&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562981	CC[C@@]1(c2cccc(-c3ccnc(OC)c3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779626	US20250313563, Compound 952754	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779626&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562982	CC[C@@]1(c2cccc(-c3ccnc(OC)c3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779626	US20250313563, Compound 952754	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779626&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562983	CC[C@@]1(c2cccc(-c3cc(C)nc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779627	US20250313563, Compound 913223	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779627	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779627&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562984	CC[C@@]1(c2cccc(-c3cc(C)nc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779627	US20250313563, Compound 913223	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779627	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779627&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562985	CC[C@@]1(c2cccc(-c3ccnc4cc(F)cnc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779628	US20250313563, Compound 952758	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779628	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779628&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562986	CC[C@@]1(c2cccc(-c3ccnc4cc(F)cnc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779628	US20250313563, Compound 952758	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779628	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779628&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562987	CCC1(c2cccc(N(C)c3ccc(OC)nc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779629	US20250313563, Compound 913252	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779629	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779629&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562988	CCC1(c2cccc(N(C)c3ccc(OC)nc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779629	US20250313563, Compound 913252	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779629	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779629&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562989	CC[C@@]1(c2cccc(-c3c(C)cnc4c(C)cccc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779630	US20250313563, Compound 952760	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779630&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562990	CC[C@@]1(c2cccc(-c3c(C)cnc4c(C)cccc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779630	US20250313563, Compound 952760	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779630&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562991	CCC1(c2cccc(NS(C)(=O)=[O:0])c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779631	US20250313563, Compound 913253	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779631&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894456	523297977							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562992	CCC1(c2cccc(NS(C)(=O)=[O:0])c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779631	US20250313563, Compound 913253	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779631&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894456	523297977							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562993	CC[C@@]1(c2cccc(C3=C4CC=CC(C)=C4N=CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779632	US20250313563, Compound 952909	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779632	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779632&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562994	CC[C@@]1(c2cccc(C3=C4CC=CC(C)=C4N=CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779632	US20250313563, Compound 952909	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779632	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779632&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562995	CCC1(c2cccc(N(C)c3ccnc(C(F)(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779633	US20250313563, Compound 913254	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779633	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779633&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562996	CCC1(c2cccc(N(C)c3ccnc(C(F)(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779633	US20250313563, Compound 913254	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779633	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779633&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562997	CC[C@@]1(c2cccc(-c3ccnc4ccncc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779634	US20250313563, Compound 952910	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779634&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1562998	CC[C@@]1(c2cccc(-c3ccnc4ccncc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779634	US20250313563, Compound 952910	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779634&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1562999	CCC1(c2cccc(N(C)c3cccc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779635	US20250313563, Compound 913255	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779635	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779635&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563000	CCC1(c2cccc(N(C)c3cccc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779635	US20250313563, Compound 913255	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779635	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779635&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563001	CC[C@@]1(c2cccc(-c3cnn(-c4ccncc4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779636	US20250313563, Compound 952912	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779636	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779636&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563002	CC[C@@]1(c2cccc(-c3cnn(-c4ccncc4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779636	US20250313563, Compound 952912	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779636	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779636&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563003	CCC1(c2cccc(N(C)c3cc(C)nc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779637	US20250313563, Compound 913256	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779637&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563004	CCC1(c2cccc(N(C)c3cc(C)nc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779637	US20250313563, Compound 913256	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779637&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563005	CC[C@@]1(c2cccc(-c3ccnc4c3cnn4C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779638	US20250313563, Compound 952913	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779638&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563006	CC[C@@]1(c2cccc(-c3ccnc4c3cnn4C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779638	US20250313563, Compound 952913	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779638&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563007	CCC1(c2cccc(S(=O)(=O)CC3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779639	US20250313563, Compound 913257	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779639	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779639&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563008	CCC1(c2cccc(S(=O)(=O)CC3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779639	US20250313563, Compound 913257	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779639	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779639&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563009	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779640	US20250313563, Compound 957497	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779640&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563010	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779640	US20250313563, Compound 957497	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779640&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563011	CCC1(c2cccc(S(=O)(=O)Cc3ccccc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779641	US20250313563, Compound 913258	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779641	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779641&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563012	CCC1(c2cccc(S(=O)(=O)Cc3ccccc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779641	US20250313563, Compound 913258	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779641	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779641&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563013	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779642	US20250313563, Compound 957518	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779642	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779642&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563014	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779642	US20250313563, Compound 957518	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779642	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779642&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563015	CCC1(c2cccc(N(c3cccnc3)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779643	US20250313563, Compound 913274	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779643	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779643&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563016	CCC1(c2cccc(N(c3cccnc3)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779643	US20250313563, Compound 913274	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779643	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779643&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563017	CCC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)C1CCC21			779644	US20250313563, Compound 861716	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779644&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563018	CCC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)C1CCC21			779644	US20250313563, Compound 861716	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779644&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563019	CC[C@@]1(c2cccc(N(C)C(=O)c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779645	US20250313563, Compound 913310	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779645	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779645&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563020	CC[C@@]1(c2cccc(N(C)C(=O)c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779645	US20250313563, Compound 913310	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779645	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779645&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563021	CCC1(c2cccc(C(F)(F)F)c2)C2=C(NC3=NN=CC31)c1ccccc1C2=O			779646	US20250313563, Compound 948205	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779646&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563022	CCC1(c2cccc(C(F)(F)F)c2)C2=C(NC3=NN=CC31)c1ccccc1C2=O			779646	US20250313563, Compound 948205	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779646&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563023	CC[C@]1(c2cccc(N(C)C(=O)c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779647	US20250313563, Compound 913311	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779647&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563024	CC[C@]1(c2cccc(N(C)C(=O)c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779647	US20250313563, Compound 913311	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779647&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563025	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(NC3=NN=CC31)c1ccccc1C2=O			779648	US20250313563, Compound 949742	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779648	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779648&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563026	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(NC3=NN=CC31)c1ccccc1C2=O			779648	US20250313563, Compound 949742	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779648	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779648&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563027	CCC1(c2cccc(Nc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779649	US20250313563, Compound 913334	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779649	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779649&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563028	CCC1(c2cccc(Nc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779649	US20250313563, Compound 913334	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779649	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779649&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563029	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(NC3=NN=CC31)c1ccccc1C2=O			779650	US20250313563, Compound 949743	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779650&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563030	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(NC3=NN=CC31)c1ccccc1C2=O			779650	US20250313563, Compound 949743	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779650&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563031	CCC1(c2cccc(-c3cc(C)ncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779651	US20250313563, Compound 913346	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779651	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779651&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563032	CCC1(c2cccc(-c3cc(C)ncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779651	US20250313563, Compound 913346	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779651	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779651&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563033	CCC1(c2cccc(C3CCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779652	US20250313563, Compound 949082	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779652	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779652&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563034	CCC1(c2cccc(C3CCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779652	US20250313563, Compound 949082	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779652	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779652&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563035	CCC1(c2cccc(-c3ccnc(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779653	US20250313563, Compound 913347	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779653	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779653&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563036	CCC1(c2cccc(-c3ccnc(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779653	US20250313563, Compound 913347	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779653	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779653&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563037	CC[C@]1(c2cccc(C3CCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779654	US20250313563, Compound 949397	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779654	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779654&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563038	CC[C@]1(c2cccc(C3CCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779654	US20250313563, Compound 949397	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779654	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779654&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563039	CCC1(c2cccc(-c3ccnc(C(F)(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779655	US20250313563, Compound 913348	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779655	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779655&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563040	CCC1(c2cccc(-c3ccnc(C(F)(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779655	US20250313563, Compound 913348	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779655	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779655&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563041	CC[C@@]1(c2cccc(C3CCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779656	US20250313563, Compound 949399	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779656	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779656&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563042	CC[C@@]1(c2cccc(C3CCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779656	US20250313563, Compound 949399	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779656	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779656&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563043	CCC1(c2cccc(-c3ccncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779657	US20250313563, Compound 913349	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779657	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779657&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563044	CCC1(c2cccc(-c3ccncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779657	US20250313563, Compound 913349	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779657	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779657&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563045	CC[C@@]1(c2cccc(C3CCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779658	US20250313563, Compound 949514	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779658	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779658&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563046	CC[C@@]1(c2cccc(C3CCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779658	US20250313563, Compound 949514	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779658	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779658&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563047	CCC1(c2cccc(-c3ccnc(C(F)(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779659	US20250313563, Compound 913350	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779659	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779659&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563048	CCC1(c2cccc(-c3ccnc(C(F)(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779659	US20250313563, Compound 913350	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779659	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779659&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563049	CC[C@]1(c2cccc(C3CCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779660	US20250313563, Compound 949521	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779660	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779660&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563050	CC[C@]1(c2cccc(C3CCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779660	US20250313563, Compound 949521	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779660	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779660&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563051	CCC1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779661	US20250313563, Compound 913351	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779661	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779661&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563052	CCC1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779661	US20250313563, Compound 913351	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779661	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779661&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563053	CCC1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)CC2			779662	US20250313563, Compound 949639	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779662	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779662&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563054	CCC1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)CC2			779662	US20250313563, Compound 949639	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779662	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779662&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563055	CCC1(c2cccc(-c3ccnc([OH:0])c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779663	US20250313563, Compound 913352	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779663	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779663&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894486	523298009							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563056	CCC1(c2cccc(-c3ccnc([OH:0])c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779663	US20250313563, Compound 913352	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779663	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779663&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894486	523298009							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563057	CCC1(c2cccc(Br)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779664	US20250313563, Compound 949805	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779664	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779664&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563058	CCC1(c2cccc(Br)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779664	US20250313563, Compound 949805	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779664	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779664&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563059	CC[C@]1(c2cccc(N(C)c3cnccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779665	US20250313563, Compound 915316	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779665	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779665&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563060	CC[C@]1(c2cccc(N(C)c3cnccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779665	US20250313563, Compound 915316	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779665	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779665&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563061	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779666	US20250313563, Compound 949840	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779666	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779666&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563062	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779666	US20250313563, Compound 949840	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779666	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779666&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563063	CC[C@@]1(c2cccc(N(C)c3cnccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779667	US20250313563, Compound 915340	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779667	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779667&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563064	CC[C@@]1(c2cccc(N(C)c3cnccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779667	US20250313563, Compound 915340	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779667	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779667&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563065	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779668	US20250313563, Compound 950272	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779668	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779668&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563066	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779668	US20250313563, Compound 950272	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779668	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779668&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563067	CC[C@]1(c2cccc(N(C)c3cncnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779669	US20250313563, Compound 915400	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779669	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779669&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563068	CC[C@]1(c2cccc(N(C)c3cncnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779669	US20250313563, Compound 915400	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779669	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779669&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563069	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779670	US20250313563, Compound 950273	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779670	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779670&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563070	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779670	US20250313563, Compound 950273	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779670	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779670&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563071	CC[C@@]1(c2cccc(N(C)c3cncnc3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779671	US20250313563, Compound 915401	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779671	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779671&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563072	CC[C@@]1(c2cccc(N(C)c3cncnc3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779671	US20250313563, Compound 915401	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779671	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779671&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563073	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779672	US20250313563, Compound 950282	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779672	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779672&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563074	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779672	US20250313563, Compound 950282	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779672	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779672&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563075	CC[C@@]1(c2cccc(N(C)c3ccnnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779673	US20250313563, Compound 915630	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779673	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779673&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563076	CC[C@@]1(c2cccc(N(C)c3ccnnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779673	US20250313563, Compound 915630	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779673	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779673&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563077	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779674	US20250313563, Compound 950283	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779674	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779674&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563078	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779674	US20250313563, Compound 950283	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779674	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779674&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563079	CC[C@]1(c2cccc(N3CCCc4ncccc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779675	US20250313563, Compound 917076	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779675	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779675&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563080	CC[C@]1(c2cccc(N3CCCc4ncccc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779675	US20250313563, Compound 917076	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779675	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779675&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563081	CCC1(c2cccc(-c3c(C)nnn3C)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779676	US20250313563, Compound 950815	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779676	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779676&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563082	CCC1(c2cccc(-c3c(C)nnn3C)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779676	US20250313563, Compound 950815	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779676	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779676&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563083	CC[C@@]1(c2cccc(N3CCCc4ncccc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779677	US20250313563, Compound 917079	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779677	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779677&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563084	CC[C@@]1(c2cccc(N3CCCc4ncccc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779677	US20250313563, Compound 917079	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779677	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779677&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563085	CC[C@@]1(c2cccc(-c3cc(C)nn3C)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779678	US20250313563, Compound 950818	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779678	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779678&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563086	CC[C@@]1(c2cccc(-c3cc(C)nn3C)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779678	US20250313563, Compound 950818	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779678	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779678&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563087	CC[C@]1(c2cccc(N(c3cccnc3)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779679	US20250313563, Compound 917086	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779679	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779679&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563088	CC[C@]1(c2cccc(N(c3cccnc3)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779679	US20250313563, Compound 917086	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779679	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779679&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563089	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779680	US20250313563, Compound 950819	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779680	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779680&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563090	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779680	US20250313563, Compound 950819	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779680	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779680&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563091	CC[C@@]1(c2cccc(N(c3cccnc3)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779681	US20250313563, Compound 917087	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779681	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779681&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563092	CC[C@@]1(c2cccc(N(c3cccnc3)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779681	US20250313563, Compound 917087	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779681	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779681&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563093	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779682	US20250313563, Compound 950826	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779682	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779682&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563094	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779682	US20250313563, Compound 950826	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779682	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779682&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563095	CCN(c1cccnc1)c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779683	US20250313563, Compound 917088	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779683&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563096	CCN(c1cccnc1)c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779683	US20250313563, Compound 917088	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779683&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563097	CC[C@]1(c2cccc(-c3cc(C)nn3C)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779684	US20250313563, Compound 950827	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779684	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779684&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563098	CC[C@]1(c2cccc(-c3cc(C)nn3C)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779684	US20250313563, Compound 950827	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779684	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779684&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563099	CCN(c1cccnc1)c1cccc([C@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779685	US20250313563, Compound 917089	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779685	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779685&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563100	CCN(c1cccnc1)c1cccc([C@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779685	US20250313563, Compound 917089	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779685	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779685&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563101	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)CC2			779686	US20250313563, Compound 951565	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779686	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779686&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563102	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)CC2			779686	US20250313563, Compound 951565	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779686	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779686&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563103	CCC1(c2cccc(N(C)C(=O)c3ccn(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779687	US20250313563, Compound 917130	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779687	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779687&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563104	CCC1(c2cccc(N(C)C(=O)c3ccn(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779687	US20250313563, Compound 917130	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779687	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779687&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563105	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)CC2			779688	US20250313563, Compound 951566	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779688	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779688&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563106	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)CC2			779688	US20250313563, Compound 951566	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779688	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779688&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563107	CCCS(=O)(=O)c1cccc(C2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779689	US20250313563, Compound 917131	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779689	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779689&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563108	CCCS(=O)(=O)c1cccc(C2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779689	US20250313563, Compound 917131	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779689	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779689&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563109	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779690	US20250313563, Compound 951702	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779690	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779690&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563110	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779690	US20250313563, Compound 951702	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779690	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779690&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563111	CCC1(c2cccc(-c3cc(C)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779691	US20250313563, Compound 917132	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779691	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779691&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563112	CCC1(c2cccc(-c3cc(C)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779691	US20250313563, Compound 917132	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779691	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779691&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563113	CC[C@]1(c2cccc(C3=CN(C)[N-]C3C)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779692	US20250313563, Compound 951710	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779692	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779692&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563114	CC[C@]1(c2cccc(C3=CN(C)[N-]C3C)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779692	US20250313563, Compound 951710	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779692	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779692&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563115	CCC1(c2cccc(N(C)c3ccnc(F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779693	US20250313563, Compound 917146	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779693	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779693&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563116	CCC1(c2cccc(N(C)c3ccnc(F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779693	US20250313563, Compound 917146	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779693	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779693&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563117	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779694	US20250313563, Compound 952205	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779694	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779694&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563118	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779694	US20250313563, Compound 952205	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779694	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779694&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563119	CCc1cc(N(C)c2cccc(C3(CC)C4=CN=NC4NC4=C3C(=O)CC(C)(C)C4)c2)ccn1			779695	US20250313563, Compound 917147	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779695	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779695&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563120	CCc1cc(N(C)c2cccc(C3(CC)C4=CN=NC4NC4=C3C(=O)CC(C)(C)C4)c2)ccn1			779695	US20250313563, Compound 917147	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779695	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779695&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563121	CC[C@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779696	US20250313563, Compound 952212	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779696	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779696&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563122	CC[C@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779696	US20250313563, Compound 952212	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779696	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779696&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563123	CCC1(c2cccc(N3CCc4ccncc4C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779697	US20250313563, Compound 917148	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779697	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779697&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563124	CCC1(c2cccc(N3CCc4ccncc4C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779697	US20250313563, Compound 917148	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779697	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779697&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563125	CCC1(c2cccc(-c3ccnc4c3CCC4)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779698	US20250313563, Compound 952557	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779698	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779698&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563126	CCC1(c2cccc(-c3ccnc4c3CCC4)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779698	US20250313563, Compound 952557	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779698	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779698&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563127	CCC1(c2cccc(N(C)c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779699	US20250313563, Compound 917149	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779699	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779699&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563128	CCC1(c2cccc(N(C)c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779699	US20250313563, Compound 917149	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779699	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779699&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563129	CC[C@@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779700	US20250313563, Compound 952562	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779700	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779700&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563130	CC[C@@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779700	US20250313563, Compound 952562	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779700	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779700&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563131	CC[C@]1(c2cccc(S(=O)(=O)CC3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779701	US20250313563, Compound 917150	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779701	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779701&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563132	CC[C@]1(c2cccc(S(=O)(=O)CC3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779701	US20250313563, Compound 917150	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779701	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779701&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563133	CC[C@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779702	US20250313563, Compound 952564	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779702	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779702&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563134	CC[C@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779702	US20250313563, Compound 952564	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779702	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779702&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563135	CC[C@@]1(c2cccc(S(=O)(=O)CC3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779703	US20250313563, Compound 917151	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779703	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779703&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563136	CC[C@@]1(c2cccc(S(=O)(=O)CC3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779703	US20250313563, Compound 917151	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779703	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779703&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563137	CCC1(c2cccc(-c3ccnc4c3CCCC4)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779704	US20250313563, Compound 952752	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779704	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779704&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563138	CCC1(c2cccc(-c3ccnc4c3CCCC4)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779704	US20250313563, Compound 952752	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779704	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779704&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563139	CCC1(c2cccc(N(C)c3ccc(F)nc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779705	US20250313563, Compound 917152	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779705	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779705&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563140	CCC1(c2cccc(N(C)c3ccc(F)nc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779705	US20250313563, Compound 917152	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779705	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779705&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563141	CC[C@@]1(c2cccc(-c3ccncc3C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779706	US20250313563, Compound 952757	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779706	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779706&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563142	CC[C@@]1(c2cccc(-c3ccncc3C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779706	US20250313563, Compound 952757	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779706	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779706&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563143	CC[C@]1(c2cccc(N3CCCC[C@H]3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779707	US20250313563, Compound 917209	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779707	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779707&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563144	CC[C@]1(c2cccc(N3CCCC[C@H]3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779707	US20250313563, Compound 917209	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779707	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779707&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563145	CC[C@]1(c2cccc(-c3ccncc3C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779708	US20250313563, Compound 952759	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779708	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779708&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563146	CC[C@]1(c2cccc(-c3ccncc3C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779708	US20250313563, Compound 952759	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779708	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779708&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563147	CC[C@@]1(c2cccc(N3CCCC[C@H]3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779709	US20250313563, Compound 917210	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779709	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779709&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563148	CC[C@@]1(c2cccc(N3CCCC[C@H]3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779709	US20250313563, Compound 917210	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779709	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779709&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563149	CN1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779710	US20250313563, Compound 826714	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779710	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779710&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563150	CN1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779710	US20250313563, Compound 826714	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779710	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779710&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563151	CCC1(c2cccc(Oc3cncnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779711	US20250313563, Compound 917212	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779711	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779711&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563152	CCC1(c2cccc(Oc3cncnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779711	US20250313563, Compound 917212	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779711	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779711&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563153	CCC1(COC)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			779712	US20250313563, Compound 841866	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779712	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779712&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563154	CCC1(COC)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			779712	US20250313563, Compound 841866	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779712	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779712&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563155	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21Cc2ccccc21			779713	US20250313563, Compound 917226	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779713	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779713&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563156	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21Cc2ccccc21			779713	US20250313563, Compound 917226	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779713	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779713&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563157	CN1CCC2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779714	US20250313563, Compound 841867	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779714	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779714&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563158	CN1CCC2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779714	US20250313563, Compound 841867	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779714	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779714&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563159	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779715	US20250313563, Compound 917289	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779715	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779715&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563160	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779715	US20250313563, Compound 917289	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779715	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779715&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563161	CC1N=NC2=C1C1(CCCCC1)C1=C(CC(C)(C)CC1=O)N2			779716	US20250313563, Compound 877288	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779716	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779716&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563162	CC1N=NC2=C1C1(CCCCC1)C1=C(CC(C)(C)CC1=O)N2			779716	US20250313563, Compound 877288	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779716	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779716&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563163	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779717	US20250313563, Compound 917291	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779717	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779717&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563164	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779717	US20250313563, Compound 917291	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779717	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779717&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563165	CCC1(CC)C2=C(CC(C)(C)CC2=O)NC2=C1C(C1CC1)N=N2			779718	US20250313563, Compound 877294	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779718	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779718&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563166	CCC1(CC)C2=C(CC(C)(C)CC2=O)NC2=C1C(C1CC1)N=N2			779718	US20250313563, Compound 877294	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779718	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779718&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563167	CC[C@@]1(c2cccc(-c3ccncc3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779719	US20250313563, Compound 917292	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779719	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779719&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563168	CC[C@@]1(c2cccc(-c3ccncc3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779719	US20250313563, Compound 917292	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779719	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779719&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563169	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(c2ccncc2)CC1			779720	US20250313563, Compound 880765	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779720	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779720&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563170	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(c2ccncc2)CC1			779720	US20250313563, Compound 880765	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779720	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779720&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563171	CC[C@]1(c2cccc(-c3ccncc3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779721	US20250313563, Compound 917293	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779721	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779721&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563172	CC[C@]1(c2cccc(-c3ccncc3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779721	US20250313563, Compound 917293	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779721	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779721&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563173	CC[C@@]1(C)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			779722	US20250313563, Compound 884020	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779722	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779722&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563174	CC[C@@]1(C)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			779722	US20250313563, Compound 884020	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779722	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779722&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563175	CCC1(c2cccc(S(=O)(=O)CCOC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779723	US20250313563, Compound 918271	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779723	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779723&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563176	CCC1(c2cccc(S(=O)(=O)CCOC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779723	US20250313563, Compound 918271	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779723	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779723&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563177	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(CO)CO			779724	US20250313563, Compound 889570	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779724	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779724&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563178	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(CO)CO			779724	US20250313563, Compound 889570	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779724	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779724&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563179	CCC1(c2cccc(N(C)c3ccc(C)nc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779725	US20250313563, Compound 918272	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779725	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779725&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563180	CCC1(c2cccc(N(C)c3ccc(C)nc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779725	US20250313563, Compound 918272	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779725	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779725&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563181	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCCNCC1			779726	US20250313563, Compound 889571	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779726	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779726&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563182	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCCNCC1			779726	US20250313563, Compound 889571	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779726	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779726&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563183	CCC1(c2cccc(S(=O)(=O)C3CCCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779727	US20250313563, Compound 918273	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779727	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779727&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563184	CCC1(c2cccc(S(=O)(=O)C3CCCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779727	US20250313563, Compound 918273	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779727	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779727&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563185	CN1CCCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779728	US20250313563, Compound 893313	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779728	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779728&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563186	CN1CCCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779728	US20250313563, Compound 893313	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779728	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779728&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563187	CCC1(c2cccc(N(C)c3cccc(F)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779729	US20250313563, Compound 918274	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779729	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779729&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563188	CCC1(c2cccc(N(C)c3cccc(F)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779729	US20250313563, Compound 918274	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779729	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779729&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563189	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(C(=O)c2ccccc2)C1			779730	US20250313563, Compound 893315	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779730	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779730&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563190	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(C(=O)c2ccccc2)C1			779730	US20250313563, Compound 893315	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779730	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779730&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563191	CCC1(c2cccc(N3CCOc4ncccc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779731	US20250313563, Compound 918279	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779731	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779731&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563192	CCC1(c2cccc(N3CCOc4ncccc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779731	US20250313563, Compound 918279	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779731	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779731&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563193	CO[C@H]1C[C@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779732	US20250313563, Compound 901472	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779732	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779732&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563194	CO[C@H]1C[C@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779732	US20250313563, Compound 901472	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779732	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779732&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563195	CCC1(c2cccc(N3CC[O:0]c4ccccc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779733	US20250313563, Compound 918280	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779733	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779733&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894557	523298079							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563196	CCC1(c2cccc(N3CC[O:0]c4ccccc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779733	US20250313563, Compound 918280	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779733	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779733&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894557	523298079							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563197	CO[C@H]1C[C@@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779734	US20250313563, Compound 901473	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779734	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779734&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563198	CO[C@H]1C[C@@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779734	US20250313563, Compound 901473	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779734	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779734&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563199	CCC1(c2cccc(-c3ccnc(C)c3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779735	US20250313563, Compound 918281	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779735	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779735&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563200	CCC1(c2cccc(-c3ccnc(C)c3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779735	US20250313563, Compound 918281	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779735	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779735&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563201	CC1OCCC12C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779736	US20250313563, Compound 911958	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779736	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779736&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563202	CC1OCCC12C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779736	US20250313563, Compound 911958	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779736	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779736&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563203	CC[C@]1(c2cccc(N3CCC[C@H]3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779737	US20250313563, Compound 918321	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779737	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779737&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563204	CC[C@]1(c2cccc(N3CCC[C@H]3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779737	US20250313563, Compound 918321	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779737	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779737&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563205	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(c2ccncc2)C1			779738	US20250313563, Compound 912077	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779738	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779738&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563206	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(c2ccncc2)C1			779738	US20250313563, Compound 912077	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779738	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779738&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563207	CC[C@@]1(c2cccc(N3CCC[C@H]3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779739	US20250313563, Compound 918322	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779739	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779739&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563208	CC[C@@]1(c2cccc(N3CCC[C@H]3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779739	US20250313563, Compound 918322	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779739	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779739&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563209	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCO[C@H](C(C)(C)C)C1			779740	US20250313563, Compound 912107	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779740	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779740&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563210	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCO[C@H](C(C)(C)C)C1			779740	US20250313563, Compound 912107	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779740	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779740&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563211	CC[C@]1(c2cccc(N3C[C@@H](C)[C@@H](C)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779741	US20250313563, Compound 918326	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779741	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779741&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563212	CC[C@]1(c2cccc(N3C[C@@H](C)[C@@H](C)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779741	US20250313563, Compound 918326	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779741	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779741&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563213	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)c2cccnc2)C1			779742	US20250313563, Compound 913265	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779742	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779742&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563214	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)c2cccnc2)C1			779742	US20250313563, Compound 913265	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779742	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779742&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563215	CC[C@@]1(c2cccc(N3C[C@@H](C)[C@@H](C)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779743	US20250313563, Compound 918327	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779743	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779743&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563216	CC[C@@]1(c2cccc(N3C[C@@H](C)[C@@H](C)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779743	US20250313563, Compound 918327	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779743	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779743&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563217	C[C@@H]1COCC[C@@]12C1=CN=NC1NC1=C2C(=O)CC(C)(C)C1			779744	US20250313563, Compound 924310	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779744	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779744&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563218	C[C@@H]1COCC[C@@]12C1=CN=NC1NC1=C2C(=O)CC(C)(C)C1			779744	US20250313563, Compound 924310	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779744	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779744&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563219	CCN(c1cccc(C2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1)c1ncccn1			779745	US20250313563, Compound 919840	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779745	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779745&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563220	CCN(c1cccc(C2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1)c1ncccn1			779745	US20250313563, Compound 919840	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779745	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779745&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563221	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(Cc2ccccc2)C1			779746	US20250313563, Compound 929436	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779746	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779746&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563222	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(Cc2ccccc2)C1			779746	US20250313563, Compound 929436	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779746	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779746&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563223	CC[C@]1(c2cccc(N3C[C@H](C)[C@@H](C)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779747	US20250313563, Compound 924312	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779747	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779747&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563224	CC[C@]1(c2cccc(N3C[C@H](C)[C@@H](C)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779747	US20250313563, Compound 924312	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779747	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779747&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563225	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(Cc2ccccn2)C1			779748	US20250313563, Compound 929438	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779748	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779748&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563226	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(Cc2ccccn2)C1			779748	US20250313563, Compound 929438	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779748	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779748&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563227	CC[C@]1(c2cccc(N3C[C@@H](C)[C@H](C)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779749	US20250313563, Compound 924504	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779749	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779749&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563228	CC[C@]1(c2cccc(N3C[C@@H](C)[C@H](C)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779749	US20250313563, Compound 924504	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779749	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779749&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563229	Cn1cc(CN2CC3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			779750	US20250313563, Compound 929439	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779750	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779750&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563230	Cn1cc(CN2CC3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			779750	US20250313563, Compound 929439	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779750	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779750&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563231	CC[C@@]1(c2cccc(N3C[C@H](C)[C@@H](C)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779751	US20250313563, Compound 924520	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779751	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779751&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563232	CC[C@@]1(c2cccc(N3C[C@H](C)[C@@H](C)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779751	US20250313563, Compound 924520	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779751	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779751&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563233	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(CCc2ccccc2)C1			779752	US20250313563, Compound 929441	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779752	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779752&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563234	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(CCc2ccccc2)C1			779752	US20250313563, Compound 929441	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779752	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779752&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563235	CC[C@@]1(c2cccc(N3C[C@@H](C)[C@H](C)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779753	US20250313563, Compound 924543	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779753	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779753&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563236	CC[C@@]1(c2cccc(N3C[C@@H](C)[C@H](C)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779753	US20250313563, Compound 924543	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779753	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779753&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563237	CCN1CC2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779754	US20250313563, Compound 929448	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779754	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779754&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563238	CCN1CC2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779754	US20250313563, Compound 929448	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779754	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779754&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563239	CCC1(c2cccc(N(C)c3nc(C)cc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779755	US20250313563, Compound 926304	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779755	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779755&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563240	CCC1(c2cccc(N(C)c3nc(C)cc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779755	US20250313563, Compound 926304	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779755	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779755&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563241	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CCCN(c2ccncc2)CC1			779756	US20250313563, Compound 932633	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779756	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779756&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563242	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CCCN(c2ccncc2)CC1			779756	US20250313563, Compound 932633	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779756	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779756&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563243	CCC1(c2cccc(-c3cnn4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779757	US20250313563, Compound 926836	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779757	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779757&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563244	CCC1(c2cccc(-c3cnn4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779757	US20250313563, Compound 926836	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779757	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779757&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563245	CC(C)N1CC2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779758	US20250313563, Compound 932650	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779758	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779758&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563246	CC(C)N1CC2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779758	US20250313563, Compound 932650	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779758	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779758&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563247	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779759	US20250313563, Compound 926840	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779759	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779759&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563248	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779759	US20250313563, Compound 926840	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779759	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779759&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563249	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(C2CCOCC2)C1			779760	US20250313563, Compound 932651	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779760	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779760&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563250	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(C2CCOCC2)C1			779760	US20250313563, Compound 932651	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779760	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779760&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563251	CCC1(c2cccc(-c3cnnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779761	US20250313563, Compound 926844	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779761	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779761&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563252	CCC1(c2cccc(-c3cnnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779761	US20250313563, Compound 926844	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779761	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779761&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563253	Cn1ccc(CN2CC3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			779762	US20250313563, Compound 932652	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779762	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779762&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563254	Cn1ccc(CN2CC3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			779762	US20250313563, Compound 932652	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779762	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779762&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563255	CC[C@@]1(c2cccc(N(C)c3cccc(C(F)(F)F)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779763	US20250313563, Compound 927338	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779763	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779763&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563256	CC[C@@]1(c2cccc(N(C)c3cccc(C(F)(F)F)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779763	US20250313563, Compound 927338	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779763	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779763&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563257	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(Cc2cnc3ccccn23)C1			779764	US20250313563, Compound 932654	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779764	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779764&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563258	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(Cc2cnc3ccccn23)C1			779764	US20250313563, Compound 932654	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779764	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779764&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563259	CC[C@]1(c2cccc(-c3cc(C)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779765	US20250313563, Compound 927339	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779765	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779765&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563260	CC[C@]1(c2cccc(-c3cc(C)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779765	US20250313563, Compound 927339	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779765	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779765&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563261	COCCN1CC2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779766	US20250313563, Compound 943544	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779766	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779766&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563262	COCCN1CC2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779766	US20250313563, Compound 943544	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779766	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779766&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563263	CC[C@@]1(c2cccc(-c3ccnc(C)c3F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779767	US20250313563, Compound 927340	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779767	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779767&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563264	CC[C@@]1(c2cccc(-c3ccnc(C)c3F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779767	US20250313563, Compound 927340	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779767	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779767&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563265	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(CC2CCOCC2)C1			779768	US20250313563, Compound 943545	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779768	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779768&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563266	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(CC2CCOCC2)C1			779768	US20250313563, Compound 943545	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779768	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779768&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563267	CC[C@]1(c2cccc(NS(C)(=O)=[O:0])c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779769	US20250313563, Compound 927341	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779769	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779769&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894592	523298115							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563268	CC[C@]1(c2cccc(NS(C)(=O)=[O:0])c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779769	US20250313563, Compound 927341	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779769	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779769&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894592	523298115							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563269	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(CC2CCCC2)C1			779770	US20250313563, Compound 943914	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779770	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779770&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563270	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(CC2CCCC2)C1			779770	US20250313563, Compound 943914	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779770	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779770&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563271	CCC1(c2cccc(-c3ccnnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779771	US20250313563, Compound 927342	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779771	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779771&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563272	CCC1(c2cccc(-c3ccnnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779771	US20250313563, Compound 927342	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779771	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779771&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563273	CCC1(c2cccc(S(=O)(=O)C3CC[O:0]CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779772	US20250313563, Compound 927344	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779772	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779772&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894595	523298118							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563274	CCC1(c2cccc(S(=O)(=O)C3CC[O:0]CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779772	US20250313563, Compound 927344	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779772	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779772&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894595	523298118							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563275	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)C2CCCC2)CC1			779773	US20250313563, Compound 909206	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779773	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779773&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563276	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)C2CCCC2)CC1			779773	US20250313563, Compound 909206	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779773	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779773&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563277	CC[C@]1(c2cccc(N(C)c3cccc(C(C)(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779774	US20250313563, Compound 927345	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779774	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779774&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563278	CC[C@]1(c2cccc(N(C)c3cccc(C(C)(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779774	US20250313563, Compound 927345	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779774	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779774&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563279	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)C2CCOCC2)CC1			779775	US20250313563, Compound 913127	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779775	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779775&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563280	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)C2CCOCC2)CC1			779775	US20250313563, Compound 913127	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779775	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779775&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563281	CC[C@@]1(c2cccc(-c3cc(C)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779776	US20250313563, Compound 927346	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779776	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779776&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563282	CC[C@@]1(c2cccc(-c3cc(C)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779776	US20250313563, Compound 927346	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779776	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779776&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563283	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)C2CCCCC2)CC1			779777	US20250313563, Compound 913128	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779777	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779777&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563284	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)C2CCCCC2)CC1			779777	US20250313563, Compound 913128	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779777	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779777&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563285	CC[C@@]1(c2cccc(-c3ccnc(C)c3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779778	US20250313563, Compound 927347	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779778	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779778&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563286	CC[C@@]1(c2cccc(-c3ccnc(C)c3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779778	US20250313563, Compound 927347	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779778	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779778&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563287	CC(C)S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779779	US20250313563, Compound 913129	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779779	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779779&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563288	CC(C)S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779779	US20250313563, Compound 913129	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779779	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779779&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563289	CC[C@@]1(c2cccc(NS(C)(=[O:0])=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779780	US20250313563, Compound 927348	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779780	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779780&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894603	523298126							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563290	CC[C@@]1(c2cccc(NS(C)(=[O:0])=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779780	US20250313563, Compound 927348	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779780	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779780&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894603	523298126							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563291	O=C1CC2(CCOC2)CC2=C1C1(CCOCC1)C1=C(N=NC1)N2			779781	US20250313563, Compound 889573	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779781	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779781&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563292	O=C1CC2(CCOC2)CC2=C1C1(CCOCC1)C1=C(N=NC1)N2			779781	US20250313563, Compound 889573	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779781	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779781&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563293	CCC1(c2cccc(N(C)c3nccc(OC)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779782	US20250313563, Compound 929387	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779782&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563294	CCC1(c2cccc(N(C)c3nccc(OC)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779782	US20250313563, Compound 929387	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779782&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563295	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CNC1			779783	US20250313563, Compound 912075	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779783	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779783&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563296	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CNC1			779783	US20250313563, Compound 912075	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779783	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779783&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563297	CCn1nccc1-c1cccc(C2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779784	US20250313563, Compound 929398	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779784	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779784&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563298	CCn1nccc1-c1cccc(C2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779784	US20250313563, Compound 929398	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779784	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779784&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563299	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COCCOC1			779785	US20250313563, Compound 912094	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779785&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563300	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COCCOC1			779785	US20250313563, Compound 912094	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779785&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563301	CCC1(c2cccc(-c3ccnn3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779786	US20250313563, Compound 929399	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779786	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779786&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563302	CCC1(c2cccc(-c3ccnn3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779786	US20250313563, Compound 929399	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779786	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779786&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563303	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCO[C@@H](C(C)(C)C)C1			779787	US20250313563, Compound 912113	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779787	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779787&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563304	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCO[C@@H](C(C)(C)C)C1			779787	US20250313563, Compound 912113	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779787	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779787&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563305	CCCn1nccc1-c1cccc(C2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779788	US20250313563, Compound 929400	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779788	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779788&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563306	CCCn1nccc1-c1cccc(C2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779788	US20250313563, Compound 929400	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779788	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779788&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563307	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(c2ccncn2)C1			779789	US20250313563, Compound 909209	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779789	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779789&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563308	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(c2ccncn2)C1			779789	US20250313563, Compound 909209	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779789	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779789&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563309	CCC1(c2cccc(-c3ccnn3CCC(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779790	US20250313563, Compound 929401	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779790	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779790&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563310	CCC1(c2cccc(-c3ccnn3CCC(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779790	US20250313563, Compound 929401	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779790	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779790&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563311	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CS(=O)(=O)C1			779791	US20250313563, Compound 912170	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779791	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779791&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563312	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CS(=O)(=O)C1			779791	US20250313563, Compound 912170	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779791	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779791&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563313	CCC1(c2cccc(-c3cc(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779792	US20250313563, Compound 929402	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779792	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779792&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563314	CCC1(c2cccc(-c3cc(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779792	US20250313563, Compound 929402	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779792	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779792&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563315	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCC[C@H](C#N)C1			779793	US20250313563, Compound 946078	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779793	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779793&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563316	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCC[C@H](C#N)C1			779793	US20250313563, Compound 946078	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779793	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779793&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563317	CC[C@@]1(c2cccc(N(C)C(=O)c3ccn(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779794	US20250313563, Compound 929442	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779794	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779794&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563318	CC[C@@]1(c2cccc(N(C)C(=O)c3ccn(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779794	US20250313563, Compound 929442	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779794	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779794&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563319	Cn1nccc1CN1CC2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779795	US20250313563, Compound 932653	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779795	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779795&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563320	Cn1nccc1CN1CC2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779795	US20250313563, Compound 932653	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779795	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779795&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563321	CC[C@]1(c2cccc(-c3ccnnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779796	US20250313563, Compound 929443	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779796	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779796&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563322	CC[C@]1(c2cccc(-c3ccnnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779796	US20250313563, Compound 929443	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779796	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779796&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563323	Cn1cc([C@H]2CC[C@@]3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			779797	US20250313563, Compound 949323	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779797	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779797&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563324	Cn1cc([C@H]2CC[C@@]3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			779797	US20250313563, Compound 949323	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779797	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779797&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563325	CC[C@]1(c2cccc(N(C)c3ccnc(F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779798	US20250313563, Compound 929444	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779798&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563326	CC[C@]1(c2cccc(N(C)c3ccnc(F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779798	US20250313563, Compound 929444	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779798&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563327	CC(C)[C@@H]1C[C@]2(CCO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779799	US20250313563, Compound 884013	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779799	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779799&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563328	CC(C)[C@@H]1C[C@]2(CCO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779799	US20250313563, Compound 884013	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779799	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779799&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563329	CCc1cc(-c2cccc(C3(CC)C4=CN=NC4NC4=C3C(=O)CC(C)(C)C4)c2)cc(CC)n1			779800	US20250313563, Compound 929445	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779800	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779800&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563330	CCc1cc(-c2cccc(C3(CC)C4=CN=NC4NC4=C3C(=O)CC(C)(C)C4)c2)cc(CC)n1			779800	US20250313563, Compound 929445	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779800	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779800&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563331	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CCCN(C(=O)c2ccccc2)CC1			779801	US20250313563, Compound 889577	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779801	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779801&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563332	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CCCN(C(=O)c2ccccc2)CC1			779801	US20250313563, Compound 889577	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779801	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779801&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563333	CCCS(=O)(=O)c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779802	US20250313563, Compound 929447	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779802	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779802&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563334	CCCS(=O)(=O)c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779802	US20250313563, Compound 929447	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779802	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779802&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563335	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCO[C@H](C(F)(F)F)C1			779803	US20250313563, Compound 884023	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779803	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779803&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563336	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCO[C@H](C(F)(F)F)C1			779803	US20250313563, Compound 884023	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779803	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779803&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563337	CCC1(c2cccc(N3CCc4cnccc4C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779804	US20250313563, Compound 929449	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779804	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779804&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563338	CCC1(c2cccc(N3CCc4cnccc4C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779804	US20250313563, Compound 929449	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779804	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779804&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563339	CC(=O)N1CC[C@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779805	US20250313563, Compound 889583	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779805	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779805&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563340	CC(=O)N1CC[C@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779805	US20250313563, Compound 889583	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779805	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779805&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563341	CC[C@]1(c2cc(N(C)C(C)=O)ccc2F)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779806	US20250313563, Compound 929450	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779806&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563342	CC[C@]1(c2cc(N(C)C(C)=O)ccc2F)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779806	US20250313563, Compound 929450	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779806&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563343	CC(=O)N1CC2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779807	US20250313563, Compound 893314	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779807&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563344	CC(=O)N1CC2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779807	US20250313563, Compound 893314	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779807&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563345	CC[C@]1(c2cc(N(C)C(C)=O)ccc2F)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779808	US20250313563, Compound 929451	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779808	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779808&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563346	CC[C@]1(c2cc(N(C)C(C)=O)ccc2F)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779808	US20250313563, Compound 929451	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779808	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779808&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563347	CCC1(CCc2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			779809	US20250313563, Compound 819563	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779809	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779809&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563348	CCC1(CCc2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			779809	US20250313563, Compound 819563	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779809	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779809&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563349	CCCS(=O)(=O)c1cccc([C@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779810	US20250313563, Compound 929452	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779810	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779810&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563350	CCCS(=O)(=O)c1cccc([C@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779810	US20250313563, Compound 929452	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779810	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779810&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563351	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCC[C@@H](C#N)C1			779811	US20250313563, Compound 946080	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779811	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779811&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563352	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCC[C@@H](C#N)C1			779811	US20250313563, Compound 946080	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779811	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779811&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563353	CC[C@@]1(c2cccc(N(C)c3ccnc(F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779812	US20250313563, Compound 929453	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779812	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779812&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563354	CC[C@@]1(c2cccc(N(C)c3ccnc(F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779812	US20250313563, Compound 929453	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779812	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779812&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563355	CCC1(CC)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			779813	US20250313563, Compound 810505	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779813&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563356	CCC1(CC)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			779813	US20250313563, Compound 810505	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779813&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563357	CC[C@@]1(c2cccc(-c3ccnnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779814	US20250313563, Compound 929454	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779814	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779814&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563358	CC[C@@]1(c2cccc(-c3ccnnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779814	US20250313563, Compound 929454	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779814	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779814&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563359	C[C@@H]1CCC[C@@]12C1=CN=NC1NC1=C2C(=O)CC(C)(C)C1			779815	US20250313563, Compound 874319	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779815	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779815&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563360	C[C@@H]1CCC[C@@]12C1=CN=NC1NC1=C2C(=O)CC(C)(C)C1			779815	US20250313563, Compound 874319	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779815	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779815&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563361	CC[C@]1(c2cccc(N(C)C(=O)c3ccn(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779816	US20250313563, Compound 929455	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779816	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779816&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563362	CC[C@]1(c2cccc(N(C)C(=O)c3ccn(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779816	US20250313563, Compound 929455	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779816	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779816&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563363	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(C)CCc1ccccc1			779817	US20250313563, Compound 819562	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779817	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779817&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563364	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(C)CCc1ccccc1			779817	US20250313563, Compound 819562	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779817	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779817&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563365	CCC1(c2cccc([OH:0])c2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			779818	US20250313563, Compound 930334	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779818	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779818&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894641	523298164							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563366	CCC1(c2cccc([OH:0])c2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			779818	US20250313563, Compound 930334	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779818	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779818&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894641	523298164							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563367	CCC1(COCc2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			779819	US20250313563, Compound 874313	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779819&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563368	CCC1(COCc2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			779819	US20250313563, Compound 874313	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779819&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563369	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1[C@@]21CCCc2ccccc21			779820	US20250313563, Compound 930565	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779820	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779820&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563370	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1[C@@]21CCCc2ccccc21			779820	US20250313563, Compound 930565	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779820	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779820&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563371	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(C2CCCCC2)C1			779821	US20250313563, Compound 929446	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779821	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779821&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563372	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(C2CCCCC2)C1			779821	US20250313563, Compound 929446	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779821	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779821&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563373	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1[C@]21CCCc2ccccc21			779822	US20250313563, Compound 930566	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779822	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779822&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563374	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1[C@]21CCCc2ccccc21			779822	US20250313563, Compound 930566	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779822	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779822&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563375	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(c2cccnc2)C1			779823	US20250313563, Compound 947813	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779823	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779823&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563376	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(c2cccnc2)C1			779823	US20250313563, Compound 947813	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779823	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779823&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563377	CCC1(c2cccc(-c3ccnc(C(C)C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779824	US20250313563, Compound 930569	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779824	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779824&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563378	CCC1(c2cccc(-c3ccnc(C(C)C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779824	US20250313563, Compound 930569	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779824	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779824&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563379	C[C@H]1CCC[C@]12C1=CN=NC1NC1=C2C(=O)CC(C)(C)C1			779825	US20250313563, Compound 874320	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779825	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779825&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563380	C[C@H]1CCC[C@]12C1=CN=NC1NC1=C2C(=O)CC(C)(C)C1			779825	US20250313563, Compound 874320	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779825	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779825&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563381	CCC1(c2cccc(-c3ccnc4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779826	US20250313563, Compound 932625	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779826&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563382	CCC1(c2cccc(-c3ccnc4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779826	US20250313563, Compound 932625	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779826&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563383	C[C@H]1COCC[C@]12C1=CN=NC1NC1=C2C(=O)CC(C)(C)C1			779827	US20250313563, Compound 924309	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779827	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779827&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563384	C[C@H]1COCC[C@]12C1=CN=NC1NC1=C2C(=O)CC(C)(C)C1			779827	US20250313563, Compound 924309	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779827	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779827&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563385	CCC1(c2cccc(-c3ccnc(OC(C)C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779828	US20250313563, Compound 932626	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779828	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779828&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563386	CCC1(c2cccc(-c3ccnc(OC(C)C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779828	US20250313563, Compound 932626	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779828	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779828&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563387	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CCCN(c2ccncn2)CC1			779829	US20250313563, Compound 917145	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779829	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779829&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563388	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CCCN(c2ccncn2)CC1			779829	US20250313563, Compound 917145	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779829	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779829&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563389	CCC1(c2cccc(-c3ccncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779830	US20250313563, Compound 932627	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779830	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779830&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563390	CCC1(c2cccc(-c3ccncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779830	US20250313563, Compound 932627	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779830	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779830&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563391	CC(C)[C@H]1C[C@@]2(CCO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779831	US20250313563, Compound 884014	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779831	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779831&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563392	CC(C)[C@H]1C[C@@]2(CCO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779831	US20250313563, Compound 884014	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779831	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779831&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563393	CCC1(c2cccc(-c3ccnc(OC)c3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779832	US20250313563, Compound 932628	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779832	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779832&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563394	CCC1(c2cccc(-c3ccnc(OC)c3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779832	US20250313563, Compound 932628	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779832	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779832&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563395	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCOC(C)(C)C1			779833	US20250313563, Compound 924298	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779833	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779833&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563396	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCOC(C)(C)C1			779833	US20250313563, Compound 924298	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779833	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779833&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563397	CCC1(c2cccc(-c3ccnc(OC(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779834	US20250313563, Compound 932629	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779834	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779834&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563398	CCC1(c2cccc(-c3ccnc(OC(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779834	US20250313563, Compound 932629	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779834	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779834&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563399	CCC1(c2cccc(-c3cc(OC)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779835	US20250313563, Compound 932630	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779835	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779835&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563400	CCC1(c2cccc(-c3cc(OC)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779835	US20250313563, Compound 932630	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779835	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779835&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563401	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(c2ccccn2)C1			779836	US20250313563, Compound 945477	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779836	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779836&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563402	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(c2ccccn2)C1			779836	US20250313563, Compound 945477	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779836	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779836&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563403	CCC1(c2cccc(-c3ccnc4ccccc34)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779837	US20250313563, Compound 932631	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779837	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779837&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563404	CCC1(c2cccc(-c3ccnc4ccccc34)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779837	US20250313563, Compound 932631	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779837	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779837&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563405	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCO[C@@H](C(F)(F)F)C1			779838	US20250313563, Compound 884024	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779838	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779838&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563406	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCO[C@@H](C(F)(F)F)C1			779838	US20250313563, Compound 884024	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779838	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779838&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563407	CCC1(c2cccc(N(C)c3ccc(C(F)(F)F)nc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779839	US20250313563, Compound 932634	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779839	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779839&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563408	CCC1(c2cccc(N(C)c3ccc(C(F)(F)F)nc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779839	US20250313563, Compound 932634	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779839	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779839&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563409	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(C)C			779840	US20250313563, Compound 786065	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779840&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563410	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C2(C)C			779840	US20250313563, Compound 786065	Glycogen synthase kinase-3 beta	Homo sapiens		>1670							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779840&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563411	CC[C@]1(c2cccc(N3CCOc4ccccc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779841	US20250313563, Compound 932635	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779841	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779841&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563412	CC[C@]1(c2cccc(N3CCOc4ccccc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779841	US20250313563, Compound 932635	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779841	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779841&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563413	CC(=O)N1CCCC2(CC1)C1=CN=NC1NC1=C2C(=O)CC(C)(C)C1			779842	US20250313563, Compound 889575	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779842	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779842&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563414	CC(=O)N1CCCC2(CC1)C1=CN=NC1NC1=C2C(=O)CC(C)(C)C1			779842	US20250313563, Compound 889575	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779842	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779842&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563415	CC[C@]1(c2cccc(N(C)c3cccc(F)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779843	US20250313563, Compound 932636	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779843	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779843&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563416	CC[C@]1(c2cccc(N(C)c3cccc(F)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779843	US20250313563, Compound 932636	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779843	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779843&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563417	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCO[C@@H](C(C)(C)C)C1			779844	US20250313563, Compound 912106	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779844	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779844&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563418	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCO[C@@H](C(C)(C)C)C1			779844	US20250313563, Compound 912106	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779844	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779844&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563419	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			779845	US20250313563, Compound 932637	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779845&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563420	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			779845	US20250313563, Compound 932637	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779845&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563421	CC(=O)N1CCC2(C1)C1=CN=NC1NC1=C2C(=O)CC(C)(C)C1			779846	US20250313563, Compound 826763	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779846	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779846&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563422	CC(=O)N1CCC2(C1)C1=CN=NC1NC1=C2C(=O)CC(C)(C)C1			779846	US20250313563, Compound 826763	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779846	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779846&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563423	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			779847	US20250313563, Compound 932638	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779847	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779847&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563424	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			779847	US20250313563, Compound 932638	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779847	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779847&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563425	CC[C@@H]1C[C@@]2(CCO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779848	US20250313563, Compound 907328	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779848	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779848&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563426	CC[C@@H]1C[C@@]2(CCO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779848	US20250313563, Compound 907328	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779848	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779848&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563427	CC[C@]1(c2cccc(N(C)c3ccnc(OC)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779849	US20250313563, Compound 932642	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779849&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563428	CC[C@]1(c2cccc(N(C)c3ccnc(OC)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779849	US20250313563, Compound 932642	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779849&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563429	CC(=O)N1CC[C@@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779850	US20250313563, Compound 889584	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779850	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779850&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563430	CC(=O)N1CC[C@@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779850	US20250313563, Compound 889584	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779850	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779850&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563431	CC[C@]1(c2cccc(N3CCOc4ncccc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779851	US20250313563, Compound 932643	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779851&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563432	CC[C@]1(c2cccc(N3CCOc4ncccc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779851	US20250313563, Compound 932643	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779851&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563433	CC[C@H]1C[C@]2(CCO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779852	US20250313563, Compound 907329	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779852	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779852&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563434	CC[C@H]1C[C@]2(CCO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779852	US20250313563, Compound 907329	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779852	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779852&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563435	CC[C@]1(c2cccc(N(C)c3cccc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779853	US20250313563, Compound 932644	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779853	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779853&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563436	CC[C@]1(c2cccc(N(C)c3cccc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779853	US20250313563, Compound 932644	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779853	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779853&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563437	CN(C)C(=O)C1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779854	US20250313563, Compound 945395	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779854	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779854&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563438	CN(C)C(=O)C1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779854	US20250313563, Compound 945395	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779854	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779854&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563439	CC[C@]1(c2cccc(N(C)c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779855	US20250313563, Compound 932645	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779855&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563440	CC[C@]1(c2cccc(N(C)c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779855	US20250313563, Compound 932645	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779855&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563441	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CO[C@H](C2CC2)C1			779856	US20250313563, Compound 913184	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779856&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563442	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CO[C@H](C2CC2)C1			779856	US20250313563, Compound 913184	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779856&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563443	CC[C@]1(c2cccc(N(C)c3cccc(OC)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779857	US20250313563, Compound 932646	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779857&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563444	CC[C@]1(c2cccc(N(C)c3cccc(OC)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779857	US20250313563, Compound 932646	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779857&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563445	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCCOCC1			779858	US20250313563, Compound 874536	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779858&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563446	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCCOCC1			779858	US20250313563, Compound 874536	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779858&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563447	CC[C@]1(c2cccc(N(C)c3ccc(F)nc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779859	US20250313563, Compound 932647	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779859&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563448	CC[C@]1(c2cccc(N(C)c3ccc(F)nc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779859	US20250313563, Compound 932647	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779859&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563449	CC[C@@]1(C)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			779860	US20250313563, Compound 884019	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779860&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563450	CC[C@@]1(C)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			779860	US20250313563, Compound 884019	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779860&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563451	CC[C@@]1(c2cccc(N3CCOc4ccccc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779861	US20250313563, Compound 932655	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779861&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563452	CC[C@@]1(c2cccc(N3CCOc4ccccc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779861	US20250313563, Compound 932655	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779861&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563453	C[C@@H]1C[C@@]2(CCO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779862	US20250313563, Compound 899559	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779862	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779862&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563454	C[C@@H]1C[C@@]2(CCO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779862	US20250313563, Compound 899559	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779862	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779862&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563455	CC[C@@]1(c2cccc(N(C)c3cccc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779863	US20250313563, Compound 932656	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779863&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563456	CC[C@@]1(c2cccc(N(C)c3cccc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779863	US20250313563, Compound 932656	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779863&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563457	CC[C@H]1C[C@@]2(CCO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779864	US20250313563, Compound 924311	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779864&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563458	CC[C@H]1C[C@@]2(CCO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779864	US20250313563, Compound 924311	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779864&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563459	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			779865	US20250313563, Compound 932657	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779865&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563460	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			779865	US20250313563, Compound 932657	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779865&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563461	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCOC1			779866	US20250313563, Compound 877314	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779866&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563462	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCOC1			779866	US20250313563, Compound 877314	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779866&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563463	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@@H](C)C2			779867	US20250313563, Compound 932658	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779867&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563464	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@@H](C)C2			779867	US20250313563, Compound 932658	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779867&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563465	CC(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779868	US20250313563, Compound 826649	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779868&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563466	CC(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779868	US20250313563, Compound 826649	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779868&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563467	CC[C@@]1(c2cccc(N(C)c3ccnc(OC)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779869	US20250313563, Compound 932662	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779869&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563468	CC[C@@]1(c2cccc(N(C)c3ccnc(OC)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779869	US20250313563, Compound 932662	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779869&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563469	C[C@@H]1C[C@H](C)C[C@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779870	US20250313563, Compound 884113	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779870&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563470	C[C@@H]1C[C@H](C)C[C@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779870	US20250313563, Compound 884113	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779870&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563471	CC[C@@]1(c2cccc(N3CCOc4ncccc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779871	US20250313563, Compound 932663	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779871&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563472	CC[C@@]1(c2cccc(N3CCOc4ncccc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779871	US20250313563, Compound 932663	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779871&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563473	CC1CCCC12C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779872	US20250313563, Compound 826765	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779872&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563474	CC1CCCC12C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779872	US20250313563, Compound 826765	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779872&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563475	CC[C@@]1(c2cccc(N(C)c3cccc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779873	US20250313563, Compound 932664	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779873&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563476	CC[C@@]1(c2cccc(N(C)c3cccc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779873	US20250313563, Compound 932664	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779873&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563477	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCCC(C)(C)C1			779874	US20250313563, Compound 883846	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779874&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563478	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCCC(C)(C)C1			779874	US20250313563, Compound 883846	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779874&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563479	CC[C@@]1(c2cccc(CN(C)c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779875	US20250313563, Compound 932665	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779875&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563480	CC[C@@]1(c2cccc(CN(C)c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779875	US20250313563, Compound 932665	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779875&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563481	CCC1(CC)C2=C(CC(C)(C)CC2=O)NC2=C1C(C)N=N2			779876	US20250313563, Compound 786061	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779876&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563482	CCC1(CC)C2=C(CC(C)(C)CC2=O)NC2=C1C(C)N=N2			779876	US20250313563, Compound 786061	Glycogen synthase kinase-3 beta	Homo sapiens		>1670							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779876&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563483	CC[C@@]1(c2cccc(N(C)c3cccc(OC)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779877	US20250313563, Compound 932666	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779877&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563484	CC[C@@]1(c2cccc(N(C)c3cccc(OC)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779877	US20250313563, Compound 932666	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779877&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563485	CC[C@H]1C[C@]2(CO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779878	US20250313563, Compound 913214	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779878&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563486	CC[C@H]1C[C@]2(CO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779878	US20250313563, Compound 913214	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779878&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563487	CC[C@@]1(c2cccc(CN(C)c3ccc(F)nc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779879	US20250313563, Compound 932667	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779879	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779879&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563488	CC[C@@]1(c2cccc(CN(C)c3ccc(F)nc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779879	US20250313563, Compound 932667	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779879	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779879&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563489	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(C(=O)OCc2ccccc2)C1			779880	US20250313563, Compound 889568	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779880	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779880&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563490	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(C(=O)OCc2ccccc2)C1			779880	US20250313563, Compound 889568	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779880	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779880&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563491	CCC1(c2cccc(N(C)c3nccc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779881	US20250313563, Compound 942642	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779881&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563492	CCC1(c2cccc(N(C)c3nccc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779881	US20250313563, Compound 942642	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779881&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563493	CC1CCC12C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779882	US20250313563, Compound 949640	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779882	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779882&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563494	CC1CCC12C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779882	US20250313563, Compound 949640	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779882	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779882&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563495	CC[C@]1(c2cccc(N(C)c3ccnnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779883	US20250313563, Compound 943492	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779883	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779883&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563496	CC[C@]1(c2cccc(N(C)c3ccnnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779883	US20250313563, Compound 943492	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779883	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779883&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563497	CC1(C)CC(=O)C2=C(NC3N=NC=C3C23CCOCC3)[C@H]1F			779884	US20250313563, Compound 883833	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779884	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779884&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563498	CC1(C)CC(=O)C2=C(NC3N=NC=C3C23CCOCC3)[C@H]1F			779884	US20250313563, Compound 883833	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779884	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779884&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563499	CC[C@]1(c2cccc(-c3cc(C)ncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779885	US20250313563, Compound 943514	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779885	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779885&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563500	CC[C@]1(c2cccc(-c3cc(C)ncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779885	US20250313563, Compound 943514	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779885	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779885&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563501	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CO[C@@H](C2CC2)C1			779886	US20250313563, Compound 913185	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779886	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779886&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563502	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CO[C@@H](C2CC2)C1			779886	US20250313563, Compound 913185	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779886	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779886&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563503	CC[C@@]1(c2cccc(-c3cc(C)ncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779887	US20250313563, Compound 943515	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779887	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779887&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563504	CC[C@@]1(c2cccc(-c3cc(C)ncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779887	US20250313563, Compound 943515	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779887	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779887&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563505	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC(C(=O)N2CCCC2)CC1			779888	US20250313563, Compound 945394	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779888	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779888&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563506	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC(C(=O)N2CCCC2)CC1			779888	US20250313563, Compound 945394	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779888	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779888&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563507	CC[C@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779889	US20250313563, Compound 943516	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779889	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779889&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563508	CC[C@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779889	US20250313563, Compound 943516	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779889	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779889&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563509	C[C@@H]1CCC[C@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779890	US20250313563, Compound 874537	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779890&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563510	C[C@@H]1CCC[C@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779890	US20250313563, Compound 874537	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779890&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563511	CC[C@@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779891	US20250313563, Compound 943517	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779891	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779891&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563512	CC[C@@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779891	US20250313563, Compound 943517	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779891	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779891&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563513	Cc1noc(C2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			779892	US20250313563, Compound 943895	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779892&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563514	Cc1noc(C2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			779892	US20250313563, Compound 943895	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779892&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563515	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779893	US20250313563, Compound 943518	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779893	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779893&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563516	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779893	US20250313563, Compound 943518	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779893	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779893&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563517	C[C@H]1C[C@]2(CCO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779894	US20250313563, Compound 899560	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779894&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563518	C[C@H]1C[C@]2(CCO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779894	US20250313563, Compound 899560	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779894&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563519	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779895	US20250313563, Compound 943519	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779895	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779895&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563520	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779895	US20250313563, Compound 943519	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779895	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779895&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563521	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(C2COC2)C1			779896	US20250313563, Compound 912076	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779896	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779896&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563522	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(C2COC2)C1			779896	US20250313563, Compound 912076	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779896	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779896&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563523	CCC1(c2cccc(-c3cnc(C)n3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779897	US20250313563, Compound 943531	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779897&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563524	CCC1(c2cccc(-c3cnc(C)n3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779897	US20250313563, Compound 943531	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779897&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563525	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(c2ccncn2)CC1			779898	US20250313563, Compound 874529	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779898&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563526	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(c2ccncn2)CC1			779898	US20250313563, Compound 874529	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779898&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563527	CCC1(c2cccc(-c3ncnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779899	US20250313563, Compound 943532	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779899&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563528	CCC1(c2cccc(-c3ncnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779899	US20250313563, Compound 943532	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779899&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563529	CCC1(c2cccc(-c3cncn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779900	US20250313563, Compound 943533	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779900	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779900&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563530	CCC1(c2cccc(-c3cncn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779900	US20250313563, Compound 943533	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779900	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779900&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563531	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CCCN(CC(F)F)CC1			779901	US20250313563, Compound 889574	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779901	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779901&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563532	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CCCN(CC(F)F)CC1			779901	US20250313563, Compound 889574	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779901	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779901&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563533	CCC1(c2cccc(-c3ccnc4c3CCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779902	US20250313563, Compound 943534	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779902	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779902&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563534	CCC1(c2cccc(-c3ccnc4c3CCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779902	US20250313563, Compound 943534	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779902	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779902&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563535	CCC1(c2cccc(-c3cnc4n3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779903	US20250313563, Compound 943535	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779903	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779903&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563536	CCC1(c2cccc(-c3cnc4n3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779903	US20250313563, Compound 943535	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779903	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779903&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563537	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)C23CCOCC3)[C@@H]1F			779904	US20250313563, Compound 883834	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779904	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779904&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563538	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)C23CCOCC3)[C@@H]1F			779904	US20250313563, Compound 883834	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779904	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779904&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563539	CCC1(c2cccc(-c3ccnc(C(C)(C)O)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779905	US20250313563, Compound 943536	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779905	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779905&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563540	CCC1(c2cccc(-c3ccnc(C(C)(C)O)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779905	US20250313563, Compound 943536	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779905	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779905&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563541	C[C@H]1CCC[C@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779906	US20250313563, Compound 893319	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779906&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563542	C[C@H]1CCC[C@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779906	US20250313563, Compound 893319	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779906&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563543	CCC1(c2cccc(N(C)c3cc(C)ccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779907	US20250313563, Compound 943537	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779907&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563544	CCC1(c2cccc(N(C)c3cc(C)ccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779907	US20250313563, Compound 943537	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779907&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563545	CC[C@@H]1C[C@@]2(CO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779908	US20250313563, Compound 913215	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779908	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779908&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563546	CC[C@@H]1C[C@@]2(CO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779908	US20250313563, Compound 913215	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779908	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779908&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563547	CCC1(c2cccc(N(C)c3cc(C)cc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779909	US20250313563, Compound 943538	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779909	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779909&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563548	CCC1(c2cccc(N(C)c3cc(C)cc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779909	US20250313563, Compound 943538	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779909	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779909&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563549	O=C1C[C@@]2(CCOC2)CC2=C1C1(CCOCC1)C1=C(N=NC1)N2			779910	US20250313563, Compound 901475	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779910&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563550	O=C1C[C@@]2(CCOC2)CC2=C1C1(CCOCC1)C1=C(N=NC1)N2			779910	US20250313563, Compound 901475	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779910&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563551	CCC1(c2cccc(-c3ccncc3CO)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779911	US20250313563, Compound 943539	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779911	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779911&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563552	CCC1(c2cccc(-c3ccncc3CO)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779911	US20250313563, Compound 943539	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779911	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779911&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563553	CC[C@@H]1C[C@]3(CO1)C2=C(N=NC2)NC4=C3C(=O)CC(C)(C)C4			779912	US20250313563, Compound 913213	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779912	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779912&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894732	523298258							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563554	CC[C@@H]1C[C@]3(CO1)C2=C(N=NC2)NC4=C3C(=O)CC(C)(C)C4			779912	US20250313563, Compound 913213	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779912	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779912&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894732	523298258							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563555	CCC1(c2cccc(-c3ccnc(C[OH:0])c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779913	US20250313563, Compound 943540	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779913	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779913&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894733	523298259							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563556	CCC1(c2cccc(-c3ccnc(C[OH:0])c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779913	US20250313563, Compound 943540	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779913	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779913&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894733	523298259							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563557	CC1(C)CC4=C(C(=O)[C@H]1F)C2(CCOCC2)C3=C(N=NC3)N4			779914	US20250313563, Compound 883836	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779914	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779914&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894734	523298260							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563558	CC1(C)CC4=C(C(=O)[C@H]1F)C2(CCOCC2)C3=C(N=NC3)N4			779914	US20250313563, Compound 883836	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779914	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779914&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894734	523298260							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563559	CC[C@@]1(c2cccc(S(=O)(=O)C3CCCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779915	US20250313563, Compound 943541	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779915	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779915&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563560	CC[C@@]1(c2cccc(S(=O)(=O)C3CCCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779915	US20250313563, Compound 943541	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779915	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779915&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563561	Cc1nn(C)c(C)c1S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779916	US20250313563, Compound 947257	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779916	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779916&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563562	Cc1nn(C)c(C)c1S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779916	US20250313563, Compound 947257	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779916	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779916&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563563	CC[C@]1(c2cccc(S(=O)(=O)CCOC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779917	US20250313563, Compound 943542	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779917	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779917&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563564	CC[C@]1(c2cccc(S(=O)(=O)CCOC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779917	US20250313563, Compound 943542	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779917	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779917&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563565	O=C1C[C@]2(CCOC2)CC2=C1C1(CCOCC1)C1=C(N=NC1)N2			779918	US20250313563, Compound 901476	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779918	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779918&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563566	O=C1C[C@]2(CCOC2)CC2=C1C1(CCOCC1)C1=C(N=NC1)N2			779918	US20250313563, Compound 901476	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779918	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779918&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563567	CC[C@@]1(c2cccc(S(=O)(=O)CCOC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779919	US20250313563, Compound 943546	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779919	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779919&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563568	CC[C@@]1(c2cccc(S(=O)(=O)CCOC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779919	US20250313563, Compound 943546	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779919	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779919&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563569	C[C@@H]1C[C@@]2(CCN1S(=O)(=O)c1ccn(C)n1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779920	US20250313563, Compound 917160	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779920	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779920&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563570	C[C@@H]1C[C@@]2(CCN1S(=O)(=O)c1ccn(C)n1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779920	US20250313563, Compound 917160	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779920	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779920&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563571	CC[C@]1(c2cccc(S(=O)(=O)C3CCCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779921	US20250313563, Compound 943547	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779921	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779921&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563572	CC[C@]1(c2cccc(S(=O)(=O)C3CCCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779921	US20250313563, Compound 943547	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779921	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779921&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563573	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CC[C@H](C(F)(F)F)C1			779922	US20250313563, Compound 952434	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779922	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779922&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563574	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CC[C@H](C(F)(F)F)C1			779922	US20250313563, Compound 952434	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779922	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779922&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563575	CC[C@@]1(c2cccc(-c3ccncc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779923	US20250313563, Compound 943913	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779923	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779923&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563576	CC[C@@]1(c2cccc(-c3ccncc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779923	US20250313563, Compound 943913	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779923	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779923&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563577	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1[C@]21CCCN(S(=O)(=O)Cc2ccccc2)CC1			779924	US20250313563, Compound 945483	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779924	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779924&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563578	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1[C@]21CCCN(S(=O)(=O)Cc2ccccc2)CC1			779924	US20250313563, Compound 945483	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779924	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779924&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563579	CC[C@]1(c2cccc(-c3ccnc(C(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779925	US20250313563, Compound 943915	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779925	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779925&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563580	CC[C@]1(c2cccc(-c3ccnc(C(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779925	US20250313563, Compound 943915	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779925	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779925&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563581	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(CC(F)F)C1			779926	US20250313563, Compound 912073	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779926	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779926&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563582	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(CC(F)F)C1			779926	US20250313563, Compound 912073	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779926	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779926&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563583	CC[C@]1(c2cccc(-c3ccncc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779927	US20250313563, Compound 943918	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779927	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779927&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563584	CC[C@]1(c2cccc(-c3ccncc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779927	US20250313563, Compound 943918	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779927	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779927&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563585	CO[C@H]1CC[C@]2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779928	US20250313563, Compound 884120	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779928	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779928&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563586	CO[C@H]1CC[C@]2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779928	US20250313563, Compound 884120	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779928	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779928&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563587	CC[C@@]1(c2cccc(-c3ccnc(C(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779929	US20250313563, Compound 943919	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779929	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779929&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563588	CC[C@@]1(c2cccc(-c3ccnc(C(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779929	US20250313563, Compound 943919	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779929	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779929&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563589	COC[C@H]1C[C@@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779930	US20250313563, Compound 912173	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779930	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779930&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563590	COC[C@H]1C[C@@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779930	US20250313563, Compound 912173	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779930	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779930&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563591	CC[C@]1(c2cccc(-c3ccnc(OC(F)(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779931	US20250313563, Compound 943988	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779931	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779931&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563592	CC[C@]1(c2cccc(-c3ccnc(OC(F)(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779931	US20250313563, Compound 943988	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779931	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779931&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563593	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCCCCC1			779932	US20250313563, Compound 883978	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779932	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779932&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563594	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCCCCC1			779932	US20250313563, Compound 883978	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779932	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779932&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563595	CC[C@@]1(c2cccc(-c3ccnc(C(F)(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779933	US20250313563, Compound 943989	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779933	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779933&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563596	CC[C@@]1(c2cccc(-c3ccnc(C(F)(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779933	US20250313563, Compound 943989	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779933	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779933&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563597	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC(C(=O)N2CCCC2)CC1			779934	US20250313563, Compound 945396	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779934	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779934&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563598	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC(C(=O)N2CCCC2)CC1			779934	US20250313563, Compound 945396	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779934	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779934&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563599	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779935	US20250313563, Compound 943990	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779935	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779935&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563600	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779935	US20250313563, Compound 943990	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779935	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779935&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563601	Cn1cc([C@H]2CC[C@]3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			779936	US20250313563, Compound 949322	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779936	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779936&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563602	Cn1cc([C@H]2CC[C@]3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			779936	US20250313563, Compound 949322	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779936	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779936&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563603	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779937	US20250313563, Compound 943991	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779937	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779937&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563604	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779937	US20250313563, Compound 943991	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779937	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779937&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563605	CC1(C)CC2=C(C(=O)[C@@H]1F)C1(CCOCC1)C1=C(N=NC1)N2			779938	US20250313563, Compound 883835	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779938	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779938&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563606	CC1(C)CC2=C(C(=O)[C@@H]1F)C1(CCOCC1)C1=C(N=NC1)N2			779938	US20250313563, Compound 883835	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779938	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779938&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563607	CC[C@]1(c2cccc(-c3ccnc([OH:0])c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779939	US20250313563, Compound 943992	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779939	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779939&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894756	523298285							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563608	CC[C@]1(c2cccc(-c3ccnc([OH:0])c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779939	US20250313563, Compound 943992	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779939	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779939&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894756	523298285							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563609	C[C@@H]1C[C@H](C)C[C@@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779940	US20250313563, Compound 884114	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779940	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779940&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563610	C[C@@H]1C[C@H](C)C[C@@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779940	US20250313563, Compound 884114	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779940	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779940&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563611	CC[C@@]1(c2cccc(-c3ccnc([OH:0])c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779941	US20250313563, Compound 943993	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779941	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779941&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894757	523298287							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563612	CC[C@@]1(c2cccc(-c3ccnc([OH:0])c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779941	US20250313563, Compound 943993	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779941	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779941&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894757	523298287							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563613	Cc1cnn(C)c1S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779942	US20250313563, Compound 945658	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779942	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779942&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563614	Cc1cnn(C)c1S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779942	US20250313563, Compound 945658	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779942	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779942&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563615	CC[C@@]1(c2cccc(-c3cnnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779943	US20250313563, Compound 943994	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779943	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779943&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563616	CC[C@@]1(c2cccc(-c3cnnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779943	US20250313563, Compound 943994	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779943	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779943&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563617	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC1			779944	US20250313563, Compound 889569	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779944	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779944&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563618	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC1			779944	US20250313563, Compound 889569	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779944	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779944&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563619	CC[C@@]1(c2cccc(-c3cnnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780365	US20250313563, Compound 943995	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780365	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780365&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563620	CC[C@@]1(c2cccc(-c3cnnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780365	US20250313563, Compound 943995	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780365	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780365&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563621	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CO[C@@H](C2CC2)C1			780366	US20250313563, Compound 913442	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780366	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780366&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563622	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CO[C@@H](C2CC2)C1			780366	US20250313563, Compound 913442	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780366	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780366&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563623	CCC1(c2cccc(-c3c(C)nnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780367	US20250313563, Compound 943996	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780367	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780367&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563624	CCC1(c2cccc(-c3c(C)nnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780367	US20250313563, Compound 943996	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780367	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780367&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563625	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)c2ccccc2F)C1			780368	US20250313563, Compound 913263	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780368	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780368&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563626	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)c2ccccc2F)C1			780368	US20250313563, Compound 913263	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780368	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780368&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563627	CCC4(c2cccc(S(=O)(=O)C1COC1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780369	US20250313563, Compound 944017	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780369	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780369&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894767	523298715							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563628	CCC4(c2cccc(S(=O)(=O)C1COC1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780369	US20250313563, Compound 944017	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780369	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780369&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894767	523298715							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563629	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCO[C@H](C(C)(C)C)C1			780370	US20250313563, Compound 912112	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780370	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780370&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563630	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCO[C@H](C(C)(C)C)C1			780370	US20250313563, Compound 912112	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780370	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780370&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563631	CCC4(c2cccc(S(=O)(=O)C1CCOC1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780371	US20250313563, Compound 944018	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780371	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780371&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894769	523298717							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563632	CCC4(c2cccc(S(=O)(=O)C1CCOC1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780371	US20250313563, Compound 944018	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780371	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780371&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894769	523298717							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563633	CC1(C(F)(F)F)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCOCC1			780372	US20250313563, Compound 901458	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780372	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780372&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563634	CC1(C(F)(F)F)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCOCC1			780372	US20250313563, Compound 901458	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780372	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780372&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563635	CCC1(c2cccc(S(=O)(=O)C3CC(F)(F)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780373	US20250313563, Compound 944019	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780373	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780373&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563636	CCC1(c2cccc(S(=O)(=O)C3CC(F)(F)C3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780373	US20250313563, Compound 944019	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780373	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780373&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563637	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CC[C@@H](c2ccncc2)CC1			780374	US20250313563, Compound 949320	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780374	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780374&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563638	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CC[C@@H](c2ccncc2)CC1			780374	US20250313563, Compound 949320	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780374	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780374&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563639	CCc1cccc(N(C)c2cccc(C3(CC)C4=CN=NC4NC4=C3C(=O)CC(C)(C)C4)c2)n1			780375	US20250313563, Compound 944023	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780375	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780375&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563640	CCc1cccc(N(C)c2cccc(C3(CC)C4=CN=NC4NC4=C3C(=O)CC(C)(C)C4)c2)n1			780375	US20250313563, Compound 944023	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780375	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780375&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563641	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCOC1			780376	US20250313563, Compound 826713	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780376	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780376&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563642	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCOC1			780376	US20250313563, Compound 826713	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780376	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780376&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563643	CCC1(c2cccc(-c3ccncc3O)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			780377	US20250313563, Compound 944024	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780377	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780377&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563644	CCC1(c2cccc(-c3ccncc3O)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			780377	US20250313563, Compound 944024	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780377	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780377&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563645	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCO[C@H](C(F)(F)F)C1			780378	US20250313563, Compound 884022	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780378	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780378&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563646	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCO[C@H](C(F)(F)F)C1			780378	US20250313563, Compound 884022	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780378	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780378&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563647	CCC1(c2cccc(-c3cnco3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780379	US20250313563, Compound 944025	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780379	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780379&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563648	CCC1(c2cccc(-c3cnco3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780379	US20250313563, Compound 944025	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780379	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780379&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563649	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(F)cn2)CC1			780380	US20250313563, Compound 947251	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780380	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780380&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563650	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(F)cn2)CC1			780380	US20250313563, Compound 947251	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780380	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780380&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563651	CCC1(c2cccc(-c3cncn3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780381	US20250313563, Compound 944026	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780381	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780381&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563652	CCC1(c2cccc(-c3cncn3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780381	US20250313563, Compound 944026	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780381	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780381&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563653	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cc(F)ccn2)CC1			780382	US20250313563, Compound 947262	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780382	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780382&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563654	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cc(F)ccn2)CC1			780382	US20250313563, Compound 947262	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780382	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780382&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563655	CCC1(c2cccc(-c3ccnc(C(C)O)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780383	US20250313563, Compound 944029	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780383	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780383&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563656	CCC1(c2cccc(-c3ccnc(C(C)O)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780383	US20250313563, Compound 944029	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780383	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780383&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563657	CC[C@H]1C[C@@]2(CO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780384	US20250313563, Compound 913216	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780384	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780384&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563658	CC[C@H]1C[C@@]2(CO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780384	US20250313563, Compound 913216	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780384	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780384&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563659	CC[C@@]1(c2cccc(-c3ccnc4ccccc34)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780385	US20250313563, Compound 944031	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780385	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780385&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563660	CC[C@@]1(c2cccc(-c3ccnc4ccccc34)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780385	US20250313563, Compound 944031	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780385	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780385&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563661	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CN(c2ccc(C(F)(F)F)cc2)C1			780386	US20250313563, Compound 945478	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780386	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780386&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563662	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CN(c2ccc(C(F)(F)F)cc2)C1			780386	US20250313563, Compound 945478	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780386	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780386&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563663	CC[C@@]1(c2cccc(-c3cc(OC)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780387	US20250313563, Compound 944032	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780387	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780387&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563664	CC[C@@]1(c2cccc(-c3cc(OC)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780387	US20250313563, Compound 944032	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780387	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780387&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563665	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21C[C@H](OCc2ccccc2)C1			780388	US20250313563, Compound 909210	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780388	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780388&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563666	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21C[C@H](OCc2ccccc2)C1			780388	US20250313563, Compound 909210	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780388	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780388&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563667	CC[C@@]1(c2cccc(-c3ccnc4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780389	US20250313563, Compound 944033	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780389	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780389&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563668	CC[C@@]1(c2cccc(-c3ccnc4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780389	US20250313563, Compound 944033	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780389	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780389&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563669	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCS(=O)(=O)CC1			780390	US20250313563, Compound 896013	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780390	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780390&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563670	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCS(=O)(=O)CC1			780390	US20250313563, Compound 896013	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780390	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780390&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563671	CC[C@]1(c2cccc(-c3ccnc4ccccc34)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780391	US20250313563, Compound 944034	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780391	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780391&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563672	CC[C@]1(c2cccc(-c3ccnc4ccccc34)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780391	US20250313563, Compound 944034	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780391	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780391&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563673	C[C@@H]1C[C@@]2(CCN1S(C)(=O)=O)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780392	US20250313563, Compound 918315	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780392	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780392&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563674	C[C@@H]1C[C@@]2(CCN1S(C)(=O)=O)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780392	US20250313563, Compound 918315	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780392	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780392&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563675	CC[C@]1(c2cccc(-c3cc(OC)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780393	US20250313563, Compound 944035	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780393	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780393&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563676	CC[C@]1(c2cccc(-c3cc(OC)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780393	US20250313563, Compound 944035	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780393	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780393&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563677	CCn1nc(C)c(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1C			780394	US20250313563, Compound 945679	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780394	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780394&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563678	CCn1nc(C)c(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1C			780394	US20250313563, Compound 945679	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780394	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780394&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563679	CC[C@]1(c2cccc(-c3ccnc4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780395	US20250313563, Compound 944036	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780395	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780395&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563680	CC[C@]1(c2cccc(-c3ccnc4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780395	US20250313563, Compound 944036	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780395	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780395&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563681	Cc1cnccc1[C@H]1CC[C@]2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780396	US20250313563, Compound 949318	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780396	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780396&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563682	Cc1cnccc1[C@H]1CC[C@]2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780396	US20250313563, Compound 949318	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780396	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780396&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563683	CC[C@]1(c2cccc(N(C)c3nccc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780397	US20250313563, Compound 945328	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780397	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780397&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563684	CC[C@]1(c2cccc(N(C)c3nccc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780397	US20250313563, Compound 945328	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780397	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780397&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563685	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCOC(C)(C)C1			780398	US20250313563, Compound 924299	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780398	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780398&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563686	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCOC(C)(C)C1			780398	US20250313563, Compound 924299	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780398	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780398&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563687	CC[C@@]1(c2cccc(N(C)c3nccc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780399	US20250313563, Compound 945329	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780399	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780399&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563688	CC[C@@]1(c2cccc(N(C)c3nccc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780399	US20250313563, Compound 945329	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780399	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780399&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563689	Cc1nccc([C@H]2CC[C@@]3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1C			780400	US20250313563, Compound 950477	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780400	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780400&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563690	Cc1nccc([C@H]2CC[C@@]3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1C			780400	US20250313563, Compound 950477	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780400	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780400&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563691	CCC1(c2cccc(-c3ccnc(C)c3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780401	US20250313563, Compound 945458	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780401	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780401&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563692	CCC1(c2cccc(-c3ccnc(C)c3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780401	US20250313563, Compound 945458	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780401	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780401&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563693	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CCCN(CC(F)(F)F)CC1			780402	US20250313563, Compound 889576	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780402	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780402&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563694	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CCCN(CC(F)(F)F)CC1			780402	US20250313563, Compound 889576	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780402	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780402&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563695	CCC1(c2cccc(-c3cc(C)nc(OC(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780403	US20250313563, Compound 945463	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780403	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780403&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563696	CCC1(c2cccc(-c3cc(C)nc(OC(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780403	US20250313563, Compound 945463	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780403	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780403&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563697	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCOC1			780404	US20250313563, Compound 877313	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780404	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780404&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563698	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCOC1			780404	US20250313563, Compound 877313	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780404	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780404&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563699	CCC1(c2cccc(N(C)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780405	US20250313563, Compound 945466	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780405	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780405&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563700	CCC1(c2cccc(N(C)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780405	US20250313563, Compound 945466	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780405	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780405&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563701	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCOCC1			780406	US20250313563, Compound 826648	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780406	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780406&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563702	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCOCC1			780406	US20250313563, Compound 826648	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780406	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780406&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563703	CCCc1cc(-c2cccc(C3(CC)C4=CN=NC4NC4=C3C(=O)CC(C)(C)C4)c2)ccn1			780407	US20250313563, Compound 945467	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780407	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780407&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563704	CCCc1cc(-c2cccc(C3(CC)C4=CN=NC4NC4=C3C(=O)CC(C)(C)C4)c2)ccn1			780407	US20250313563, Compound 945467	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780407	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780407&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563705	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC1			780408	US20250313563, Compound 874509	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780408	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780408&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563706	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC1			780408	US20250313563, Compound 874509	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780408	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780408&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563707	CCC1(c2cccc(-c3cc(C)ncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780409	US20250313563, Compound 945468	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780409	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780409&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563708	CCC1(c2cccc(-c3cc(C)ncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780409	US20250313563, Compound 945468	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780409	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780409&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563709	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCO[C@@H](C(F)(F)F)C1			780410	US20250313563, Compound 884021	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780410	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780410&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563710	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCO[C@@H](C(F)(F)F)C1			780410	US20250313563, Compound 884021	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780410	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780410&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563711	CC[C@]1(c2cccc(-c3ccncc3CO)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780411	US20250313563, Compound 945469	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780411	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780411&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563712	CC[C@]1(c2cccc(-c3ccncc3CO)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780411	US20250313563, Compound 945469	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780411	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780411&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563713	COC(=O)C1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780412	US20250313563, Compound 918270	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780412	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780412&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563714	COC(=O)C1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780412	US20250313563, Compound 918270	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780412	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780412&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563715	CC[C@@]1(c2cccc(-c3ccncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780413	US20250313563, Compound 945471	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780413	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780413&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563716	CC[C@@]1(c2cccc(-c3ccncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780413	US20250313563, Compound 945471	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780413	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780413&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563717	C[C@H]1CC[C@@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780414	US20250313563, Compound 883840	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780414	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780414&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563718	C[C@H]1CC[C@@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780414	US20250313563, Compound 883840	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780414	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780414&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563719	CC[C@]1(c2cccc(-c3ncnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780415	US20250313563, Compound 945472	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780415	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780415&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563720	CC[C@]1(c2cccc(-c3ncnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780415	US20250313563, Compound 945472	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780415	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780415&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563721	CNC(=O)C1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780416	US20250313563, Compound 945397	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780416	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780416&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563722	CNC(=O)C1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780416	US20250313563, Compound 945397	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780416	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780416&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563723	CC[C@@]1(c2cccc(N(C)c3ccc(C(F)(F)F)nc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780417	US20250313563, Compound 945474	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780417	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780417&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563724	CC[C@@]1(c2cccc(N(C)c3ccc(C(F)(F)F)nc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780417	US20250313563, Compound 945474	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780417	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780417&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563725	CC1N=NC2=C1C1(CCOCC1)C1=C(CC(C)(C)C(F)C1=O)N2			780418	US20250313563, Compound 912072	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780418	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780418&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563726	CC1N=NC2=C1C1(CCOCC1)C1=C(CC(C)(C)C(F)C1=O)N2			780418	US20250313563, Compound 912072	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780418	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780418&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563727	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)[C@@H](F)C(C)(C)C2			780419	US20250313563, Compound 945475	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780419	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780419&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563728	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)[C@@H](F)C(C)(C)C2			780419	US20250313563, Compound 945475	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780419	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780419&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563729	C[C@H]1C[C@@]2(CCO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780420	US20250313563, Compound 924307	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780420	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780420&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563730	C[C@H]1C[C@@]2(CCO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780420	US20250313563, Compound 924307	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780420	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780420&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563731	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)[C@H](F)C(C)(C)C2			780421	US20250313563, Compound 945476	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780421	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780421&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563732	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)[C@H](F)C(C)(C)C2			780421	US20250313563, Compound 945476	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780421	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780421&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563733	C[C@@H]1C[C@]2(CCO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780422	US20250313563, Compound 924308	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780422	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780422&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563734	C[C@@H]1C[C@]2(CCO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780422	US20250313563, Compound 924308	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780422	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780422&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563735	CC[C@@]1(c2cccc(-c3ccncc3CO)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780423	US20250313563, Compound 945479	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780423	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780423&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563736	CC[C@@]1(c2cccc(-c3ccncc3CO)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780423	US20250313563, Compound 945479	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780423	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780423&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563737	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(CC(F)F)CC1			780424	US20250313563, Compound 883962	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780424	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780424&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563738	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(CC(F)F)CC1			780424	US20250313563, Compound 883962	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780424	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780424&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563739	CC[C@]1(c2cccc(-c3ccncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780425	US20250313563, Compound 945481	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780425	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780425&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563740	CC[C@]1(c2cccc(-c3ccncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780425	US20250313563, Compound 945481	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780425	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780425&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563741	C[C@@H]1CC[C@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780426	US20250313563, Compound 883841	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780426	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780426&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563742	C[C@@H]1CC[C@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780426	US20250313563, Compound 883841	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780426	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780426&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563743	CC[C@@]1(c2cccc(-c3ncnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780427	US20250313563, Compound 945482	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780427	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780427&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563744	CC[C@@]1(c2cccc(-c3ncnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780427	US20250313563, Compound 945482	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780427	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780427&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563745	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CC[C@@H](C(F)(F)F)C1			780428	US20250313563, Compound 952437	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780428	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780428&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563746	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CC[C@@H](C(F)(F)F)C1			780428	US20250313563, Compound 952437	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780428	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780428&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563747	CC[C@]1(c2cccc(CN(C)c3ccc(C(F)(F)F)nc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780429	US20250313563, Compound 945484	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780429	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780429&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563748	CC[C@]1(c2cccc(CN(C)c3ccc(C(F)(F)F)nc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780429	US20250313563, Compound 945484	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780429	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780429&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563749	C[C@H]1CCC[C@@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780430	US20250313563, Compound 893318	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780430	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780430&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563750	C[C@H]1CCC[C@@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780430	US20250313563, Compound 893318	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780430	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780430&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563751	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)[C@H](F)C(C)(C)C2			780431	US20250313563, Compound 945485	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780431	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780431&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563752	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)[C@H](F)C(C)(C)C2			780431	US20250313563, Compound 945485	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780431	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780431&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563753	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCC[C@@H](C#N)C1			780432	US20250313563, Compound 945906	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780432	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780432&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563754	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCC[C@@H](C#N)C1			780432	US20250313563, Compound 945906	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780432	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780432&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563755	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)[C@@H](F)C(C)(C)C2			780433	US20250313563, Compound 945486	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780433	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780433&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563756	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)[C@@H](F)C(C)(C)C2			780433	US20250313563, Compound 945486	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780433	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780433&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563757	CC(C)c1ccccc1S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780434	US20250313563, Compound 947473	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780434	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780434&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563758	CC(C)c1ccccc1S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780434	US20250313563, Compound 947473	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780434	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780434&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563759	CCC1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780435	US20250313563, Compound 945527	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780435	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780435&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563760	CCC1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780435	US20250313563, Compound 945527	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780435	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780435&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563761	O=C1CC2(CSC2)CC2=C1C1(CCCC1)C1=CN=NC1N2			780436	US20250313563, Compound 913441	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780436	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780436&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563762	O=C1CC2(CSC2)CC2=C1C1(CCCC1)C1=CN=NC1N2			780436	US20250313563, Compound 913441	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780436	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780436&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563763	CCC1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780437	US20250313563, Compound 945528	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780437	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780437&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563764	CCC1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780437	US20250313563, Compound 945528	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780437	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780437&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563765	O=C1CC2(CCCCC2)CC2=C1C1(CCOCC1)C1=C(N=NC1)N2			780438	US20250313563, Compound 893307	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780438	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780438&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563766	O=C1CC2(CCCCC2)CC2=C1C1(CCOCC1)C1=C(N=NC1)N2			780438	US20250313563, Compound 893307	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780438	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780438&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563767	CCC1(c2cccc(-c3ccnc(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780439	US20250313563, Compound 945529	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780439	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780439&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563768	CCC1(c2cccc(-c3ccnc(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780439	US20250313563, Compound 945529	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780439	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780439&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563769	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CO[C@H](c2ccccc2)C1			780440	US20250313563, Compound 946072	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780440	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780440&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563770	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CO[C@H](c2ccccc2)C1			780440	US20250313563, Compound 946072	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780440	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780440&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563771	CCC1(c2cccc(-c3cc(C)ncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780441	US20250313563, Compound 945530	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780441	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780441&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563772	CCC1(c2cccc(-c3cc(C)ncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780441	US20250313563, Compound 945530	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780441	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780441&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563773	O=C1CC2(CCC2)CC2=C1C1(CCOCC1)C1=C(N=NC1)N2			780442	US20250313563, Compound 909208	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780442	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780442&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563774	O=C1CC2(CCC2)CC2=C1C1(CCOCC1)C1=C(N=NC1)N2			780442	US20250313563, Compound 909208	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780442	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780442&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563775	CCC1(c2cccc(-c3ccnn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780443	US20250313563, Compound 945531	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780443	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780443&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563776	CCC1(c2cccc(-c3ccnn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780443	US20250313563, Compound 945531	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780443	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780443&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563777	C[C@@H]1C[C@]2(CCN1S(C)(=O)=O)C1=CN=NC1NC1=C2C(=O)CC(C)(C)C1			780444	US20250313563, Compound 918316	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780444	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780444&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563778	C[C@@H]1C[C@]2(CCN1S(C)(=O)=O)C1=CN=NC1NC1=C2C(=O)CC(C)(C)C1			780444	US20250313563, Compound 918316	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780444	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780444&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563779	CCC1(c2cccc(-c3cc(C)nn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780445	US20250313563, Compound 945532	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780445	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780445&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563780	CCC1(c2cccc(-c3cc(C)nn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780445	US20250313563, Compound 945532	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780445	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780445&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563781	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21C[C@@H](OCc2ccccc2)C1			780446	US20250313563, Compound 909211	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780446	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780446&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563782	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21C[C@@H](OCc2ccccc2)C1			780446	US20250313563, Compound 909211	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780446	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780446&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563783	CC[C@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780447	US20250313563, Compound 945543	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780447	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780447&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563784	CC[C@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780447	US20250313563, Compound 945543	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780447	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780447&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563785	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1[C@@]21CO[C@@H](c2ccccc2)C1			780448	US20250313563, Compound 946073	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780448	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780448&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563786	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1[C@@]21CO[C@@H](c2ccccc2)C1			780448	US20250313563, Compound 946073	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780448	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780448&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563787	CC[C@@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780449	US20250313563, Compound 945544	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780449	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780449&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563788	CC[C@@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780449	US20250313563, Compound 945544	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780449	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780449&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563789	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CC(C(F)(F)F)C1			780450	US20250313563, Compound 874527	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780450	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780450&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563790	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CC(C(F)(F)F)C1			780450	US20250313563, Compound 874527	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780450	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780450&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563791	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780451	US20250313563, Compound 945545	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780451	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780451&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563792	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780451	US20250313563, Compound 945545	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780451	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780451&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563793	CC[C@@H]1C[C@]2(CCO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780452	US20250313563, Compound 924715	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780452	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780452&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563794	CC[C@@H]1C[C@]2(CCO1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780452	US20250313563, Compound 924715	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780452	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780452&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563795	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780453	US20250313563, Compound 945546	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780453	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780453&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563796	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780453	US20250313563, Compound 945546	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780453	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780453&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563797	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(CC(F)(F)F)C1			780454	US20250313563, Compound 912074	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780454	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780454&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563798	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(CC(F)(F)F)C1			780454	US20250313563, Compound 912074	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780454	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780454&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563799	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1[C@@]21CCCc2c(-c3ccncc3)cccc21			780455	US20250313563, Compound 945547	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780455	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780455&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563800	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1[C@@]21CCCc2c(-c3ccncc3)cccc21			780455	US20250313563, Compound 945547	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780455	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780455&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563801	C[C@H]1CC[C@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780456	US20250313563, Compound 897751	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780456	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780456&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563802	C[C@H]1CC[C@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780456	US20250313563, Compound 897751	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780456	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780456&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563803	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1[C@]21CCCc2c(-c3ccncc3)cccc21			780457	US20250313563, Compound 945548	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780457	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780457&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563804	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1[C@]21CCCc2c(-c3ccncc3)cccc21			780457	US20250313563, Compound 945548	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780457	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780457&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563805	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCCN(S(=O)(=O)C2CC2)CC1			780458	US20250313563, Compound 932659	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780458	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780458&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563806	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCCN(S(=O)(=O)C2CC2)CC1			780458	US20250313563, Compound 932659	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780458	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780458&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563807	Cc1cc(-c2cccc3c2CCC[C@@]32C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)ccn1			780459	US20250313563, Compound 945549	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780459	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780459&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563808	Cc1cc(-c2cccc3c2CCC[C@@]32C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)ccn1			780459	US20250313563, Compound 945549	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780459	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780459&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563809	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CSC1			780460	US20250313563, Compound 889567	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780460	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780460&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563810	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CSC1			780460	US20250313563, Compound 889567	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780460	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780460&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563811	Cc1cc(-c2cccc3c2CCC[C@]32C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)ccn1			780461	US20250313563, Compound 945550	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780461	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780461&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563812	Cc1cc(-c2cccc3c2CCC[C@]32C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)ccn1			780461	US20250313563, Compound 945550	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780461	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780461&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563813	Cn1ccc(S(=O)(=O)N2CCC[C@@]3(CC2)C2=CN=NC2NC2=C3C(=O)CC(C)(C)C2)n1			780462	US20250313563, Compound 932660	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780462	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780462&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563814	Cn1ccc(S(=O)(=O)N2CCC[C@@]3(CC2)C2=CN=NC2NC2=C3C(=O)CC(C)(C)C2)n1			780462	US20250313563, Compound 932660	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780462	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780462&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563815	Cn1nccc1-c1cccc2c1CCC[C@@]21C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780463	US20250313563, Compound 945551	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780463	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780463&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563816	Cn1nccc1-c1cccc2c1CCC[C@@]21C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780463	US20250313563, Compound 945551	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780463	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780463&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563817	COC(=O)C1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780464	US20250313563, Compound 918277	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780464	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780464&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563818	COC(=O)C1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780464	US20250313563, Compound 918277	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780464	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780464&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563819	Cn1nccc1-c1cccc2c1CCC[C@]21C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780465	US20250313563, Compound 945552	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780465	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780465&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563820	Cn1nccc1-c1cccc2c1CCC[C@]21C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780465	US20250313563, Compound 945552	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780465	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780465&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563821	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)[C@]23CC[C@H](C(F)(F)F)CC3)C1F			780466	US20250313563, Compound 917136	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780466	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780466&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563822	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)[C@]23CC[C@H](C(F)(F)F)CC3)C1F			780466	US20250313563, Compound 917136	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780466	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780466&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563823	CCc1cc(N(C)c2cccc(C3(CC)C4=CN=NC4NC4=C3C(=O)CC(C)(C)C4)c2)ccn1			780467	US20250313563, Compound 945600	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780467	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780467&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563824	CCc1cc(N(C)c2cccc(C3(CC)C4=CN=NC4NC4=C3C(=O)CC(C)(C)C4)c2)ccn1			780467	US20250313563, Compound 945600	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780467	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780467&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563825	Cc1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c(C)s1			780468	US20250313563, Compound 945674	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780468	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780468&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563826	Cc1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c(C)s1			780468	US20250313563, Compound 945674	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780468	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780468&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563827	CCC3(c1cccc(CS(C)(=O)=O)c1)C2=CN=NC2NC4=C3C(=O)CC(C)(C)C4			780469	US20250313563, Compound 945601	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780469	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780469&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894864	523298815							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563828	CCC3(c1cccc(CS(C)(=O)=O)c1)C2=CN=NC2NC4=C3C(=O)CC(C)(C)C4			780469	US20250313563, Compound 945601	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780469	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780469&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894864	523298815							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563829	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CC[C@H](C(F)(F)F)C1			780470	US20250313563, Compound 952435	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780470	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780470&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563830	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CC[C@H](C(F)(F)F)C1			780470	US20250313563, Compound 952435	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780470	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780470&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563831	CC[C@@]1(c2cccc(-c3cncn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780471	US20250313563, Compound 945605	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780471	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780471&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563832	CC[C@@]1(c2cccc(-c3cncn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780471	US20250313563, Compound 945605	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780471	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780471&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563833	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1[C@]21C[C@H](c2ccncc2)C1			780472	US20250313563, Compound 889664	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780472	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780472&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563834	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1[C@]21C[C@H](c2ccncc2)C1			780472	US20250313563, Compound 889664	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780472	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780472&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563835	CC[C@@]1(c2cccc(-c3ccnc4c3CCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780473	US20250313563, Compound 945606	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780473	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780473&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563836	CC[C@@]1(c2cccc(-c3ccnc4c3CCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780473	US20250313563, Compound 945606	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780473	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780473&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563837	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(CC(F)(F)F)CC1			780474	US20250313563, Compound 874528	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780474	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780474&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563838	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(CC(F)(F)F)CC1			780474	US20250313563, Compound 874528	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780474	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780474&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563839	CC[C@@]1(c2cccc(-c3cnc4n3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780475	US20250313563, Compound 945607	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780475&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563840	CC[C@@]1(c2cccc(-c3cnc4n3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780475	US20250313563, Compound 945607	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780475&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563841	C[C@H]1C[C@@]2(CCN1S(=O)(=O)c1ccn(C)n1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780476	US20250313563, Compound 926832	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780476	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780476&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563842	C[C@H]1C[C@@]2(CCN1S(=O)(=O)c1ccn(C)n1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780476	US20250313563, Compound 926832	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780476	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780476&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563843	CC[C@@]1(c2cccc(N(C)c3cc(C)ccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780477	US20250313563, Compound 945609	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780477	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780477&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563844	CC[C@@]1(c2cccc(N(C)c3cc(C)ccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780477	US20250313563, Compound 945609	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780477	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780477&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563845	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)C23CCN(S(=O)(=O)c2ccccc2C(F)F)CC3)[C@H]1F			780478	US20250313563, Compound 951839	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780478	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780478&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563846	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)C23CCN(S(=O)(=O)c2ccccc2C(F)F)CC3)[C@H]1F			780478	US20250313563, Compound 951839	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780478	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780478&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563847	CC[C@@]1(c2cccc(N(C)c3cc(C)cc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780479	US20250313563, Compound 945610	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780479	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780479&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563848	CC[C@@]1(c2cccc(N(C)c3cc(C)cc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780479	US20250313563, Compound 945610	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780479	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780479&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563849	COc1ccccc1S(=O)(=O)N1CCCC2(CC1)C1=CN=NC1NC1=C2C(=O)CC(C)(C)C1			780480	US20250313563, Compound 917142	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780480	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780480&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563850	COc1ccccc1S(=O)(=O)N1CCCC2(CC1)C1=CN=NC1NC1=C2C(=O)CC(C)(C)C1			780480	US20250313563, Compound 917142	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780480	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780480&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563851	CC[C@@]1(c2cccc(-c3cnc(C)n3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780481	US20250313563, Compound 945612	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780481	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780481&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563852	CC[C@@]1(c2cccc(-c3cnc(C)n3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780481	US20250313563, Compound 945612	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780481	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780481&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563853	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1[C@@]21CCCN(S(=O)(=O)Cc2ccccc2)CC1			780482	US20250313563, Compound 945473	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780482	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780482&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563854	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1[C@@]21CCCN(S(=O)(=O)Cc2ccccc2)CC1			780482	US20250313563, Compound 945473	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780482	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780482&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563855	CC[C@]1(c2cccc(-c3cnc(C)n3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780483	US20250313563, Compound 945613	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780483	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780483&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563856	CC[C@]1(c2cccc(-c3cnc(C)n3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780483	US20250313563, Compound 945613	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780483	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780483&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563857	COc1cccc(S(=O)(=O)N2CCCC3(CC2)C2=CN=NC2NC2=C3C(=O)CC(C)(C)C2)c1			780484	US20250313563, Compound 917140	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780484	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780484&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563858	COc1cccc(S(=O)(=O)N2CCCC3(CC2)C2=CN=NC2NC2=C3C(=O)CC(C)(C)C2)c1			780484	US20250313563, Compound 917140	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780484	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780484&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563859	CC[C@]1(c2cccc(CN(C)c3cc(C)cc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780485	US20250313563, Compound 945615	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780485	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780485&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563860	CC[C@]1(c2cccc(CN(C)c3cc(C)cc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780485	US20250313563, Compound 945615	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780485	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780485&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563861	CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)C21CCCCC1			780486	US20250313563, Compound 883865	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780486	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780486&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563862	CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)C21CCCCC1			780486	US20250313563, Compound 883865	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780486	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780486&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563863	CC[C@]1(c2cccc(N(C)c3cc(C)ccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780487	US20250313563, Compound 945616	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780487	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780487&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563864	CC[C@]1(c2cccc(N(C)c3cc(C)ccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780487	US20250313563, Compound 945616	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780487	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780487&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563865	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnnn2-c2ccccc2)CC1			780488	US20250313563, Compound 947466	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780488	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780488&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563866	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnnn2-c2ccccc2)CC1			780488	US20250313563, Compound 947466	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780488	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780488&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563867	CC[C@]1(c2cccc(-c3cnc4n3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780489	US20250313563, Compound 945618	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780489	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780489&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563868	CC[C@]1(c2cccc(-c3cnc4n3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780489	US20250313563, Compound 945618	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780489	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780489&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563869	Cc1ccc(C)c(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780490	US20250313563, Compound 947471	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780490	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780490&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563870	Cc1ccc(C)c(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780490	US20250313563, Compound 947471	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780490	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780490&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563871	CC[C@]1(c2cccc(-c3ccnc4c3CCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780491	US20250313563, Compound 945619	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780491	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780491&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563872	CC[C@]1(c2cccc(-c3ccnc4c3CCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780491	US20250313563, Compound 945619	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780491	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780491&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563873	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCCSCC1			780492	US20250313563, Compound 913126	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780492&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563874	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCCSCC1			780492	US20250313563, Compound 913126	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780492&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563875	CC[C@]1(c2cccc(-c3cncn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780493	US20250313563, Compound 945620	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780493	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780493&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563876	CC[C@]1(c2cccc(-c3cncn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780493	US20250313563, Compound 945620	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780493	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780493&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563877	COc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c(C)c1C			780494	US20250313563, Compound 945662	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780494	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780494&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563878	COc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c(C)c1C			780494	US20250313563, Compound 945662	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780494	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780494&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563879	CCC1(c2cccc(-c3c(C)cncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780495	US20250313563, Compound 945703	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780495&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563880	CCC1(c2cccc(-c3c(C)cncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780495	US20250313563, Compound 945703	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780495&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563881	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CCCS(=O)(=O)CC1			780496	US20250313563, Compound 927343	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780496	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780496&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563882	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CCCS(=O)(=O)CC1			780496	US20250313563, Compound 927343	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780496	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780496&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563883	CCC1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780497	US20250313563, Compound 945704	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780497	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780497&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563884	CCC1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780497	US20250313563, Compound 945704	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780497	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780497&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563885	COc1ccc(S(=O)(=O)N2CCC[C@]3(CC2)C2=CN=NC2NC2=C3C(=O)CC(C)(C)C2)cc1			780498	US20250313563, Compound 932641	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780498	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780498&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563886	COc1ccc(S(=O)(=O)N2CCC[C@]3(CC2)C2=CN=NC2NC2=C3C(=O)CC(C)(C)C2)cc1			780498	US20250313563, Compound 932641	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780498	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780498&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563887	CC[C@@]1(c2cccc(C(F)F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780499	US20250313563, Compound 945708	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780499	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780499&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563888	CC[C@@]1(c2cccc(C(F)F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780499	US20250313563, Compound 945708	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780499	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780499&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563889	O=C1CC2(CCCC2)CC2=C1C1(CCOCC1)C1=C(N=NC1)N2			780500	US20250313563, Compound 893308	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780500	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780500&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563890	O=C1CC2(CCCC2)CC2=C1C1(CCOCC1)C1=C(N=NC1)N2			780500	US20250313563, Compound 893308	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780500	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780500&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563891	CC[C@]1(c2cccc(C(F)F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780501	US20250313563, Compound 945710	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780501&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563892	CC[C@]1(c2cccc(C(F)F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780501	US20250313563, Compound 945710	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780501&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563893	CC1(C)CC2=C(C(=O)C1F)[C@]1(CC[C@@H](C(F)(F)F)CC1)C1=CN=NC1N2			780502	US20250313563, Compound 917134	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780502	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780502&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563894	CC1(C)CC2=C(C(=O)C1F)[C@]1(CC[C@@H](C(F)(F)F)CC1)C1=CN=NC1N2			780502	US20250313563, Compound 917134	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780502	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780502&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563895	CC[C@@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780503	US20250313563, Compound 945713	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780503	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780503&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563896	CC[C@@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780503	US20250313563, Compound 945713	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780503	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780503&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563897	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)[C@]23CC[C@@H](C(F)(F)F)CC3)[C@@H]1F			780504	US20250313563, Compound 918284	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780504	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780504&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563898	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)[C@]23CC[C@@H](C(F)(F)F)CC3)[C@@H]1F			780504	US20250313563, Compound 918284	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780504	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780504&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563899	C.CC[C@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780505	US20250313563, Compound 945715	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780505	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780505&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563900	C.CC[C@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780505	US20250313563, Compound 945715	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780505	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780505&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563901	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCSC1			780506	US20250313563, Compound 883973	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780506	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780506&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563902	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCSC1			780506	US20250313563, Compound 883973	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780506	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780506&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563903	CC[C@@]1(c2cccc(-c3ccncc3O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780507	US20250313563, Compound 945724	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780507	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780507&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563904	CC[C@@]1(c2cccc(-c3ccncc3O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780507	US20250313563, Compound 945724	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780507	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780507&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563905	C[C@@H]1CCC[C@@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780508	US20250313563, Compound 874532	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780508	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780508&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563906	C[C@@H]1CCC[C@@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780508	US20250313563, Compound 874532	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780508	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780508&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563907	CC[C@@]1(c2cccc(-c3cncn3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780509	US20250313563, Compound 945725	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780509	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780509&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563908	CC[C@@]1(c2cccc(-c3cncn3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780509	US20250313563, Compound 945725	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780509	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780509&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563909	COc1ccc(C)c(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780510	US20250313563, Compound 947245	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780510	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780510&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563910	COc1ccc(C)c(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780510	US20250313563, Compound 947245	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780510	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780510&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563911	CCc1cccc(N(C)c2cccc([C@]3(CC)C4=CN=NC4NC4=C3C(=O)CC(C)(C)C4)c2)n1			780511	US20250313563, Compound 945726	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780511	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780511&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563912	CCc1cccc(N(C)c2cccc([C@]3(CC)C4=CN=NC4NC4=C3C(=O)CC(C)(C)C4)c2)n1			780511	US20250313563, Compound 945726	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780511	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780511&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563913	CC1N=NC2=C1C1(CCCC1)C1=C(CC(C)(C)CC1=O)N2			780512	US20250313563, Compound 786072	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780512	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780512&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563914	CC1N=NC2=C1C1(CCCC1)C1=C(CC(C)(C)CC1=O)N2			780512	US20250313563, Compound 786072	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780512	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780512&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563915	CC[C@]1(c2cccc(-c3ccncc3O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780513	US20250313563, Compound 945728	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780513	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780513&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563916	CC[C@]1(c2cccc(-c3ccncc3O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780513	US20250313563, Compound 945728	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780513	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780513&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563917	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cc(Cl)ccc2Cl)CC1			780514	US20250313563, Compound 948122	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780514	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780514&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563918	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cc(Cl)ccc2Cl)CC1			780514	US20250313563, Compound 948122	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780514	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780514&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563919	CC[C@]1(c2cccc(-c3cncn3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780515	US20250313563, Compound 945729	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780515	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780515&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563920	CC[C@]1(c2cccc(-c3cncn3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780515	US20250313563, Compound 945729	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780515	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780515&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563921	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC(F)(F)CC1			780516	US20250313563, Compound 883972	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780516&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563922	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC(F)(F)CC1			780516	US20250313563, Compound 883972	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780516&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563923	CCc1cccc(N(C)c2cccc([C@]3(CC)C4=CN=NC4NC4=C3C(=O)CC(C)(C)C4)c2)n1			780517	US20250313563, Compound 945730	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780517	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780517&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563924	CCc1cccc(N(C)c2cccc([C@]3(CC)C4=CN=NC4NC4=C3C(=O)CC(C)(C)C4)c2)n1			780517	US20250313563, Compound 945730	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780517	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780517&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563925	CC1(C)CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780518	US20250313563, Compound 884107	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780518	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780518&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563926	CC1(C)CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780518	US20250313563, Compound 884107	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780518	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780518&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563927	CC[C@]1(c2cccc(Oc3cncnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780519	US20250313563, Compound 945933	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780519	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780519&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563928	CC[C@]1(c2cccc(Oc3cncnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780519	US20250313563, Compound 945933	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780519	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780519&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563929	CC[C@@]1(c2cccc(Oc3cncnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780520	US20250313563, Compound 945939	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780520&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563930	CC[C@@]1(c2cccc(Oc3cncnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780520	US20250313563, Compound 945939	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780520&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563931	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCCC1			780521	US20250313563, Compound 790666	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780521	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780521&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563932	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCCC1			780521	US20250313563, Compound 790666	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780521	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780521&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563933	CC[C@]1(c2cccc(Nc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780522	US20250313563, Compound 945943	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780522&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563934	CC[C@]1(c2cccc(Nc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780522	US20250313563, Compound 945943	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780522&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563935	Cc1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)ccc1OC(C)C			780523	US20250313563, Compound 945678	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780523	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780523&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563936	Cc1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)ccc1OC(C)C			780523	US20250313563, Compound 945678	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780523	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780523&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563937	CC[C@@]1(c2cccc(Nc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780524	US20250313563, Compound 945958	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780524	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780524&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563938	CC[C@@]1(c2cccc(Nc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780524	US20250313563, Compound 945958	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780524	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780524&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563939	CO[C@H]1CC[C@@]2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780525	US20250313563, Compound 884119	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780525&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563940	CO[C@H]1CC[C@@]2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780525	US20250313563, Compound 884119	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780525&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563941	CCC4(c2cccc(c1ccnc(CCO)c1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780526	US20250313563, Compound 945992	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780526	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780526&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894920	523298872							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563942	CCC4(c2cccc(c1ccnc(CCO)c1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780526	US20250313563, Compound 945992	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780526	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780526&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894920	523298872							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563943	COc1ccc(S(=O)(=O)N2CCC[C@@]3(CC2)C2=CN=NC2NC2=C3C(=O)CC(C)(C)C2)cc1			780527	US20250313563, Compound 932661	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780527	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780527&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563944	COc1ccc(S(=O)(=O)N2CCC[C@@]3(CC2)C2=CN=NC2NC2=C3C(=O)CC(C)(C)C2)cc1			780527	US20250313563, Compound 932661	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780527	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780527&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563945	CC[C@@]1(c2cccc(-c3cc(C)ncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780528	US20250313563, Compound 945995	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780528&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563946	CC[C@@]1(c2cccc(-c3cc(C)ncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780528	US20250313563, Compound 945995	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780528&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563947	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)C23CCCCC3)[C@@H]1F			780529	US20250313563, Compound 951705	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780529	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780529&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563948	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)C23CCCCC3)[C@@H]1F			780529	US20250313563, Compound 951705	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780529	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780529&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563949	CC[C@@]1(c2cccc(-c3ccnc(C)c3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780530	US20250313563, Compound 945997	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780530	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780530&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563950	CC[C@@]1(c2cccc(-c3ccnc(C)c3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780530	US20250313563, Compound 945997	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780530	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780530&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563951	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CC(C)(C)C1			780531	US20250313563, Compound 883864	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780531&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563952	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CC(C)(C)C1			780531	US20250313563, Compound 883864	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780531&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563953	CC[C@@]4(c2cccc(S(=O)(=O)C1COC1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780532	US20250313563, Compound 945998	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780532	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780532&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894926	523298878							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563954	CC[C@@]4(c2cccc(S(=O)(=O)C1COC1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780532	US20250313563, Compound 945998	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780532	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780532&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894926	523298878							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563955	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)C23CCN(S(=O)(=O)c2ccccc2C(F)F)CC3)[C@@H]1F			780533	US20250313563, Compound 951846	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780533	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780533&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563956	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)C23CCN(S(=O)(=O)c2ccccc2C(F)F)CC3)[C@@H]1F			780533	US20250313563, Compound 951846	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780533	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780533&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563957	CC[C@]1(c2cccc(-c3cc(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780534	US20250313563, Compound 946000	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780534	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780534&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563958	CC[C@]1(c2cccc(-c3cc(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780534	US20250313563, Compound 946000	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780534	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780534&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563959	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC(c2ccccc2)CC1			780535	US20250313563, Compound 874975	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780535	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780535&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563960	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC(c2ccccc2)CC1			780535	US20250313563, Compound 874975	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780535	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780535&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563961	CC[C@]1(c2cccc(-c3ccnc(C)c3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780536	US20250313563, Compound 946002	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780536	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780536&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563962	CC[C@]1(c2cccc(-c3ccnc(C)c3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780536	US20250313563, Compound 946002	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780536	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780536&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563963	COC(=O)C1(c2ccccc2)CC2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780537	US20250313563, Compound 942344	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780537	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780537&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563964	COC(=O)C1(c2ccccc2)CC2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780537	US20250313563, Compound 942344	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780537	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780537&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563965	CC[C@]4(c2cccc(S(=O)(=O)C1COC1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780538	US20250313563, Compound 946003	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780538	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780538&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177894932	523298884							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563966	CC[C@]4(c2cccc(S(=O)(=O)C1COC1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780538	US20250313563, Compound 946003	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780538	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780538&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177894932	523298884							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563967	Cc1cc([C@H]2CC[C@@]3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)ccn1			780539	US20250313563, Compound 948416	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780539	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780539&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563968	Cc1cc([C@H]2CC[C@@]3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)ccn1			780539	US20250313563, Compound 948416	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780539	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780539&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563969	CC[C@]1(c2cccc(-c3cc[n+]([O-])c(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780540	US20250313563, Compound 946055	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780540&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563970	CC[C@]1(c2cccc(-c3cc[n+]([O-])c(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780540	US20250313563, Compound 946055	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780540&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563971	C[C@@H]1CC[C@@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780541	US20250313563, Compound 897750	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780541	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780541&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563972	C[C@@H]1CC[C@@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780541	US20250313563, Compound 897750	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780541	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780541&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563973	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C(O)C(C)(C)C2			780542	US20250313563, Compound 946056	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780542	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780542&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563974	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C(O)C(C)(C)C2			780542	US20250313563, Compound 946056	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780542	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780542&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563975	C[C@@H]1CCC[C@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780543	US20250313563, Compound 893320	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780543	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780543&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563976	C[C@@H]1CCC[C@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780543	US20250313563, Compound 893320	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780543	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780543&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563977	CCn1nccc1-c1cccc([C@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			780544	US20250313563, Compound 946089	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780544	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780544&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563978	CCn1nccc1-c1cccc([C@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			780544	US20250313563, Compound 946089	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780544	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780544&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563979	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21Cc2ccccc2C1			780545	US20250313563, Compound 897752	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780545	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780545&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563980	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21Cc2ccccc2C1			780545	US20250313563, Compound 897752	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780545	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780545&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563981	CCn1nccc1-c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			780546	US20250313563, Compound 946090	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780546	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780546&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563982	CCn1nccc1-c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			780546	US20250313563, Compound 946090	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780546	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780546&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563983	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCCN(S(=O)(=O)C2CC2)CC1			780547	US20250313563, Compound 932639	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780547	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780547&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563984	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCCN(S(=O)(=O)C2CC2)CC1			780547	US20250313563, Compound 932639	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780547	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780547&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563985	CC[C@@]1(c2cccc(-c3ccnn3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780548	US20250313563, Compound 946091	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780548	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780548&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563986	CC[C@@]1(c2cccc(-c3ccnn3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780548	US20250313563, Compound 946091	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780548	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780548&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563987	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)[C@]23CC[C@@H](C(F)(F)F)CC3)C1F			780549	US20250313563, Compound 917135	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780549	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780549&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563988	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)[C@]23CC[C@@H](C(F)(F)F)CC3)C1F			780549	US20250313563, Compound 917135	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780549	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780549&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563989	CC[C@]1(c2cccc(-c3ccnn3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780550	US20250313563, Compound 946092	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780550	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780550&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563990	CC[C@]1(c2cccc(-c3ccnn3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780550	US20250313563, Compound 946092	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780550	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780550&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563991	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CCCN(S(=O)(=O)C2CC2)CC1			780551	US20250313563, Compound 917137	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780551&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563992	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CCCN(S(=O)(=O)C2CC2)CC1			780551	US20250313563, Compound 917137	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780551&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563993	CCCn1nccc1-c1cccc([C@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			780552	US20250313563, Compound 946093	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780552	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780552&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563994	CCCn1nccc1-c1cccc([C@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			780552	US20250313563, Compound 946093	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780552	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780552&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563995	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CCCN(S(=O)(=O)Cc2ccccc2)CC1			780553	US20250313563, Compound 932632	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780553&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563996	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CCCN(S(=O)(=O)Cc2ccccc2)CC1			780553	US20250313563, Compound 932632	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780553&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563997	CCCn1nccc1-c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			780554	US20250313563, Compound 946094	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780554	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780554&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1563998	CCCn1nccc1-c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			780554	US20250313563, Compound 946094	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780554	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780554&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1563999	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cn3c(n2)CCCC3)CC1			780555	US20250313563, Compound 947472	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780555&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564000	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cn3c(n2)CCCC3)CC1			780555	US20250313563, Compound 947472	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780555&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564001	CC[C@@]1(c2cccc(-c3ccnn3CCC(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780556	US20250313563, Compound 946095	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780556	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780556&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564002	CC[C@@]1(c2cccc(-c3ccnn3CCC(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780556	US20250313563, Compound 946095	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780556	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780556&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564003	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCCOCC1			780557	US20250313563, Compound 874535	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780557	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780557&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564004	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCCOCC1			780557	US20250313563, Compound 874535	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780557	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780557&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564005	CC[C@]1(c2cccc(-c3ccnn3CCC(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780558	US20250313563, Compound 946096	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780558	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780558&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564006	CC[C@]1(c2cccc(-c3ccnn3CCC(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780558	US20250313563, Compound 946096	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780558	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780558&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564007	C[C@H]1C[C@@]2(CCN1S(C)(=O)=O)C1=CN=NC1NC1=C2C(=O)CC(C)(C)C1			780559	US20250313563, Compound 926827	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780559	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780559&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564008	C[C@H]1C[C@@]2(CCN1S(C)(=O)=O)C1=CN=NC1NC1=C2C(=O)CC(C)(C)C1			780559	US20250313563, Compound 926827	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780559	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780559&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564009	CC[C@@]1(c2cccc(-c3cc(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780560	US20250313563, Compound 946097	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780560	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780560&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564010	CC[C@@]1(c2cccc(-c3cc(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780560	US20250313563, Compound 946097	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780560	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780560&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564011	Cc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1			780561	US20250313563, Compound 947459	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780561	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780561&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564012	Cc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1			780561	US20250313563, Compound 947459	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780561	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780561&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564013	CC[C@]1(c2cccc(-c3cc(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780562	US20250313563, Compound 946098	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780562	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780562&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564014	CC[C@]1(c2cccc(-c3cc(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780562	US20250313563, Compound 946098	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780562	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780562&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564015	CCn1nc(C)cc1S(=O)(=O)N1CCC2(CC1)C1=CN=NC1NC1=C2C(=O)CC(C)(C)C1			780563	US20250313563, Compound 947609	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780563	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780563&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564016	CCn1nc(C)cc1S(=O)(=O)N1CCC2(CC1)C1=CN=NC1NC1=C2C(=O)CC(C)(C)C1			780563	US20250313563, Compound 947609	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780563	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780563&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564017	CC[C@]1(c2cccc(-c3c(C)nnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780564	US20250313563, Compound 946099	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780564&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564018	CC[C@]1(c2cccc(-c3c(C)nnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780564	US20250313563, Compound 946099	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780564&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564019	CC1(C)CC(=O)C2=C(NC3N=NC=C3C23CCCCC3)[C@H]1F			780565	US20250313563, Compound 951711	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780565	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780565&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564020	CC1(C)CC(=O)C2=C(NC3N=NC=C3C23CCCCC3)[C@H]1F			780565	US20250313563, Compound 951711	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780565	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780565&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564021	CC[C@@]1(c2cccc(-c3c(C)nnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780566	US20250313563, Compound 946100	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780566&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564022	CC[C@@]1(c2cccc(-c3c(C)nnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780566	US20250313563, Compound 946100	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780566&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564023	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC(c2ccccc2)CC1			780567	US20250313563, Compound 912084	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780567	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780567&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564024	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC(c2ccccc2)CC1			780567	US20250313563, Compound 912084	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780567	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780567&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564025	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780568	US20250313563, Compound 946101	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780568	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780568&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564026	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780568	US20250313563, Compound 946101	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780568	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780568&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564027	COc1ccc(S(=O)(=O)N2CCCC3(CC2)C2=CN=NC2NC2=C3C(=O)CC(C)(C)C2)cc1			780569	US20250313563, Compound 917141	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780569&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564028	COc1ccc(S(=O)(=O)N2CCCC3(CC2)C2=CN=NC2NC2=C3C(=O)CC(C)(C)C2)cc1			780569	US20250313563, Compound 917141	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780569&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564029	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780570	US20250313563, Compound 946102	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780570	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780570&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564030	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780570	US20250313563, Compound 946102	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780570	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780570&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564031	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC(n2cnnc2)CC1			780571	US20250313563, Compound 943894	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780571	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780571&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564032	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC(n2cnnc2)CC1			780571	US20250313563, Compound 943894	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780571	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780571&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564033	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780572	US20250313563, Compound 946103	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780572&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564034	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780572	US20250313563, Compound 946103	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780572&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564035	C[C@@H]1CCC[C@@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780573	US20250313563, Compound 893321	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780573	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780573&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564036	C[C@@H]1CCC[C@@]2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780573	US20250313563, Compound 893321	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780573	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780573&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564037	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780574	US20250313563, Compound 946104	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780574	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780574&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564038	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780574	US20250313563, Compound 946104	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780574	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780574&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564039	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnccc2C(F)(F)F)CC1			780575	US20250313563, Compound 947463	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780575	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780575&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564040	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnccc2C(F)(F)F)CC1			780575	US20250313563, Compound 947463	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780575	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780575&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564041	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780576	US20250313563, Compound 947324	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780576	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780576&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564042	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780576	US20250313563, Compound 947324	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780576	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780576&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564043	Cn1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)nn1			780577	US20250313563, Compound 947898	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780577	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780577&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564044	Cn1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)nn1			780577	US20250313563, Compound 947898	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780577	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780577&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564045	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780578	US20250313563, Compound 947325	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780578	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780578&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564046	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780578	US20250313563, Compound 947325	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780578	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780578&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564047	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)C2CCCCC2)C1			780579	US20250313563, Compound 918275	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780579&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564048	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)C2CCCCC2)C1			780579	US20250313563, Compound 918275	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780579&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564049	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780580	US20250313563, Compound 947326	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780580	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780580&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564050	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780580	US20250313563, Compound 947326	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780580	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780580&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564051	COc1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)ccc1Cl			780581	US20250313563, Compound 945669	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780581	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780581&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564052	COc1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)ccc1Cl			780581	US20250313563, Compound 945669	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780581	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780581&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564053	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780582	US20250313563, Compound 947327	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780582	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780582&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564054	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780582	US20250313563, Compound 947327	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780582	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780582&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564055	Cc1cc([C@H]2CC[C@]3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)ccn1			780583	US20250313563, Compound 948415	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780583	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780583&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564056	Cc1cc([C@H]2CC[C@]3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)ccn1			780583	US20250313563, Compound 948415	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780583	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780583&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564057	CC[C@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780584	US20250313563, Compound 947328	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780584	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780584&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564058	CC[C@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780584	US20250313563, Compound 947328	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780584	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780584&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564059	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCCCC1			780585	US20250313563, Compound 826650	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780585	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780585&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564060	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCCCC1			780585	US20250313563, Compound 826650	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780585	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780585&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564061	CC[C@@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780586	US20250313563, Compound 947329	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780586&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564062	CC[C@@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780586	US20250313563, Compound 947329	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780586&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564063	Cc1c(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cnn1C			780587	US20250313563, Compound 947460	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780587	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780587&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564064	Cc1c(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cnn1C			780587	US20250313563, Compound 947460	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780587	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780587&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564065	CCN(c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1)c1ncccn1			780588	US20250313563, Compound 947333	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780588	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780588&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564066	CCN(c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1)c1ncccn1			780588	US20250313563, Compound 947333	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780588	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780588&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564067	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CC[C@H](c2ccncc2)CC1			780589	US20250313563, Compound 949321	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780589	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780589&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564068	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CC[C@H](c2ccncc2)CC1			780589	US20250313563, Compound 949321	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780589	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780589&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564069	CCN(c1cccc([C@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1)c1ncccn1			780590	US20250313563, Compound 947334	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780590	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780590&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564070	CCN(c1cccc([C@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1)c1ncccn1			780590	US20250313563, Compound 947334	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780590	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780590&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564071	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC(c2ccccc2)CC1			780591	US20250313563, Compound 877320	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780591	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780591&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564072	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC(c2ccccc2)CC1			780591	US20250313563, Compound 877320	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780591	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780591&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564073	CC[C@]1(c2cccc(N(C)c3nccc(OC)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780592	US20250313563, Compound 947336	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780592&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564074	CC[C@]1(c2cccc(N(C)c3nccc(OC)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780592	US20250313563, Compound 947336	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780592&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564075	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)[C@]23CC[C@@H](C(F)(F)F)CC3)[C@H]1F			780593	US20250313563, Compound 918285	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780593	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780593&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564076	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)[C@]23CC[C@@H](C(F)(F)F)CC3)[C@H]1F			780593	US20250313563, Compound 918285	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780593	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780593&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564077	CC[C@@]1(c2cccc(N(C)c3nccc(OC)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780594	US20250313563, Compound 947337	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780594	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780594&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564078	CC[C@@]1(c2cccc(N(C)c3nccc(OC)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780594	US20250313563, Compound 947337	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780594	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780594&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564079	COc1cccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780595	US20250313563, Compound 943962	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780595&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564080	COc1cccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780595	US20250313563, Compound 943962	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780595&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564081	CC[C@]1(c2cccc(-c3cc(C)ncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780596	US20250313563, Compound 947363	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780596&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564082	CC[C@]1(c2cccc(-c3cc(C)ncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780596	US20250313563, Compound 947363	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780596&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564083	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnn3c2CCCC3)CC1			780597	US20250313563, Compound 947474	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780597&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564084	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnn3c2CCCC3)CC1			780597	US20250313563, Compound 947474	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780597&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564085	CC[C@@]1(c2cccc(-c3cc(C)ncc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			780598	US20250313563, Compound 947364	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780598	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780598&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564086	CC[C@@]1(c2cccc(-c3cc(C)ncc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			780598	US20250313563, Compound 947364	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780598	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780598&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564087	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(c2ccccc2)C1			780599	US20250313563, Compound 948298	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780599	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780599&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564088	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(c2ccccc2)C1			780599	US20250313563, Compound 948298	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780599	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780599&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564089	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780600	US20250313563, Compound 947365	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780600&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564090	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780600	US20250313563, Compound 947365	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780600&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564091	Cn1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)[C@@H]2F)n1			780601	US20250313563, Compound 951708	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780601&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564092	Cn1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)[C@@H]2F)n1			780601	US20250313563, Compound 951708	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780601&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564093	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780602	US20250313563, Compound 947372	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780602&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564094	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780602	US20250313563, Compound 947372	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780602&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564095	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21C[C@H](n2cccn2)C1			780603	US20250313563, Compound 884005	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780603&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564096	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21C[C@H](n2cccn2)C1			780603	US20250313563, Compound 884005	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780603&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564097	CC[C@]1(c2cccc(-c3cc(C)nn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780604	US20250313563, Compound 947383	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780604	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780604&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564098	CC[C@]1(c2cccc(-c3cc(C)nn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780604	US20250313563, Compound 947383	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780604	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780604&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564099	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CC(c2ccccc2)C1			780605	US20250313563, Compound 917081	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780605&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564100	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CC(c2ccccc2)C1			780605	US20250313563, Compound 917081	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780605&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564101	CC[C@@]1(c2cccc(-c3cc(C)nn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780606	US20250313563, Compound 947384	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780606	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780606&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564102	CC[C@@]1(c2cccc(-c3cc(C)nn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780606	US20250313563, Compound 947384	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780606	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780606&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564103	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc3c2CCCC3)CC1			780607	US20250313563, Compound 947470	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780607	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780607&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564104	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc3c2CCCC3)CC1			780607	US20250313563, Compound 947470	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780607	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780607&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564105	CCC1(c2cccc(-c3cnnn3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780608	US20250313563, Compound 947397	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780608&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564106	CCC1(c2cccc(-c3cnnn3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780608	US20250313563, Compound 947397	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780608&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564107	Cn1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)[C@H]2F)n1			780609	US20250313563, Compound 951709	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780609	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780609&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564108	Cn1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)[C@H]2F)n1			780609	US20250313563, Compound 951709	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780609	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780609&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564109	CCC1(c2cccc(-c3cnnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780610	US20250313563, Compound 947398	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780610	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780610&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564110	CCC1(c2cccc(-c3cnnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780610	US20250313563, Compound 947398	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780610	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780610&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564111	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCN(S(C)(=O)=O)C1			780611	US20250313563, Compound 942462	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780611	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780611&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564112	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCN(S(C)(=O)=O)C1			780611	US20250313563, Compound 942462	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780611	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780611&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564113	CCC1(c2cccc(Oc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780612	US20250313563, Compound 947400	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780612	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780612&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564114	CCC1(c2cccc(Oc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780612	US20250313563, Compound 947400	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780612	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780612&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564115	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CCCN(S(=O)(=O)c2ccccc2)CC1			780613	US20250313563, Compound 889578	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780613&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564116	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CCCN(S(=O)(=O)c2ccccc2)CC1			780613	US20250313563, Compound 889578	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780613&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564117	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCOC1)C2			780614	US20250313563, Compound 947406	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780614&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564118	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCOC1)C2			780614	US20250313563, Compound 947406	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780614&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564119	CC1(C)CC2=C(C(=O)[C@H]1F)[C@]1(CC[C@H](C(F)(F)F)CC1)C1=C(N=NC1)N2			780615	US20250313563, Compound 918282	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780615&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564120	CC1(C)CC2=C(C(=O)[C@H]1F)[C@]1(CC[C@H](C(F)(F)F)CC1)C1=C(N=NC1)N2			780615	US20250313563, Compound 918282	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780615&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564121	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCOC1)C2			780616	US20250313563, Compound 947407	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780616&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564122	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCOC1)C2			780616	US20250313563, Compound 947407	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780616&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564123	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1			780617	US20250313563, Compound 947256	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780617	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780617&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564124	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1			780617	US20250313563, Compound 947256	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780617	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780617&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564125	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCOC1)C2			780618	US20250313563, Compound 947411	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780618&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564126	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCOC1)C2			780618	US20250313563, Compound 947411	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780618&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564127	Cc1cccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780619	US20250313563, Compound 947261	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780619&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564128	Cc1cccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780619	US20250313563, Compound 947261	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780619&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564129	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCOC1)C2			780620	US20250313563, Compound 947412	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780620	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780620&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564130	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCOC1)C2			780620	US20250313563, Compound 947412	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780620	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780620&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564131	COc1cccc(S(=O)(=O)N2CC[C@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780621	US20250313563, Compound 951790	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780621&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564132	COc1cccc(S(=O)(=O)N2CC[C@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780621	US20250313563, Compound 951790	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780621&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564133	CCC1(c2cccc(C(C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780622	US20250313563, Compound 947434	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780622&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564134	CCC1(c2cccc(C(C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780622	US20250313563, Compound 947434	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780622&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564135	CC1(C)CC2=C(C(=O)C1F)[C@]1(CC[C@H](C(F)(F)F)CC1)C1=C(N=NC1)N2			780623	US20250313563, Compound 917133	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780623&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564136	CC1(C)CC2=C(C(=O)C1F)[C@]1(CC[C@H](C(F)(F)F)CC1)C1=C(N=NC1)N2			780623	US20250313563, Compound 917133	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780623&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564137	CCC1(c2cccc(-c3ccnc(C(C)(C)C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780624	US20250313563, Compound 947490	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780624	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780624&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564138	CCC1(c2cccc(-c3ccnc(C(C)(C)C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780624	US20250313563, Compound 947490	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780624	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780624&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564139	Cn1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)NC(C)(C)C2)n1			780625	US20250313563, Compound 943961	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780625&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564140	Cn1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)NC(C)(C)C2)n1			780625	US20250313563, Compound 943961	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780625&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564141	CCC1(c2cccc(-c3c(C)cnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780626	US20250313563, Compound 947491	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780626&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564142	CCC1(c2cccc(-c3c(C)cnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780626	US20250313563, Compound 947491	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780626&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564143	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccccc2C(F)(F)F)CC1			780627	US20250313563, Compound 945667	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780627	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780627&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564144	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccccc2C(F)(F)F)CC1			780627	US20250313563, Compound 945667	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780627	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780627&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564145	CCC1(c2cccc(-c3cnn(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780628	US20250313563, Compound 947492	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780628	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780628&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564146	CCC1(c2cccc(-c3cnn(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780628	US20250313563, Compound 947492	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780628	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780628&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564147	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CCN(S(=O)(=O)c2cnc3n2CCC3)CC1			780629	US20250313563, Compound 947467	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780629	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780629&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564148	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CCN(S(=O)(=O)c2cnc3n2CCC3)CC1			780629	US20250313563, Compound 947467	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780629	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780629&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564149	CCc1cc(-c2cccc(C3(CC)C4=CN=NC4NC4=C3C(=O)CC(C)(C)C4)c2)ccn1			780630	US20250313563, Compound 947493	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780630&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564150	CCc1cc(-c2cccc(C3(CC)C4=CN=NC4NC4=C3C(=O)CC(C)(C)C4)c2)ccn1			780630	US20250313563, Compound 947493	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780630&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564151	Cc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c(C)c1			780631	US20250313563, Compound 947468	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780631&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564152	Cc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c(C)c1			780631	US20250313563, Compound 947468	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780631&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564153	CCC1(c2cccc(-c3cnn4c3CCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780632	US20250313563, Compound 947494	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780632	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780632&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564154	CCC1(c2cccc(-c3cnn4c3CCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780632	US20250313563, Compound 947494	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780632	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780632&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564155	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCN(S(=O)(=O)c2cccc(F)c2)C1			780633	US20250313563, Compound 951862	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780633	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780633&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564156	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCN(S(=O)(=O)c2cccc(F)c2)C1			780633	US20250313563, Compound 951862	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780633	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780633&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564157	CC[C@]1(c2cccc(Cc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780634	US20250313563, Compound 947498	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780634&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564158	CC[C@]1(c2cccc(Cc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780634	US20250313563, Compound 947498	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780634&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564159	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(C)(=O)=O)C1			780635	US20250313563, Compound 912092	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780635	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780635&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564160	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(C)(=O)=O)C1			780635	US20250313563, Compound 912092	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780635	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780635&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564161	CC[C@@]1(c2cccc(Cc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780636	US20250313563, Compound 947499	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780636	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780636&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564162	CC[C@@]1(c2cccc(Cc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780636	US20250313563, Compound 947499	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780636	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780636&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564163	Cn1ccc(S(=O)(=O)N2CC3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			780637	US20250313563, Compound 913260	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780637&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564164	Cn1ccc(S(=O)(=O)N2CC3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			780637	US20250313563, Compound 913260	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780637&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564165	CC[C@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780638	US20250313563, Compound 947511	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780638&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564166	CC[C@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780638	US20250313563, Compound 947511	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780638&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564167	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC(S(C)(=O)=O)CC1			780639	US20250313563, Compound 913356	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780639	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780639&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564168	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC(S(C)(=O)=O)CC1			780639	US20250313563, Compound 913356	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780639	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780639&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564169	CC[C@@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780640	US20250313563, Compound 947512	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780640&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564170	CC[C@@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780640	US20250313563, Compound 947512	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780640&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564171	Cc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1Cl			780641	US20250313563, Compound 947241	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780641	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780641&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564172	Cc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1Cl			780641	US20250313563, Compound 947241	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780641	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780641&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564173	CCC1(c2cccc(Cc3ncccc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780642	US20250313563, Compound 947548	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780642	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780642&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564174	CCC1(c2cccc(Cc3ncccc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780642	US20250313563, Compound 947548	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780642	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780642&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564175	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(Cl)c2Cl)CC1			780643	US20250313563, Compound 947249	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780643	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780643&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564176	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(Cl)c2Cl)CC1			780643	US20250313563, Compound 947249	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780643	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780643&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564177	CCC1(c2cccc(-c3ccncc3S(C)(=O)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780644	US20250313563, Compound 947569	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780644&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564178	CCC1(c2cccc(-c3ccncc3S(C)(=O)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780644	US20250313563, Compound 947569	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780644&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564179	Cc1nccc([C@H]2CC[C@]3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1C			780645	US20250313563, Compound 950478	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780645	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780645&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564180	Cc1nccc([C@H]2CC[C@]3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1C			780645	US20250313563, Compound 950478	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780645	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780645&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564181	CC[C@@]4(c2cccc(c1cc[n+]([O-])cc1S(C)=O)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780646	US20250313563, Compound 947570	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780646&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177895030	523298992							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564182	CC[C@@]4(c2cccc(c1cc[n+]([O-])cc1S(C)=O)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780646	US20250313563, Compound 947570	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780646&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177895030	523298992							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564183	C[C@@H]1C[C@]2(CCN1S(=O)(=O)c1ccn(C)n1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780647	US20250313563, Compound 917161	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780647&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564184	C[C@@H]1C[C@]2(CCN1S(=O)(=O)c1ccn(C)n1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780647	US20250313563, Compound 917161	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780647&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564185	CC[C@@]1(c2cccc(-c3cc[n+](O)cc3[S@@](C)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780648	US20250313563, Compound 947571	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780648	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780648&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564186	CC[C@@]1(c2cccc(-c3cc[n+](O)cc3[S@@](C)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780648	US20250313563, Compound 947571	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780648	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780648&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564187	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(C)(=O)=O)C1			780649	US20250313563, Compound 942432	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780649	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780649&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564188	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(C)(=O)=O)C1			780649	US20250313563, Compound 942432	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780649	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780649&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564189	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780650	US20250313563, Compound 947650	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780650&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564190	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780650	US20250313563, Compound 947650	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780650&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564191	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCN(S(=O)(=O)c2ccccc2F)C1			780651	US20250313563, Compound 945719	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780651	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780651&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564192	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCN(S(=O)(=O)c2ccccc2F)C1			780651	US20250313563, Compound 945719	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780651	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780651&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564193	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780652	US20250313563, Compound 947651	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780652	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780652&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564194	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780652	US20250313563, Compound 947651	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780652	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780652&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564195	Cc1nc(C)c(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)s1			780653	US20250313563, Compound 947259	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780653	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780653&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564196	Cc1nc(C)c(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)s1			780653	US20250313563, Compound 947259	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780653	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780653&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564197	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780654	US20250313563, Compound 947652	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780654	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780654&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564198	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780654	US20250313563, Compound 947652	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780654	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780654&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564199	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(F)c(Cl)c2)CC1			780655	US20250313563, Compound 948117	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780655	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780655&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564200	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(F)c(Cl)c2)CC1			780655	US20250313563, Compound 948117	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780655	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780655&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564201	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780656	US20250313563, Compound 947653	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780656	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780656&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564202	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780656	US20250313563, Compound 947653	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780656	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780656&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564203	CC1(C)CC2=C(C(=O)[C@@H]1F)[C@]1(CC[C@H](C(F)(F)F)CC1)C1=CN=NC1N2			780657	US20250313563, Compound 918283	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780657	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780657&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564204	CC1(C)CC2=C(C(=O)[C@@H]1F)[C@]1(CC[C@H](C(F)(F)F)CC1)C1=CN=NC1N2			780657	US20250313563, Compound 918283	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780657	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780657&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564205	CC[C@]1(c2cccc(-c3cc(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780658	US20250313563, Compound 947655	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780658	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780658&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564206	CC[C@]1(c2cccc(-c3cc(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780658	US20250313563, Compound 947655	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780658	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780658&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564207	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnn(C(C)(C)C)c2)CC1			780659	US20250313563, Compound 945677	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780659	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780659&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564208	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnn(C(C)(C)C)c2)CC1			780659	US20250313563, Compound 945677	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780659	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780659&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564209	CC[C@@]1(c2cccc(-c3cc(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780660	US20250313563, Compound 947656	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780660	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780660&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564210	CC[C@@]1(c2cccc(-c3cc(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780660	US20250313563, Compound 947656	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780660	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780660&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564211	COCCn1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780661	US20250313563, Compound 947477	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780661	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780661&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564212	COCCn1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780661	US20250313563, Compound 947477	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780661	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780661&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564213	CC[C@@]1(c2cccc(-c3cc(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780662	US20250313563, Compound 947657	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780662	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780662&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564214	CC[C@@]1(c2cccc(-c3cc(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780662	US20250313563, Compound 947657	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780662	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780662&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564215	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)C23CCN(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC3)[C@H]1F			780663	US20250313563, Compound 951713	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780663	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780663&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564216	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)C23CCN(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC3)[C@H]1F			780663	US20250313563, Compound 951713	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780663	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780663&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564217	CC[C@]1(c2cccc(-c3c(C)cncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780664	US20250313563, Compound 947658	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780664	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780664&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564218	CC[C@]1(c2cccc(-c3c(C)cncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780664	US20250313563, Compound 947658	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780664	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780664&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564219	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CC[C@@H](C(F)(F)F)C1			780665	US20250313563, Compound 952436	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780665	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780665&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564220	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CC[C@@H](C(F)(F)F)C1			780665	US20250313563, Compound 952436	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780665	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780665&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564221	CC[C@@]1(c2cccc(-c3c(C)cncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780666	US20250313563, Compound 947659	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780666	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780666&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564222	CC[C@@]1(c2cccc(-c3c(C)cncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780666	US20250313563, Compound 947659	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780666	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780666&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564223	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CC(c2ccccc2)C1			780667	US20250313563, Compound 917082	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780667	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780667&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564224	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CC(c2ccccc2)C1			780667	US20250313563, Compound 917082	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780667	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780667&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564225	CC[C@]1(c2cccc(Cc3ncccc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780668	US20250313563, Compound 947664	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780668	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780668&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564226	CC[C@]1(c2cccc(Cc3ncccc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780668	US20250313563, Compound 947664	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780668	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780668&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564227	C[C@H]1C[C@]2(CCN1S(=O)(=O)c1ccn(C)n1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780669	US20250313563, Compound 926815	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780669	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780669&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564228	C[C@H]1C[C@]2(CCN1S(=O)(=O)c1ccn(C)n1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780669	US20250313563, Compound 926815	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780669	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780669&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564229	CC[C@@]1(c2cccc(Cc3ncccc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780670	US20250313563, Compound 947665	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780670	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780670&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564230	CC[C@@]1(c2cccc(Cc3ncccc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780670	US20250313563, Compound 947665	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780670	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780670&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564231	Cn1nccc1S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780671	US20250313563, Compound 932649	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780671	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780671&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564232	Cn1nccc1S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780671	US20250313563, Compound 932649	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780671	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780671&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564233	CC[C@@]1(c2cccc(-c3cnnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780672	US20250313563, Compound 947802	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780672	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780672&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564234	CC[C@@]1(c2cccc(-c3cnnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780672	US20250313563, Compound 947802	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780672	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780672&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564235	Cn1cc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780673	US20250313563, Compound 943483	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780673	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780673&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564236	Cn1cc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780673	US20250313563, Compound 943483	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780673	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780673&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564237	CC[C@@]1(c2cccc(Oc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780674	US20250313563, Compound 947808	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780674	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780674&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564238	CC[C@@]1(c2cccc(Oc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780674	US20250313563, Compound 947808	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780674	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780674&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564239	CCn1nccc1S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780675	US20250313563, Compound 945664	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780675	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780675&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564240	CCn1nccc1S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780675	US20250313563, Compound 945664	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780675	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780675&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564241	CC[C@@]4(c2cccc(c1ccnc(CCO)c1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780676	US20250313563, Compound 947810	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780676	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780676&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177895059	523299022							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564242	CC[C@@]4(c2cccc(c1ccnc(CCO)c1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780676	US20250313563, Compound 947810	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780676	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780676&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177895059	523299022							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564243	Cc1cc(S(=O)(=O)N2CCC3(CC2)C2=CN=NC2NC2=C3C(=O)CC(C)(C)C2)ccc1Cl			780677	US20250313563, Compound 947475	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780677	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780677&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564244	Cc1cc(S(=O)(=O)N2CCC3(CC2)C2=CN=NC2NC2=C3C(=O)CC(C)(C)C2)ccc1Cl			780677	US20250313563, Compound 947475	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780677	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780677&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564245	CC[C@]4(c2cccc(c1ccnc(CCO)c1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780678	US20250313563, Compound 947816	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780678	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780678&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177895061	523299024							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564246	CC[C@]4(c2cccc(c1ccnc(CCO)c1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780678	US20250313563, Compound 947816	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780678	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780678&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177895061	523299024							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564247	CC(C)n1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780679	US20250313563, Compound 947607	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780679	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780679&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564248	CC(C)n1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780679	US20250313563, Compound 947607	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780679	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780679&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564249	CC[C@]1(c2cccc(Oc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780680	US20250313563, Compound 947818	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780680	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780680&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564250	CC[C@]1(c2cccc(Oc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780680	US20250313563, Compound 947818	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780680	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780680&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564251	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnc3ccccn23)CC1			780681	US20250313563, Compound 947610	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780681	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780681&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564252	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnc3ccccn23)CC1			780681	US20250313563, Compound 947610	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780681	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780681&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564253	CC[C@]1(c2cccc(-c3cnnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780682	US20250313563, Compound 947824	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780682	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780682&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564254	CC[C@]1(c2cccc(-c3cnnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780682	US20250313563, Compound 947824	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780682	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780682&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564255	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnn3ccccc23)CC1			780683	US20250313563, Compound 947615	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780683&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564256	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnn3ccccc23)CC1			780683	US20250313563, Compound 947615	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780683&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564257	CC[C@]1(c2cccc(OC(C)C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780684	US20250313563, Compound 947867	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780684	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780684&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564258	CC[C@]1(c2cccc(OC(C)C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780684	US20250313563, Compound 947867	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780684	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780684&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564259	Cn1ccc(S(=O)(=O)N2CCCC3(CC2)C2=CN=NC2NC2=C3C(=O)CC(C)(C)C2)n1			780685	US20250313563, Compound 917138	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780685	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780685&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564260	Cn1ccc(S(=O)(=O)N2CCCC3(CC2)C2=CN=NC2NC2=C3C(=O)CC(C)(C)C2)n1			780685	US20250313563, Compound 917138	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780685	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780685&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564261	CC[C@]1(c2ccc(OC(C)C)cc2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780686	US20250313563, Compound 947868	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780686	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780686&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564262	CC[C@]1(c2ccc(OC(C)C)cc2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780686	US20250313563, Compound 947868	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780686	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780686&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564263	Cn1ccc(S(=O)(=O)N2CCC[C@]3(CC2)C2=CN=NC2NC2=C3C(=O)CC(C)(C)C2)n1			780687	US20250313563, Compound 932640	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780687	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780687&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564264	Cn1ccc(S(=O)(=O)N2CCC[C@]3(CC2)C2=CN=NC2NC2=C3C(=O)CC(C)(C)C2)n1			780687	US20250313563, Compound 932640	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780687	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780687&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564265	CC[C@@]1(c2cccc(OC(C)C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780688	US20250313563, Compound 947872	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780688	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780688&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564266	CC[C@@]1(c2cccc(OC(C)C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780688	US20250313563, Compound 947872	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780688	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780688&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564267	Cn1nc(C(F)(F)F)cc1S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780689	US20250313563, Compound 947606	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780689	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780689&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564268	Cn1nc(C(F)(F)F)cc1S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780689	US20250313563, Compound 947606	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780689	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780689&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564269	CC[C@@]1(c2ccc(OC(C)C)cc2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780690	US20250313563, Compound 947873	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780690	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780690&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564270	CC[C@@]1(c2ccc(OC(C)C)cc2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780690	US20250313563, Compound 947873	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780690	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780690&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564271	Cc1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n(C)n1			780691	US20250313563, Compound 947608	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780691	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780691&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564272	Cc1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n(C)n1			780691	US20250313563, Compound 947608	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780691	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780691&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564273	CC[C@]1(c2cccc([C@H](C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780692	US20250313563, Compound 948057	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780692	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780692&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564274	CC[C@]1(c2cccc([C@H](C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780692	US20250313563, Compound 948057	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780692	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780692&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564275	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCN(S(=O)(=O)c2ccccc2)C1			780693	US20250313563, Compound 951788	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780693	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780693&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564276	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCN(S(=O)(=O)c2ccccc2)C1			780693	US20250313563, Compound 951788	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780693	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780693&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564277	CC[C@]1(c2cccc([C@@H](C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780694	US20250313563, Compound 948058	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780694	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780694&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564278	CC[C@]1(c2cccc([C@@H](C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780694	US20250313563, Compound 948058	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780694	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780694&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564279	Cc1cccc(S(=O)(=O)N2CC[C@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780695	US20250313563, Compound 951864	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780695	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780695&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564280	Cc1cccc(S(=O)(=O)N2CC[C@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780695	US20250313563, Compound 951864	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780695	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780695&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564281	CC[C@@]1(c2cccc([C@H](C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780696	US20250313563, Compound 948060	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780696	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780696&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564282	CC[C@@]1(c2cccc([C@H](C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780696	US20250313563, Compound 948060	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780696	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780696&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564283	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21C[C@@H](n2cccn2)C1			780697	US20250313563, Compound 884004	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780697	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780697&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564284	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21C[C@@H](n2cccn2)C1			780697	US20250313563, Compound 884004	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780697	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780697&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564285	CC[C@@]1(c2cccc([C@@H](C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780698	US20250313563, Compound 948061	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780698	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780698&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564286	CC[C@@]1(c2cccc([C@@H](C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780698	US20250313563, Compound 948061	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780698	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780698&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564287	CN1CC2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780699	US20250313563, Compound 913264	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780699	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780699&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564288	CN1CC2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780699	US20250313563, Compound 913264	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780699	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780699&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564289	CCC1(c2cccc(-c3ccnc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780700	US20250313563, Compound 948088	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780700	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780700&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564290	CCC1(c2cccc(-c3ccnc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780700	US20250313563, Compound 948088	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780700	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780700&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564291	Cn1nccc1S(=O)(=O)N1CC2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780701	US20250313563, Compound 932648	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780701	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780701&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564292	Cn1nccc1S(=O)(=O)N1CC2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780701	US20250313563, Compound 932648	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780701	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780701&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564293	CCC4(c2cccc(c1cc(C)ncn1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780702	US20250313563, Compound 948089	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780702	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780702&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			178185068	523299048							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564294	CCC4(c2cccc(c1cc(C)ncn1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780702	US20250313563, Compound 948089	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780702	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780702&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			178185068	523299048							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564295	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccccc2C(F)F)CC1			780703	US20250313563, Compound 945657	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780703	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780703&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564296	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccccc2C(F)F)CC1			780703	US20250313563, Compound 945657	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780703	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780703&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564297	CCC1(c2cccc(-c3ncnc(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780704	US20250313563, Compound 948090	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780704	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780704&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564298	CCC1(c2cccc(-c3ncnc(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780704	US20250313563, Compound 948090	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780704	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780704&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564299	CCn1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			780705	US20250313563, Compound 945671	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780705	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780705&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564300	CCn1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			780705	US20250313563, Compound 945671	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780705	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780705&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564301	CCC1(c2cccc(-c3nc(C)ncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780706	US20250313563, Compound 948091	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780706	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780706&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564302	CCC1(c2cccc(-c3nc(C)ncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780706	US20250313563, Compound 948091	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780706	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780706&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564303	CC(C)Oc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780707	US20250313563, Compound 945676	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780707	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780707&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564304	CC(C)Oc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780707	US20250313563, Compound 945676	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780707	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780707&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564305	CCC1(c2cccc(-c3ccnc(OC)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780708	US20250313563, Compound 948092	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780708	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780708&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564306	CCC1(c2cccc(-c3ccnc(OC)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780708	US20250313563, Compound 948092	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780708	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780708&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564307	CN(C)C(=O)c1cccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780709	US20250313563, Compound 947247	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780709	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780709&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564308	CN(C)C(=O)c1cccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780709	US20250313563, Compound 947247	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780709	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780709&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564309	CCC1(c2cccc(-c3cc(OC)ncn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780710	US20250313563, Compound 948093	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780710	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780710&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564310	CCC1(c2cccc(-c3cc(OC)ncn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780710	US20250313563, Compound 948093	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780710	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780710&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564311	COc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1Cl			780711	US20250313563, Compound 947612	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780711	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780711&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564312	COc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1Cl			780711	US20250313563, Compound 947612	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780711	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780711&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564313	CC[C@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780712	US20250313563, Compound 948545	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780712	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780712&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564314	CC[C@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780712	US20250313563, Compound 948545	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780712	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780712&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564315	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnn(-c3ccccc3)c2)CC1			780713	US20250313563, Compound 947904	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780713	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780713&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564316	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnn(-c3ccccc3)c2)CC1			780713	US20250313563, Compound 947904	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780713	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780713&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564317	CC[C@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780714	US20250313563, Compound 948546	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780714	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780714&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564318	CC[C@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780714	US20250313563, Compound 948546	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780714	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780714&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564319	Cn1cc(S(=O)(=O)N2CC[C@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780715	US20250313563, Compound 951726	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780715	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780715&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564320	Cn1cc(S(=O)(=O)N2CC[C@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780715	US20250313563, Compound 951726	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780715	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780715&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564321	CC[C@@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780716	US20250313563, Compound 948547	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780716	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780716&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564322	CC[C@@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780716	US20250313563, Compound 948547	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780716	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780716&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564323	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)c2cccc(F)c2)C1			780717	US20250313563, Compound 918278	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780717	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780717&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564324	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)c2cccc(F)c2)C1			780717	US20250313563, Compound 918278	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780717	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780717&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564325	CC[C@@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780718	US20250313563, Compound 948548	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780718	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780718&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564326	CC[C@@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780718	US20250313563, Compound 948548	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780718	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780718&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564327	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)Cc2ccccc2)C1			780719	US20250313563, Compound 943543	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780719	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780719&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564328	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)Cc2ccccc2)C1			780719	US20250313563, Compound 943543	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780719	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780719&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564329	CCC1(c2cccc(C(F)(F)C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780720	US20250313563, Compound 948615	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780720	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780720&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564330	CCC1(c2cccc(C(F)(F)C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780720	US20250313563, Compound 948615	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780720	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780720&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564331	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccccc2C#N)CC1			780721	US20250313563, Compound 947479	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780721	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780721&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564332	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccccc2C#N)CC1			780721	US20250313563, Compound 947479	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780721	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780721&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564333	CCC4(c2cccc(C1CN(C(C)=O)C1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780722	US20250313563, Compound 948779	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780722	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780722&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177895103	523299068							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564334	CCC4(c2cccc(C1CN(C(C)=O)C1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780722	US20250313563, Compound 948779	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780722	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780722&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177895103	523299068							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564335	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc3c(c2)OCCO3)CC1			780723	US20250313563, Compound 947900	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780723	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780723&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564336	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc3c(c2)OCCO3)CC1			780723	US20250313563, Compound 947900	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780723	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780723&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564337	CCC1(c2cccc(OCC(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780724	US20250313563, Compound 948793	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780724	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780724&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564338	CCC1(c2cccc(OCC(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780724	US20250313563, Compound 948793	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780724	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780724&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564339	Cc1cnccc1[C@H]1CC[C@@]2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780725	US20250313563, Compound 949319	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780725	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780725&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564340	Cc1cnccc1[C@H]1CC[C@@]2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780725	US20250313563, Compound 949319	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780725	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780725&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564341	CCc1cccc(C2(CC)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)c1			780726	US20250313563, Compound 949083	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780726	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780726&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564342	CCc1cccc(C2(CC)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)c1			780726	US20250313563, Compound 949083	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780726	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780726&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564343	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC(C(F)(F)F)CC1			780727	US20250313563, Compound 865193	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780727	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780727&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564344	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC(C(F)(F)F)CC1			780727	US20250313563, Compound 865193	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780727	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780727&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564345	CC[C@]1(c2cccc(C(F)(F)C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780728	US20250313563, Compound 949103	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780728	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780728&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564346	CC[C@]1(c2cccc(C(F)(F)C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780728	US20250313563, Compound 949103	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780728	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780728&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564347	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(C)(=O)=O)CC1			780729	US20250313563, Compound 880776	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780729	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780729&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564348	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(C)(=O)=O)CC1			780729	US20250313563, Compound 880776	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780729	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780729&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564349	CC[C@]1(c2cccc(OCC(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780730	US20250313563, Compound 949104	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780730	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780730&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564350	CC[C@]1(c2cccc(OCC(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780730	US20250313563, Compound 949104	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780730	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780730&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564351	CC(C)Oc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1			780731	US20250313563, Compound 945673	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780731	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780731&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564352	CC(C)Oc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1			780731	US20250313563, Compound 945673	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780731	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780731&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564353	CC[C@@]1(c2cccc(OCC(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780732	US20250313563, Compound 949113	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780732	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780732&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564354	CC[C@@]1(c2cccc(OCC(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780732	US20250313563, Compound 949113	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780732	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780732&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564355	COc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1C			780733	US20250313563, Compound 945680	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780733	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780733&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564356	COc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1C			780733	US20250313563, Compound 945680	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780733	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780733&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564357	CC[C@]4(c2cccc(C1CN(C(C)=O)C1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780734	US20250313563, Compound 949131	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780734	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780734&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177895114	523299080							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564358	CC[C@]4(c2cccc(C1CN(C(C)=O)C1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780734	US20250313563, Compound 949131	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780734	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780734&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177895114	523299080							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564359	COCc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1			780735	US20250313563, Compound 947250	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780735	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780735&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564360	COCc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1			780735	US20250313563, Compound 947250	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780735	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780735&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564361	CC[C@@]4(c2cccc(C1CN(C(C)=O)C1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780736	US20250313563, Compound 949132	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780736	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780736&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177895116	523299082							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564362	CC[C@@]4(c2cccc(C1CN(C(C)=O)C1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			780736	US20250313563, Compound 949132	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780736	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780736&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177895116	523299082							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564363	COc1cncc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780737	US20250313563, Compound 947465	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780737	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780737&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564364	COc1cncc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780737	US20250313563, Compound 947465	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780737	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780737&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564365	CC[C@@]1(c2cccc(C(F)(F)C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780738	US20250313563, Compound 949268	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780738	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780738&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564366	CC[C@@]1(c2cccc(C(F)(F)C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780738	US20250313563, Compound 949268	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780738	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780738&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564367	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnc3n2CCCC3)CC1			780739	US20250313563, Compound 947480	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780739	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780739&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564368	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnc3n2CCCC3)CC1			780739	US20250313563, Compound 947480	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780739	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780739&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564369	CCc1cccc([C@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			780740	US20250313563, Compound 949391	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780740	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780740&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564370	CCc1cccc([C@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			780740	US20250313563, Compound 949391	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780740	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780740&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564371	COCc1cccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780741	US20250313563, Compound 947605	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780741	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780741&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564372	COCc1cccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780741	US20250313563, Compound 947605	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780741	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780741&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564373	CCc1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			780742	US20250313563, Compound 949401	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780742	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780742&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564374	CCc1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			780742	US20250313563, Compound 949401	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780742	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780742&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564375	Cc1csc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			780743	US20250313563, Compound 947897	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780743	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780743&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564376	Cc1csc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			780743	US20250313563, Compound 947897	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780743	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780743&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564377	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCN(C)C1=O)C2			780744	US20250313563, Compound 949753	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780744	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780744&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564378	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCN(C)C1=O)C2			780744	US20250313563, Compound 949753	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780744	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780744&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564379	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc3ccncc23)CC1			780745	US20250313563, Compound 947901	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780745	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780745&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564380	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc3ccncc23)CC1			780745	US20250313563, Compound 947901	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780745	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780745&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564381	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCN(C)C1=O)C2			780746	US20250313563, Compound 949754	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780746	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780746&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564382	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCN(C)C1=O)C2			780746	US20250313563, Compound 949754	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780746	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780746&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564383	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(F)c2)CC1			780747	US20250313563, Compound 901466	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780747	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780747&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564384	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(F)c2)CC1			780747	US20250313563, Compound 901466	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780747	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780747&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564385	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCN(C)C1=O)C2			780748	US20250313563, Compound 949759	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780748	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780748&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564386	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCN(C)C1=O)C2			780748	US20250313563, Compound 949759	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780748	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780748&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564387	Cn1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			780749	US20250313563, Compound 901471	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780749	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780749&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564388	Cn1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			780749	US20250313563, Compound 901471	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780749	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780749&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564389	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCN(C)C1=O)C2			780750	US20250313563, Compound 949760	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780750	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780750&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564390	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCN(C)C1=O)C2			780750	US20250313563, Compound 949760	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780750	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780750&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564391	COc1cccc(S(=O)(=O)N2CC3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780751	US20250313563, Compound 918276	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780751	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780751&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564392	COc1cccc(S(=O)(=O)N2CC3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780751	US20250313563, Compound 918276	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780751	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780751&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564393	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCNC1=O)C2			780752	US20250313563, Compound 950160	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780752	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780752&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564394	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCNC1=O)C2			780752	US20250313563, Compound 950160	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780752	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780752&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564395	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)C2CCCC2)C1			780753	US20250313563, Compound 943482	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780753	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780753&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564396	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)C2CCCC2)C1			780753	US20250313563, Compound 943482	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780753	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780753&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564397	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCNC1=O)C2			780754	US20250313563, Compound 950161	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780754	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780754&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564398	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCNC1=O)C2			780754	US20250313563, Compound 950161	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780754	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780754&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564399	COc1cccc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780755	US20250313563, Compound 943486	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780755	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780755&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564400	COc1cccc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780755	US20250313563, Compound 943486	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780755	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780755&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564401	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCNC1=O)C2			780756	US20250313563, Compound 950164	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780756	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780756&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564402	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCNC1=O)C2			780756	US20250313563, Compound 950164	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780756	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780756&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564403	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2cccc(F)c2)C1			780757	US20250313563, Compound 943488	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780757	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780757&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564404	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2cccc(F)c2)C1			780757	US20250313563, Compound 943488	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780757	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780757&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564405	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCNC1=O)C2			780758	US20250313563, Compound 950165	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780758	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780758&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564406	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCNC1=O)C2			780758	US20250313563, Compound 950165	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780758	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780758&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564407	Cc1cccc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780759	US20250313563, Compound 943489	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780759	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780759&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564408	Cc1cccc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780759	US20250313563, Compound 943489	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780759	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780759&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564409	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCNC1=O)C2			780760	US20250313563, Compound 950324	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780760	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780760&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564410	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCNC1=O)C2			780760	US20250313563, Compound 950324	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780760	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780760&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564411	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccccc2Cl)CC1			780761	US20250313563, Compound 945655	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780761	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780761&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564412	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccccc2Cl)CC1			780761	US20250313563, Compound 945655	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780761	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780761&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564413	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCN(C)C1=O)C2			780762	US20250313563, Compound 950325	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780762	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780762&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564414	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCN(C)C1=O)C2			780762	US20250313563, Compound 950325	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780762	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780762&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564415	CN(C)C(=O)c1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1			780763	US20250313563, Compound 945659	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780763	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780763&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564416	CN(C)C(=O)c1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1			780763	US20250313563, Compound 945659	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780763	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780763&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564417	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCN(C)C1=O)C2			780764	US20250313563, Compound 950326	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780764	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780764&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564418	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCN(C)C1=O)C2			780764	US20250313563, Compound 950326	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780764	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780764&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564419	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1			780765	US20250313563, Compound 945660	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780765	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780765&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564420	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1			780765	US20250313563, Compound 945660	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780765	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780765&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564421	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCN(C)C1=O)C2			780766	US20250313563, Compound 950329	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780766	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780766&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564422	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCN(C)C1=O)C2			780766	US20250313563, Compound 950329	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780766	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780766&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564423	CC(C)c1nc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1C			780767	US20250313563, Compound 945663	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780767	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780767&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564424	CC(C)c1nc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1C			780767	US20250313563, Compound 945663	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780767	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780767&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564425	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCN(C)C1=O)C2			780768	US20250313563, Compound 950330	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780768	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780768&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564426	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCN(C)C1=O)C2			780768	US20250313563, Compound 950330	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780768	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780768&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564427	COc1ccc(F)c(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780769	US20250313563, Compound 945665	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780769	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780769&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564428	COc1ccc(F)c(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780769	US20250313563, Compound 945665	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780769	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780769&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564429	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCNC1=O)C2			780770	US20250313563, Compound 950331	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780770	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780770&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564430	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCNC1=O)C2			780770	US20250313563, Compound 950331	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780770	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780770&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564431	Cn1ccc(S(=O)(=O)N2CC[C@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			780771	US20250313563, Compound 945714	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780771	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780771&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564432	Cn1ccc(S(=O)(=O)N2CC[C@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			780771	US20250313563, Compound 945714	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780771	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780771&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564433	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCNC1=O)C2			780772	US20250313563, Compound 950332	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780772	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780772&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564434	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@@]1(CCNC1=O)C2			780772	US20250313563, Compound 950332	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780772	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780772&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564435	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnn(CCF)c2)CC1			780773	US20250313563, Compound 947903	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780773	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780773&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564436	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnn(CCF)c2)CC1			780773	US20250313563, Compound 947903	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780773	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780773&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564437	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCNC1=O)C2			780774	US20250313563, Compound 950333	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780774	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780774&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564438	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@]1(CCNC1=O)C2			780774	US20250313563, Compound 950333	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780774	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780774&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564439	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(F)c(F)c2)CC1			780775	US20250313563, Compound 948119	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780775	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780775&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564440	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(F)c(F)c2)CC1			780775	US20250313563, Compound 948119	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780775	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780775&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564441	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780776	US20250313563, Compound 957196	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780776	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780776&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564442	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780776	US20250313563, Compound 957196	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780776	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780776&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564443	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)C23CCN(S(=O)(=O)C2CC2)CC3)C1F			780777	US20250313563, Compound 950814	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780777	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780777&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564444	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)C23CCN(S(=O)(=O)C2CC2)CC3)C1F			780777	US20250313563, Compound 950814	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780777	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780777&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564445	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780778	US20250313563, Compound 957197	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780778	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780778&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564446	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780778	US20250313563, Compound 957197	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780778	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780778&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564447	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)C23CCN(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC3)[C@@H]1F			780779	US20250313563, Compound 951703	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780779	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780779&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564448	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)C23CCN(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC3)[C@@H]1F			780779	US20250313563, Compound 951703	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780779	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780779&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564449	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780780	US20250313563, Compound 957199	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780780	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780780&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564450	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780780	US20250313563, Compound 957199	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780780	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780780&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564451	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCN(S(=O)(=O)CC2CC2)C1			780781	US20250313563, Compound 951724	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780781	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780781&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564452	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCN(S(=O)(=O)CC2CC2)C1			780781	US20250313563, Compound 951724	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780781	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780781&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564453	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780782	US20250313563, Compound 957200	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780782&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564454	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780782	US20250313563, Compound 957200	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780782&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564455	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccccc2)CC1			780783	US20250313563, Compound 874530	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780783	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780783&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564456	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccccc2)CC1			780783	US20250313563, Compound 874530	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780783	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780783&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564457	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@@H](F)C(C)(C)C2			780784	US20250313563, Compound 957403	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780784	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780784&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564458	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@@H](F)C(C)(C)C2			780784	US20250313563, Compound 957403	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780784	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780784&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564459	Cn1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780785	US20250313563, Compound 901467	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780785&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564460	Cn1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780785	US20250313563, Compound 901467	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780785&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564461	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@H](F)C(C)(C)C2			780786	US20250313563, Compound 957404	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780786	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780786&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564462	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@H](F)C(C)(C)C2			780786	US20250313563, Compound 957404	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780786	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780786&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564463	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc3c(c2)CCO3)CC1			780787	US20250313563, Compound 913251	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780787	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780787&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564464	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc3c(c2)CCO3)CC1			780787	US20250313563, Compound 913251	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780787	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780787&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564465	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@@H](F)C(C)(C)C2			780788	US20250313563, Compound 957405	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780788	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780788&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564466	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@@H](F)C(C)(C)C2			780788	US20250313563, Compound 957405	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780788	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780788&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564467	COc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1			780789	US20250313563, Compound 917143	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780789	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780789&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564468	COc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1			780789	US20250313563, Compound 917143	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780789	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780789&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564469	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@H](F)C(C)(C)C2			780790	US20250313563, Compound 957406	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780790	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780790&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564470	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)[C@H](F)C(C)(C)C2			780790	US20250313563, Compound 957406	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780790	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780790&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564471	COC(=O)C1(c2ccccc2)CC2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780791	US20250313563, Compound 942366	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780791	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780791&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564472	COC(=O)C1(c2ccccc2)CC2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780791	US20250313563, Compound 942366	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780791	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780791&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564473	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780792	US20250313563, Compound 957504	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780792	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780792&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564474	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780792	US20250313563, Compound 957504	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780792	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780792&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564475	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)CC2CC2)C1			780793	US20250313563, Compound 943481	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780793	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780793&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564476	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)CC2CC2)C1			780793	US20250313563, Compound 943481	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780793	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780793&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564477	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780794	US20250313563, Compound 957505	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780794	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780794&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564478	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780794	US20250313563, Compound 957505	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780794	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780794&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564479	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(Cl)cc2)CC1			780795	US20250313563, Compound 945661	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780795	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780795&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564480	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(Cl)cc2)CC1			780795	US20250313563, Compound 945661	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780795	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780795&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564481	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780796	US20250313563, Compound 957506	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780796	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780796&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564482	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780796	US20250313563, Compound 957506	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780796	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780796&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564483	COc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780797	US20250313563, Compound 945666	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780797	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780797&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564484	COc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780797	US20250313563, Compound 945666	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780797	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780797&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564485	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780798	US20250313563, Compound 957507	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780798&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564486	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780798	US20250313563, Compound 957507	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780798&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564487	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC1			780799	US20250313563, Compound 947244	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780799	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780799&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564488	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC1			780799	US20250313563, Compound 947244	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780799	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780799&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564489	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780800	US20250313563, Compound 957508	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780800	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780800&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564490	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780800	US20250313563, Compound 957508	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780800	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780800&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564491	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)C2=CN=C3CC=CC=C3C2)CC1			780801	US20250313563, Compound 947462	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780801	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780801&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564492	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)C2=CN=C3CC=CC=C3C2)CC1			780801	US20250313563, Compound 947462	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780801	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780801&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564493	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780802	US20250313563, Compound 957509	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780802	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780802&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564494	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780802	US20250313563, Compound 957509	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780802	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780802&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564495	COc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1F			780803	US20250313563, Compound 947478	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780803	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780803&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564496	COc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1F			780803	US20250313563, Compound 947478	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780803	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780803&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564497	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780804	US20250313563, Compound 957510	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780804	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780804&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564498	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780804	US20250313563, Compound 957510	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780804	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780804&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564499	Cc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780805	US20250313563, Compound 947482	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780805	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780805&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564500	Cc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780805	US20250313563, Compound 947482	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780805	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780805&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564501	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780806	US20250313563, Compound 957511	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780806&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564502	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780806	US20250313563, Compound 957511	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780806&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564503	Cc1ncc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)s1			780807	US20250313563, Compound 947899	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780807&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564504	Cc1ncc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)s1			780807	US20250313563, Compound 947899	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780807&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564505	CC[C@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780808	US20250313563, Compound 959341	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780808	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780808&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564506	CC[C@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780808	US20250313563, Compound 959341	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780808	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780808&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564507	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnc3cccnn23)CC1			780809	US20250313563, Compound 948120	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780809	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780809&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564508	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnc3cccnn23)CC1			780809	US20250313563, Compound 948120	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780809	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780809&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564509	CC[C@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780810	US20250313563, Compound 959342	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780810	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780810&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564510	CC[C@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780810	US20250313563, Compound 959342	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780810	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780810&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564511	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cc(F)ccc2F)CC1			780811	US20250313563, Compound 948121	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780811	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780811&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564512	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cc(F)ccc2F)CC1			780811	US20250313563, Compound 948121	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780811	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780811&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564513	CC[C@@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780812	US20250313563, Compound 959343	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780812	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780812&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564514	CC[C@@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780812	US20250313563, Compound 959343	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780812	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780812&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564515	COc1cccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780813	US20250313563, Compound 901468	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780813&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564516	COc1cccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780813	US20250313563, Compound 901468	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780813&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564517	CC[C@@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780814	US20250313563, Compound 959344	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780814	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780814&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564518	CC[C@@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780814	US20250313563, Compound 959344	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780814	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780814&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564519	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)c2ccccc2)C1			780815	US20250313563, Compound 901474	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780815	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780815&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564520	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)c2ccccc2)C1			780815	US20250313563, Compound 901474	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780815	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780815&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564521	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)CC2CC2)C1			780816	US20250313563, Compound 929440	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780816	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780816&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564522	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)CC2CC2)C1			780816	US20250313563, Compound 929440	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780816	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780816&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564523	Cn1ccc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			780817	US20250313563, Compound 943484	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780817	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780817&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564524	Cn1ccc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			780817	US20250313563, Compound 943484	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780817	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780817&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564525	CCC1(c2cccc(-c3cncn3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2F			780818	US20250313563, Compound 963155	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780818	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780818&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564526	CCC1(c2cccc(-c3cncn3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2F			780818	US20250313563, Compound 963155	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780818	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780818&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564527	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(Cl)c2)CC1			780819	US20250313563, Compound 947243	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780819&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564528	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(Cl)c2)CC1			780819	US20250313563, Compound 947243	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780819&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564529	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(OC(F)F)cc2)CC1			780820	US20250313563, Compound 947246	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780820	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780820&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564530	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(OC(F)F)cc2)CC1			780820	US20250313563, Compound 947246	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780820	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780820&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564531	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(C(F)F)cc2)CC1			780821	US20250313563, Compound 947248	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780821	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780821&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564532	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(C(F)F)cc2)CC1			780821	US20250313563, Compound 947248	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780821	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780821&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564533	CC[C@@]1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)[C@H]1CC[C@@H]2C1			780822	US20250313563, Compound 791266	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780822	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780822&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564534	CC[C@@]1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)[C@H]1CC[C@@H]2C1			780822	US20250313563, Compound 791266	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780822	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780822&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564535	CCc1ncc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)s1			780823	US20250313563, Compound 947252	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780823	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780823&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564536	CCc1ncc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)s1			780823	US20250313563, Compound 947252	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780823	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780823&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564537	CC[C@]1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)[C@H]1CC[C@@H]2C1			780824	US20250313563, Compound 791268	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780824	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780824&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564538	CC[C@]1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)[C@H]1CC[C@@H]2C1			780824	US20250313563, Compound 791268	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780824	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780824&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564539	CC(C)n1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			780825	US20250313563, Compound 947258	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780825	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780825&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564540	CC(C)n1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			780825	US20250313563, Compound 947258	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780825	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780825&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564541	CC[C@@]1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)[C@@H]1CC[C@H]2C1			780826	US20250313563, Compound 791269	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780826&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564542	CC[C@@]1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)[C@@H]1CC[C@H]2C1			780826	US20250313563, Compound 791269	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780826&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564543	COc1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)ccc1F			780827	US20250313563, Compound 947263	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780827	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780827&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564544	COc1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)ccc1F			780827	US20250313563, Compound 947263	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780827	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780827&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564545	CC[C@]1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)[C@@H]1CC[C@H]2C1			780828	US20250313563, Compound 791270	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780828	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780828&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564546	CC[C@]1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)[C@@H]1CC[C@H]2C1			780828	US20250313563, Compound 791270	Glycogen synthase kinase-3 beta	Homo sapiens		>1700							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780828	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780828&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564547	Cc1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)ccn1			780829	US20250313563, Compound 947481	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780829	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780829&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564548	Cc1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)ccn1			780829	US20250313563, Compound 947481	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780829	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780829&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564549	O=C1C2=C(NC3N=NC=C3C23CCOCC3)C2CCC1C2			780830	US20250313563, Compound 901464	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780830	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780830&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564550	O=C1C2=C(NC3N=NC=C3C23CCOCC3)C2CCC1C2			780830	US20250313563, Compound 901464	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780830	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780830&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564551	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnn3c2OCCC3)CC1			780831	US20250313563, Compound 947483	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780831	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780831&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564552	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnn3c2OCCC3)CC1			780831	US20250313563, Compound 947483	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780831	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780831&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564553	O=C1C2=C(NC3N=NC=C3C23CCOCC3)[C@H]2CC[C@@H]1C2			780832	US20250313563, Compound 912080	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780832	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780832&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564554	O=C1C2=C(NC3N=NC=C3C23CCOCC3)[C@H]2CC[C@@H]1C2			780832	US20250313563, Compound 912080	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780832	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780832&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564555	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccnc2)CC1			780833	US20250313563, Compound 947613	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780833	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780833&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564556	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccnc2)CC1			780833	US20250313563, Compound 947613	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780833	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780833&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564557	O=C1C2=C(NC3N=NC=C3C23CCOCC3)[C@@H]2CC[C@H]1C2			780834	US20250313563, Compound 912081	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780834	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780834&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564558	O=C1C2=C(NC3N=NC=C3C23CCOCC3)[C@@H]2CC[C@H]1C2			780834	US20250313563, Compound 912081	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780834	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780834&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564559	Cc1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc(C)n1			780835	US20250313563, Compound 947616	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780835	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780835&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564560	Cc1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc(C)n1			780835	US20250313563, Compound 947616	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780835	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780835&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564561	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(N=NC2)NC2=C1C(=O)[C@H]1CC[C@@H]2C1			780836	US20250313563, Compound 943916	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780836	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780836&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564562	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(N=NC2)NC2=C1C(=O)[C@H]1CC[C@@H]2C1			780836	US20250313563, Compound 943916	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780836	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780836&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564563	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21C[C@@H](c2ccncc2)C1			780837	US20250313563, Compound 889665	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780837	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780837&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564564	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21C[C@@H](c2ccncc2)C1			780837	US20250313563, Compound 889665	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780837	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780837&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564565	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(N=NC2)NC2=C1C(=O)[C@H]1CC[C@@H]2C1			780838	US20250313563, Compound 943917	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780838	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780838&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564566	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(N=NC2)NC2=C1C(=O)[C@H]1CC[C@@H]2C1			780838	US20250313563, Compound 943917	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780838	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780838&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564567	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(F)cc2)CC1			780839	US20250313563, Compound 893311	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780839	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780839&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564568	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(F)cc2)CC1			780839	US20250313563, Compound 893311	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780839	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780839&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564569	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(N=NC2)NC2=C1C[C@@H]1CC[C@H]2C1			780840	US20250313563, Compound 943920	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780840&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564570	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(N=NC2)NC2=C1C[C@@H]1CC[C@H]2C1			780840	US20250313563, Compound 943920	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780840&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564571	COc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1			780841	US20250313563, Compound 901469	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780841	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780841&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564572	COc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1			780841	US20250313563, Compound 901469	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780841	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780841&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564573	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)[C@@H]1CC[C@H]2C1			780842	US20250313563, Compound 943921	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780842	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780842&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564574	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)[C@@H]1CC[C@H]2C1			780842	US20250313563, Compound 943921	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780842	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780842&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564575	COc1ccccc1S(=O)(=O)N1CC2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780843	US20250313563, Compound 913261	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780843	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780843&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564576	COc1ccccc1S(=O)(=O)N1CC2(C1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780843	US20250313563, Compound 913261	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780843	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780843&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564577	CCC1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)NCCC2			780844	US20250313563, Compound 913355	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780844	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780844&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564578	CCC1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)NCCC2			780844	US20250313563, Compound 913355	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780844	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780844&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564579	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)C2CCCC2)C1			780845	US20250313563, Compound 917139	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780845&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564580	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)C2CCCC2)C1			780845	US20250313563, Compound 917139	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780845&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564581	CCC1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(C)C2C			780846	US20250313563, Compound 911957	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780846	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780846&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564582	CCC1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(C)C2C			780846	US20250313563, Compound 911957	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780846	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780846&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564583	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2ccccc2)C1			780847	US20250313563, Compound 943485	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780847	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780847&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564584	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2ccccc2)C1			780847	US20250313563, Compound 943485	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780847	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780847&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564585	CCC1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)NC2(C)C			780848	US20250313563, Compound 912104	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780848	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780848&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564586	CCC1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)NC2(C)C			780848	US20250313563, Compound 912104	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780848	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780848&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564587	COc1cccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1F			780849	US20250313563, Compound 945656	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780849&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564588	COc1cccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1F			780849	US20250313563, Compound 945656	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780849&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564589	CCC1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)NC2			780850	US20250313563, Compound 913156	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780850	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780850&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564590	CCC1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)NC2			780850	US20250313563, Compound 913156	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780850	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780850&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564591	CCOc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1			780851	US20250313563, Compound 945670	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780851&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564592	CCOc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1			780851	US20250313563, Compound 945670	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780851&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564593	CCC1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(C)C2(C)C			780852	US20250313563, Compound 913198	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780852	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780852&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564594	CCC1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(C)C2(C)C			780852	US20250313563, Compound 913198	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780852	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780852&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564595	Cc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)s1			780853	US20250313563, Compound 945672	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780853	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780853&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564596	Cc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)s1			780853	US20250313563, Compound 945672	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780853	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780853&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564597	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)NC2(C)C			780854	US20250313563, Compound 913451	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780854	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780854&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564598	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)NC2(C)C			780854	US20250313563, Compound 913451	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780854	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780854&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564599	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)NC2(C)C			780855	US20250313563, Compound 913452	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780855&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564600	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)NC2(C)C			780855	US20250313563, Compound 913452	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780855&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564601	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(OC(F)F)c2)CC1			780856	US20250313563, Compound 947242	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780856&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564602	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(OC(F)F)c2)CC1			780856	US20250313563, Compound 947242	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780856&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564603	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(C)[C@@H]2C			780857	US20250313563, Compound 913454	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780857&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564604	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(C)[C@@H]2C			780857	US20250313563, Compound 913454	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780857&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564605	CCOc1cccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780858	US20250313563, Compound 947253	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780858&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564606	CCOc1cccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780858	US20250313563, Compound 947253	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780858&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564607	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(C)[C@H]2C			780859	US20250313563, Compound 913473	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780859&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564608	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(C)[C@H]2C			780859	US20250313563, Compound 913473	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780859&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564609	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(C#N)c2)CC1			780860	US20250313563, Compound 947254	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780860&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564610	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(C#N)c2)CC1			780860	US20250313563, Compound 947254	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780860&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564611	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(C)[C@@H]2C			780861	US20250313563, Compound 913475	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780861&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564612	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(C)[C@@H]2C			780861	US20250313563, Compound 913475	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780861&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564613	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc3ncccc23)CC1			780862	US20250313563, Compound 947469	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780862	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780862&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564614	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc3ncccc23)CC1			780862	US20250313563, Compound 947469	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780862	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780862&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564615	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(C)[C@H]2C			780863	US20250313563, Compound 913495	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780863&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564616	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(C)[C@H]2C			780863	US20250313563, Compound 913495	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780863&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564617	Cc1ncc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)o1			780864	US20250313563, Compound 947611	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780864&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564618	Cc1ncc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)o1			780864	US20250313563, Compound 947611	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780864&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564619	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)NC2			780865	US20250313563, Compound 917157	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780865&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564620	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)NC2			780865	US20250313563, Compound 917157	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780865&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564621	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(C(F)(F)F)cn2)CC1			780866	US20250313563, Compound 947902	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780866&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564622	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(C(F)(F)F)cn2)CC1			780866	US20250313563, Compound 947902	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780866&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564623	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)NC2			780867	US20250313563, Compound 917158	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780867&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564624	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)NC2			780867	US20250313563, Compound 917158	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780867&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564625	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(Cl)c2F)CC1			780868	US20250313563, Compound 948118	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780868&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564626	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(Cl)c2F)CC1			780868	US20250313563, Compound 948118	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780868&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564627	CCC1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)C2			780869	US20250313563, Compound 917159	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780869&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564628	CCC1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)C2			780869	US20250313563, Compound 917159	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780869&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564629	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnn(CC(F)(F)F)c2)CC1			780870	US20250313563, Compound 948123	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780870&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564630	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnn(CC(F)(F)F)c2)CC1			780870	US20250313563, Compound 948123	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780870&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564631	CCC1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)C2C			780871	US20250313563, Compound 917162	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780871&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564632	CCC1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)C2C			780871	US20250313563, Compound 917162	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780871&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564633	Cn1cc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780872	US20250313563, Compound 951725	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780872&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564634	Cn1cc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780872	US20250313563, Compound 951725	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780872&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564635	CCC1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(C)C2			780873	US20250313563, Compound 917294	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780873&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564636	CCC1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(C)C2			780873	US20250313563, Compound 917294	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780873&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564637	COc1ccccc1S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780874	US20250313563, Compound 893310	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780874&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564638	COc1ccccc1S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780874	US20250313563, Compound 893310	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780874&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564639	CCC1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)NC2C			780875	US20250313563, Compound 917295	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780875&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564640	CCC1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)NC2C			780875	US20250313563, Compound 917295	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780875&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564641	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccccc2F)CC1			780876	US20250313563, Compound 901465	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780876&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564642	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccccc2F)CC1			780876	US20250313563, Compound 901465	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780876&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564643	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(C)C2(C)C			780877	US20250313563, Compound 918251	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780877&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564644	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(C)C2(C)C			780877	US20250313563, Compound 918251	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780877&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564645	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)C2CC2)CC1			780878	US20250313563, Compound 901470	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780878&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564646	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)C2CC2)CC1			780878	US20250313563, Compound 901470	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780878&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564647	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(C)C2(C)C			780879	US20250313563, Compound 918252	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780879	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780879&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564648	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(C)C2(C)C			780879	US20250313563, Compound 918252	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780879	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780879&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564649	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)C2CC2)C1			780880	US20250313563, Compound 913259	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780880	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780880&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564650	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)C2CC2)C1			780880	US20250313563, Compound 913259	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780880	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780880&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564651	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccccc1)C2			780881	US20250313563, Compound 918313	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780881&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564652	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccccc1)C2			780881	US20250313563, Compound 918313	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780881&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564653	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)c2ccccn2)C1			780882	US20250313563, Compound 913262	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780882	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780882&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564654	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)c2ccccn2)C1			780882	US20250313563, Compound 913262	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780882	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780882&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564655	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)C2			780883	US20250313563, Compound 929388	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780883	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780883&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564656	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)C2			780883	US20250313563, Compound 929388	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780883	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780883&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564657	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)c2ccc(F)cc2)C1			780884	US20250313563, Compound 917144	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780884	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780884&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564658	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)c2ccc(F)cc2)C1			780884	US20250313563, Compound 917144	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780884	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780884&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564659	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)C2			780885	US20250313563, Compound 929389	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780885	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780885&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564660	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)C2			780885	US20250313563, Compound 929389	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780885	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780885&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564661	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)Cc2ccccc2)CC1			780886	US20250313563, Compound 929437	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780886	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780886&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564662	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)Cc2ccccc2)CC1			780886	US20250313563, Compound 929437	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780886	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780886&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564663	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)[C@@H]2C			780887	US20250313563, Compound 930330	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780887	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780887&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564664	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)[C@@H]2C			780887	US20250313563, Compound 930330	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780887	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780887&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564665	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccccc2OC(F)F)CC1			780888	US20250313563, Compound 945668	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780888	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780888&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564666	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccccc2OC(F)F)CC1			780888	US20250313563, Compound 945668	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780888	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780888&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564667	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)[C@H]2C			780889	US20250313563, Compound 930331	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780889	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780889&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564668	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)[C@H]2C			780889	US20250313563, Compound 930331	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780889	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780889&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564669	Cn1ccc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			780890	US20250313563, Compound 945712	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780890&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564670	Cn1ccc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			780890	US20250313563, Compound 945712	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780890&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564671	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)[C@@H]2C			780891	US20250313563, Compound 930332	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780891	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780891&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564672	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)[C@@H]2C			780891	US20250313563, Compound 930332	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780891	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780891&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564673	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc3c2OCCO3)CC1			780892	US20250313563, Compound 947464	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780892&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564674	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc3c2OCCO3)CC1			780892	US20250313563, Compound 947464	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780892&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564675	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)[C@H]2C			780893	US20250313563, Compound 930333	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780893	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780893&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564676	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)[C@H]2C			780893	US20250313563, Compound 930333	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780893	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780893&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564677	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2c(F)cc(F)cc2F)CC1			780894	US20250313563, Compound 947484	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780894&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564678	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2c(F)cc(F)cc2F)CC1			780894	US20250313563, Compound 947484	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780894&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564679	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(C)C2			780895	US20250313563, Compound 945367	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780895	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780895&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564680	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(C)C2			780895	US20250313563, Compound 945367	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780895	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780895&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564681	Cc1cnc2c(S(=O)(=O)N3CCC4(CC3)C3=C(N=NC3)NC3=C4C(=O)CC(C)(C)C3)cccc2c1			780896	US20250313563, Compound 947614	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780896	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780896&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564682	Cc1cnc2c(S(=O)(=O)N3CCC4(CC3)C3=C(N=NC3)NC3=C4C(=O)CC(C)(C)C3)cccc2c1			780896	US20250313563, Compound 947614	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780896	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780896&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564683	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(C)C2			780897	US20250313563, Compound 945368	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780897&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564684	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(C)C2			780897	US20250313563, Compound 945368	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780897&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564685	CC(C)S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)[C@H]1F			780898	US20250313563, Compound 951701	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780898&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564686	CC(C)S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)[C@H]1F			780898	US20250313563, Compound 951701	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780898&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564687	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(c1ccccc1)C2			780899	US20250313563, Compound 945376	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780899&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564688	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(c1ccccc1)C2			780899	US20250313563, Compound 945376	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780899&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564689	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2ccccc2)C1			780900	US20250313563, Compound 951787	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780900	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780900&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564690	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2ccccc2)C1			780900	US20250313563, Compound 951787	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780900	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780900&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564691	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccccc1)C2			780901	US20250313563, Compound 945377	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780901	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780901&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564692	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccccc1)C2			780901	US20250313563, Compound 945377	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780901	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780901&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564693	COc1cccc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780902	US20250313563, Compound 951789	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780902	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780902&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564694	COc1cccc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780902	US20250313563, Compound 951789	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780902	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780902&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564695	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N[C@@H]2C			780903	US20250313563, Compound 945378	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780903	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780903&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564696	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N[C@@H]2C			780903	US20250313563, Compound 945378	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780903	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780903&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564697	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2cccc(F)c2)C1			780904	US20250313563, Compound 951861	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780904	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780904&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564698	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2cccc(F)c2)C1			780904	US20250313563, Compound 951861	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780904	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780904&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564699	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N[C@H]2C			780905	US20250313563, Compound 945379	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780905	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780905&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564700	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N[C@H]2C			780905	US20250313563, Compound 945379	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780905	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780905&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564701	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)CC2CC2)CC1			780906	US20250313563, Compound 909207	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780906&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564702	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)CC2CC2)CC1			780906	US20250313563, Compound 909207	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780906&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564703	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N[C@@H]2C			780907	US20250313563, Compound 945380	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780907&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564704	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N[C@@H]2C			780907	US20250313563, Compound 945380	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780907&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564705	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2ccccc2F)C1			780908	US20250313563, Compound 943487	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780908	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780908&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564706	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2ccccc2F)C1			780908	US20250313563, Compound 943487	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780908	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780908&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564707	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N[C@H]2C			780909	US20250313563, Compound 945381	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780909	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780909&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564708	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N[C@H]2C			780909	US20250313563, Compound 945381	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780909	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780909&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564709	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2ccccc2F)C1			780910	US20250313563, Compound 945718	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780910&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564710	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2ccccc2F)C1			780910	US20250313563, Compound 945718	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780910&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564711	CC[C@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)C2			780911	US20250313563, Compound 948549	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780911	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780911&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564712	CC[C@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)C2			780911	US20250313563, Compound 948549	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780911	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780911&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564713	COc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c(F)c1			780912	US20250313563, Compound 947255	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780912	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780912&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564714	COc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c(F)c1			780912	US20250313563, Compound 947255	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780912	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780912&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564715	CC[C@@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)C2			780913	US20250313563, Compound 948550	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780913	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780913&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564716	CC[C@@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)C2			780913	US20250313563, Compound 948550	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780913	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780913&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564717	COc1ncccc1S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780914	US20250313563, Compound 947260	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780914	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780914&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564718	COc1ncccc1S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780914	US20250313563, Compound 947260	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780914	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780914&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564719	CC[C@]1(c2cccc(-c3ccnc4c3CCCC4)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)C2			780915	US20250313563, Compound 948551	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780915	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780915&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564720	CC[C@]1(c2cccc(-c3ccnc4c3CCCC4)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)C2			780915	US20250313563, Compound 948551	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780915	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780915&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564721	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(C(F)F)c2)CC1			780916	US20250313563, Compound 947264	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780916	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780916&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564722	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(C(F)F)c2)CC1			780916	US20250313563, Compound 947264	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780916	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780916&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564723	CC[C@@]1(c2cccc(-c3ccnc4c3CCCC4)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)C2			780917	US20250313563, Compound 948552	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780917	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780917&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564724	CC[C@@]1(c2cccc(-c3ccnc4c3CCCC4)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)C2			780917	US20250313563, Compound 948552	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780917	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780917&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564725	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccn(-c3ccccc3)n2)CC1			780918	US20250313563, Compound 947461	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780918	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780918&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564726	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccn(-c3ccccc3)n2)CC1			780918	US20250313563, Compound 947461	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780918	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780918&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564727	CCC1(c2ccccc2)C2=C(N=NC2)NC(C)=C1C(C)=O			780919	US20250313563, Compound 806940	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780919	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780919&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564728	CCC1(c2ccccc2)C2=C(N=NC2)NC(C)=C1C(C)=O			780919	US20250313563, Compound 806940	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780919	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780919&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564729	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)C2=CC=C3CC=CC=C3N2)CC1			780920	US20250313563, Compound 947476	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780920	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780920&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564730	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)C2=CC=C3CC=CC=C3N2)CC1			780920	US20250313563, Compound 947476	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780920	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780920&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564731	CCC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CSC2			780921	US20250313563, Compound 801406	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780921	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780921&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564732	CCC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CSC2			780921	US20250313563, Compound 801406	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780921	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780921&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564733	CC(C)S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)[C@@H]1F			780922	US20250313563, Compound 951714	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780922	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780922&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564734	CC(C)S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)[C@@H]1F			780922	US20250313563, Compound 951714	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780922	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780922&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564735	CCC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CS(=O)(=O)C2			780923	US20250313563, Compound 811512	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780923	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780923&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564736	CCC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)CS(=O)(=O)C2			780923	US20250313563, Compound 811512	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780923	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780923&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564737	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)CC2CC2)C1			780924	US20250313563, Compound 951723	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780924	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780924&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564738	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)CC2CC2)C1			780924	US20250313563, Compound 951723	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780924	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780924&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564739	CCC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)SC2			780925	US20250313563, Compound 862028	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780925	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780925&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564740	CCC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)SC2			780925	US20250313563, Compound 862028	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780925	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780925&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564741	Cc1cccc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780926	US20250313563, Compound 951863	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780926	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780926&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564742	Cc1cccc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780926	US20250313563, Compound 951863	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780926	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780926&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564743	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			780927	US20250313563, Compound 823130	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780927	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780927&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564744	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			780927	US20250313563, Compound 823130	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780927	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780927&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564745	CC1N=NC2=C1C1(CC3(CCC3)C1)C1=C(CC(C)(C)CC1=O)N2			780928	US20250313563, Compound 877295	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780928	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780928&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564746	CC1N=NC2=C1C1(CC3(CCC3)C1)C1=C(CC(C)(C)CC1=O)N2			780928	US20250313563, Compound 877295	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780928	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780928&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564747	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C(C)C)CC2			780929	US20250313563, Compound 825755	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780929	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780929&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564748	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C(C)C)CC2			780929	US20250313563, Compound 825755	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780929	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780929&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564749	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CC2(COC2)C1			780930	US20250313563, Compound 912168	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780930	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780930&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564750	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CC2(COC2)C1			780930	US20250313563, Compound 912168	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780930	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780930&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564751	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			780931	US20250313563, Compound 826790	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780931	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780931&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564752	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			780931	US20250313563, Compound 826790	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780931	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780931&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564753	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			780932	US20250313563, Compound 826791	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780932	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780932&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564754	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			780932	US20250313563, Compound 826791	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780932	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780932&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564755	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C(C)C)CC2			780933	US20250313563, Compound 857336	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780933	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780933&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564756	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C(C)C)CC2			780933	US20250313563, Compound 857336	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780933	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780933&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564757	CC(=O)N1CC2(C1)C[C@@]1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			780934	US20250313563, Compound 926861	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780934	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780934&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564758	CC(=O)N1CC2(C1)C[C@@]1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			780934	US20250313563, Compound 926861	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780934	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780934&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564759	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C(C)C)CC2			780935	US20250313563, Compound 857362	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780935	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780935&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564760	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C(C)C)CC2			780935	US20250313563, Compound 857362	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780935	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780935&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564761	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)Cc3ccccc3)C2)C1			780936	US20250313563, Compound 947306	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780936	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780936&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564762	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)Cc3ccccc3)C2)C1			780936	US20250313563, Compound 947306	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780936	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780936&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564763	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NCC2			780937	US20250313563, Compound 870263	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780937	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780937&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564764	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NCC2			780937	US20250313563, Compound 870263	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780937	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780937&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564765	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21COC2(CN(C(=O)Cc3ccccc3)C2)C1			780938	US20250313563, Compound 948037	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780938	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780938&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564766	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21COC2(CN(C(=O)Cc3ccccc3)C2)C1			780938	US20250313563, Compound 948037	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780938	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780938&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564767	CCC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)N(C)CC2			780939	US20250313563, Compound 883867	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780939	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780939&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564768	CCC1(c2ccccc2)C2=C(N=NC2)NC2=C1C(=O)N(C)CC2			780939	US20250313563, Compound 883867	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780939	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780939&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564769	CC(=O)N1C[C@]2(C[C@@]3(CO2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)[C@H]1C			780940	US20250313563, Compound 948437	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780940	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780940&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564770	CC(=O)N1C[C@]2(C[C@@]3(CO2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)[C@H]1C			780940	US20250313563, Compound 948437	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780940	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780940&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564771	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)C[C@@H]2C			780941	US20250313563, Compound 883979	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780941	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780941&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564772	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)C[C@@H]2C			780941	US20250313563, Compound 883979	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780941	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780941&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564773	CC(=O)N1C[C@]2(C[C@]3(CO2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)[C@H]1C			780942	US20250313563, Compound 948439	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780942	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780942&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564774	CC(=O)N1C[C@]2(C[C@]3(CO2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)[C@H]1C			780942	US20250313563, Compound 948439	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780942	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780942&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564775	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)C[C@H]2C			780943	US20250313563, Compound 883980	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780943	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780943&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564776	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)C[C@H]2C			780943	US20250313563, Compound 883980	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780943	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780943&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564777	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)C[C@@H]2C			780944	US20250313563, Compound 883981	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780944	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780944&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564778	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)C[C@@H]2C			780944	US20250313563, Compound 883981	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780944	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780944&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564779	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC2(CCC(=O)N2C(=O)OC(C)(C)C)CC1			780945	US20250313563, Compound 912217	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780945	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780945&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564780	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC2(CCC(=O)N2C(=O)OC(C)(C)C)CC1			780945	US20250313563, Compound 912217	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780945	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780945&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564781	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)C[C@H]2C			780946	US20250313563, Compound 883982	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780946	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780946&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564782	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)C[C@H]2C			780946	US20250313563, Compound 883982	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780946	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780946&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564783	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCOC2(CCC2)C1			780947	US20250313563, Compound 897755	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780947	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780947&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564784	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCOC2(CCC2)C1			780947	US20250313563, Compound 897755	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780947	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780947&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564785	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(Cc1ccccc1)CC2			780948	US20250313563, Compound 897749	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780948	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780948&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564786	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(Cc1ccccc1)CC2			780948	US20250313563, Compound 897749	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780948	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780948&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564787	CC(C)(C)CC(=O)N1CC2(C1)CC1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			780949	US20250313563, Compound 947301	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780949	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780949&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564788	CC(C)(C)CC(=O)N1CC2(C1)CC1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			780949	US20250313563, Compound 947301	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780949	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780949&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564789	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)C2			780950	US20250313563, Compound 911956	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780950	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780950&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564790	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)C2			780950	US20250313563, Compound 911956	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780950	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780950&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564791	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCOC2(CCC2)C1			780951	US20250313563, Compound 897756	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780951	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780951&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564792	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCOC2(CCC2)C1			780951	US20250313563, Compound 897756	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780951	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780951&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564793	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(Cc1ccccc1)CC2			780952	US20250313563, Compound 912005	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780952	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780952&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564794	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(Cc1ccccc1)CC2			780952	US20250313563, Compound 912005	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780952	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780952&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564795	CC1CC(C(=O)N2CC3(C2)C[C@]2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)C1			780953	US20250313563, Compound 947732	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780953	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780953&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564796	CC1CC(C(=O)N2CC3(C2)C[C@]2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)C1			780953	US20250313563, Compound 947732	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780953	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780953&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564797	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(Cc1ccccc1)CC2			780954	US20250313563, Compound 912006	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780954	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780954&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564798	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(Cc1ccccc1)CC2			780954	US20250313563, Compound 912006	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780954	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780954&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564799	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CN(C(=O)C3CCCC3)C2)C1			780955	US20250313563, Compound 943958	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780955	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780955&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564800	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CN(C(=O)C3CCCC3)C2)C1			780955	US20250313563, Compound 943958	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780955	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780955&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564801	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@H](C)C2			780956	US20250313563, Compound 912096	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780956	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780956&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564802	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@H](C)C2			780956	US20250313563, Compound 912096	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780956	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780956&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564803	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CN(C(=O)c3ccccc3)C2)C1			780957	US20250313563, Compound 943956	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780957	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780957&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564804	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CN(C(=O)c3ccccc3)C2)C1			780957	US20250313563, Compound 943956	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780957	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780957&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564805	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@@H](C)C2			780958	US20250313563, Compound 912097	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780958	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780958&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564806	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@@H](C)C2			780958	US20250313563, Compound 912097	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780958	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780958&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564807	Cc1cc(C)cc(C(=O)N2CC3(C2)C[C@]2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)c1			780959	US20250313563, Compound 948222	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780959	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780959&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564808	Cc1cc(C)cc(C(=O)N2CC3(C2)C[C@]2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)c1			780959	US20250313563, Compound 948222	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780959	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780959&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564809	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@H](C)C2			780960	US20250313563, Compound 912098	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780960	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780960&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564810	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@H](C)C2			780960	US20250313563, Compound 912098	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780960	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780960&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564811	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(S(=O)(=O)c3ccccc3)C2)C1			780961	US20250313563, Compound 913002	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780961	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780961&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564812	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(S(=O)(=O)c3ccccc3)C2)C1			780961	US20250313563, Compound 913002	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780961	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780961&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564813	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@@H](C)C2			780962	US20250313563, Compound 912099	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780962	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780962&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564814	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@@H](C)C2			780962	US20250313563, Compound 912099	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780962	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780962&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564815	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21COC2(CN(C(=O)[C@H]3CC3(F)F)C2)C1			780963	US20250313563, Compound 948217	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780963	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780963&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564816	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21COC2(CN(C(=O)[C@H]3CC3(F)F)C2)C1			780963	US20250313563, Compound 948217	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780963	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780963&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564817	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(CC(F)(F)F)CC2			780964	US20250313563, Compound 912205	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780964	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780964&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564818	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(CC(F)(F)F)CC2			780964	US20250313563, Compound 912205	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780964	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780964&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564819	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)OC(C)(C)C)C2)C1			780965	US20250313563, Compound 911083	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780965	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780965&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564820	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)OC(C)(C)C)C2)C1			780965	US20250313563, Compound 911083	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780965	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780965&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564821	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(CC(F)(F)F)CC2			780966	US20250313563, Compound 912206	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780966	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780966&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564822	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(CC(F)(F)F)CC2			780966	US20250313563, Compound 912206	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780966	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780966&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564823	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCOC2(CCCC2)C1			780967	US20250313563, Compound 907326	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780967	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780967&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564824	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCOC2(CCCC2)C1			780967	US20250313563, Compound 907326	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780967	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780967&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564825	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NCC2			780968	US20250313563, Compound 912622	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780968	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780968&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564826	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NCC2			780968	US20250313563, Compound 912622	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780968	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780968&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564827	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1[C@]21CCOC2(CCCC2)C1			780969	US20250313563, Compound 907327	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780969	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780969&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564828	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1[C@]21CCOC2(CCCC2)C1			780969	US20250313563, Compound 907327	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780969	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780969&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564829	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NCC2			780970	US20250313563, Compound 912668	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780970	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780970&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564830	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NCC2			780970	US20250313563, Compound 912668	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780970	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780970&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564831	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21COC2(CCC2)C1			780971	US20250313563, Compound 917129	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780971	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780971&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564832	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21COC2(CCC2)C1			780971	US20250313563, Compound 917129	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780971	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780971&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564833	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			780972	US20250313563, Compound 913004	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780972	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780972&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564834	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			780972	US20250313563, Compound 913004	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780972	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780972&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564835	CC(=O)N1CC[C@@]2(C1)C[C@@]1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			780973	US20250313563, Compound 948320	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780973	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780973&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564836	CC(=O)N1CC[C@@]2(C1)C[C@@]1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			780973	US20250313563, Compound 948320	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780973	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780973&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564837	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			780974	US20250313563, Compound 913006	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780974	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780974&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564838	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			780974	US20250313563, Compound 913006	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780974	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780974&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564839	Cc1ccc(C(=O)N2CC3(C2)C[C@@]2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)cc1C			780975	US20250313563, Compound 948039	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780975	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780975&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564840	Cc1ccc(C(=O)N2CC3(C2)C[C@@]2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)cc1C			780975	US20250313563, Compound 948039	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780975	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780975&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564841	CCC1(c2cccc(C(C)(C)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)CC2			780976	US20250313563, Compound 913178	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780976	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780976&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564842	CCC1(c2cccc(C(C)(C)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)CC2			780976	US20250313563, Compound 913178	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780976	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780976&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564843	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC2(CCC(=O)N2)CC1			780977	US20250313563, Compound 913056	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780977	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780977&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564844	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC2(CCC(=O)N2)CC1			780977	US20250313563, Compound 913056	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780977	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780977&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564845	CCC1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)NC(C)C2			780978	US20250313563, Compound 913225	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780978	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780978&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564846	CCC1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)NC(C)C2			780978	US20250313563, Compound 913225	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780978	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780978&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564847	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCOC2(CCOCC2)C1			780979	US20250313563, Compound 924306	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780979	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780979&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564848	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCOC2(CCOCC2)C1			780979	US20250313563, Compound 924306	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780979	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780979&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564849	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)C2			780980	US20250313563, Compound 913357	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780980	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780980&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564850	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)C2			780980	US20250313563, Compound 913357	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780980	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780980&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564851	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CN(S(C)(=O)=O)C2)C1			780981	US20250313563, Compound 926823	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780981	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780981&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564852	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CN(S(C)(=O)=O)C2)C1			780981	US20250313563, Compound 926823	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780981	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780981&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564853	CCC1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			780982	US20250313563, Compound 913439	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780982	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780982&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564854	CCC1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			780982	US20250313563, Compound 913439	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780982	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780982&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564855	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21C[C@@]2(CCN(CC(F)(F)F)C2)C1			780983	US20250313563, Compound 913138	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780983	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780983&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564856	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21C[C@@]2(CCN(CC(F)(F)F)C2)C1			780983	US20250313563, Compound 913138	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780983	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780983&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564857	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			780984	US20250313563, Compound 914308	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780984	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780984&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564858	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			780984	US20250313563, Compound 914308	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780984	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780984&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564859	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CCC2)C1			780985	US20250313563, Compound 911973	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780985	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780985&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564860	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CCC2)C1			780985	US20250313563, Compound 911973	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780985	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780985&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564861	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			780986	US20250313563, Compound 914344	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780986	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780986&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564862	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			780986	US20250313563, Compound 914344	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780986	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780986&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564863	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21C[C@@]2(CCN(CC(F)F)C2)C1			780987	US20250313563, Compound 913139	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780987	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780987&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564864	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21C[C@@]2(CCN(CC(F)F)C2)C1			780987	US20250313563, Compound 913139	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780987	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780987&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564865	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			780988	US20250313563, Compound 914930	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780988	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780988&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564866	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			780988	US20250313563, Compound 914930	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780988	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780988&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564867	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CN(C(=O)Cc3ccccc3)C2)C1			780989	US20250313563, Compound 948036	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780989	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780989&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564868	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CN(C(=O)Cc3ccccc3)C2)C1			780989	US20250313563, Compound 948036	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780989	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780989&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564869	CCC1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			780990	US20250313563, Compound 914971	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780990	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780990&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564870	CCC1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			780990	US20250313563, Compound 914971	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780990	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780990&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564871	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21COC2(CN(C(=O)[C@@H]3CC3(F)F)C2)C1			780991	US20250313563, Compound 948221	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780991	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780991&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564872	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21COC2(CN(C(=O)[C@@H]3CC3(F)F)C2)C1			780991	US20250313563, Compound 948221	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780991	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780991&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564873	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccccc1)CC2			780992	US20250313563, Compound 917211	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780992	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780992&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564874	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccccc1)CC2			780992	US20250313563, Compound 917211	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780992	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780992&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564875	CC(=O)N1CC2(C1)C[C@]1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			780993	US20250313563, Compound 926872	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780993	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780993&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564876	CC(=O)N1CC2(C1)C[C@]1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			780993	US20250313563, Compound 926872	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780993	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780993&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564877	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)CC2			780994	US20250313563, Compound 917282	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780994	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780994&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564878	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)CC2			780994	US20250313563, Compound 917282	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780994	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780994&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564879	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CCC2)C1			780995	US20250313563, Compound 917128	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780995	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780995&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564880	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CCC2)C1			780995	US20250313563, Compound 917128	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780995	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780995&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564881	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)CC2			780996	US20250313563, Compound 917283	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780996	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780996&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564882	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)CC2			780996	US20250313563, Compound 917283	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780996	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780996&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564883	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21COC2(CN(C(=O)C3(F)CCC3)C2)C1			780997	US20250313563, Compound 947736	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780997	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780997&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564884	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21COC2(CN(C(=O)C3(F)CCC3)C2)C1			780997	US20250313563, Compound 947736	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780997	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780997&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564885	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(c1ccccc1)C2			780998	US20250313563, Compound 917284	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780998	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780998&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564886	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(c1ccccc1)C2			780998	US20250313563, Compound 917284	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780998	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780998&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564887	Cc1cccc(C(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)c1C			780999	US20250313563, Compound 947284	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780999	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780999&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564888	Cc1cccc(C(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)c1C			780999	US20250313563, Compound 947284	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780999	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780999&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564889	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NCC2C			781000	US20250313563, Compound 919318	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781000	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781000&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564890	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NCC2C			781000	US20250313563, Compound 919318	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781000	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781000&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564891	Cc1ccc(C(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)c(C)c1			781001	US20250313563, Compound 947294	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781001	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781001&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564892	Cc1ccc(C(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)c(C)c1			781001	US20250313563, Compound 947294	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781001	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781001&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564893	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@H](C)C2			781002	US20250313563, Compound 926212	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781002	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781002&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564894	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@H](C)C2			781002	US20250313563, Compound 926212	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781002	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781002&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564895	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC2(CC1)COC2			781003	US20250313563, Compound 883977	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781003	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781003&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564896	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC2(CC1)COC2			781003	US20250313563, Compound 883977	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781003	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781003&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564897	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@@H](C)C2			781004	US20250313563, Compound 926299	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781004	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781004&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564898	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@@H](C)C2			781004	US20250313563, Compound 926299	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781004	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781004&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564899	CC1(C)CC(=O)C3=C(C1)NC2=C(CN=N2)[C@]36COC5(CN(C(=O)C4CCOCC4)C5)C6			781005	US20250313563, Compound 945407	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781005	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781005&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177895369	523299351							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564900	CC1(C)CC(=O)C3=C(C1)NC2=C(CN=N2)[C@]36COC5(CN(C(=O)C4CCOCC4)C5)C6			781005	US20250313563, Compound 945407	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781005	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781005&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177895369	523299351							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564901	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@H](C)C2			781006	US20250313563, Compound 926300	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781006	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781006&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564902	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@H](C)C2			781006	US20250313563, Compound 926300	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781006	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781006&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564903	CC1CCCC1C(=O)N1CC2(C1)CC1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			781007	US20250313563, Compound 947274	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781007	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781007&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564904	CC1CCCC1C(=O)N1CC2(C1)CC1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			781007	US20250313563, Compound 947274	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781007	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781007&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564905	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@@H](C)C2			781008	US20250313563, Compound 926302	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781008	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781008&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564906	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@@H](C)C2			781008	US20250313563, Compound 926302	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781008	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781008&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564907	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CN(C(=O)C(F)(F)F)C2)C1			781009	US20250313563, Compound 948156	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781009	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781009&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564908	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CN(C(=O)C(F)(F)F)C2)C1			781009	US20250313563, Compound 948156	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781009	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781009&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564909	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781010	US20250313563, Compound 927325	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781010	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781010&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564910	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781010	US20250313563, Compound 927325	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781010	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781010&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564911	Cc1ccc(C)c(C(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)c1			781011	US20250313563, Compound 947285	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781011	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781011&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564912	Cc1ccc(C)c(C(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)c1			781011	US20250313563, Compound 947285	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781011	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781011&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564913	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781012	US20250313563, Compound 927326	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781012	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781012&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564914	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781012	US20250313563, Compound 927326	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781012	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781012&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564915	Cc1ccccc1C(=O)N1CC2(C1)CC1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			781013	US20250313563, Compound 947287	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781013	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781013&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564916	Cc1ccccc1C(=O)N1CC2(C1)CC1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			781013	US20250313563, Compound 947287	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781013	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781013&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564917	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781014	US20250313563, Compound 927389	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781014	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781014&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564918	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781014	US20250313563, Compound 927389	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781014	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781014&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564919	CC(=O)N1CCC2(C1)CC1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			781015	US20250313563, Compound 948040	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781015	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781015&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564920	CC(=O)N1CCC2(C1)CC1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			781015	US20250313563, Compound 948040	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781015	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781015&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564921	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781016	US20250313563, Compound 927390	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781016	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781016&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564922	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781016	US20250313563, Compound 927390	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781016	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781016&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564923	CC1(C)CC(=O)C3=C(C1)NC2=C(CN=N2)[C@@]37COC6(CN(C(=O)C4CCC5(CC4)COC5)C6)C7			781017	US20250313563, Compound 944075	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781017	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781017&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177895381	523299363							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564924	CC1(C)CC(=O)C3=C(C1)NC2=C(CN=N2)[C@@]37COC6(CN(C(=O)C4CCC5(CC4)COC5)C6)C7			781017	US20250313563, Compound 944075	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781017	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781017&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177895381	523299363							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564925	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccccc1)CC2			781018	US20250313563, Compound 929474	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781018	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781018&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564926	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccccc1)CC2			781018	US20250313563, Compound 929474	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781018	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781018&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564927	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21COC2(CN(C(=O)C(C)(F)F)C2)C1			781019	US20250313563, Compound 947839	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781019	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781019&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564928	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21COC2(CN(C(=O)C(C)(F)F)C2)C1			781019	US20250313563, Compound 947839	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781019	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781019&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564929	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccccc1)CC2			781020	US20250313563, Compound 929475	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781020	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781020&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564930	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccccc1)CC2			781020	US20250313563, Compound 929475	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781020	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781020&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564931	CCC(C)C(=O)N1CC2(C1)CC1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			781021	US20250313563, Compound 947270	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781021	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781021&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564932	CCC(C)C(=O)N1CC2(C1)CC1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			781021	US20250313563, Compound 947270	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781021	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781021&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564933	CCC1(c2cccc(-c3cc(C)nn3C)c2)C2=C(N=NC2)NC2=C1C(=O)NC(C)(C)C2			781022	US20250313563, Compound 943371	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781022	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781022&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564934	CCC1(c2cccc(-c3cc(C)nn3C)c2)C2=C(N=NC2)NC2=C1C(=O)NC(C)(C)C2			781022	US20250313563, Compound 943371	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781022	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781022&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564935	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3CCC(F)CC3)C2)C1			781023	US20250313563, Compound 947267	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781023	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781023&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564936	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3CCC(F)CC3)C2)C1			781023	US20250313563, Compound 947267	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781023	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781023&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564937	CCC1(c2cccc(-c3cnnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781024	US20250313563, Compound 943496	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781024	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781024&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564938	CCC1(c2cccc(-c3cnnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781024	US20250313563, Compound 943496	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781024	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781024&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564939	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3CCCCCC3)C2)C1			781025	US20250313563, Compound 947308	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781025	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781025&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564940	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3CCCCCC3)C2)C1			781025	US20250313563, Compound 947308	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781025	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781025&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564941	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781026	US20250313563, Compound 943912	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781026	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781026&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564942	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781026	US20250313563, Compound 943912	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781026	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781026&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564943	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3CCC(F)(F)C3)C2)C1			781027	US20250313563, Compound 947265	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781027	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781027&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564944	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3CCC(F)(F)C3)C2)C1			781027	US20250313563, Compound 947265	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781027	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781027&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564945	CC1(C)CC2=C(C(=O)N1)C1(CCN(S(C)(=O)=O)CC1)C1=C(N=NC1)N2			781028	US20250313563, Compound 943959	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781028	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781028&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564946	CC1(C)CC2=C(C(=O)N1)C1(CCN(S(C)(=O)=O)CC1)C1=C(N=NC1)N2			781028	US20250313563, Compound 943959	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781028	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781028&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564947	CC(C)C(=O)N1CC2(C1)CC1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			781029	US20250313563, Compound 947304	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781029	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781029&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564948	CC(C)C(=O)N1CC2(C1)CC1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			781029	US20250313563, Compound 947304	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781029	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781029&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564949	CC1(C)CC2=C(C(=O)N1)C1(CCN(S(=O)(=O)C3CCCC3)CC1)C1=C(N=NC1)N2			781030	US20250313563, Compound 943960	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781030	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781030&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564950	CC1(C)CC2=C(C(=O)N1)C1(CCN(S(=O)(=O)C3CCCC3)CC1)C1=C(N=NC1)N2			781030	US20250313563, Compound 943960	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781030	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781030&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564951	CC(=O)N1CC[C@]2(C1)C[C@@]1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			781031	US20250313563, Compound 948319	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781031	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781031&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564952	CC(=O)N1CC[C@]2(C1)C[C@@]1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			781031	US20250313563, Compound 948319	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781031	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781031&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564953	Cn1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)NC(C)(C)C2)n1			780625	US20250313563, Compound 943961	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780625&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564954	Cn1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)NC(C)(C)C2)n1			780625	US20250313563, Compound 943961	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780625&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564955	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3(C)CC(F)C3)C2)C1			781032	US20250313563, Compound 947271	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781032	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781032&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564956	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3(C)CC(F)C3)C2)C1			781032	US20250313563, Compound 947271	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781032	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781032&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564957	COc1cccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780595	US20250313563, Compound 943962	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780595&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564958	COc1cccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780595	US20250313563, Compound 943962	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780595&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564959	CC1CCC(C(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)C1			781033	US20250313563, Compound 947268	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781033	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781033&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564960	CC1CCC(C(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)C1			781033	US20250313563, Compound 947268	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781033	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781033&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564961	CC1(C)CC2=C(C(=O)N1)C1(CCN(S(=O)(=O)c3ccc(F)cc3)CC1)C1=C(N=NC1)N2			781034	US20250313563, Compound 943963	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781034	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781034&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564962	CC1(C)CC2=C(C(=O)N1)C1(CCN(S(=O)(=O)c3ccc(F)cc3)CC1)C1=C(N=NC1)N2			781034	US20250313563, Compound 943963	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781034	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781034&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564963	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3CC(C)(C)C3)C2)C1			781035	US20250313563, Compound 947282	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781035	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781035&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564964	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3CC(C)(C)C3)C2)C1			781035	US20250313563, Compound 947282	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781035	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781035&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564965	CC[C@]1(c2cccc(N(C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781036	US20250313563, Compound 943964	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781036	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781036&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564966	CC[C@]1(c2cccc(N(C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781036	US20250313563, Compound 943964	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781036	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781036&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564967	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3CCCC3)C2)C1			781037	US20250313563, Compound 917232	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781037	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781037&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564968	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3CCCC3)C2)C1			781037	US20250313563, Compound 917232	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781037	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781037&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564969	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781038	US20250313563, Compound 943965	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781038	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781038&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564970	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781038	US20250313563, Compound 943965	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781038	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781038&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564971	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3CCCCC3)C2)C1			781039	US20250313563, Compound 947291	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781039	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781039&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564972	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3CCCCC3)C2)C1			781039	US20250313563, Compound 947291	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781039	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781039&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564973	CC[C@]1(c2cccc(-c3cc(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781040	US20250313563, Compound 943966	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781040	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781040&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564974	CC[C@]1(c2cccc(-c3cc(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781040	US20250313563, Compound 943966	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781040	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781040&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564975	CC(=O)N1C[C@@]2(C[C@@]3(CO2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)[C@@H]1C			781041	US20250313563, Compound 948438	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781041	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781041&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564976	CC(=O)N1C[C@@]2(C[C@@]3(CO2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)[C@@H]1C			781041	US20250313563, Compound 948438	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781041	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781041&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564977	CC[C@@]1(c2cccc(-c3cc(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781042	US20250313563, Compound 943967	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781042	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781042&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564978	CC[C@@]1(c2cccc(-c3cc(C)nn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781042	US20250313563, Compound 943967	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781042	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781042&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564979	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)CC3CC(F)(F)C3)C2)C1			781043	US20250313563, Compound 947278	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781043	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781043&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564980	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)CC3CC(F)(F)C3)C2)C1			781043	US20250313563, Compound 947278	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781043	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781043&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564981	CCC1(c2cccc(S(C)(=O)=O)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781044	US20250313563, Compound 944020	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781044	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781044&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564982	CCC1(c2cccc(S(C)(=O)=O)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781044	US20250313563, Compound 944020	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781044	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781044&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564983	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)CC3CCC3)C2)C1			781045	US20250313563, Compound 947299	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781045	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781045&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564984	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)CC3CCC3)C2)C1			781045	US20250313563, Compound 947299	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781045	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781045&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564985	CCC1(c2cccc(-c3cnn(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781046	US20250313563, Compound 944021	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781046	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781046&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564986	CCC1(c2cccc(-c3cnn(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781046	US20250313563, Compound 944021	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781046	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781046&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564987	CC1(C)CC(=O)C3=C(C1)NC2=C(CN=N2)[C@@]35COC4(CN(S(C)(=O)=O)C4)C5			781047	US20250313563, Compound 913057	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781047	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781047&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177895409	523299393							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564988	CC1(C)CC(=O)C3=C(C1)NC2=C(CN=N2)[C@@]35COC4(CN(S(C)(=O)=O)C4)C5			781047	US20250313563, Compound 913057	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781047	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781047&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177895409	523299393							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564989	CCC1(c2cccc(C3=CN=NC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781048	US20250313563, Compound 944022	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781048	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781048&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564990	CCC1(c2cccc(C3=CN=NC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781048	US20250313563, Compound 944022	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781048	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781048&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564991	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21COC2(CN(C(=O)C3CCCC3)C2)C1			781049	US20250313563, Compound 943957	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781049	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781049&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564992	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21COC2(CN(C(=O)C3CCCC3)C2)C1			781049	US20250313563, Compound 943957	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781049	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781049&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564993	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781050	US20250313563, Compound 944027	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781050	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781050&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564994	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781050	US20250313563, Compound 944027	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781050	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781050&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564995	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C(C)(C)F)C2)C1			781051	US20250313563, Compound 947276	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781051	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781051&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564996	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C(C)(C)F)C2)C1			781051	US20250313563, Compound 947276	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781051	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781051&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564997	CCC1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781052	US20250313563, Compound 944028	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781052	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781052&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1564998	CCC1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781052	US20250313563, Compound 944028	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781052	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781052&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1564999	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC2(CC2)CC1			781053	US20250313563, Compound 893312	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781053	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781053&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565000	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC2(CC2)CC1			781053	US20250313563, Compound 893312	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781053	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781053&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565001	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781054	US20250313563, Compound 944030	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781054	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781054&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565002	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781054	US20250313563, Compound 944030	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781054	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781054&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565003	CC(C)CC(=O)N1CC2(C1)CC1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			781055	US20250313563, Compound 947302	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781055	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781055&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565004	CC(C)CC(=O)N1CC2(C1)CC1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			781055	US20250313563, Compound 947302	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781055	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781055&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565005	CC[C@]1(c2cccc(-c3cnnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781056	US20250313563, Compound 944071	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781056	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781056&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565006	CC[C@]1(c2cccc(-c3cnnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781056	US20250313563, Compound 944071	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781056	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781056&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565007	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3CCC(F)C3)C2)C1			781057	US20250313563, Compound 947486	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781057	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781057&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565008	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3CCC(F)C3)C2)C1			781057	US20250313563, Compound 947486	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781057	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781057&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565009	CC[C@@]1(c2cccc(-c3cnnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781058	US20250313563, Compound 944074	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781058	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781058&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565010	CC[C@@]1(c2cccc(-c3cnnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781058	US20250313563, Compound 944074	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781058	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781058&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565011	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)c3ccccc3F)C2)C1			781059	US20250313563, Compound 947289	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781059	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781059&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565012	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)c3ccccc3F)C2)C1			781059	US20250313563, Compound 947289	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781059	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781059&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565013	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@H](c1ccccc1)C2			781060	US20250313563, Compound 945361	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781060	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781060&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565014	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@H](c1ccccc1)C2			781060	US20250313563, Compound 945361	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781060	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781060&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565015	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3CC3)C2)C1			781061	US20250313563, Compound 947297	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781061	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781061&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565016	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3CC3)C2)C1			781061	US20250313563, Compound 947297	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781061	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781061&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565017	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@@H](c1ccccc1)C2			781062	US20250313563, Compound 945362	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781062	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781062&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565018	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@@H](c1ccccc1)C2			781062	US20250313563, Compound 945362	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781062	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781062&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565019	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3(F)CCCC3)C2)C1			781063	US20250313563, Compound 947277	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781063	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781063&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565020	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3(F)CCCC3)C2)C1			781063	US20250313563, Compound 947277	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781063	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781063&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565021	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@H](c1ccccc1)C2			781064	US20250313563, Compound 945363	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781064	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781064&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565022	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@H](c1ccccc1)C2			781064	US20250313563, Compound 945363	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781064	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781064&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565023	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)c3cccc(F)c3)C2)C1			781065	US20250313563, Compound 947283	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781065	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781065&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565024	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)c3cccc(F)c3)C2)C1			781065	US20250313563, Compound 947283	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781065	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781065&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565025	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@@H](c1ccccc1)C2			781066	US20250313563, Compound 945364	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781066	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781066&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565026	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@@H](c1ccccc1)C2			781066	US20250313563, Compound 945364	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781066	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781066&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565027	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)c3ccc(F)cc3)C2)C1			781067	US20250313563, Compound 947292	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781067	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781067&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565028	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)c3ccc(F)cc3)C2)C1			781067	US20250313563, Compound 947292	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781067	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781067&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565029	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC[C@@H]2C			781068	US20250313563, Compound 945382	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781068	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781068&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565030	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC[C@@H]2C			781068	US20250313563, Compound 945382	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781068	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781068&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565031	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3(C)CCCC3)C2)C1			781069	US20250313563, Compound 947307	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781069	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781069&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565032	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3(C)CCCC3)C2)C1			781069	US20250313563, Compound 947307	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781069	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781069&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565033	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC[C@H]2C			781070	US20250313563, Compound 945383	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781070	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781070&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565034	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC[C@H]2C			781070	US20250313563, Compound 945383	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781070	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781070&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565035	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3(F)CC3)C2)C1			781071	US20250313563, Compound 947487	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781071	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781071&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565036	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3(F)CC3)C2)C1			781071	US20250313563, Compound 947487	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781071	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781071&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565037	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC[C@@H]2C			781072	US20250313563, Compound 945384	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781072	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781072&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565038	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC[C@@H]2C			781072	US20250313563, Compound 945384	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781072	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781072&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565039	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C(C)(C)C)C2)C1			781073	US20250313563, Compound 947303	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781073	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781073&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565040	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C(C)(C)C)C2)C1			781073	US20250313563, Compound 947303	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781073	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781073&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565041	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC[C@H]2C			781074	US20250313563, Compound 945385	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781074	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781074&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565042	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC[C@H]2C			781074	US20250313563, Compound 945385	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781074	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781074&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565043	CCCC(=O)N1CC2(C1)CC1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			781075	US20250313563, Compound 947300	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781075	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781075&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565044	CCCC(=O)N1CC2(C1)CC1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			781075	US20250313563, Compound 947300	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781075	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781075&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565045	CCC1(c2cccc(C3=CN=NC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781076	US20250313563, Compound 945459	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781076	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781076&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565046	CCC1(c2cccc(C3=CN=NC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781076	US20250313563, Compound 945459	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781076	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781076&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565047	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CN(C(=O)[C@@H]3CC3(F)F)C2)C1			781077	US20250313563, Compound 948219	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781077	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781077&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565048	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CN(C(=O)[C@@H]3CC3(F)F)C2)C1			781077	US20250313563, Compound 948219	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781077	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781077&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565049	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781078	US20250313563, Compound 945460	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781078	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781078&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565050	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781078	US20250313563, Compound 945460	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781078	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781078&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565051	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)c3ccccc3)C2)C1			781079	US20250313563, Compound 917231	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781079	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781079&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565052	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)c3ccccc3)C2)C1			781079	US20250313563, Compound 917231	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781079	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781079&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565053	CCC1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781080	US20250313563, Compound 945461	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781080	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781080&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565054	CCC1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781080	US20250313563, Compound 945461	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781080	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781080&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565055	CC(C)C1CC(C(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)C1			781081	US20250313563, Compound 947273	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781081	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781081&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565056	CC(C)C1CC(C(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)C1			781081	US20250313563, Compound 947273	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781081	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781081&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565057	CCC1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781082	US20250313563, Compound 945462	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781082	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781082&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565058	CCC1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781082	US20250313563, Compound 945462	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781082	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781082&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565059	Cc1ccc(C(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)cc1C			781083	US20250313563, Compound 947286	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781083	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781083&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565060	Cc1ccc(C(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)cc1C			781083	US20250313563, Compound 947286	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781083	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781083&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565061	CCC1(c2cccc(S(=O)(=O)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781084	US20250313563, Compound 945464	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781084	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781084&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565062	CCC1(c2cccc(S(=O)(=O)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781084	US20250313563, Compound 945464	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781084	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781084&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565063	Cc1ccc(C(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)cc1			781085	US20250313563, Compound 947290	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781085	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781085&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565064	Cc1ccc(C(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)cc1			781085	US20250313563, Compound 947290	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781085	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781085&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565065	CCC1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781086	US20250313563, Compound 945465	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781086	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781086&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565066	CCC1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781086	US20250313563, Compound 945465	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781086	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781086&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565067	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)CC3CCCC3)C2)C1			781087	US20250313563, Compound 947293	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781087	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781087&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565068	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)CC3CCCC3)C2)C1			781087	US20250313563, Compound 947293	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781087	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781087&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565069	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781088	US20250313563, Compound 945470	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781088	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781088&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565070	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781088	US20250313563, Compound 945470	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781088	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781088&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565071	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)CC3CC3)C2)C1			781089	US20250313563, Compound 947298	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781089	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781089&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565072	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)CC3CC3)C2)C1			781089	US20250313563, Compound 947298	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781089	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781089&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565073	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781090	US20250313563, Compound 945480	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781090	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781090&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565074	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781090	US20250313563, Compound 945480	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781090	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781090&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565075	CC1(C)CC(=O)C3=C(C1)NC2=C(CN=N2)[C@@]35COC4(CN(S(C)(=O)=O)C4)C5			781091	US20250313563, Compound 926808	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781091	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781091&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177895409	523299437							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565076	CC1(C)CC(=O)C3=C(C1)NC2=C(CN=N2)[C@@]35COC4(CN(S(C)(=O)=O)C4)C5			781091	US20250313563, Compound 926808	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781091	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781091&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177895409	523299437							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565077	CCC1(c2cccc(-c3cncn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781092	US20250313563, Compound 945597	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781092	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781092&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565078	CCC1(c2cccc(-c3cncn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781092	US20250313563, Compound 945597	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781092	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781092&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565079	CC1CC(C(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)C1			781093	US20250313563, Compound 947266	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781093	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781093&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565080	CC1CC(C(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)C1			781093	US20250313563, Compound 947266	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781093	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781093&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565081	CCC1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781094	US20250313563, Compound 945598	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781094	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781094&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565082	CCC1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781094	US20250313563, Compound 945598	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781094	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781094&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565083	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3CC3(F)F)C2)C1			781095	US20250313563, Compound 947272	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781095	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781095&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565084	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3CC3(F)F)C2)C1			781095	US20250313563, Compound 947272	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781095	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781095&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565085	CCC1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781096	US20250313563, Compound 945599	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781096	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781096&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565086	CCC1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781096	US20250313563, Compound 945599	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781096	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781096&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565087	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3(F)CCC3)C2)C1			781097	US20250313563, Compound 947279	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781097	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781097&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565088	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3(F)CCC3)C2)C1			781097	US20250313563, Compound 947279	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781097	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781097&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565089	CCC4(c2cccc(N1CCOCC1)c2)C3=CN=NC3NC5=C4C(=O)NC(C)(C)C5			781098	US20250313563, Compound 945602	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781098	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781098&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177895458	523299444							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565090	CCC4(c2cccc(N1CCOCC1)c2)C3=CN=NC3NC5=C4C(=O)NC(C)(C)C5			781098	US20250313563, Compound 945602	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781098	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781098&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177895458	523299444							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565091	Cc1cc(C)cc(C(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)c1			781099	US20250313563, Compound 947296	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781099	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781099&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565092	Cc1cc(C)cc(C(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)c1			781099	US20250313563, Compound 947296	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781099	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781099&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565093	CCC1(c2cccc(-c3cnn4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781100	US20250313563, Compound 945603	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781100	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781100&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565094	CCC1(c2cccc(-c3cnn4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781100	US20250313563, Compound 945603	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781100	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781100&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565095	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CC2(CCCC2)C1			781101	US20250313563, Compound 874477	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781101	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781101&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565096	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CC2(CCCC2)C1			781101	US20250313563, Compound 874477	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781101	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781101&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565097	CC[C@@]1(c2cccc(S(C)(=O)=O)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781102	US20250313563, Compound 945604	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781102	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781102&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565098	CC[C@@]1(c2cccc(S(C)(=O)=O)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781102	US20250313563, Compound 945604	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781102	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781102&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565099	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21COC2(CN(C(=O)c3ccccc3)C2)C1			781103	US20250313563, Compound 943955	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781103	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781103&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565100	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21COC2(CN(C(=O)c3ccccc3)C2)C1			781103	US20250313563, Compound 943955	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781103	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781103&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565101	CC[C@@]1(c2cccc(-c3cnn(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781104	US20250313563, Compound 945608	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781104	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781104&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565102	CC[C@@]1(c2cccc(-c3cnn(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781104	US20250313563, Compound 945608	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781104	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781104&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565103	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C(F)(F)F)C2)C1			781105	US20250313563, Compound 947280	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781105	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781105&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565104	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C(F)(F)F)C2)C1			781105	US20250313563, Compound 947280	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781105	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781105&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565105	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781106	US20250313563, Compound 945611	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781106	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781106&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565106	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781106	US20250313563, Compound 945611	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781106	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781106&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565107	Cc1ccccc1CC(=O)N1CC2(C1)CC1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			781107	US20250313563, Compound 947295	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781107	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781107&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565108	Cc1ccccc1CC(=O)N1CC2(C1)CC1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			781107	US20250313563, Compound 947295	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781107	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781107&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565109	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781108	US20250313563, Compound 945614	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781108	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781108&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565110	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781108	US20250313563, Compound 945614	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781108	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781108&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565111	CC1CCC(CC(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)C1			781109	US20250313563, Compound 947269	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781109	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781109&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565112	CC1CCC(CC(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)C1			781109	US20250313563, Compound 947269	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781109	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781109&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565113	CC[C@]1(c2cccc(-c3cnn(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781110	US20250313563, Compound 945617	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781110	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781110&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565114	CC[C@]1(c2cccc(-c3cnn(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781110	US20250313563, Compound 945617	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781110	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781110&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565115	Cc1ccc(CC(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)cc1			781111	US20250313563, Compound 947281	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781111	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781111&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565116	Cc1ccc(CC(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)cc1			781111	US20250313563, Compound 947281	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781111	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781111&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565117	CC[C@]1(c2cccc(S(C)(=O)=O)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781112	US20250313563, Compound 945621	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781112	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781112&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565118	CC[C@]1(c2cccc(S(C)(=O)=O)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781112	US20250313563, Compound 945621	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781112	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781112&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565119	CC1CC(C(=O)N2CC3(C2)C[C@@]2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)C1			781113	US20250313563, Compound 947733	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781113	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781113&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565120	CC1CC(C(=O)N2CC3(C2)C[C@@]2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)C1			781113	US20250313563, Compound 947733	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781113	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781113&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565121	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C(C)(C)C)CC2			781114	US20250313563, Compound 945633	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781114	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781114&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565122	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C(C)(C)C)CC2			781114	US20250313563, Compound 945633	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781114	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781114&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565123	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CN(C(=O)C3(F)CCC3)C2)C1			781115	US20250313563, Compound 947735	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781115	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781115&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565124	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CN(C(=O)C3(F)CCC3)C2)C1			781115	US20250313563, Compound 947735	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781115	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781115&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565125	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C(C)(C)C)CC2			781116	US20250313563, Compound 945634	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781116	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781116&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565126	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C(C)(C)C)CC2			781116	US20250313563, Compound 945634	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781116	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781116&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565127	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CC2(CCOCC2)C1			781117	US20250313563, Compound 874534	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781117	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781117&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565128	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CC2(CCOCC2)C1			781117	US20250313563, Compound 874534	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781117	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781117&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565129	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C(C)(C)C)C2			781118	US20250313563, Compound 945635	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781118	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781118&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565130	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C(C)(C)C)C2			781118	US20250313563, Compound 945635	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781118	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781118&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565131	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C(C)(F)F)C2)C1			781119	US20250313563, Compound 947275	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781119	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781119&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565132	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C(C)(F)F)C2)C1			781119	US20250313563, Compound 947275	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781119	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781119&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565133	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cccnc1)CC2			781120	US20250313563, Compound 945637	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781120	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781120&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565134	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cccnc1)CC2			781120	US20250313563, Compound 945637	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781120	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781120&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565135	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3CCC3)C2)C1			781121	US20250313563, Compound 947288	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781121	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781121&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565136	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3CCC3)C2)C1			781121	US20250313563, Compound 947288	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781121	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781121&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565137	CCC1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781122	US20250313563, Compound 945722	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781122	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781122&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565138	CCC1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781122	US20250313563, Compound 945722	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781122	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781122&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565139	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)CC3CCCCC3)C2)C1			781123	US20250313563, Compound 947305	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781123	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781123&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565140	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)CC3CCCCC3)C2)C1			781123	US20250313563, Compound 947305	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781123	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781123&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565141	CCC1(c2cccc(N3CCCC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781124	US20250313563, Compound 945723	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781124	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781124&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565142	CCC1(c2cccc(N3CCCC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781124	US20250313563, Compound 945723	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781124	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781124&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565143	Cc1ccc(C(=O)N2CC3(C2)C[C@]2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)cc1C			781125	US20250313563, Compound 948038	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781125	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781125&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565144	Cc1ccc(C(=O)N2CC3(C2)C[C@]2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)cc1C			781125	US20250313563, Compound 948038	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781125	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781125&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565145	CC[C@]1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781126	US20250313563, Compound 945727	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781126	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781126&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565146	CC[C@]1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781126	US20250313563, Compound 945727	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781126	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781126&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565147	CC(=O)N1CC2(C1)CC1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			781127	US20250313563, Compound 913058	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781127	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781127&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565148	CC(=O)N1CC2(C1)CC1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			781127	US20250313563, Compound 913058	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781127	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781127&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565149	CC[C@@]1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781128	US20250313563, Compound 945731	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781128	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781128&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565150	CC[C@@]1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781128	US20250313563, Compound 945731	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781128	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781128&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565151	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C(F)F)C2)C1			781129	US20250313563, Compound 947485	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781129	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781129&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565152	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C(F)F)C2)C1			781129	US20250313563, Compound 947485	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781129	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781129&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565153	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@H](C(C)(C)C)C2			781130	US20250313563, Compound 945920	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781130	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781130&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565154	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@H](C(C)(C)C)C2			781130	US20250313563, Compound 945920	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781130	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781130&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565155	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CN(C(=O)[C@H]3CC3(F)F)C2)C1			781131	US20250313563, Compound 948215	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781131	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781131&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565156	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CN(C(=O)[C@H]3CC3(F)F)C2)C1			781131	US20250313563, Compound 948215	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781131	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781131&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565157	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@@H](C(C)(C)C)C2			781132	US20250313563, Compound 945921	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781132	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781132&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565158	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@@H](C(C)(C)C)C2			781132	US20250313563, Compound 945921	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781132	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781132&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565159	Cc1cc(C)cc(C(=O)N2CC3(C2)C[C@@]2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)c1			781133	US20250313563, Compound 948223	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781133	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781133&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565160	Cc1cc(C)cc(C(=O)N2CC3(C2)C[C@@]2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)c1			781133	US20250313563, Compound 948223	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781133	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781133&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565161	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@H](C(C)(C)C)C2			781134	US20250313563, Compound 945922	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781134	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781134&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565162	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@H](C(C)(C)C)C2			781134	US20250313563, Compound 945922	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781134	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781134&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565163	CC(=O)N1C[C@@]2(C[C@]3(CO2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)[C@@H]1C			781135	US20250313563, Compound 948440	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781135	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781135&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565164	CC(=O)N1C[C@@]2(C[C@]3(CO2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)[C@@H]1C			781135	US20250313563, Compound 948440	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781135	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781135&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565165	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@@H](C(C)(C)C)C2			781136	US20250313563, Compound 945923	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781136	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781136&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565166	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@@H](C(C)(C)C)C2			781136	US20250313563, Compound 945923	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781136	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781136&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565167	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CN(C(=O)C(C)(F)F)C2)C1			781137	US20250313563, Compound 947838	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781137	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781137&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565168	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CN(C(=O)C(C)(F)F)C2)C1			781137	US20250313563, Compound 947838	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781137	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781137&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565169	CCC1(c2cccc(-c3cnn4c3CCCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781138	US20250313563, Compound 945993	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781138	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781138&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565170	CCC1(c2cccc(-c3cnn4c3CCCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781138	US20250313563, Compound 945993	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781138	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781138&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565171	C[C@@H]1C[C@@H]2C[C@@]3(C[C@@H]2C1)C1=CN=NC1NC1=C3C(=O)CC(C)(C)C1			781139	US20250313563, Compound 943898	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781139	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781139&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565172	C[C@@H]1C[C@@H]2C[C@@]3(C[C@@H]2C1)C1=CN=NC1NC1=C3C(=O)CC(C)(C)C1			781139	US20250313563, Compound 943898	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781139	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781139&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565173	CCC1(c2cccc(-c3ccnc(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781140	US20250313563, Compound 945994	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781140	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781140&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565174	CCC1(c2cccc(-c3ccnc(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781140	US20250313563, Compound 945994	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781140	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781140&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565175	C[C@H]1C[C@@H]2C[C@@]3(C[C@@H]2C1)C1=CN=NC1NC1=C3C(=O)CC(C)(C)C1			781141	US20250313563, Compound 943896	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781141	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781141&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565176	C[C@H]1C[C@@H]2C[C@@]3(C[C@@H]2C1)C1=CN=NC1NC1=C3C(=O)CC(C)(C)C1			781141	US20250313563, Compound 943896	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781141	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781141&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565177	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781142	US20250313563, Compound 945996	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781142	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781142&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565178	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781142	US20250313563, Compound 945996	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781142	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781142&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565179	CC1(C)CC2=C(C(=O)N1)C1(CCN(S(=O)(=O)c3cnn(C(C)(C)C)c3)CC1)C1=C(N=NC1)N2			778789	US20250313563, Compound 947835	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778789	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778789&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565180	CC1(C)CC2=C(C(=O)N1)C1(CCN(S(=O)(=O)c3cnn(C(C)(C)C)c3)CC1)C1=C(N=NC1)N2			778789	US20250313563, Compound 947835	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778789	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778789&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565181	CC[C@@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781143	US20250313563, Compound 945999	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781143	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781143&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565182	CC[C@@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781143	US20250313563, Compound 945999	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781143	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781143&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565183	CCn1ccc(S(=O)(=O)N2CCC3(CC2)C2=CN=NC2NC2=C3C(=O)NC(C)(C)C2)n1			778791	US20250313563, Compound 947836	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778791	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778791&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565184	CCn1ccc(S(=O)(=O)N2CCC3(CC2)C2=CN=NC2NC2=C3C(=O)NC(C)(C)C2)n1			778791	US20250313563, Compound 947836	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778791	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778791&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565185	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781144	US20250313563, Compound 946001	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781144	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781144&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565186	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781144	US20250313563, Compound 946001	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781144	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781144&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565187	CC1(C)CC2=C(C(=O)N1)C1(CCN(S(C)(=O)=O)CC1)C1=C(N=NC1)N2			781028	US20250313563, Compound 943959	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781028	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781028&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565188	CC1(C)CC2=C(C(=O)N1)C1(CCN(S(C)(=O)=O)CC1)C1=C(N=NC1)N2			781028	US20250313563, Compound 943959	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781028	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781028&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565189	CC[C@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781145	US20250313563, Compound 946004	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781145	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781145&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565190	CC[C@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781145	US20250313563, Compound 946004	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781145	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781145&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565191	CCc1ncc(S(=O)(=O)N2CCC3(CC2)C2=CN=NC2NC2=C3C(=O)NC(C)(C)C2)s1			778793	US20250313563, Compound 947837	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778793	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778793&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565192	CCc1ncc(S(=O)(=O)N2CCC3(CC2)C2=CN=NC2NC2=C3C(=O)NC(C)(C)C2)s1			778793	US20250313563, Compound 947837	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778793	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778793&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565193	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccc(OC)cc1)CC2			781146	US20250313563, Compound 947332	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781146	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781146&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565194	CCC1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccc(OC)cc1)CC2			781146	US20250313563, Compound 947332	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781146	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781146&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565195	CC1(C)CC2=C(C(=O)N1)C1(CCN(S(=O)(=O)c3ccc(F)cc3)CC1)C1=C(N=NC1)N2			781034	US20250313563, Compound 943963	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781034	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781034&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565196	CC1(C)CC2=C(C(=O)N1)C1(CCN(S(=O)(=O)c3ccc(F)cc3)CC1)C1=C(N=NC1)N2			781034	US20250313563, Compound 943963	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781034	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781034&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565197	CCC1(c2cccc(S(C)(=O)=O)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781147	US20250313563, Compound 947395B:	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781147	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781147&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565198	CCC1(c2cccc(S(C)(=O)=O)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781147	US20250313563, Compound 947395B:	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781147	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781147&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565199	CC1(C)CC2=C(C(=O)N1)C1(CCN(S(=O)(=O)C3CCCC3)CC1)C1=C(N=NC1)N2			781030	US20250313563, Compound 943960	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781030	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781030&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565200	CC1(C)CC2=C(C(=O)N1)C1(CCN(S(=O)(=O)C3CCCC3)CC1)C1=C(N=NC1)N2			781030	US20250313563, Compound 943960	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781030	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781030&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565201	CC[C@@]1(c2cccc(-c3cncn3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779189	US20250313563, Compound 949010	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779189	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779189&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565202	CC[C@@]1(c2cccc(-c3cncn3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779189	US20250313563, Compound 949010	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779189	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779189&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565203	CC[C@@]1(c2cccc(-c3ccnc(C)c3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780530	US20250313563, Compound 945997	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780530	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780530&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565204	CC[C@@]1(c2cccc(-c3ccnc(C)c3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780530	US20250313563, Compound 945997	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780530	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780530&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565205	CC[C@@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780503	US20250313563, Compound 945713	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780503	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780503&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565206	CC[C@@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780503	US20250313563, Compound 945713	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780503	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780503&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565207	CC(C)S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)[C@@H]1F			780922	US20250313563, Compound 951714	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780922	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780922&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565208	CC(C)S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)[C@@H]1F			780922	US20250313563, Compound 951714	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780922	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780922&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565209	CC[C@]1(c2cccc(OC(C)C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780684	US20250313563, Compound 947867	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780684	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780684&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565210	CC[C@]1(c2cccc(OC(C)C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780684	US20250313563, Compound 947867	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780684	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780684&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565211	CC[C@]1(c2cccc(N(C)c3cccnn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779458	US20250313563, Compound 911975	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779458	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779458&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565212	CC[C@]1(c2cccc(N(C)c3cccnn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779458	US20250313563, Compound 911975	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779458	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779458&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565213	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780576	US20250313563, Compound 947324	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780576	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780576&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565214	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780576	US20250313563, Compound 947324	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780576	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780576&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565215	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CN(C(=O)[C@H]3CC3(F)F)C2)C1			781131	US20250313563, Compound 948215	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781131	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781131&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565216	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CN(C(=O)[C@H]3CC3(F)F)C2)C1			781131	US20250313563, Compound 948215	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781131	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781131&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565217	CC[C@@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780586	US20250313563, Compound 947329	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780586&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565218	CC[C@@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780586	US20250313563, Compound 947329	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780586&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565219	CC[C@@]1(c2cccc(-c3ccnc4c3CCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779133	US20250313563, Compound 948778	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779133	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779133&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565220	CC[C@@]1(c2cccc(-c3ccnc4c3CCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779133	US20250313563, Compound 948778	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779133	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779133&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565221	CC[C@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780714	US20250313563, Compound 948546	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780714	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780714&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565222	CC[C@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780714	US20250313563, Compound 948546	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780714	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780714&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565223	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2cccc(F)c2)C1			780904	US20250313563, Compound 951861	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780904	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780904&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565224	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2cccc(F)c2)C1			780904	US20250313563, Compound 951861	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780904	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780904&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565225	CC[C@@]1(c2cccc(-c3cncn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779555	US20250313563, Compound 913032	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779555&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565226	CC[C@@]1(c2cccc(-c3cncn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779555	US20250313563, Compound 913032	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779555&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565227	Cc1ccc(CC(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)cc1			781111	US20250313563, Compound 947281	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781111	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781111&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565228	Cc1ccc(CC(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)cc1			781111	US20250313563, Compound 947281	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781111	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781111&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565229	CC[C@@]1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779104	US20250313563, Compound 819575	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779104	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779104&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565230	CC[C@@]1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779104	US20250313563, Compound 819575	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779104	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779104&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565231	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)CC2CC2)C1			780793	US20250313563, Compound 943481	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780793	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780793&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565232	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)CC2CC2)C1			780793	US20250313563, Compound 943481	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780793	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780793&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565233	CC[C@@]1(c2cccc(-c3cn(C)nc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779475	US20250313563, Compound 950563	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779475&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565234	CC[C@@]1(c2cccc(-c3cn(C)nc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779475	US20250313563, Compound 950563	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779475&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565235	Cc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)s1			780853	US20250313563, Compound 945672	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780853	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780853&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565236	Cc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)s1			780853	US20250313563, Compound 945672	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780853	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780853&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565237	CC[C@@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778907	US20250313563, Compound 948185	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778907&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565238	CC[C@@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778907	US20250313563, Compound 948185	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778907&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565239	CC[C@@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780716	US20250313563, Compound 948547	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780716	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780716&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565240	CC[C@@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780716	US20250313563, Compound 948547	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780716	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780716&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565241	CC[C@]1(c2cccc(C3=CN=NC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778945	US20250313563, Compound 948307	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778945	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778945&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565242	CC[C@]1(c2cccc(C3=CN=NC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778945	US20250313563, Compound 948307	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778945	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778945&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565243	CC[C@@]1(c2ccccc2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)F)=C21			779248	US20250313563, Compound 874510	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779248	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779248&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565244	CC[C@@]1(c2ccccc2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)F)=C21			779248	US20250313563, Compound 874510	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779248	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779248&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565245	CC[C@]1(c2cccc(C(F)F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780501	US20250313563, Compound 945710	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780501&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565246	CC[C@]1(c2cccc(C(F)F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780501	US20250313563, Compound 945710	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780501&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565247	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C(C)(F)F)C2)C1			781119	US20250313563, Compound 947275	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781119	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781119&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565248	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C(C)(F)F)C2)C1			781119	US20250313563, Compound 947275	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781119	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781119&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565249	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778772	US20250313563, Compound 947814	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778772	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778772&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565250	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778772	US20250313563, Compound 947814	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778772	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778772&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565251	CC[C@@]1(c2cccc(-c3c(F)cncc3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778983	US20250313563, Compound 948371	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778983	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778983&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565252	CC[C@@]1(c2cccc(-c3c(F)cncc3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778983	US20250313563, Compound 948371	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778983	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778983&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565253	CCC1(c2cccc(S(=O)(=O)C3CC3)c2)C2=C(CC(C)(C)NC2=O)NC2=C1C(C(F)(F)F)N=N2			778797	US20250313563, Compound 947859	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778797	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778797&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565254	CCC1(c2cccc(S(=O)(=O)C3CC3)c2)C2=C(CC(C)(C)NC2=O)NC2=C1C(C(F)(F)F)N=N2			778797	US20250313563, Compound 947859	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778797	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778797&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565255	CC[C@@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			779251	US20250313563, Compound 949177	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779251	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779251&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565256	CC[C@@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			779251	US20250313563, Compound 949177	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779251	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779251&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565257	CC[C@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780638	US20250313563, Compound 947511	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780638&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565258	CC[C@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780638	US20250313563, Compound 947511	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780638&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565259	Cc1cc(C)cc(C(=O)N2CC3(C2)C[C@@]2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)c1			781133	US20250313563, Compound 948223	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781133	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781133&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565260	Cc1cc(C)cc(C(=O)N2CC3(C2)C[C@@]2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)c1			781133	US20250313563, Compound 948223	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781133	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781133&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565261	CC[C@]1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779102	US20250313563, Compound 819574	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779102	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779102&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565262	CC[C@]1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779102	US20250313563, Compound 819574	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779102	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779102&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565263	CC1(C)CC2=C(C(=O)N1)C1(CCN(S(=O)(=O)C3CCCC3)CC1)C1=C(N=NC1)N2			781030	US20250313563, Compound 943960	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781030	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781030&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565264	CC1(C)CC2=C(C(=O)N1)C1(CCN(S(=O)(=O)C3CCCC3)CC1)C1=C(N=NC1)N2			781030	US20250313563, Compound 943960	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781030	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781030&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565265	CC[C@]1(c2cccc(S(C)(=O)=O)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778993	US20250313563, Compound 948418	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778993	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778993&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565266	CC[C@]1(c2cccc(S(C)(=O)=O)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778993	US20250313563, Compound 948418	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778993	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778993&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565267	CC1(C)CC2=C(C(=O)N1)C1(CCN(S(=O)(=O)C3CCCC3)CC1)C1=C(N=NC1)N2			781030	US20250313563, Compound 943960	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781030	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781030&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565268	CC1(C)CC2=C(C(=O)N1)C1(CCN(S(=O)(=O)C3CCCC3)CC1)C1=C(N=NC1)N2			781030	US20250313563, Compound 943960	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781030	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781030&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565269	CC[C@@]1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778777	US20250313563, Compound 947819	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778777	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778777&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565270	CC[C@@]1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778777	US20250313563, Compound 947819	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778777	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778777&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565271	COc1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)ccc1F			780827	US20250313563, Compound 947263	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780827	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780827&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565272	COc1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)ccc1F			780827	US20250313563, Compound 947263	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780827	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780827&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565273	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779022	US20250313563, Compound 811565	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779022	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779022&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565274	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779022	US20250313563, Compound 811565	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779022	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779022&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565275	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			780984	US20250313563, Compound 914308	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780984	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780984&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565276	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			780984	US20250313563, Compound 914308	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780984	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780984&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565277	CC[C@]1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779042	US20250313563, Compound 816800	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779042	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779042&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565278	CC[C@]1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779042	US20250313563, Compound 816800	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779042	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779042&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565279	COc1cccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780813	US20250313563, Compound 901468	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780813&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565280	COc1cccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780813	US20250313563, Compound 901468	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780813&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565281	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779561	US20250313563, Compound 913035	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779561	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779561&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565282	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779561	US20250313563, Compound 913035	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779561	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779561&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565283	CC[C@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)C2			780911	US20250313563, Compound 948549	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780911	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780911&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565284	CC[C@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)C2			780911	US20250313563, Compound 948549	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780911	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780911&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565285	CC[C@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779577	US20250313563, Compound 913043	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779577	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779577&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565286	CC[C@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779577	US20250313563, Compound 913043	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779577	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779577&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565287	CC[C@]1(c2cccc(C(F)(F)C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780728	US20250313563, Compound 949103	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780728	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780728&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565288	CC[C@]1(c2cccc(C(F)(F)C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780728	US20250313563, Compound 949103	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780728	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780728&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565289	CC[C@]1(c2cccc(-c3cc(C)nnc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779423	US20250313563, Compound 949917	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779423	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779423&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565290	CC[C@]1(c2cccc(-c3cc(C)nnc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779423	US20250313563, Compound 949917	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779423	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779423&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565291	CC[C@@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780812	US20250313563, Compound 959343	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780812	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780812&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565292	CC[C@@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780812	US20250313563, Compound 959343	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780812	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780812&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565293	CC[C@@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778999	US20250313563, Compound 948421	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778999	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778999&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565294	CC[C@@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778999	US20250313563, Compound 948421	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778999	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778999&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565295	CCC1(c2cccc(S(C)(=O)=O)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781148	US20250313563, Compound 947395	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781148	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781148&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565296	CCC1(c2cccc(S(C)(=O)=O)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781148	US20250313563, Compound 947395	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781148	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781148&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565297	CCC1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780435	US20250313563, Compound 945527	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780435	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780435&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565298	CCC1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780435	US20250313563, Compound 945527	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780435	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780435&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565299	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCOCC1)C2			778961	US20250313563, Compound 948359	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778961	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778961&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565300	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCOCC1)C2			778961	US20250313563, Compound 948359	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778961	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778961&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565301	CCN(c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1)c1ncccn1			780588	US20250313563, Compound 947333	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780588	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780588&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565302	CCN(c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1)c1ncccn1			780588	US20250313563, Compound 947333	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780588	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780588&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565303	CC[C@]1(c2cccc(N(C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781036	US20250313563, Compound 943964	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781036	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781036&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565304	CC[C@]1(c2cccc(N(C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781036	US20250313563, Compound 943964	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781036	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781036&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565305	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780602	US20250313563, Compound 947372	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780602&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565306	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780602	US20250313563, Compound 947372	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780602&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565307	Cc1ncc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)o1			780864	US20250313563, Compound 947611	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780864&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565308	Cc1ncc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)o1			780864	US20250313563, Compound 947611	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780864&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565309	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779259	US20250313563, Compound 949181	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779259	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779259&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565310	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779259	US20250313563, Compound 949181	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779259	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779259&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565311	CCC1(c2cccc(C(F)(F)F)c2)C2=C(NC3=NN=CC31)c1ccccc1C2=O			779646	US20250313563, Compound 948205	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779646&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565312	CCC1(c2cccc(C(F)(F)F)c2)C2=C(NC3=NN=CC31)c1ccccc1C2=O			779646	US20250313563, Compound 948205	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779646&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565313	CCC1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780497	US20250313563, Compound 945704	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780497	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780497&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565314	CCC1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780497	US20250313563, Compound 945704	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780497	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780497&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565315	CC[C@]1(c2cccc(-c3ccncc3C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779708	US20250313563, Compound 952759	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779708	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779708&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565316	CC[C@]1(c2cccc(-c3ccncc3C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779708	US20250313563, Compound 952759	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779708	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779708&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565317	CC[C@]1(c2cccc(S(=O)(=O)CC3CC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779247	US20250313563, Compound 949175	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779247	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779247&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565318	CC[C@]1(c2cccc(S(=O)(=O)CC3CC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779247	US20250313563, Compound 949175	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779247	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779247&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565319	CC[C@@]1(c2cccc(-c3ccnn3C3CC3(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779501	US20250313563, Compound 950824	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779501&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565320	CC[C@@]1(c2cccc(-c3ccnn3C3CC3(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779501	US20250313563, Compound 950824	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779501&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565321	CC[C@]1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779520	US20250313563, Compound 951607	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779520&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565322	CC[C@]1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779520	US20250313563, Compound 951607	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779520&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565323	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnc3cccnn23)CC1			780809	US20250313563, Compound 948120	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780809	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780809&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565324	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnc3cccnn23)CC1			780809	US20250313563, Compound 948120	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780809	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780809&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565325	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)Nc2[nH]nc(Cl)c21			779311	US20250313563, Compound 949336	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779311	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779311&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565326	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)Nc2[nH]nc(Cl)c21			779311	US20250313563, Compound 949336	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779311	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779311&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565327	CCOc1cccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780858	US20250313563, Compound 947253	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780858&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565328	CCOc1cccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780858	US20250313563, Compound 947253	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780858&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565329	CCC1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)NC2=O)Nc2[nH]nc(C(F)(F)F)c21			778696	US20250313563, Compound 947404	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778696	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778696&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565330	CCC1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)NC2=O)Nc2[nH]nc(C(F)(F)F)c21			778696	US20250313563, Compound 947404	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778696	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778696&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565331	CC[C@]1(c2cccc(C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778954	US20250313563, Compound 810373	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778954	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778954&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565332	CC[C@]1(c2cccc(C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778954	US20250313563, Compound 810373	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778954	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778954&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565333	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778957	US20250313563, Compound 948314	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778957	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778957&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565334	CCC1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778957	US20250313563, Compound 948314	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778957	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778957&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565335	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779165	US20250313563, Compound 948998	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779165	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779165&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565336	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779165	US20250313563, Compound 948998	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779165	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779165&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565337	CC[C@]1(c2cccc(S(=O)(=O)C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778995	US20250313563, Compound 948419	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778995	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778995&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565338	CC[C@]1(c2cccc(S(=O)(=O)C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778995	US20250313563, Compound 948419	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778995	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778995&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565339	CC[C@@]1(c2cccc(-c3cc(C)ncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779395	US20250313563, Compound 949650	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779395	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779395&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565340	CC[C@@]1(c2cccc(-c3cc(C)ncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779395	US20250313563, Compound 949650	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779395	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779395&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565341	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780580	US20250313563, Compound 947326	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780580	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780580&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565342	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780580	US20250313563, Compound 947326	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780580	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780580&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565343	COc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1			780841	US20250313563, Compound 901469	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780841	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780841&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565344	COc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1			780841	US20250313563, Compound 901469	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780841	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780841&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565345	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779469	US20250313563, Compound 950497	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779469	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779469&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565346	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779469	US20250313563, Compound 950497	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779469	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779469&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565347	CC[C@@]1(c2cccc(-c3ccncc3O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780507	US20250313563, Compound 945724	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780507	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780507&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565348	CC[C@@]1(c2cccc(-c3ccncc3O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780507	US20250313563, Compound 945724	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780507	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780507&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565349	CC[C@@]1(c2cccc(Oc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780674	US20250313563, Compound 947808	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780674	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780674&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565350	CC[C@@]1(c2cccc(Oc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780674	US20250313563, Compound 947808	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780674	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780674&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565351	CC[C@@]1(c2ccccc2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778826	US20250313563, Compound 792340	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778826&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565352	CC[C@@]1(c2ccccc2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778826	US20250313563, Compound 792340	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778826&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565353	CC[C@]1(c2cccc(S(C)(=O)=O)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778768	US20250313563, Compound 947811	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778768	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778768&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565354	CC[C@]1(c2cccc(S(C)(=O)=O)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778768	US20250313563, Compound 947811	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778768	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778768&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565355	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2ccccc2)C1			780847	US20250313563, Compound 943485	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780847	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780847&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565356	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2ccccc2)C1			780847	US20250313563, Compound 943485	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780847	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780847&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565357	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779534	US20250313563, Compound 951740	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779534	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779534&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565358	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779534	US20250313563, Compound 951740	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779534	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779534&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565359	CC[C@@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778700	US20250313563, Compound 947408	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778700	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778700&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565360	CC[C@@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778700	US20250313563, Compound 947408	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778700	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778700&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565361	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21COC2(CN(C(=O)Cc3ccccc3)C2)C1			780938	US20250313563, Compound 948037	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780938	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780938&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565362	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21COC2(CN(C(=O)Cc3ccccc3)C2)C1			780938	US20250313563, Compound 948037	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780938	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780938&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565363	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(F)cc2)CC1			780839	US20250313563, Compound 893311	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780839	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780839&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565364	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(F)cc2)CC1			780839	US20250313563, Compound 893311	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780839	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780839&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565365	CC[C@]1(c2cccc(-c3ccncc3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779721	US20250313563, Compound 917293	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779721	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779721&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565366	CC[C@]1(c2cccc(-c3ccncc3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779721	US20250313563, Compound 917293	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779721	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779721&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565367	CC[C@@]1(c2cccc(-c3ccnc(C)c3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779778	US20250313563, Compound 927347	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779778	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779778&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565368	CC[C@@]1(c2cccc(-c3ccnc(C)c3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779778	US20250313563, Compound 927347	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779778	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779778&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565369	CC[C@@]1(c2cccc(-c3ccncc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779923	US20250313563, Compound 943913	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779923	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779923&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565370	CC[C@@]1(c2cccc(-c3ccncc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779923	US20250313563, Compound 943913	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779923	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779923&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565371	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)C[C@H]2C			780943	US20250313563, Compound 883980	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780943	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780943&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565372	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)C[C@H]2C			780943	US20250313563, Compound 883980	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780943	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780943&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565373	CC[C@@]1(c2cccc(-c3cc(C)nn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780606	US20250313563, Compound 947384	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780606	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780606&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565374	CC[C@@]1(c2cccc(-c3cc(C)nn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780606	US20250313563, Compound 947384	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780606	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780606&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565375	CCN(c1cccnc1)c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779683	US20250313563, Compound 917088	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779683&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565376	CCN(c1cccnc1)c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779683	US20250313563, Compound 917088	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779683&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565377	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779474	US20250313563, Compound 911992	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779474	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779474&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565378	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779474	US20250313563, Compound 911992	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779474	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779474&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565379	CC[C@]1(c2cccc(-c3c(C#N)cnn3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779600	US20250313563, Compound 952410	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779600&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565380	CC[C@]1(c2cccc(-c3c(C#N)cnn3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779600	US20250313563, Compound 952410	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779600&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565381	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)C2CCCCC2)CC1			779777	US20250313563, Compound 913128	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779777	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779777&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565382	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)C2CCCCC2)CC1			779777	US20250313563, Compound 913128	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779777	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779777&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565383	CC[C@@]1(c2cccc(-c3cnnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779943	US20250313563, Compound 943994	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779943	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779943&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565384	CC[C@@]1(c2cccc(-c3cnnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779943	US20250313563, Compound 943994	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779943	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779943&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565385	CC[C@@]1(c2cccc(-c3cncn3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780509	US20250313563, Compound 945725	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780509	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780509&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565386	CC[C@@]1(c2cccc(-c3cncn3C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780509	US20250313563, Compound 945725	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780509	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780509&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565387	CCc1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			780742	US20250313563, Compound 949401	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780742	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780742&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565388	CCc1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			780742	US20250313563, Compound 949401	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780742	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780742&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565389	CCC1(c2cccc(-c3ccnc(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780439	US20250313563, Compound 945529	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780439	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780439&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565390	CCC1(c2cccc(-c3ccnc(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780439	US20250313563, Compound 945529	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780439	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780439&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565391	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2cccc(F)c2)C1			780757	US20250313563, Compound 943488	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780757	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780757&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565392	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2cccc(F)c2)C1			780757	US20250313563, Compound 943488	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780757	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780757&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565393	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)C2CCCC2)CC1			779773	US20250313563, Compound 909206	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779773	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779773&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565394	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)C2CCCC2)CC1			779773	US20250313563, Compound 909206	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779773	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779773&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565395	Cc1cccc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780926	US20250313563, Compound 951863	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780926	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780926&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565396	Cc1cccc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780926	US20250313563, Compound 951863	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780926	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780926&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565397	CC[C@]1(c2cccc(-c3ccncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780425	US20250313563, Compound 945481	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780425	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780425&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565398	CC[C@]1(c2cccc(-c3ccncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780425	US20250313563, Compound 945481	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780425	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780425&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565399	CCC1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779289	US20250313563, Compound 949324	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779289	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779289&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565400	CCC1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779289	US20250313563, Compound 949324	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779289	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779289&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565401	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			779427	US20250313563, Compound 950055	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779427	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779427&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565402	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			779427	US20250313563, Compound 950055	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779427	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779427&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565403	Cn1ccc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			780817	US20250313563, Compound 943484	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780817	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780817&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565404	Cn1ccc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			780817	US20250313563, Compound 943484	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780817	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780817&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565405	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)C2CCOCC2)CC1			779775	US20250313563, Compound 913127	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779775	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779775&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565406	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)C2CCOCC2)CC1			779775	US20250313563, Compound 913127	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779775	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779775&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565407	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(Cl)c2)CC1			780819	US20250313563, Compound 947243	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780819&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565408	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(Cl)c2)CC1			780819	US20250313563, Compound 947243	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780819&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565409	CC[C@]1(c2cccc(-c3cc(C)ncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780596	US20250313563, Compound 947363	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780596&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565410	CC[C@]1(c2cccc(-c3cc(C)ncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780596	US20250313563, Compound 947363	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780596&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565411	CC[C@@]1(c2cccc(-c3c(C)cncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779137	US20250313563, Compound 948812	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779137	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779137&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565412	CC[C@@]1(c2cccc(-c3c(C)cncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779137	US20250313563, Compound 948812	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779137	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779137&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565413	CC(=O)N1CC2(C1)C[C@@]1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			780934	US20250313563, Compound 926861	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780934	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780934&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565414	CC(=O)N1CC2(C1)C[C@@]1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			780934	US20250313563, Compound 926861	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780934	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780934&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565415	CC1CCC(CC(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)C1			781109	US20250313563, Compound 947269	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781109	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781109&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565416	CC1CCC(CC(=O)N2CC3(C2)CC2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)C1			781109	US20250313563, Compound 947269	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781109	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781109&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565417	CCC1(c2cccc(-c3ccnn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780443	US20250313563, Compound 945531	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780443	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780443&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565418	CCC1(c2cccc(-c3ccnn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780443	US20250313563, Compound 945531	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780443	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780443&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565419	CC[C@]1(c2cccc(N(c3cccnc3)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779679	US20250313563, Compound 917086	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779679	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779679&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565420	CC[C@]1(c2cccc(N(c3cccnc3)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779679	US20250313563, Compound 917086	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779679	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779679&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565421	CC[C@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=C(CC(C)(C)NC2=O)NC2=C1C(C(F)(F)F)N=N2			779119	US20250313563, Compound 948771	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779119	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779119&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565422	CC[C@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=C(CC(C)(C)NC2=O)NC2=C1C(C(F)(F)F)N=N2			779119	US20250313563, Compound 948771	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779119	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779119&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565423	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778708	US20250313563, Compound 947414	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778708	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778708&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565424	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778708	US20250313563, Compound 947414	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778708	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778708&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565425	CC[C@@]1(c2cccc(C3=CN=NC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779541	US20250313563, Compound 913025	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779541	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779541&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565426	CC[C@@]1(c2cccc(C3=CN=NC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779541	US20250313563, Compound 913025	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779541	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779541&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565427	CC[C@@]1(c2cccc([C@H](C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780696	US20250313563, Compound 948060	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780696	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780696&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565428	CC[C@@]1(c2cccc([C@H](C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780696	US20250313563, Compound 948060	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780696	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780696&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565429	CC[C@]1(c2cccc(Br)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778944	US20250313563, Compound 810366	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778944	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778944&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565430	CC[C@]1(c2cccc(Br)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778944	US20250313563, Compound 810366	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778944	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778944&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565431	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccccc2)CC1			780783	US20250313563, Compound 874530	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780783	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780783&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565432	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccccc2)CC1			780783	US20250313563, Compound 874530	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780783	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780783&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565433	CC[C@]1(c2cccc(-c3c(C)nnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780564	US20250313563, Compound 946099	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780564&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565434	CC[C@]1(c2cccc(-c3c(C)nnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780564	US20250313563, Compound 946099	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780564&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565435	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779235	US20250313563, Compound 949169	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779235	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779235&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565436	CCC1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779235	US20250313563, Compound 949169	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779235	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779235&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565437	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779585	US20250313563, Compound 913047	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779585	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779585&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565438	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779585	US20250313563, Compound 913047	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779585	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779585&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565439	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CC2(CCCC2)C1			781101	US20250313563, Compound 874477	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781101	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781101&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565440	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CC2(CCCC2)C1			781101	US20250313563, Compound 874477	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781101	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781101&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565441	CC[C@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779563	US20250313563, Compound 913036	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779563	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779563&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565442	CC[C@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779563	US20250313563, Compound 913036	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779563	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779563&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565443	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)C2CCCC2)C1			780845	US20250313563, Compound 917139	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780845&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565444	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CN(S(=O)(=O)C2CCCC2)C1			780845	US20250313563, Compound 917139	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780845&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565445	CCC1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778799	US20250313563, Compound 947860	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778799	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778799&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565446	CCC1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778799	US20250313563, Compound 947860	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778799	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778799&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565447	CC[C@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780447	US20250313563, Compound 945543	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780447	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780447&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565448	CC[C@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780447	US20250313563, Compound 945543	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780447	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780447&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565449	CC(C)S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779779	US20250313563, Compound 913129	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779779	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779779&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565450	CC(C)S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			779779	US20250313563, Compound 913129	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779779	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779779&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565451	CC[C@]1(c2cccc(-c3c(C)cncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780664	US20250313563, Compound 947658	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780664	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780664&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565452	CC[C@]1(c2cccc(-c3c(C)cncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780664	US20250313563, Compound 947658	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780664	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780664&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565453	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)C2=CN=C3CC=CC=C3C2)CC1			780801	US20250313563, Compound 947462	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780801	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780801&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565454	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)C2=CN=C3CC=CC=C3C2)CC1			780801	US20250313563, Compound 947462	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780801	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780801&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565455	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2ccccc2F)C1			780910	US20250313563, Compound 945718	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780910&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565456	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2ccccc2F)C1			780910	US20250313563, Compound 945718	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780910&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565457	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC(C(F)(F)F)CC1			780727	US20250313563, Compound 865193	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780727	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780727&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565458	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCC(C(F)(F)F)CC1			780727	US20250313563, Compound 865193	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780727	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780727&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565459	CC[C@]1(c2cccc(N3CCOCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779078	US20250313563, Compound 816885	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779078	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779078&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565460	CC[C@]1(c2cccc(N3CCOCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779078	US20250313563, Compound 816885	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779078	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779078&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565461	CC[C@@]1(c2cccc(-c3cc(C)ncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780528	US20250313563, Compound 945995	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780528&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565462	CC[C@@]1(c2cccc(-c3cc(C)ncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780528	US20250313563, Compound 945995	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780528&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565463	CC[C@@]1(c2cccc(C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779467	US20250313563, Compound 950494	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779467	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779467&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565464	CC[C@@]1(c2cccc(C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779467	US20250313563, Compound 950494	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779467	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779467&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565465	CC[C@@]1(c2cccc(-c3ccnc4cccnc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779608	US20250313563, Compound 952560	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779608&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565466	CC[C@@]1(c2cccc(-c3ccnc4cccnc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779608	US20250313563, Compound 952560	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779608&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565467	CC[C@@]1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779263	US20250313563, Compound 949183	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779263	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779263&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565468	CC[C@@]1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779263	US20250313563, Compound 949183	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779263	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779263&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565469	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)C2CCCC2)C1			780753	US20250313563, Compound 943482	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780753	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780753&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565470	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)C2CCCC2)C1			780753	US20250313563, Compound 943482	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780753	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780753&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565471	CC(=O)N1C[C@]2(C[C@@]3(CO2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)[C@H]1C			780940	US20250313563, Compound 948437	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780940	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780940&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565472	CC(=O)N1C[C@]2(C[C@@]3(CO2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)[C@H]1C			780940	US20250313563, Compound 948437	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780940	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780940&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565473	CC[C@@]1(c2cccc(-c3c(F)cncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779033	US20250313563, Compound 948525	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779033	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779033&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565474	CC[C@@]1(c2cccc(-c3c(F)cncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779033	US20250313563, Compound 948525	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779033	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779033&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565475	CCC1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778694	US20250313563, Compound 947403	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778694	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778694&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565476	CCC1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778694	US20250313563, Compound 947403	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778694	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778694&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565477	CC[C@]1(c2cccc(C3CCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779660	US20250313563, Compound 949521	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779660	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779660&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565478	CC[C@]1(c2cccc(C3CCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779660	US20250313563, Compound 949521	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779660	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779660&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565479	CC[C@@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778881	US20250313563, Compound 948150	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778881&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565480	CC[C@@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778881	US20250313563, Compound 948150	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778881&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565481	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			778959	US20250313563, Compound 948358	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778959	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778959&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565482	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			778959	US20250313563, Compound 948358	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778959	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778959&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565483	CC[C@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779470	US20250313563, Compound 911990	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779470	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779470&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565484	CC[C@]1(c2cccc(-c3c(C)nn(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779470	US20250313563, Compound 911990	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779470	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779470&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565485	CC[C@@]1(c2cccc(-c3ccncc3C3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779431	US20250313563, Compound 950059	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779431	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779431&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565486	CC[C@@]1(c2cccc(-c3ccncc3C3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779431	US20250313563, Compound 950059	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779431	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779431&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565487	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778976	US20250313563, Compound 810466	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778976	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778976&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565488	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778976	US20250313563, Compound 810466	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778976	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778976&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565489	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			780931	US20250313563, Compound 826790	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780931	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780931&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565490	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			780931	US20250313563, Compound 826790	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780931	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780931&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565491	CC[C@@]1(c2cccc(C(F)F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779564	US20250313563, Compound 951948	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779564&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565492	CC[C@@]1(c2cccc(C(F)F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779564	US20250313563, Compound 951948	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779564&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565493	CC[C@@]1(c2cccc(-c3ccnnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779814	US20250313563, Compound 929454	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779814	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779814&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565494	CC[C@@]1(c2cccc(-c3ccnnc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779814	US20250313563, Compound 929454	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779814	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779814&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565495	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779595	US20250313563, Compound 913052	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779595&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565496	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779595	US20250313563, Compound 913052	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779595&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565497	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnc(OC)nc1)[C@@H](C)C2			779319	US20250313563, Compound 949352	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779319	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779319&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565498	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cnc(OC)nc1)[C@@H](C)C2			779319	US20250313563, Compound 949352	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779319	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779319&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565499	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779537	US20250313563, Compound 913023	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779537	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779537&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565500	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779537	US20250313563, Compound 913023	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779537	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779537&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565501	CC(C)S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)[C@H]1F			780898	US20250313563, Compound 951701	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780898&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565502	CC(C)S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)[C@H]1F			780898	US20250313563, Compound 951701	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780898&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565503	CC[C@]1(c2cccc(N(C)c3nccc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780397	US20250313563, Compound 945328	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780397	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780397&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565504	CC[C@]1(c2cccc(N(C)c3nccc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780397	US20250313563, Compound 945328	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780397	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780397&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565505	CC[C@@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778890	US20250313563, Compound 801413	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778890&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565506	CC[C@@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778890	US20250313563, Compound 801413	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778890&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565507	CC[C@@]1(c2cccc(OC)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779332	US20250313563, Compound 884117	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779332	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779332&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565508	CC[C@@]1(c2cccc(OC)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779332	US20250313563, Compound 884117	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779332	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779332&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565509	Cn1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			780749	US20250313563, Compound 901471	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780749	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780749&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565510	Cn1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			780749	US20250313563, Compound 901471	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780749	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780749&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565511	CC[C@]1(c2cccc(S(C)(=O)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779142	US20250313563, Compound 826718	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779142	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779142&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565512	CC[C@]1(c2cccc(S(C)(=O)=O)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779142	US20250313563, Compound 826718	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779142	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779142&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565513	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCCOC1)C2			779219	US20250313563, Compound 949115	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779219	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779219&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565514	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCCOC1)C2			779219	US20250313563, Compound 949115	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779219	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779219&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565515	CC[C@@]1(c2cccc(-c3ccnc4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780389	US20250313563, Compound 944033	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780389	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780389&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565516	CC[C@@]1(c2cccc(-c3ccnc4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780389	US20250313563, Compound 944033	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780389	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780389&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565517	CC[C@@]1(c2cccc(-c3ccnc4c(F)cccc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779161	US20250313563, Compound 948828	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779161	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779161&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565518	CC[C@@]1(c2cccc(-c3ccnc4c(F)cccc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779161	US20250313563, Compound 948828	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779161	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779161&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565519	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779717	US20250313563, Compound 917291	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779717	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779717&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565520	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779717	US20250313563, Compound 917291	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779717	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779717&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565521	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			778964	US20250313563, Compound 810450	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778964	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778964&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565522	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)C[C@H](C)C2			778964	US20250313563, Compound 810450	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778964	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778964&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565523	CC[C@@]1(c2cccc(S(=O)(=O)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779613	US20250313563, Compound 913135	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779613&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565524	CC[C@@]1(c2cccc(S(=O)(=O)C(C)C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779613	US20250313563, Compound 913135	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779613&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565525	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccnc2)CC1			780833	US20250313563, Compound 947613	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780833	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780833&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565526	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccnc2)CC1			780833	US20250313563, Compound 947613	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780833	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780833&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565527	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779464	US20250313563, Compound 911981	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779464	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779464&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565528	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779464	US20250313563, Compound 911981	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779464	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779464&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565529	CCOc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1			780851	US20250313563, Compound 945670	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780851&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565530	CCOc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc1			780851	US20250313563, Compound 945670	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780851&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565531	CC[C@]1(c2cccc(N(C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779462	US20250313563, Compound 911980	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779462	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779462&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565532	CC[C@]1(c2cccc(N(C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779462	US20250313563, Compound 911980	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779462	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779462&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565533	Cc1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc(C)n1			780835	US20250313563, Compound 947616	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780835	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780835&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565534	Cc1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cc(C)n1			780835	US20250313563, Compound 947616	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780835	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780835&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565535	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)CC2CC2)CC1			780906	US20250313563, Compound 909207	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780906&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565536	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)CC2CC2)CC1			780906	US20250313563, Compound 909207	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780906&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565537	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779397	US20250313563, Compound 949651	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779397	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779397&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565538	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779397	US20250313563, Compound 949651	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779397	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779397&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565539	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779935	US20250313563, Compound 943990	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779935	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779935&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565540	CC[C@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779935	US20250313563, Compound 943990	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779935	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779935&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565541	CC[C@@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778905	US20250313563, Compound 948184	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778905	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778905&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565542	CC[C@@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778905	US20250313563, Compound 948184	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778905	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778905&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565543	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780652	US20250313563, Compound 947651	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780652	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780652&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565544	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780652	US20250313563, Compound 947651	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780652	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780652&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565545	CC[C@]1(c2cccc([C@@H](C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780694	US20250313563, Compound 948058	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780694	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780694&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565546	CC[C@]1(c2cccc([C@@H](C)c3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780694	US20250313563, Compound 948058	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780694	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780694&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565547	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccccc2OC(F)F)CC1			780888	US20250313563, Compound 945668	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780888	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780888&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565548	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccccc2OC(F)F)CC1			780888	US20250313563, Compound 945668	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780888	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780888&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565549	CC[C@@]1(c2cccc(-c3ccnc4c3CCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780473	US20250313563, Compound 945606	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780473	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780473&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565550	CC[C@@]1(c2cccc(-c3ccnc4c3CCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780473	US20250313563, Compound 945606	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780473	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780473&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565551	CCC1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778801	US20250313563, Compound 947861	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778801	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778801&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565552	CCC1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778801	US20250313563, Compound 947861	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778801	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778801&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565553	CC[C@]1(c2cccc(-c3cnc(C)n3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780483	US20250313563, Compound 945613	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780483	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780483&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565554	CC[C@]1(c2cccc(-c3cnc(C)n3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780483	US20250313563, Compound 945613	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780483	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780483&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565555	CC[C@]1(c2cccc(Cl)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778834	US20250313563, Compound 801308	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778834	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778834&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565556	CC[C@]1(c2cccc(Cl)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			778834	US20250313563, Compound 801308	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778834	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778834&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565557	Cn1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780785	US20250313563, Compound 901467	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780785&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565558	Cn1cc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780785	US20250313563, Compound 901467	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780785&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565559	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780453	US20250313563, Compound 945546	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780453	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780453&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565560	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780453	US20250313563, Compound 945546	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780453	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780453&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565561	CC[C@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778792	US20250313563, Compound 790733	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778792	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778792&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565562	CC[C@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778792	US20250313563, Compound 790733	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778792	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778792&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565563	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)Cc3ccccc3)C2)C1			780936	US20250313563, Compound 947306	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780936	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780936&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565564	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)Cc3ccccc3)C2)C1			780936	US20250313563, Compound 947306	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780936	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780936&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565565	Cn1cc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780872	US20250313563, Compound 951725	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780872&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565566	Cn1cc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780872	US20250313563, Compound 951725	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780872&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565567	CCC1(c2cccc(-c3ccnc4c3CCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778803	US20250313563, Compound 947862	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778803	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778803&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565568	CCC1(c2cccc(-c3ccnc4c3CCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778803	US20250313563, Compound 947862	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778803	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778803&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565569	CC[C@]1(c2cccc(C3CCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779654	US20250313563, Compound 949397	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779654	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779654&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565570	CC[C@]1(c2cccc(C3CCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779654	US20250313563, Compound 949397	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779654	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779654&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565571	CC[C@]1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779519	US20250313563, Compound 951606	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779519	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779519&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565572	CC[C@]1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779519	US20250313563, Compound 951606	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779519	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779519&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565573	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780650	US20250313563, Compound 947650	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780650&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565574	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780650	US20250313563, Compound 947650	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780650&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565575	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779267	US20250313563, Compound 949185	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779267	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779267&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565576	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779267	US20250313563, Compound 949185	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779267	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779267&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565577	CC[C@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)[C@@H](F)C(C)(C)C2			779174	US20250313563, Compound 835315	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779174	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779174&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565578	CC[C@]1(c2cccc(Br)c2)C2=CN=NC2NC2=C1C(=O)[C@@H](F)C(C)(C)C2			779174	US20250313563, Compound 835315	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779174	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779174&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565579	CCC1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780437	US20250313563, Compound 945528	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780437	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780437&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565580	CCC1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780437	US20250313563, Compound 945528	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780437	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780437&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565581	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781014	US20250313563, Compound 927389	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781014	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781014&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565582	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781014	US20250313563, Compound 927389	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781014	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781014&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565583	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779893	US20250313563, Compound 943518	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779893	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779893&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565584	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779893	US20250313563, Compound 943518	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779893	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779893&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565585	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781088	US20250313563, Compound 945470	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781088	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781088&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565586	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781088	US20250313563, Compound 945470	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781088	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781088&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565587	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779391	US20250313563, Compound 949648	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779391	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779391&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565588	CC[C@@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779391	US20250313563, Compound 949648	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779391	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779391&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565589	CC[C@]1(c2cccc(S(=O)(=O)CCOC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779917	US20250313563, Compound 943542	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779917	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779917&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565590	CC[C@]1(c2cccc(S(=O)(=O)CCOC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779917	US20250313563, Compound 943542	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779917	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779917&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565591	CC(=O)N1C[C@]2(C[C@]3(CO2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)[C@H]1C			780942	US20250313563, Compound 948439	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780942	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780942&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565592	CC(=O)N1C[C@]2(C[C@]3(CO2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)[C@H]1C			780942	US20250313563, Compound 948439	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780942	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780942&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565593	CCC1(c2cccc(-c3cc(C)nnc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779245	US20250313563, Compound 949174	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779245	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779245&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565594	CCC1(c2cccc(-c3cc(C)nnc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779245	US20250313563, Compound 949174	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779245	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779245&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565595	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778821	US20250313563, Compound 947877	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778821	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778821&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565596	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778821	US20250313563, Compound 947877	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778821	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778821&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565597	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779527	US20250313563, Compound 913018	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779527	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779527&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565598	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779527	US20250313563, Compound 913018	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779527	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779527&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565599	COc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c(F)c1			780912	US20250313563, Compound 947255	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780912	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780912&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565600	COc1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c(F)c1			780912	US20250313563, Compound 947255	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780912	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780912&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565601	CC[C@@]1(c2cccc(-c3c(C)cnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779578	US20250313563, Compound 952021	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779578	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779578&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565602	CC[C@@]1(c2cccc(-c3c(C)cnn3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779578	US20250313563, Compound 952021	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779578	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779578&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565603	CC[C@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780712	US20250313563, Compound 948545	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780712	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780712&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565604	CC[C@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780712	US20250313563, Compound 948545	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780712	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780712&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565605	CCC1(c2cccc(-c3cc(C)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778690	US20250313563, Compound 947401	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778690	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778690&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565606	CCC1(c2cccc(-c3cc(C)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778690	US20250313563, Compound 947401	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778690	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778690&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565607	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778698	US20250313563, Compound 947405	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778698	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778698&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565608	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			778698	US20250313563, Compound 947405	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778698	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778698&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565609	CC[C@@]1(c2cccc(-c3ccnc(C)c3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778965	US20250313563, Compound 948361	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778965	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778965&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565610	CC[C@@]1(c2cccc(-c3ccnc(C)c3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778965	US20250313563, Compound 948361	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778965	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778965&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565611	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21C[C@@H](c2ccncc2)C1			780837	US20250313563, Compound 889665	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780837	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780837&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565612	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21C[C@@H](c2ccncc2)C1			780837	US20250313563, Compound 889665	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780837	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780837&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565613	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779522	US20250313563, Compound 951612	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779522&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565614	CC[C@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779522	US20250313563, Compound 951612	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779522&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565615	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccccc2F)CC1			780876	US20250313563, Compound 901465	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780876&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565616	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccccc2F)CC1			780876	US20250313563, Compound 901465	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780876&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565617	CC[C@@]1(c2cccc(-c3cc(C)nnc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779301	US20250313563, Compound 949331	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779301	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779301&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565618	CC[C@@]1(c2cccc(-c3cc(C)nnc3C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779301	US20250313563, Compound 949331	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779301	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779301&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565619	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			779179	US20250313563, Compound 949005	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779179	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779179&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565620	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)N(C)C(C)(C)C2			779179	US20250313563, Compound 949005	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779179	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779179&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565621	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779200	US20250313563, Compound 865169	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779200	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779200&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565622	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779200	US20250313563, Compound 865169	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779200	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779200&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565623	CC(=O)N1CC2(C1)CC1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			781127	US20250313563, Compound 913058	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781127	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781127&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565624	CC(=O)N1CC2(C1)CC1(CO2)C2=C(N=NC2)NC2=C1C(=O)CC(C)(C)C2			781127	US20250313563, Compound 913058	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781127	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781127&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565625	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			780974	US20250313563, Compound 913006	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780974	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780974&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565626	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			780974	US20250313563, Compound 913006	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780974	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780974&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565627	COc1ncccc1S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780914	US20250313563, Compound 947260	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780914	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780914&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565628	COc1ncccc1S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780914	US20250313563, Compound 947260	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780914	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780914&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565629	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CN(C(=O)[C@@H]3CC3(F)F)C2)C1			781077	US20250313563, Compound 948219	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781077	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781077&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565630	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21COC2(CN(C(=O)[C@@H]3CC3(F)F)C2)C1			781077	US20250313563, Compound 948219	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781077	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781077&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565631	CCC1(c2cccc(-c3c(C)nnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780367	US20250313563, Compound 943996	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780367	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780367&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565632	CCC1(c2cccc(-c3c(C)nnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780367	US20250313563, Compound 943996	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780367	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780367&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565633	CC[C@]1(c2cccc(-c3ccnc(OC)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779466	US20250313563, Compound 911988	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779466	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779466&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565634	CC[C@]1(c2cccc(-c3ccnc(OC)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779466	US20250313563, Compound 911988	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779466	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779466&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565635	Cn1ccc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			780890	US20250313563, Compound 945712	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780890&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565636	Cn1ccc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)n1			780890	US20250313563, Compound 945712	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780890&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565637	CC[C@]1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779566	US20250313563, Compound 951949	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779566&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565638	CC[C@]1(c2cccc(Oc3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779566	US20250313563, Compound 951949	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779566&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565639	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC1(CCCC1)C2			778840	US20250313563, Compound 801311	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778840&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565640	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC1(CCCC1)C2			778840	US20250313563, Compound 801311	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778840&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565641	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cccnc1)CC2			778712	US20250313563, Compound 947432	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778712	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778712&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565642	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cccnc1)CC2			778712	US20250313563, Compound 947432	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778712	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778712&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565643	CCC1(c2cccc(-c3ccnc(C(F)(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779659	US20250313563, Compound 913350	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779659	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779659&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565644	CCC1(c2cccc(-c3ccnc(C(F)(F)F)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779659	US20250313563, Compound 913350	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779659	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779659&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565645	CC[C@@]1(c2cccc(C(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779181	US20250313563, Compound 949006	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779181	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779181&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565646	CC[C@@]1(c2cccc(C(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779181	US20250313563, Compound 949006	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779181	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779181&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565647	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779425	US20250313563, Compound 949919	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779425	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779425&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565648	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779425	US20250313563, Compound 949919	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779425	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779425&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565649	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			779178	US20250313563, Compound 837683	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779178	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779178&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565650	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			779178	US20250313563, Compound 837683	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779178	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779178&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565651	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781144	US20250313563, Compound 946001	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781144	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781144&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565652	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781144	US20250313563, Compound 946001	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781144	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781144&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565653	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780654	US20250313563, Compound 947652	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780654	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780654&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565654	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780654	US20250313563, Compound 947652	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780654	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780654&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565655	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779239	US20250313563, Compound 949171	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779239	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779239&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565656	CCC1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779239	US20250313563, Compound 949171	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779239	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779239&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565657	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccccn1)CC2			779285	US20250313563, Compound 949310	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779285	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779285&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565658	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1ccccn1)CC2			779285	US20250313563, Compound 949310	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779285	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779285&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565659	CC[C@]1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779581	US20250313563, Compound 913045	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779581	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779581&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565660	CC[C@]1(c2cccc(-c3cnn(C)c3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779581	US20250313563, Compound 913045	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779581	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779581&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565661	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCCOC1)C2			779041	US20250313563, Compound 948529	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779041	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779041&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565662	CC[C@@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)N[C@]1(CCCOC1)C2			779041	US20250313563, Compound 948529	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779041	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779041&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565663	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(NC3=NN=CC31)c1ccccc1C2=O			779650	US20250313563, Compound 949743	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779650&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565664	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(NC3=NN=CC31)c1ccccc1C2=O			779650	US20250313563, Compound 949743	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779650&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565665	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)C23CCN(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC3)[C@@H]1F			780779	US20250313563, Compound 951703	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780779	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780779&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565666	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)C23CCN(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC3)[C@@H]1F			780779	US20250313563, Compound 951703	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780779	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780779&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565667	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCCC1)C2			778855	US20250313563, Compound 948022	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778855&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565668	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCCC1)C2			778855	US20250313563, Compound 948022	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778855&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565669	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cncnc1)CC2			778985	US20250313563, Compound 948379	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778985	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778985&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565670	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N(c1cncnc1)CC2			778985	US20250313563, Compound 948379	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778985	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778985&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565671	CC[C@@]1(c2cccc(C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779274	US20250313563, Compound 883873	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779274	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779274&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565672	CC[C@@]1(c2cccc(C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779274	US20250313563, Compound 883873	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779274	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779274&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565673	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccccc2C(F)F)CC1			780703	US20250313563, Compound 945657	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780703	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780703&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565674	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccccc2C(F)F)CC1			780703	US20250313563, Compound 945657	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780703	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780703&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565675	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2ccccc2F)C1			780908	US20250313563, Compound 943487	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780908	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780908&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565676	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2ccccc2F)C1			780908	US20250313563, Compound 943487	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780908	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780908&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565677	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779108	US20250313563, Compound 819577	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779108	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779108&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565678	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779108	US20250313563, Compound 819577	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779108	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779108&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565679	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(OC(F)F)c2)CC1			780856	US20250313563, Compound 947242	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780856&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565680	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(OC(F)F)c2)CC1			780856	US20250313563, Compound 947242	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780856&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565681	CC[C@@]1(c2cccc(-c3cnn(C)c3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779143	US20250313563, Compound 948815	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779143	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779143&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565682	CC[C@@]1(c2cccc(-c3cnn(C)c3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779143	US20250313563, Compound 948815	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779143	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779143&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565683	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(Cl)c2F)CC1			780868	US20250313563, Compound 948118	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780868&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565684	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(Cl)c2F)CC1			780868	US20250313563, Compound 948118	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780868&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565685	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@H](C(C)(C)C)C2			781130	US20250313563, Compound 945920	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781130	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781130&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565686	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)N[C@H](C(C)(C)C)C2			781130	US20250313563, Compound 945920	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781130	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781130&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565687	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(C(F)F)c2)CC1			780916	US20250313563, Compound 947264	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780916	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780916&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565688	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(C(F)F)c2)CC1			780916	US20250313563, Compound 947264	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780916	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780916&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565689	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780806	US20250313563, Compound 957511	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780806&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565690	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780806	US20250313563, Compound 957511	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780806&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565691	CCC1(c2cccc(-c3cc(C)nn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780445	US20250313563, Compound 945532	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780445	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780445&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565692	CCC1(c2cccc(-c3cc(C)nn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			780445	US20250313563, Compound 945532	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780445	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780445&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565693	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780574	US20250313563, Compound 946104	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780574	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780574&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565694	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780574	US20250313563, Compound 946104	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780574	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780574&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565695	CC[C@]1(c2cccc(S(=O)(=O)CC3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779701	US20250313563, Compound 917150	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779701	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779701&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565696	CC[C@]1(c2cccc(S(=O)(=O)CC3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779701	US20250313563, Compound 917150	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779701	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779701&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565697	CC[C@@]1(c2cccc(S(=O)(=O)C3CCCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779915	US20250313563, Compound 943541	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779915	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779915&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565698	CC[C@@]1(c2cccc(S(=O)(=O)C3CCCCC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779915	US20250313563, Compound 943541	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779915	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779915&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565699	CC[C@]1(c2cccc(Cl)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778846	US20250313563, Compound 801314	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778846	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778846&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565700	CC[C@]1(c2cccc(Cl)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(Br)=C21			778846	US20250313563, Compound 801314	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778846	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778846&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565701	CC[C@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779696	US20250313563, Compound 952212	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779696	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779696&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565702	CC[C@]1(c2cccc(N(C)c3ncccn3)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779696	US20250313563, Compound 952212	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779696	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779696&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565703	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(OC(F)F)cc2)CC1			780820	US20250313563, Compound 947246	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780820	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780820&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565704	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2ccc(OC(F)F)cc2)CC1			780820	US20250313563, Compound 947246	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780820	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780820&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565705	CCC1(c2cccc(OCC(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780724	US20250313563, Compound 948793	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780724	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780724&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565706	CCC1(c2cccc(OCC(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780724	US20250313563, Compound 948793	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780724	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780724&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565707	CCC1(c2cccc(N3CCCc4ncccc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779392	US20250313563, Compound 889639	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779392	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779392&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565708	CCC1(c2cccc(N3CCCc4ncccc43)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779392	US20250313563, Compound 889639	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779392	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779392&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565709	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			779120	US20250313563, Compound 823721	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779120	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779120&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565710	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)C[C@@H](C)C2			779120	US20250313563, Compound 823721	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779120	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779120&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565711	CCCS(=O)(=O)c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779802	US20250313563, Compound 929447	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779802	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779802&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565712	CCCS(=O)(=O)c1cccc([C@@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			779802	US20250313563, Compound 929447	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779802	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779802&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565713	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779443	US20250313563, Compound 950163	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779443	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779443&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565714	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)F)=C21			779443	US20250313563, Compound 950163	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779443	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779443&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565715	CC[C@]1(c2cccc(-c3cc(C)ncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779591	US20250313563, Compound 913050	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779591	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779591&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565716	CC[C@]1(c2cccc(-c3cc(C)ncc3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779591	US20250313563, Compound 913050	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779591	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779591&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565717	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781010	US20250313563, Compound 927325	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781010	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781010&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565718	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781010	US20250313563, Compound 927325	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781010	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781010&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565719	Cc1ccc(C(=O)N2CC3(C2)C[C@]2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)cc1C			781125	US20250313563, Compound 948038	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781125	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781125&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565720	Cc1ccc(C(=O)N2CC3(C2)C[C@]2(CO3)C3=C(N=NC3)NC3=C2C(=O)CC(C)(C)C3)cc1C			781125	US20250313563, Compound 948038	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781125	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781125&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565721	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781108	US20250313563, Compound 945614	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781108	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781108&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565722	CC[C@@]1(c2cccc(-c3cnn(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			781108	US20250313563, Compound 945614	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781108	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781108&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565723	CCC1(c2cccc(S(=O)(=O)c3ccccc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779605	US20250313563, Compound 913123	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779605&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565724	CCC1(c2cccc(S(=O)(=O)c3ccccc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779605	US20250313563, Compound 913123	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779605&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565725	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779690	US20250313563, Compound 951702	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779690	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779690&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565726	CC[C@@]1(c2cccc(-c3cn(C)nc3C)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779690	US20250313563, Compound 951702	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779690	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779690&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565727	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(C#N)c2)CC1			780860	US20250313563, Compound 947254	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780860&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565728	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc(C#N)c2)CC1			780860	US20250313563, Compound 947254	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780860&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565729	CCC1(c2cccc(-c3cnc(C)n3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779897	US20250313563, Compound 943531	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779897&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565730	CCC1(c2cccc(-c3cnc(C)n3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779897	US20250313563, Compound 943531	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779897&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565731	CC[C@@]1(c2cccc(-c3ccncc3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778865	US20250313563, Compound 948142	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778865&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565732	CC[C@@]1(c2cccc(-c3ccncc3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778865	US20250313563, Compound 948142	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778865&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565733	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCN(S(=O)(=O)c2ccccc2)C1			780693	US20250313563, Compound 951788	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780693	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780693&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565734	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CCN(S(=O)(=O)c2ccccc2)C1			780693	US20250313563, Compound 951788	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780693	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780693&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565735	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCCC1)C2			779445	US20250313563, Compound 950252	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779445	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779445&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565736	CC[C@]1(c2cccc(-c3cn(C)nc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCCC1)C2			779445	US20250313563, Compound 950252	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779445	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779445&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565737	Cc1cccc(S(=O)(=O)N2CC[C@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780695	US20250313563, Compound 951864	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780695	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780695&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565738	Cc1cccc(S(=O)(=O)N2CC[C@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780695	US20250313563, Compound 951864	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780695	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780695&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565739	CC[C@@]1(c2cccc(S(=O)(=O)C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778820	US20250313563, Compound 947876	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778820	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778820&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565740	CC[C@@]1(c2cccc(S(=O)(=O)C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			778820	US20250313563, Compound 947876	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778820	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778820&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565741	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780796	US20250313563, Compound 957506	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780796	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780796&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565742	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780796	US20250313563, Compound 957506	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780796	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780796&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565743	CCn1nccc1-c1cccc([C@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			780544	US20250313563, Compound 946089	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780544	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780544&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565744	CCn1nccc1-c1cccc([C@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			780544	US20250313563, Compound 946089	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780544	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780544&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565745	CC[C@@]1(c2cccc(-c3cnnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781058	US20250313563, Compound 944074	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781058	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781058&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565746	CC[C@@]1(c2cccc(-c3cnnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			781058	US20250313563, Compound 944074	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781058	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781058&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565747	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)Cc2ccccc2)CC1			780886	US20250313563, Compound 929437	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780886	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780886&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565748	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)Cc2ccccc2)CC1			780886	US20250313563, Compound 929437	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780886	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780886&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565749	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@H](C)C2			781006	US20250313563, Compound 926300	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781006	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781006&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565750	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@H](C)C2			781006	US20250313563, Compound 926300	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781006	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781006&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565751	CC[C@@]1(c2cccc(-c3c(Cl)cncc3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779013	US20250313563, Compound 948515	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779013	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779013&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565752	CC[C@@]1(c2cccc(-c3c(Cl)cncc3Cl)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779013	US20250313563, Compound 948515	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779013	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779013&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565753	CC[C@]1(c2cc(-c3ccncc3)ccc2C)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779402	US20250313563, Compound 893323	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779402	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779402&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565754	CC[C@]1(c2cc(-c3ccncc3)ccc2C)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779402	US20250313563, Compound 893323	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779402	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779402&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565755	CC[C@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779518	US20250313563, Compound 912171	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779518	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779518&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565756	CC[C@]1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779518	US20250313563, Compound 912171	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779518	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779518&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565757	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)C2			780883	US20250313563, Compound 929388	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780883	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780883&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565758	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=C(N=NC2)NC2=C1C(=O)N(Cc1ccccc1)C2			780883	US20250313563, Compound 929388	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780883	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780883&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565759	CC[C@@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779127	US20250313563, Compound 948775	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779127	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779127&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565760	CC[C@@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C(F)(F)F)=C21			779127	US20250313563, Compound 948775	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779127	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779127&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565761	CC[C@@]1(c2cccc(-c3ccnc4ccncc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779634	US20250313563, Compound 952910	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779634&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565762	CC[C@@]1(c2cccc(-c3ccnc4ccncc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779634	US20250313563, Compound 952910	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779634&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565763	COc1cccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1F			780849	US20250313563, Compound 945656	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780849&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565764	COc1cccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1F			780849	US20250313563, Compound 945656	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780849&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565765	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)C23CCN(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC3)[C@H]1F			780663	US20250313563, Compound 951713	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780663	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780663&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565766	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)C23CCN(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC3)[C@H]1F			780663	US20250313563, Compound 951713	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780663	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780663&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565767	CC[C@@]1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779276	US20250313563, Compound 883874	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779276	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779276&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565768	CC[C@@]1(c2cccc(N3CCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779276	US20250313563, Compound 883874	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779276	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779276&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565769	CC[C@@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778704	US20250313563, Compound 947410	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778704	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778704&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565770	CC[C@@]1(c2cccc(-c3cnn4c3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778704	US20250313563, Compound 947410	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778704	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778704&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565771	CC[C@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779889	US20250313563, Compound 943516	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779889	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779889&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565772	CC[C@]1(c2cccc(-c3ccnc(C)c3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779889	US20250313563, Compound 943516	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779889	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779889&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565773	CC[C@]4(c2cccc(C1CCOCC1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			779112	US20250313563, Compound 819638	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779112	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779112&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search			177893945	523297458							1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565774	CC[C@]4(c2cccc(C1CCOCC1)c2)C3=CN=NC3NC5=C4C(=O)CC(C)(C)C5			779112	US20250313563, Compound 819638	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent		10.7270/Q22F7T60			US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779112	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779112&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search			177893945	523297458							1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565775	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			779176	US20250313563, Compound 837646	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779176	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779176&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565776	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			779176	US20250313563, Compound 837646	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779176	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779176&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565777	Cn1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)NC(C)(C)C2)n1			780625	US20250313563, Compound 943961	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780625&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565778	Cn1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)NC(C)(C)C2)n1			780625	US20250313563, Compound 943961	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780625&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565779	CCCn1nccc1-c1cccc([C@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			780552	US20250313563, Compound 946093	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780552	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780552&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565780	CCCn1nccc1-c1cccc([C@]2(CC)C3=CN=NC3NC3=C2C(=O)CC(C)(C)C3)c1			780552	US20250313563, Compound 946093	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780552	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780552&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565781	Cn1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)NC(C)(C)C2)n1			780625	US20250313563, Compound 943961	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780625&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565782	Cn1ccc(S(=O)(=O)N2CCC3(CC2)C2=C(N=NC2)NC2=C3C(=O)NC(C)(C)C2)n1			780625	US20250313563, Compound 943961	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780625&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565783	CCC1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779428	US20250313563, Compound 909204	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779428	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779428&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565784	CCC1(c2cccc(S(=O)(=O)C3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779428	US20250313563, Compound 909204	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779428	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779428&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565785	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)[C@H](F)C(C)(C)C2			780421	US20250313563, Compound 945476	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780421	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780421&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565786	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)[C@H](F)C(C)(C)C2			780421	US20250313563, Compound 945476	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780421	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780421&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565787	COc1ccccc1S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780874	US20250313563, Compound 893310	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780874&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565788	COc1ccccc1S(=O)(=O)N1CCC2(CC1)C1=C(N=NC1)NC1=C2C(=O)CC(C)(C)C1			780874	US20250313563, Compound 893310	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780874&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565789	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCOC1)C2			780614	US20250313563, Compound 947406	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780614&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565790	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)N[C@@]1(CCOC1)C2			780614	US20250313563, Compound 947406	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780614&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565791	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc3c2OCCO3)CC1			780892	US20250313563, Compound 947464	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780892&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565792	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cccc3c2OCCO3)CC1			780892	US20250313563, Compound 947464	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780892&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565793	CC[C@]1(c2cccc(C(C)C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779409	US20250313563, Compound 949761	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779409	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779409&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565794	CC[C@]1(c2cccc(C(C)C)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779409	US20250313563, Compound 949761	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779409	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779409&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565795	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)CC2CC2)C1			780924	US20250313563, Compound 951723	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780924	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780924&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565796	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)CC2CC2)C1			780924	US20250313563, Compound 951723	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780924	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780924&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565797	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CC[C@@H](C(F)(F)F)C1			780665	US20250313563, Compound 952436	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780665	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780665&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565798	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@@]21CC[C@@H](C(F)(F)F)C1			780665	US20250313563, Compound 952436	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780665	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780665&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565799	CC[C@@]1(c2cccc(-c3cc(C)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779776	US20250313563, Compound 927346	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779776	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779776&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565800	CC[C@@]1(c2cccc(-c3cc(C)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779776	US20250313563, Compound 927346	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779776	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779776&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565801	Cn1cc(S(=O)(=O)N2CC[C@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780715	US20250313563, Compound 951726	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780715	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780715&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565802	Cn1cc(S(=O)(=O)N2CC[C@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)cn1			780715	US20250313563, Compound 951726	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780715	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780715&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565803	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778813	US20250313563, Compound 947869	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778813&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565804	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778813	US20250313563, Compound 947869	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778813&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565805	CC[C@@]1(c2cccc(-c3cnc4n3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780475	US20250313563, Compound 945607	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780475&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565806	CC[C@@]1(c2cccc(-c3cnc4n3CCCC4)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780475	US20250313563, Compound 945607	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780475&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565807	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2ccccc2)C1			780900	US20250313563, Compound 951787	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780900	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780900&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565808	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)[C@]21CCN(S(=O)(=O)c2ccccc2)C1			780900	US20250313563, Compound 951787	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780900	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780900&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565809	CC[C@@]1(c2cccc(C3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779505	US20250313563, Compound 950828	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779505	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779505&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565810	CC[C@@]1(c2cccc(C3CC3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779505	US20250313563, Compound 950828	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779505	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779505&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565811	CC[C@@]1(c2cccc(-c3ccncc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779586	US20250313563, Compound 952025	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779586&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565812	CC[C@@]1(c2cccc(-c3ccncc3C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779586	US20250313563, Compound 952025	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779586&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565813	CC[C@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780808	US20250313563, Compound 959341	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780808	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780808&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565814	CC[C@]1(c2cccc(-c3ccncc3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780808	US20250313563, Compound 959341	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780808	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780808&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565815	CCC1(c2cccc(N(C)c3nccc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779881	US20250313563, Compound 942642	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779881&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565816	CCC1(c2cccc(N(C)c3nccc(C)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779881	US20250313563, Compound 942642	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779881&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565817	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)[C@@H](F)C(C)(C)C2			780419	US20250313563, Compound 945475	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780419	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780419&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565818	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)[C@@H](F)C(C)(C)C2			780419	US20250313563, Compound 945475	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780419	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780419&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565819	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780798	US20250313563, Compound 957507	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780798&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565820	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780798	US20250313563, Compound 957507	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780798&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565821	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)[C@]23CC[C@@H](C(F)(F)F)CC3)[C@H]1F			780593	US20250313563, Compound 918285	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780593	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780593&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565822	CC1(C)CC(=O)C2=C(NC3=C(CN=N3)[C@]23CC[C@@H](C(F)(F)F)CC3)[C@H]1F			780593	US20250313563, Compound 918285	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780593	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780593&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565823	CCC1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779241	US20250313563, Compound 949172	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779241	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779241&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565824	CCC1(c2cccc(N(C)c3ncccn3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(F)=C21			779241	US20250313563, Compound 949172	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779241	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779241&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565825	CC[C@]1(c2cccc(C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778755	US20250313563, Compound 789560	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778755	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778755&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565826	CC[C@]1(c2cccc(C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778755	US20250313563, Compound 789560	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778755	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778755&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565827	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)C2CC2)CC1			780878	US20250313563, Compound 901470	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780878&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565828	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)C2CC2)CC1			780878	US20250313563, Compound 901470	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780878&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565829	CC[C@@]1(c2cccc(-c3cnn4ccncc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779614	US20250313563, Compound 952565	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779614&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565830	CC[C@@]1(c2cccc(-c3cnn4ccncc34)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779614	US20250313563, Compound 952565	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779614&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565831	CC[C@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779702	US20250313563, Compound 952564	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779702	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779702&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565832	CC[C@]1(c2cccc(-c3c(F)cncc3OC)c2)C2=C(N=NC2)NC2=C1C(=O)C(C)(C)C2			779702	US20250313563, Compound 952564	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779702	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779702&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565833	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780794	US20250313563, Compound 957505	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780794	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780794&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565834	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780794	US20250313563, Compound 957505	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780794	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780794&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565835	CC[C@]1(c2cccc(C(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779140	US20250313563, Compound 826717	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779140	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779140&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565836	CC[C@]1(c2cccc(C(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779140	US20250313563, Compound 826717	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779140	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779140&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565837	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780782	US20250313563, Compound 957200	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780782&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565838	CC[C@@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780782	US20250313563, Compound 957200	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780782&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565839	CC[C@]1(c2cccc(-c3ccnc4c3CCC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778955	US20250313563, Compound 948313	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778955	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778955&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565840	CC[C@]1(c2cccc(-c3ccnc4c3CCC4)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			778955	US20250313563, Compound 948313	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778955	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778955&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565841	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780572	US20250313563, Compound 946103	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780572&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565842	CC[C@]1(c2cccc(-c3ccnc(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780572	US20250313563, Compound 946103	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780572&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565843	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779349	US20250313563, Compound 949422	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779349	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779349&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565844	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779349	US20250313563, Compound 949422	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779349	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779349&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565845	CC[C@]1(c2cccc(-c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			780792	US20250313563, Compound 957504	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780792	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780792&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565846	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3CCC3)C2)C1			781121	US20250313563, Compound 947288	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781121	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781121&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565847	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21COC2(CN(C(=O)C3CCC3)C2)C1			781121	US20250313563, Compound 947288	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781121	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781121&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565848	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			779180	US20250313563, Compound 837753	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779180	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779180&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565849	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@@H]2F			779180	US20250313563, Compound 837753	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779180	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779180&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565850	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnn(CC(F)(F)F)c2)CC1			780870	US20250313563, Compound 948123	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780870&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565851	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cnn(CC(F)(F)F)c2)CC1			780870	US20250313563, Compound 948123	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780870&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565852	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			779182	US20250313563, Compound 837803	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779182	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779182&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565853	CC[C@@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			779182	US20250313563, Compound 837803	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779182	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779182&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565854	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cc(F)ccc2F)CC1			780811	US20250313563, Compound 948121	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780811	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780811&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565855	CC1(C)CC(=O)C2=C(C1)NC1=C(CN=N1)C21CCN(S(=O)(=O)c2cc(F)ccc2F)CC1			780811	US20250313563, Compound 948121	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780811	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780811&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565856	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779583	US20250313563, Compound 913046	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779583	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779583&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565857	CC[C@]1(c2cccc(-c3ccnn3C)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779583	US20250313563, Compound 913046	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779583	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779583&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565858	CC[C@]1(c2cccc(C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779393	US20250313563, Compound 949649	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779393	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779393&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565859	CC[C@]1(c2cccc(C(C)C)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(C)=C21			779393	US20250313563, Compound 949649	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779393	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779393&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565860	CC[C@]1(c2cccc(N(C)C(=O)c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779647	US20250313563, Compound 913311	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779647&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565861	CC[C@]1(c2cccc(N(C)C(=O)c3cnn(C)c3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779647	US20250313563, Compound 913311	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779647&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565862	CC[C@@]1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779330	US20250313563, Compound 884116	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779330	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779330&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565863	CC[C@@]1(c2cccc(N3CCCCC3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779330	US20250313563, Compound 884116	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779330	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779330&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565864	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779715	US20250313563, Compound 917289	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779715	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779715&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565865	CC[C@@]1(c2cccc(-c3ccnc(C)c3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779715	US20250313563, Compound 917289	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779715	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779715&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565866	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779407	US20250313563, Compound 949757	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779407	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779407&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565867	CC[C@@]1(c2cccc(-c3ccncc3F)c2)C2=C(CC(C)(C)NC2=O)NC2N=NC(Cl)=C21			779407	US20250313563, Compound 949757	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779407	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779407&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565868	CC[C@@]1(c2cccc(-c3ccncc3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779719	US20250313563, Compound 917292	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779719	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779719&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565869	CC[C@@]1(c2cccc(-c3ccncc3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C(F)(F)F)=C21			779719	US20250313563, Compound 917292	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779719	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779719&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565870	CC[C@@]1(c2cccc(-c3ccn(C)n3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779551	US20250313563, Compound 913030	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779551&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565871	CC[C@@]1(c2cccc(-c3ccn(C)n3)c2)C2=C(CC(C)(C)CC2=O)NC2N=NC(C)=C21			779551	US20250313563, Compound 913030	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779551&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565872	CC[C@@]1(c2cccc(-c3ccncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780413	US20250313563, Compound 945471	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780413	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780413&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565873	CC[C@@]1(c2cccc(-c3ccncc3OC)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780413	US20250313563, Compound 945471	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780413	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780413&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565874	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			779007	US20250313563, Compound 948512	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779007	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779007&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565875	CC[C@@]1(c2cccc(-c3ccncc3C)c2)C2=CN=NC2NC2=C1C(=O)NC1(CCC1)C2			779007	US20250313563, Compound 948512	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779007	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779007&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565876	CC[C@@]1(c2cccc(-c3ncnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780427	US20250313563, Compound 945482	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780427	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780427&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565877	CC[C@@]1(c2cccc(-c3ncnn3C)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780427	US20250313563, Compound 945482	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780427	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780427&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565878	CC[C@@]1(c2cccc(-c3cc(OC)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780387	US20250313563, Compound 944032	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780387	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780387&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565879	CC[C@@]1(c2cccc(-c3cc(OC)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780387	US20250313563, Compound 944032	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780387	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780387&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565880	CC[C@@]1(c2cccc(Cc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780636	US20250313563, Compound 947499	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780636	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780636&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565881	CC[C@@]1(c2cccc(Cc3ncccn3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780636	US20250313563, Compound 947499	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780636	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780636&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565882	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778798	US20250313563, Compound 790754	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778798&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565883	CC[C@]1(c2cccc(C(F)(F)F)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			778798	US20250313563, Compound 790754	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=778798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=778798&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565884	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780778	US20250313563, Compound 957197	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780778	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780778&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565885	CC[C@]1(c2ccccc2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)[C@H]2F			780778	US20250313563, Compound 957197	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780778	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780778&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565886	COc1cccc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780902	US20250313563, Compound 951789	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780902	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780902&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565887	COc1cccc(S(=O)(=O)N2CC[C@@]3(C2)C2=C(N=NC2)NC2=C3C(=O)CC(C)(C)C2)c1			780902	US20250313563, Compound 951789	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780902	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780902&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565888	CC[C@]1(c2cccc(-c3cc(OC)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779207	US20250313563, Compound 949108	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779207	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779207&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565889	CC[C@]1(c2cccc(-c3cc(OC)ncc3F)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779207	US20250313563, Compound 949108	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779207	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779207&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565890	CC[C@]1(c2cccc(N(C)c3nccc(OC)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780592	US20250313563, Compound 947336	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780592&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565891	CC[C@]1(c2cccc(N(C)c3nccc(OC)n3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			780592	US20250313563, Compound 947336	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=780592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=780592&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565892	CC[C@@]1(c2cccc(-c3cnn(C(C)(C)C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779215	US20250313563, Compound 949112	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779215	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779215&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565893	CC[C@@]1(c2cccc(-c3cnn(C(C)(C)C)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779215	US20250313563, Compound 949112	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779215	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779215&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565894	CC[C@@]1(c2cccc(C3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779010	US20250313563, Compound 811557	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779010	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779010&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565895	CC[C@@]1(c2cccc(C3CC3)c2)C2=CN=NC2NC2=C1C(=O)CC(C)(C)C2			779010	US20250313563, Compound 811557	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779010	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779010&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565896	CC[C@@]1(c2cccc(-c3cnn(-c4ccccn4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779616	US20250313563, Compound 952566	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779616&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565897	CC[C@@]1(c2cccc(-c3cnn(-c4ccccn4)c3)c2)C2=CN=NC2NC2=C1C(=O)NC(C)(C)C2			779616	US20250313563, Compound 952566	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=779616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=779616&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565898	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CC2(CCOCC2)C1			781117	US20250313563, Compound 874534	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781117	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781117&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565899	CC1(C)CC(=O)C2=C(C1)NC1N=NC=C1C21CC2(CCOCC2)C1			781117	US20250313563, Compound 874534	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781117	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781117&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565900	CC(C)(C)CC1N=NC2=C1[C@](C)(c1cccc(S(=O)(=O)CC3CC3)c1)C1=C(CC(C)(C)NC1=O)N2			781149	US20250313563, Compound 108005	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781149	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781149&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565901	CC(C)(C)CC1N=NC2=C1[C@](C)(c1cccc(S(=O)(=O)CC3CC3)c1)C1=C(CC(C)(C)NC1=O)N2			781149	US20250313563, Compound 108005	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781149	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781149&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565902	CC(C)(C)CC1N=NC2=C1[C@@](C)(c1cccc(S(=O)(=O)CC3CC3)c1)C1=C(CC(C)(C)NC1=O)N2			781150	US20250313563, Compound 108006	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781150	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781150&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565903	CC(C)(C)CC1N=NC2=C1[C@@](C)(c1cccc(S(=O)(=O)CC3CC3)c1)C1=C(CC(C)(C)NC1=O)N2			781150	US20250313563, Compound 108006	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781150	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781150&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565904	CC(C)(C)CC1N=NC2=C1[C@](C)(c1cccc(S(=O)(=O)N3CCCC3)c1)C1=C(CC(C)(C)NC1=O)N2			781151	US20250313563, Compound 108791	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781151	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781151&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565905	CC(C)(C)CC1N=NC2=C1[C@](C)(c1cccc(S(=O)(=O)N3CCCC3)c1)C1=C(CC(C)(C)NC1=O)N2			781151	US20250313563, Compound 108791	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781151	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781151&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565906	C[S@@](=O)c1cccc([C@@]2(C)C3=C(CC(C)(C)CC3=O)NC3=C2C(CC(C)(C)C)N=N3)c1			781152	US20250313563, Compound 126193	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781152	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781152&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565907	CC(C)(C)CC1N=NC2=C1[C@@](C)(c1cccc(S(=O)(=O)N3CCCC3)c1)C1=C(CC(C)(C)NC1=O)N2			781153	US20250313563, Compound 108794	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781153	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781153&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565908	CC(C)(C)CC1N=NC2=C1[C@@](C)(c1cccc(S(=O)(=O)N3CCCC3)c1)C1=C(CC(C)(C)NC1=O)N2			781153	US20250313563, Compound 108794	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781153	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781153&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565909	Cn1ccc(-c2cccc([C@]3(C)C4=C(CC(C)(C)CC4=O)NC4=C3C(CC(C)(C)C)N=N4)c2)n1			781154	US20250313563, Compound 126366	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781154	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781154&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565910	Cn1ccc(-c2cccc([C@]3(C)C4=C(CC(C)(C)CC4=O)NC4=C3C(CC(C)(C)C)N=N4)c2)n1			781154	US20250313563, Compound 126366	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781154	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781154&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565911	COc1cncc(F)c1-c1cccc([C@]2(C)C3=C(CC(C)(C)CC3=O)NC3=C2C(CC(C)(C)C)N=N3)c1			781155	US20250313563, Compound 108954	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781155	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781155&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565912	COc1cncc(F)c1-c1cccc([C@]2(C)C3=C(CC(C)(C)CC3=O)NC3=C2C(CC(C)(C)C)N=N3)c1			781155	US20250313563, Compound 108954	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781155	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781155&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565913	Cn1cc(-c2cccc([C@@]3(C)C4=C(CC(C)(C)CC4=O)NC4=C3C(CC(C)(C)C)N=N4)c2)cn1			781156	US20250313563, Compound 126367	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781156	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781156&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565914	Cn1cc(-c2cccc([C@@]3(C)C4=C(CC(C)(C)CC4=O)NC4=C3C(CC(C)(C)C)N=N4)c2)cn1			781156	US20250313563, Compound 126367	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781156	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781156&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565915	COc1cncc(F)c1-c1cccc([C@@]2(C)C3=C(CC(C)(C)CC3=O)NC3=C2C(CC(C)(C)C)N=N3)c1			781157	US20250313563, Compound 108956	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781157	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781157&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565916	COc1cncc(F)c1-c1cccc([C@@]2(C)C3=C(CC(C)(C)CC3=O)NC3=C2C(CC(C)(C)C)N=N3)c1			781157	US20250313563, Compound 108956	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781157	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781157&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565917	Cn1cc(-c2cccc([C@]3(C)C4=C(CC(C)(C)CC4=O)NC4=C3C(CC(C)(C)C)N=N4)c2)cn1			781158	US20250313563, Compound 126393	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781158	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781158&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565918	Cn1cc(-c2cccc([C@]3(C)C4=C(CC(C)(C)CC4=O)NC4=C3C(CC(C)(C)C)N=N4)c2)cn1			781158	US20250313563, Compound 126393	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781158	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781158&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565919	CC(C)(C)CC1N=NC2=C1[C@](C)(c1ccccc1)C1=C(CC(C)(C)NC1=O)N2			781159	US20250313563, Compound 114531	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781159	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781159&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565920	CC(C)(C)CC1N=NC2=C1[C@](C)(c1ccccc1)C1=C(CC(C)(C)NC1=O)N2			781159	US20250313563, Compound 114531	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781159	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781159&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565921	Cn1cc(-c2cccc([C@@]3(C)C4=C(CC(C)(C)CC4=O)NC4=C3C(CC(C)(C)C)N=N4)c2)cn1			781160	US20250313563, Compound 126394	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781160	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781160&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565922	CC(C)(C)CC1N=NC2=C1[C@@](C)(c1ccccc1)C1=C(CC(C)(C)NC1=O)N2			781161	US20250313563, Compound 114532	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781161	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781161&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565923	CC(C)(C)CC1N=NC2=C1[C@](C)(c1cccc(S(=O)(=O)C(F)(F)F)c1)C1=C(CC(C)(C)CC1=O)N2			781162	US20250313563, Compound 126395	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781162	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781162&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565924	CC(C)(C)CC1N=NC2=C1[C@](C)(c1cccc(S(=O)(=O)C(F)(F)F)c1)C1=C(CC(C)(C)CC1=O)N2			781162	US20250313563, Compound 126395	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781162	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781162&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565925	CC1(C)CC2=C(C(=O)N1)[C@@](C)(c1cccc(S(C)(=O)=O)c1)C1=C(N=NC1C1CC1)N2			781163	US20250313563, Compound 114679	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781163	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781163&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565926	CC1(C)CC2=C(C(=O)N1)[C@@](C)(c1cccc(S(C)(=O)=O)c1)C1=C(N=NC1C1CC1)N2			781163	US20250313563, Compound 114679	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781163	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781163&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565927	CC(C)(C)CC1N=NC2=C1[C@@](C)(c1cccc(S(=O)(=O)C(F)(F)F)c1)C1=C(CC(C)(C)CC1=O)N2			781164	US20250313563, Compound 126396	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781164	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781164&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565928	CC(C)(C)CC1N=NC2=C1[C@@](C)(c1cccc(S(=O)(=O)C(F)(F)F)c1)C1=C(CC(C)(C)CC1=O)N2			781164	US20250313563, Compound 126396	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781164	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781164&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565929	CC(C)(C)CC1N=NC2=C1[C@](C)(c1cccc(S(C)(=O)=O)c1)C1=C(CC(C)(C)CC1=O)N2			781165	US20250313563, Compound 114687	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781165	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781165&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565930	CC(C)(C)CC1N=NC2=C1[C@](C)(c1cccc(S(C)(=O)=O)c1)C1=C(CC(C)(C)CC1=O)N2			781165	US20250313563, Compound 114687	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781165	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781165&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565931	Cc1ccc(S(C)(=O)=O)cc1[C@]1(C)C2=C(CC(C)(C)CC2=O)NC2=C1C(CC(C)(C)C)N=N2			781166	US20250313563, Compound 126397	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781166	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781166&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565932	Cc1ccc(S(C)(=O)=O)cc1[C@]1(C)C2=C(CC(C)(C)CC2=O)NC2=C1C(CC(C)(C)C)N=N2			781166	US20250313563, Compound 126397	Glycogen synthase kinase-3 beta	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781166	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781166&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565933	Cc1ccc(S(C)(=O)=O)cc1[C@@]1(C)C2=C(CC(C)(C)CC2=O)NC2=C1C(CC(C)(C)C)N=N2			781167	US20250313563, Compound 126398	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781167	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781167&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565934	CC(C)(C)CC1N=NC2=C1[C@@](C)(c1cccc(N3C=COCC3)c1)C1=C(CC(C)(C)CC1=O)N2			781168	US20250313563, Compound 126399	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781168	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781168&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565935	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)[C@@]21COc2ccccc21			781169	US20250313563, Compound 117093	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781169	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781169&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565936	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)[C@@]21COc2ccccc21			781169	US20250313563, Compound 117093	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781169	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781169&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565937	CN1C[C@]2(C3=C(CC(C)(C)CC3=O)NC3N=NC(C4CC(F)(F)C4)=C32)c2ccccc21			781170	US20250313563, Compound 119047	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781170	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781170&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565938	CN1C[C@]2(C3=C(CC(C)(C)CC3=O)NC3N=NC(C4CC(F)(F)C4)=C32)c2ccccc21			781170	US20250313563, Compound 119047	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781170	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781170&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565939	CC1(C)CC(=O)C2=C(C1)NC1N=NC(C3CC(F)(F)C3)=C1[C@]21COc2ccccc21			781171	US20250313563, Compound 127429	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781171	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781171&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565940	CC1(C)CC(=O)C2=C(C1)NC1N=NC(C3CC(F)(F)C3)=C1[C@]21COc2ccccc21			781171	US20250313563, Compound 127429	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781171	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781171&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565941	CN1C[C@@]2(C3=C(CC(C)(C)CC3=O)NC3N=NC(C4CC(F)(F)C4)=C32)c2ccccc21			781172	US20250313563, Compound 119048	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781172	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781172&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565942	CN1C[C@@]2(C3=C(CC(C)(C)CC3=O)NC3N=NC(C4CC(F)(F)C4)=C32)c2ccccc21			781172	US20250313563, Compound 119048	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781172	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781172&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565943	CC1(C)CC(=O)C2=C(C1)NC1N=NC(C3CC(F)(F)C3)=C1[C@@]21COc2ccccc21			781173	US20250313563, Compound 127430	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781173	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781173&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565944	CC1(C)CC(=O)C2=C(C1)NC1N=NC(C3CC(F)(F)C3)=C1[C@@]21COc2ccccc21			781173	US20250313563, Compound 127430	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781173	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781173&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565945	CC(C)(C)CC1N=NC2=C1[C@](C)(c1cc(S(C)(=O)=O)ccc1F)C1=C(CC(C)(C)CC1=O)N2			781174	US20250313563, Compound 125976	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781174	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781174&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565946	CC(C)(C)CC1N=NC2=C1[C@](C)(c1cc(S(C)(=O)=O)ccc1F)C1=C(CC(C)(C)CC1=O)N2			781174	US20250313563, Compound 125976	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781174	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781174&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565947	CC(C)(C)CC1N=NC2=C1C1(CN(S(=O)(=O)CC3CC3)C1)C1=C(CC(C)(C)CC1=O)N2			781175	US20250313563, Compound 90285	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781175	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781175&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565948	CC(C)(C)CC1N=NC2=C1C1(CN(S(=O)(=O)CC3CC3)C1)C1=C(CC(C)(C)CC1=O)N2			781175	US20250313563, Compound 90285	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781175	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781175&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565949	CC(C)(C)CC1N=NC2=C1[C@@](C)(c1cc(S(C)(=O)=O)ccc1F)C1=C(CC(C)(C)CC1=O)N2			781176	US20250313563, Compound 125977	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781176	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781176&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565950	CC(C)(C)Cc1n[nH]c2c1C1(CN(C(=O)OCc3ccccc3)C1)C1=C(CC(C)(C)CC1=O)N2			781177	US20250313563, Compound 90330	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781177	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781177&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565951	CC(C)(C)Cc1n[nH]c2c1C1(CN(C(=O)OCc3ccccc3)C1)C1=C(CC(C)(C)CC1=O)N2			781177	US20250313563, Compound 90330	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781177	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781177&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565952	CN1C[C@]2(C3=C(CC(C)(C)CC3=O)NC3N=NC(CC(C)(C)C)=C32)c2ccccc21			781178	US20250313563, Compound 125978	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781178	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781178&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565953	CN1C[C@]2(C3=C(CC(C)(C)CC3=O)NC3N=NC(CC(C)(C)C)=C32)c2ccccc21			781178	US20250313563, Compound 125978	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781178	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781178&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565954	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)C21COC1			781179	US20250313563, Compound 90709	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781179	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781179&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565955	CN1C[C@@]2(C3=C(CC(C)(C)CC3=O)NC3N=NC(CC(C)(C)C)=C32)c2ccccc21			781180	US20250313563, Compound 125979	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781180	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781180&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565956	CN1C[C@@]2(C3=C(CC(C)(C)CC3=O)NC3N=NC(CC(C)(C)C)=C32)c2ccccc21			781180	US20250313563, Compound 125979	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781180	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781180&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565957	CC(=O)N1CC2(C1)C1=C(CC(C)(C)CC1=O)NC1N=NC(CC(C)(C)C)=C12			781181	US20250313563, Compound 90991	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781181	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781181&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565958	CN(C)S(=O)(=O)c1cccc([C@]2(C)C3=C(CC(C)(C)CC3=O)NC3=C2C(CC(C)(C)C)N=N3)c1			781182	US20250313563, Compound 126012	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781182	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781182&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565959	CN(C)S(=O)(=O)c1cccc([C@]2(C)C3=C(CC(C)(C)CC3=O)NC3=C2C(CC(C)(C)C)N=N3)c1			781182	US20250313563, Compound 126012	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781182	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781182&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565960	CN(C)S(=O)(=O)c1cccc([C@@]2(C)C3=C(CC(C)(C)CC3=O)NC3=C2C(CC(C)(C)C)N=N3)c1			781183	US20250313563, Compound 126013	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781183	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781183&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565961	CC(C)(C)CC1N=NC2=C1C1(CN(S(=O)(=O)c3ccccc3)C1)C1=C(CC(C)(C)CC1=O)N2			781184	US20250313563, Compound 92737	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781184	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781184&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565962	CC(C)(C)CC1N=NC2=C1C1(CN(S(=O)(=O)c3ccccc3)C1)C1=C(CC(C)(C)CC1=O)N2			781184	US20250313563, Compound 92737	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781184	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781184&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565963	Cn1cncc1-c1cccc([C@]2(C)C3=C(CC(C)(C)CC3=O)NC3=C2C(CC(C)(C)C)N=N3)c1			781185	US20250313563, Compound 126014	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781185	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781185&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565964	Cn1cncc1-c1cccc([C@]2(C)C3=C(CC(C)(C)CC3=O)NC3=C2C(CC(C)(C)C)N=N3)c1			781185	US20250313563, Compound 126014	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781185	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781185&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565965	CC(C)(C)CC1N=NC2=C1C1(CN(c3ccccc3)C1)C1=C(CC(C)(C)CC1=O)N2			781186	US20250313563, Compound 93429	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781186	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781186&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565966	CC(C)(C)CC1N=NC2=C1C1(CN(c3ccccc3)C1)C1=C(CC(C)(C)CC1=O)N2			781186	US20250313563, Compound 93429	Glycogen synthase kinase-3 beta	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781186	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781186&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565967	Cn1cncc1-c1cccc([C@@]2(C)C3=C(CC(C)(C)CC3=O)NC3=C2C(CC(C)(C)C)N=N3)c1			781187	US20250313563, Compound 126015	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781187	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781187&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565968	Cn1cncc1-c1cccc([C@@]2(C)C3=C(CC(C)(C)CC3=O)NC3=C2C(CC(C)(C)C)N=N3)c1			781187	US20250313563, Compound 126015	Glycogen synthase kinase-3 beta	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781187	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781187&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565969	CC1N=NC2=C1C1(CN(S(=O)(=O)CC3CC3)C1)C1=C(CC(C)(C)CC1=O)N2			781188	US20250313563, Compound 107828	Glycogen synthase kinase-3 alpha	Homo sapiens		<100							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781188	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781188&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565970	CC1N=NC2=C1C1(CN(S(=O)(=O)CC3CC3)C1)C1=C(CC(C)(C)CC1=O)N2			781188	US20250313563, Compound 107828	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781188	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781188&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565971	C[S@](=O)c1cccc([C@]2(C)C3=C(CC(C)(C)CC3=O)NC3=C2C(CC(C)(C)C)N=N3)c1			781189	US20250313563, Compound 126190	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781189	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781189&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565972	C[S@](=O)c1cccc([C@]2(C)C3=C(CC(C)(C)CC3=O)NC3=C2C(CC(C)(C)C)N=N3)c1			781189	US20250313563, Compound 126190	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781189	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781189&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565973	CC(C)(C)CC1N=NC2=C1C1(CN(S(=O)(=O)CC3CC3)C1)C1=C(CC3(CCC3)CC1=O)N2			781190	US20250313563, Compound 107829	Glycogen synthase kinase-3 alpha	Homo sapiens		 3000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781190	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781190&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565974	CC(C)(C)CC1N=NC2=C1C1(CN(S(=O)(=O)CC3CC3)C1)C1=C(CC3(CCC3)CC1=O)N2			781190	US20250313563, Compound 107829	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781190	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781190&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565975	C[S@@](=O)c1cccc([C@]2(C)C3=C(CC(C)(C)CC3=O)NC3=C2C(CC(C)(C)C)N=N3)c1			781191	US20250313563, Compound 126191B:	Glycogen synthase kinase-3 alpha	Homo sapiens		>5000							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781191	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781191&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565976	C[S@@](=O)c1cccc([C@]2(C)C3=C(CC(C)(C)CC3=O)NC3=C2C(CC(C)(C)C)N=N3)c1			781191	US20250313563, Compound 126191B:	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781191	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781191&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565977	CC1(C)CC(=O)C2=C(C1)NC1=C(C(C3CC3)N=N1)C21CN(S(=O)(=O)CC2CC2)C1			781192	US20250313563, Compound 109152	Glycogen synthase kinase-3 alpha	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781192	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781192&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565978	CC1(C)CC(=O)C2=C(C1)NC1=C(C(C3CC3)N=N1)C21CN(S(=O)(=O)CC2CC2)C1			781192	US20250313563, Compound 109152	Glycogen synthase kinase-3 beta	Homo sapiens		 550							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781192	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781192&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565979	CC(C)(C)CC1N=NC2=C1C1(CN(S(=O)(=O)CC3CC3)C1)C1=C(CC(C)(C)CC1=O)N2			781175	US20250313563, Compound 90285	Glycogen synthase kinase-3 beta	Homo sapiens		 3.00							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781175	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781175&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565980	CC(C)(C)CC1N=NC2=C1C1(CN(S(=O)(=O)CC3CC3)C1)C1=C(CC(C)(C)CC1=O)N2			781175	US20250313563, Compound 90285	Glycogen synthase kinase-3 beta	Homo sapiens		 55.0							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781175	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781175&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565981	CC(C)(C)CC1N=NC2=C1C1(CN(S(=O)(=O)CC3CC3)C1)C1=C(CC(C)(C)CC1=O)N2			781175	US20250313563, Compound 90285	Glycogen synthase kinase-3 alpha	Homo sapiens		 51.0							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781175	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781175&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565982	CC(C)(C)CC1N=NC2=C1C1(CN(S(=O)(=O)CC3CC3)C1)C1=C(CC(C)(C)CC1=O)N2			781175	US20250313563, Compound 90285	Glycogen synthase kinase-3 alpha	Homo sapiens		 956							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781175	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781175&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565983	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)C21COC1			781179	US20250313563, Compound 90709	Glycogen synthase kinase-3 beta	Homo sapiens		 38.0							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781179	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781179&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565984	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)C21COC1			781179	US20250313563, Compound 90709	Glycogen synthase kinase-3 beta	Homo sapiens		 1738							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781179	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781179&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565985	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)C21COC1			781179	US20250313563, Compound 90709	Glycogen synthase kinase-3 alpha	Homo sapiens		 1791							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781179	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781179&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565986	CC(C)(C)CC1=C2C(N=N1)NC1=C(C(=O)CC(C)(C)C1)C21COC1			781179	US20250313563, Compound 90709	Glycogen synthase kinase-3 alpha	Homo sapiens		 13719							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781179	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781179&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565987	CC(=O)N1CC2(C1)C1=C(CC(C)(C)CC1=O)NC1N=NC(CC(C)(C)C)=C12			781181	US20250313563, Compound 90991	Glycogen synthase kinase-3 beta	Homo sapiens		 113							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781181	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781181&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565988	CC(=O)N1CC2(C1)C1=C(CC(C)(C)CC1=O)NC1N=NC(CC(C)(C)C)=C12			781181	US20250313563, Compound 90991	Glycogen synthase kinase-3 beta	Homo sapiens		 3403							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781181	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781181&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565989	CC(=O)N1CC2(C1)C1=C(CC(C)(C)CC1=O)NC1N=NC(CC(C)(C)C)=C12			781181	US20250313563, Compound 90991	Glycogen synthase kinase-3 alpha	Homo sapiens		 3012							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781181	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781181&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565990	CC(=O)N1CC2(C1)C1=C(CC(C)(C)CC1=O)NC1N=NC(CC(C)(C)C)=C12			781181	US20250313563, Compound 90991	Glycogen synthase kinase-3 alpha	Homo sapiens		 17541							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781181	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781181&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565991	CC(C)(C)CC1N=NC2=C1C1(CN(S(=O)(=O)c3ccccc3)C1)C1=C(CC(C)(C)CC1=O)N2			781184	US20250313563, Compound 92737	Glycogen synthase kinase-3 beta	Homo sapiens		 66.0							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781184	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781184&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565992	CC(C)(C)CC1N=NC2=C1C1(CN(S(=O)(=O)c3ccccc3)C1)C1=C(CC(C)(C)CC1=O)N2			781184	US20250313563, Compound 92737	Glycogen synthase kinase-3 alpha	Homo sapiens		 438							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781184	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781184&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1565993	CC(C)(C)CC1N=NC2=C1C1(CN(c3ccccc3)C1)C1=C(CC(C)(C)CC1=O)N2			781186	US20250313563, Compound 93429	Glycogen synthase kinase-3 beta	Homo sapiens		 134							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781186	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1003&target=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781186&enzyme=Glycogen+synthase+kinase-3+beta&column=ki&startPg=0&Increment=50&submit=Search											1	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST	8FF8,8DJE,8DJD,8DJC,4PTG,4PTE,4PTC,4IQ6,4ACH,4ACG,4ACD,4ACC,6V6L,6H0U,6B8J,5OY4,3PUP,3M1S,2JLD,1J1C,1J1B,1I09,5KPM,5KPL,5KPK,5HLP,5HLN,4J71,4J1R,3SAY,3DU8,1PYX,9HV3,9HUL,9HUK,9FR9,9FR8,9FR7,9FR6,9FR5,8XN6,3Q3B,1Q4L,1Q41,1Q3W,1Q3D,6GJO,3L1S,3I4B,1Q5K,1R0E,4NU1,4NM3,4NM0,4NM7,4NM5,3ZRM,3ZRL,3ZRK,1GNG,4AFJ,6GN1,2O5K,8VMG,8VMF,8VME,8QJI,7Z1G,7Z1F,8AV1,8AUZ,7B6F,9PE9,9X2Y,9X2X,9X2W,9X2V,9X2U,9X2Q,5K5N,6TCU,2OW3,7U36,7U33,7OY5,3GB2,7U31,7SXJ,5F95,5F94,6Y9S,6Y9R,6HK4,6HK3,4B7T,3ZDI,3SD0,3F7Z,7U2Z,7SXH,6HK7	Glycogen synthase kinase-3 beta	GSK3B_HUMAN	P49841	D3DN89 Q9BWH3 Q9UL47		Glycogen synthase kinase-3 beta	Q6FI27_HUMAN	Q6FI27	D3DN88																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																													
1565994	CC(C)(C)CC1N=NC2=C1C1(CN(c3ccccc3)C1)C1=C(CC(C)(C)CC1=O)N2			781186	US20250313563, Compound 93429	Glycogen synthase kinase-3 alpha	Homo sapiens		 360							US Patent					US20250313563	Wagner, FF; Capacci, AG; Yousaf, Z; Chen, T; Ma, B; Lucas, BS; Shekhar, M; Kyei-Baffour, K; Weiwer, M; Gould, A	10/9/2025	1/31/2026	The Broad Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=781186	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1017&target=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=781186&enzyme=Glycogen+synthase+kinase-3+alpha&column=ki&startPg=0&Increment=50&submit=Search											1	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS	7SXF,7SXG,8VMG,8VMF,8VME,4NM7,4NM5	Glycogen synthase kinase-3 alpha	GSK3A_HUMAN	P49840	O14959